Therapeutic agents useful for treating pain

ABSTRACT

A compound of formula:  
                 
 
     wherein Ar 1 , A, R 3 , x, and m are as disclosed herein and Ar 2  is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson&#39;s disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington&#39;s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

[0001] This application claims the benefit of U.S. Provisional Application No. 60/435,917, filed Dec. 24, 2002; U.S. Provisional Application No. 60/459,626, filed Apr. 3, 2003; and U.S. Provisional Application No. 60/473,856, filed May 29, 2003, all of which are incorporated herein by reference in their entirety.

1. FIELD OF THE INVENTION

[0002] The present invention relates to Benzoazolylpiperazine Compounds, compositions comprising a Benzoazolylpiperazine Compound and methods for treating or preventing pain, urinary incontinence (UI), an ulcer, inflammatory-bowel disease (IBD), irritable-bowel syndrome (IBS), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression, comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound.

2. BACKGROUND OF THE INVENTION

[0003] Pain is the most common symptom for which patients seek medical advice and treatment. Pain can be acute or chronic. While acute pain is usually self-limited, chronic pain persists for 3 months or longer and can lead to significant changes in a patient's personality, lifestyle, functional ability and overall quality of life (K. M. Foley, Pain, in Cecil Textbook of Medicine 100-107(J. C. Bennett and F. Plum eds., 20th ed. 1996)).

[0004] Pain has been traditionally managed by administering non-opioid analgesics, such as acetylsalicylic acid, choline magnesium trisalicylate, acetaminophen, ibuprofen, fenoprofen, diflusinal, and naproxen; or opioid analgesics, including morphine, hydromorphone, methadone, levorphanol, fentanyl, oxycodone, and oxymorphone. Id.

[0005] UI is uncontrollable urination, generally caused by bladder-detrusor-muscle instability. UI affects people of all ages and levels of physical health, both in health care settings and in the community at large. At present, UI afflicts 15-30% of elderly people living at home, one-third of those living in acute-care settings, and at least one-half of those living in long-term care institutions (R. M. Resnick, Lancet 346:94 (1995)). Persons having UI are predisposed to also having urinary-tract infections, pressure ulcers, perineal rashes and urosepsis. Psychosocially, UI is associated with embarrassment, social stigmatization, depression and a risk of institutionalization (Herzo et al., Annu. Rev. Gerontol. Geriatr. 9:74 (1989)). Economically, the costs of UI are great; in the United States alone, health-care costs associated with UI are over $15 billion per annum.

[0006] Physiologic bladder contraction results in large part from acetylcholine-induced stimulation of post-ganglionic muscarinic-receptor sites on bladder smooth muscle. Treatments for UI include the administration of drugs having bladder-relaxant properties, which help to control bladder-detrusor-muscle overactivity. For example, anticholinergics such as propantheline bromide and glycopyrrolate, and combinations of smooth-muscle relaxants such as a combination of racemic oxybutynin and dicyclomine or an anticholinergic, have been used to treat UI (See, e.g., A. J. Wein, Urol. Clin. N. Am. 22:557-577 (1995); Levin et al., J. Urol. 128:396-398 (1982); Cooke et al., S. Afr. Med. J. 63:3 (1983); R. K. Mirakhur et al., Anaesthesia 38:1195-1204 (1983)). These drugs are not effective, however, in all patients having uninhibited bladder contractions. Administration of anticholinergic medications represent the mainstay of this type of treatment.

[0007] None of the existing commercial drug treatments for UI, however, has achieved complete success in all classes of UI patients, nor has treatment occurred without significant adverse side effects. For example, drowsiness, dry mouth, constipation, blurred vision, headaches, tachycardia, and cardiac arrhythmia, which are related to the anticholinergic activity of traditional anti-UI drugs, can occur frequently and adversely affect patient compliance. Yet despite the prevalence of unwanted anticholinergic effects in many patients, anticholinergic drugs are currently prescribed for patients having UI. The Merck Manual of Medical Information 631-634 (R. Berkow ed., 1997).

[0008] Ulcers are sores occurring where the lining of the digestive tract has been eroded by stomach acids or digestive juices. The sores are typically well-defined round or oval lesions primarily occurring in the stomach and duodenum. About 1 in 10 people develop an ulcer. Ulcers develop as a result of an imbalance between acid-secretory factors, also known as “aggressive factors,” such as stomach acid, pepsin, and Helicobacter pylori infection, and local mucosal-protective factors, such as secretion of bicarbonate, mucus, and prostaglandins.

[0009] Treatment of ulcers typically involves reducing or inhibiting the aggressive factors. For example, antacids such as aluminum hydroxide, magnesium hydroxide, sodium bicarbonate, and calcium bicarbonate can be used to neutralize stomach acids. Antacids, however, can cause alkalosis, leading to nausea, headache, and weakness. Antacids can also interfere with the absorption of other drugs into the blood stream and cause diarrhea.

[0010] H₂ antagonists, such as cimetidine, ranitidine, famotidine, and nizatidine, are also used to treat ulcers. H₂ antagonists promote ulcer healing by reducing gastric acid and digestive-enzyme secretion elicited by histamine and other H₂ agonists in the stomach and duodenum. H₂ antagonists, however, can cause breast enlargement and impotence in men, mental changes (especially in the elderly), headache, dizziness, nausea, myalgia, diarrhea, rash, and fever.

[0011] H⁺, K⁺—ATPase inhibitors such as omeprazole and lansoprazole are also used to treat ulcers. H⁺, K⁺—ATPase inhibitors inhibit the production of enzymes used by the stomach to secrete acid. Side effects associated with H⁺, K⁺—ATPase inhibitors include nausea, diarrhea, abdominal colic, headache, dizziness, somnolence, skin rashes, and transient elevations of plasma activities of aminotransferases.

[0012] Sucraflate is also used to treat ulcers. Sucraflate adheres to epithelial cells and is believed to form a protective coating at the base of an ulcer to promote healing. Sucraflate, however, can cause constipation, dry mouth, and interfere with the absorption of other drugs.

[0013] Antibiotics are used when Helicobacter pylori is the underlying cause of the ulcer. Often antibiotic therapy is coupled with the administration of bismuth compounds such as bismuth subsalicylate and colloidal bismuth citrate. The bismuth compounds are believed to enhance secretion of mucous and HCO₃ ⁻, inhibit pepsin activity, and act as an antibacterial against H. pylori. Ingestion of bismuth compounds, however, can lead to elevated plasma concentrations of Bi⁺³ and can interfere with the absorption of other drugs.

[0014] Prostaglandin analogues, such as misoprostal, inhibit secretion of acid and stimulate the secretion of mucous and bicarbonate and are also used to treat ulcers, especially ulcers in patients who require nonsteroidal anti-inflammatory drugs. Effective oral doses of prostaglandin analogues, however, can cause diarrhea and abdominal cramping. In addition, some prostaglandin analogues are abortifacients.

[0015] Carbenoxolone, a mineral corticoid, can also be used to treat ulcers. Carbenoxolone appears to alter the composition and quantity of mucous, thereby enhancing the mucosal barrier. Carbenoxolone, however, can lead to Na⁺ and fluid retention, hypertension, hypokalemia, and impaired glucose tolerance.

[0016] Muscarinic cholinergic antagonists such as pirenzapine and telenzapine can also be used to reduce acid secretion and treat ulcers. Side effects of muscarinic cholinergic antagonists include dry mouth, blurred vision, and constipation. The Merck Manual of Medical Information 496-500 (R. Berkow ed., 1997) and Goodman and Gilman 's The Pharmacological Basis of Therapeutics 901-915 (J. Hardman and L. Limbird eds., 9^(th) ed. 1996).

[0017] IBD is a chronic disorder in which the bowel becomes inflamed, often causing recurring abdominal cramps and diarrhea. The two types of IBD are Crohn's disease and ulcerative colitis.

[0018] Crohn's disease, which can include regional enteritis, granulomatous ileitis, and ileocolitis, is a chronic inflammation of the intestinal wall. Crohn's disease occurs equally in both sexes and is more common in Jews of eastern-European ancestry. Most cases of Crohn's disease begin before age 30 and the majority start between the ages of 14 and 24. The disease typically affects the full thickness of the intestinal wall. Generally the disease affects the lowest portion of the small intestine (ileum) and the large intestine, but can occur in any part of the digestive tract.

[0019] Early symptoms of Crohn's disease are chronic diarrhea, crampy abdominal pain, fever, loss of appetite, and weight loss. Complications associated with Crohn's disease include the development of intestinal obstructions, abnormal connecting channels (fistulas), and abscesses. The risk of cancer of the large intestine is increased in people who have Crohn's disease. Often Crohn's disease is associated with other disorders such as gallstones, inadequate absorption of nutrients, amyloidosis, arthritis, episcleritis, aphthous stomatitis, erythema nodosum, pyoderma gangrenosum, ankylosing spondylitis, sacroilitis, uveitis, and primary sclerosing cholangitis. There is no known cure for Crohn's disease.

[0020] Cramps and diarrhea, side effects associated with Crohn's disease, can be relieved by anticholinergic drugs, diphenoxylate, loperamide, deodorized opium tincture, or codeine. Generally, the drug is taken orally before a meal.

[0021] Broad-spectrum antibiotics are often administered to treat the symptoms of Crohn's disease. The antibiotic metronidazole is often administered when the disease affects the large intestine or causes abscesses and fistulas around the anus. Long-term use of metronidazole, however, can damage nerves, resulting in pins-and-needles sensations in the arms and legs. Sulfasalazine and chemically related drugs can suppress mild inflammation, especially in the large intestine. These drugs, however, are less effective in sudden, severe flare-ups. Corticosteroids, such as prednisone, reduce fever and diarrhea and relieve abdominal pain and tenderness. Long-term corticosteroid therapy, however, invariably results in serious side effects such as high blood-sugar levels, increased risk of infection, osteoporosis, water retention, and fragility of the skin. Drugs such as azathioprine and mercaptourine can compromise the immune system and are often effective for Crohn's disease in patients that do not respond to other drugs. These drugs, however, usually need 3 to 6 months before they produce benefits and can cause serious side effects such as allergy, pancreatitis, and low white-blood-cell count.

[0022] When Crohn's disease causes the intestine to be obstructed or when abscesses or fistulas do not heal, surgery can be necessary to remove diseased sections of the intestine. Surgery, however, does not cure the disease, and inflammation tends to recur where the intestine is rejoined. In almost half of the cases a second operation is needed. The Merck Manual of Medical Information 528-530 (R. Berkow ed., 1997).

[0023] Ulcerative colitis is a chronic disease in which the large intestine becomes inflamed and ulcerated, leading to episodes of bloody diarrhea, abdominal cramps, and fever. Ulcerative colitis usually begins between ages 15 and 30; however, a small group of people have their first attack between ages 50 and 70. Unlike Crohn's disease, ulcerative colitis never affects the small intestine and does not affect the full thickness of the intestine. The disease usually begins in the rectum and the sigmoid colon and eventually spreads partially or completely through out the large intestine. The cause of ulcerative colitis is unknown.

[0024] Treatment of ulcerative colitis is directed to controlling inflammation, reducing symptoms, and replacing lost fluids and nutrients. Anticholinergic drugs and low doses of diphenoxylate or loperamide are administered for treating mild diarrhea. For more intense diarrhea higher doses of diphenoxylate or loperamide, or deodorized opium tincture or codeine are administered. Sulfasalazine, olsalazie, prednisone, or mesalamine can be used to reduce inflammation. Azathioprine and mercaptopurine have been used to maintain remissions in ulcerative-colitis patients who would otherwise need long-term corticosteroid treatment. In severe cases of ulcerative colitis the patient is hospitalized and given corticosteroids intravenously. People with severe rectal bleeding can require transfusions and intravenous fluids. If toxic colitis develops and treatments fail, surgery to remove the large intestine can be necessary. Non-emergency surgery can be performed if cancer is diagnosed, precancerous legions are detected, or unremitting chronic disease would otherwise make the person an invalid or dependent on high doses of corticosteroids. Complete removal of the large intestine and rectum permanently cures ulcerative colitis. The Merck Manual of Medical Information 530-532 (R. Berkow ed., 1997) and Goodman and Gilman 's The Pharmacological Basis of Therapeutics (J. Hardman and L. Limbird eds., 9^(th) ed. 1996).

[0025] IBS is a disorder of motility of the entire gastrointestinal tract, causing abdominal pain, constipation, and/or diarrhea. IBS affects three-times more women than men. In IBS stimuli such as stress, diet, drugs, hormones, or irritants can cause the gastrointestinal tract to contract abnormally. During an episode of IBS contractions of the gastrointestinal tract become stronger and more frequent, resulting in the rapid transit of food and feces through the small intestine, often leading to diarrhea. Cramps result from the strong contractions of the large intestine and increased sensitivity of pain receptors in the large intestine.

[0026] There are two major types of IBS. The first type, spastic-colon type, is commonly triggered by eating, and usually produces periodic constipation and diarrhea with pain. Mucous often appears in the stool. The pain can come in bouts of continuous dull aching pain or cramps, usually in the lower abdomen. The person suffering from spastic-colon type IBS can also experience bloating, gas, nausea, headache, fatigue, depression, anxiety, and difficulty concentrating. The second type of IBS usually produces painless diarrhea or constipation. The diarrhea can begin suddenly and with extreme urgency. Often the diarrhea occurs soon after a meal and can sometimes occur immediately upon awakening.

[0027] Treatment of IBS typically involves modification of an IBS-patient's diet. Often it is recommended that an IBS patient avoid beans, cabbage, sorbitol, and fructose. A low-fat, high-fiber diet can also help some IBS patients. Regular physical activity can also help keep the gastrointestinal tract functioning properly. Drugs such as propantheline that slow the function of the gastrointestinal tract are generally not effective for treating IBS. Antidiarrheal drugs, such as diphenoxylate and loperamide, help with diarrhea. The Merck Manual of Medical Information 525-526 (R. Berkow ed., 1997).

[0028] Many drugs can cause physical and/or psychological addiction. Those most well known types of these drugs include opiates, such as heroin, opium, and morphine; sympathomimetics, including cocaine and amphetamines; sedative-hypnotics, including alcohol, benzodiazepines and barbiturates; and nicotine, which has effects similar to opioids and sympathomimetics. Drug addiction is characterized by a craving or compulsion for taking the drug and an inability to limit its intake. Additionally, drug dependence is associated with drug tolerance, the loss of effect of the drug following repeated administration, and withdrawal, the appearance of physical and behavioral symptoms when the drug is not consumed. Sensitization occurs if repeated administration of a drug leads to an increased response to each dose. Tolerance, sensitization, and withdrawal are phenomena evidencing a change in the central nervous system resulting from continued use of the drug. This change can motivate the addicted individual to continue consuming the drug despite serious social, legal, physical and/or professional consequences. (See, e.g., U.S. Pat. No. 6,109,269 to Rise et al.).

[0029] Certain pharmaceutical agents have been administered for treating addiction. U.S. Pat. No. 5,556,838 to Mayer et al. discloses the use of nontoxic NMDA-blocking agents co-administered with an addictive substance to prevent the development of tolerance or withdrawal symptoms. U.S. Pat. No. 5,574,052 to Rose et al. discloses co-administration of an addictive substance with an antagonist to partially block the pharmacological effects of the substance. U.S. Pat. No. 5,075,341 to Mendelson et al. discloses the use of a mixed opiate agonist/antagonist to treat cocaine and opiate addiction. U.S. Pat. No. 5,232,934 to Downs discloses administration of 3-phenoxypyridine to treat addiction. U.S. Pat. Nos. 5,039,680 and 5,198,459 to Imperato et al. disclose using a serotonin antagonist to treat chemical addiction. U.S. Pat. No. 5,556,837 to Nestler et. al. discloses infusing BDNF or NT-4 growth factors to inhibit or reverse neurological adaptive changes that correlate with behavioral changes in an addicted individual. U.S. Pat. No. 5,762,925 to Sagan discloses implanting encapsulated adrenal medullary cells into an animal's central nervous system to inhibit the development of opioid intolerance. U.S. Pat. No. 6,204,284 to Beer et al. discloses racemic (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane for use in the prevention or relief of a withdrawal syndrome resulting from addiction to drugs and for the treatment of chemical dependencies.

[0030] Parkinson's disease is a clinical syndrome comprising bradykinesia (slowness and poverty of movement), muscular rigidity, resting tremor (which usually abates during voluntary movement), and an impairment of postural balance leading to disturbance of gait and falling. The features of Parkinson's disease are a loss of pigmented, dopaminergic neurons of the substantia nigra pars compacta and the appearance of intracellular inclusions known as Lewy bodies (Goodman and Gillman 's The Pharmaceutical Basis of Therapeutics 506 (9^(th) ed. 1996)). Without treatment, Parkinson's disease progresses to a rigid akinetic state in which patients are incapable of caring for themselves. Death frequently results from complications of immobility, including aspiration pneumonia or pulmonary embolism. Drugs commonly used for the treatment of Parkinson's disease include carbidopa/levodopa, pergolide, bromocriptine, selegiline, amantadine, and trihexyphenidyl hydrochloride. There remains, however, a need for drugs useful for the treatment of Parkinson's disease and having an improved therapeutic profile.

[0031] Anxiety is a fear, apprehension, or dread of impending danger often accompanied by restlessness, tension, tachycardia, and dyspnea. Other symptoms commonly associated with anxiety include depression, especially accompanied with dysthymic disorder (chronic “neurotic” depression); panic disorder; agoraphobia and other specific phobias; eating disorders; and many personality disorders. Often anxiety is unattached to a clearly identified treatable primary illness. If a primary illness is found, however, it can be desirable to deal with the anxiety at the same time as the primary illness.

[0032] Currently, benzodiazepines are the most commonly used anti-anxiety agents for generalized anxiety disorder. Benzodiazepines, however, carry the risk of producing impairment of cognition and skilled motor functions, particularly in the elderly, which can result in confusion, delerium, and falls with fractures. Sedatives are also commonly prescribed for treating anxiety. The azapirones, such as buspirone, are also used to treat moderate anxiety. The azapirones, however, are less useful for treating severe anxiety accompanied with panic attacks.

[0033] Epilepsy is a disorder characterized by the tendency to have recurring seizures. The etiology commonly consists of lesions in some part of the cortex, such as a tumor; developmental malformation; or damage due to trauma or stroke. In some cases the etiology is genetic. An epileptic seizure can be triggered by repetitive sounds, flashing lights, video games, or touching certain parts of the body. Epilepsy is typically treated with anti-seizure drugs. In epilepsy cases, where anti-seizure drugs are ineffective, and the defect in the brain is isolated to a small area of the brain, surgical removal of that part of the brain can be helpful in alleviating the seizures. In patients who have several sources for the seizures or who have seizures that spread quickly to all parts of the brain, surgical removal of the nerve fibers that connect the two sides of the brain can be helpful.

[0034] Examples of drugs for treating a seizure and epilepsy include carbamazepine, ethosuximide, gabapentin, lamotrignine, phenobarbital, phenytoin, primidone, valproic acid, trimethadione, bemzodiaepines, γ-vinyl GABA, acetazolamide, and felbamate. Anti-seizure drugs, however, can have side effects such as drowsiness; hyperactivity; hallucinations; inability to concentrate; central and peripheral nervous system toxicity, such as nystagmus, ataxia, diplopia, and vertigo; gingival hyperplasia; gastrointestinal disturbances such as nausea, vomiting, epigastric pain, and anorexia; endocrine effects such as inhibition of antidiuretic hormone, hyperglycemia, glycosuria, osteomalacia; and hypersensitivity such as scarlatiniform rash, morbilliform rash, Stevens-Johnson syndrome, systemic lupus erythematosus, and hepatic necrosis; and hematological reactions such as red-cell aplasia, agranulocytosis, thrombocytopenia, aplastic anemia, and megaloblastic anemia. The Merck Manual of Medical Information 345-350 (R. Berkow ed., 1997).

[0035] A seizure is the result of abnormal electrical discharge in the brain. The discharge can involve a small area of the brain and lead to the person only noticing an odd taste or smell or it can involve a large area of the brain and lead to convulsions, i.e., a seizure that causes jerking and spasms of the muscles throughout the body. Convulsions can also result in brief attacks of altered consciousness and loss of consciousness, muscle control, or bladder control. A seizures is often preceded by auras, i.e., unusual sensations of smell, taste, or vision or an intense feeling that a seizure is about to begin. A seizure typically lasts for about 2 to 5 minutes. When the seizure ends the person can have headache, sore muscles, unusual sensations, confusion, and profound fatigue (postictal state). Usually the person cannot remember what happened during the seizure.

[0036] A stroke or cerebrovascular accident, is the death of brain tissue (cerebral infarction) resulting from the lack of blood flow and insufficient oxygen to the brain. A stroke can be either ischemic or hemorrhagic. In an ischemic stroke, blood supply to the brain is cut off because of athersclerosis or a blood clot that has blocked a blood vessel. In a hemorrhagic stroke, a blood vessel bursts preventing normal blood flow and allowing blood to leak into an area of the brain and destroying it. Most strokes develop rapidly and cause brain damage within minutes. In some cases, however, strokes can continue to worsen for several hours or days. Symptoms of strokes vary depending on what part of the brain is effected. Symptoms include loss or abnormal sensations in an arm or leg or one side of the body, weakness or paralysis of an arm or leg or one side of the body, partial loss of vison or hearing, double vision, dizziness, slurred speech, difficulty in thinking of the appropriate word or saying it, inability to recognize parts of the body, unusual movements, loss of bladder control, imbalance, and falling, and fainting. The symptoms can be permanent and can be associated with coma or stupor. Strokes can cause edema or swelling of the brain which can further damage brain tissue. For persons suffering from a stroke, intensive rehabilitation can help overcome the disability caused by impairment of brain tissue. Rehabilitation trains other parts of the brain to assume the tasks previously performed by the damaged part.

[0037] Examples of drugs for treating strokes include anticoagulants such as heparin, drugs that break up clots such as streptokinase or tissue plasminogen activator, and drugs that reduce swelling such as mannitol or corticosteroids. The Merck Manual of Medical Information 352-355 (R. Berkow ed., 1997).

[0038] Pruritus is an unpleasant sensation that prompts scratching. Pruritus can be attributed to dry skin, scabies, dermatitis, herpetiformis, atopic dermatitis, pruritus vulvae et ani, miliaria, insect bites, pediculosis, contact dermatitis, drug reactions, urticaria, urticarial eruptions of pregnancy, psoriasis, lichen planus, lichen simplex chronicus, exfoliative dermatitis, folliculitis, bullous pemphigoid, and fiberglass dermatitis. Conventionally, pruritus is treated by phototherapy with ultraviolet B or PUVA or with therapeutic agents such as naltrexone, nalmefene, danazol, tricyclics, and antidepressants.

[0039] Selective antagonists of the metabotropic glutamate receptor 5 (“mGluR5”) have been shown to exert analgesic activity in in vivo animal models (K. Walker et al., Neuropharmacology 40:1-9 (2000) and A. Dogrul et al., Neuroscience Letters, 292(2): 115-118 (2000)).

[0040] Selective antagonists of the mGluR5 receptor have also been shown to exert anxiolytic and anti-depressant activity in in vivo animal models (E. Tatarczynska et al., Br. J. Pharmacol. 132(7):1423-1430 (2001) and P. J. M. Will et al., Trends in Pharmacological Sciences 22(7):331-37 (2001)).

[0041] Selective antagonists of the mGluR5 receptor have also been shown to exert anti-Parkinson activity in vivo (K. J. Ossowska et al., Neuropharmacology 41(4):413-20 (2001) and P. J. M. Will et al., Trends in Pharmacological Sciences 22(7):331-37 (2001)).

[0042] Selective antagonists of the mGluR5 receptor have also been shown to exert anti-dependence activity in vivo (C. Chiamulera et al., Nature Neuroscience 4(9):873-74 (2001)).

[0043] U.S. Pat. No. 6,150,129 to Cook et al. describes a class of dinitrogen heterocycles useful as antibiotics.

[0044] U.S. Pat. No. 5,529,998 to Habich et al. describes a class of benzooxazolyl- and benzothiazolyloxazolidones useful as antibacterials.

[0045] International publication no. WO 01/57008 describes a class of 2-benzothiazolyl urea derivatives useful as inhibitors of serine/threonine and tyrosine kinases.

[0046] International publication no. WO 02/08221 describes aryl piperazine compounds useful for treating chronic and acute pain conditions, itch, and urinary incontinence.

[0047] International publication no. WO 99/37304 describes substituted oxoazaheterocycly compounds useful for inhibiting factor Xa.

[0048] International publication no. WO 00/59510 describes aminopyrimidines useful as sorbitol dehydrogenase inhibitors.

[0049] Japanese patent application no. 11-199573 to Kiyoshi et al. describes benzothiazole derivatives that are neuronal 5HT3 receptor agonists in the intestinal canal nervous system and useful for treating digestive disorders and pancreatic insufficiency.

[0050] German patent application no 199 34 799 to Rainer et al. describes a chiral-smectic liquid crystal mixture containing compounds with 2 linked (hetero)aromatic rings or compounds with 3 linked (hetero)aromatic rings.

[0051] M. Chu-Moyer et al., J. Med. Chem. 45:511-528 (2002) describes heterocycle-substituted piperazino-pyrimidines useful as sorbitol dehydrogenase inhibitors.

[0052] B. G. Khadse et al., Bull. Haff. Instt. 1(3):27-32 (1975) describes 2-(N⁴-substituted-N¹-piperazinyl)pyrido(3,2-d)thiazoles and 5-nitro-2-(N⁴-substituted-N¹-piperazinyl)benzthiazoles useful as anthelmintic agents.

[0053] There remains, however, a clear need in the art for new drugs useful for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression.

[0054] Citation of any reference in Section 2 of this application is not to be construed as an admission that such reference is prior art to the present application.

3. SUMMARY OF THE INVENTION

[0055] The present invention encompasses compounds having the formula (Ia):

[0056] and pharmaceutically acceptable salts thereof, wherein

[0057] Ar₁ is

[0058] A is

[0059] R₁ is —Cl, —Br, —I, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0060] each R² is independently:

[0061] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0062] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0063] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0064] each R₃ is independently:

[0065] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0066] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0067] (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0068] R₄ is —H or —(C₁-C₆)alkyl;

[0069] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R_(—7), or —S(O)₂R₇;

[0070] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0071] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0072] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0073] each -halo is —F, —Cl, —Br,— or —I;

[0074] n is an integer ranging from 0 to 3;

[0075] p is an integer ranging from 0 to 2;

[0076] m is 0 or 1; and

[0077] x is 0 or 1.

[0078] The present invention encompasses compounds having the formula (Ib):

[0079] and pharmaceutically acceptable salts thereof, wherein

[0080] Ar₁ is

[0081] A is

[0082] R₁is —H, -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0083] each R² is independently:

[0084] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0085] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0086] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0087] each R₃ is independently:

[0088] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0089] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0090] (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0091] R₄ is —H or —(C₁-C₆)alkyl;

[0092] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0093] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0094] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0095] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0096] each -halo is —F, —Cl, —Br,— or —I;

[0097] p is an integer ranging from 0 to 2;

[0098] m is 0 or 1; and

[0099] x is 0 or 1.

[0100] The present invention encompasses compounds having the formula (IIa):

[0101] and pharmaceutically acceptable salts thereof, wherein

[0102] R₁ is —Cl, —Br, —I, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0103] each R² is independently:

[0104] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0105] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0106] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0107] each R₃ is independently:

[0108] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0109] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0110] (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0111] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0112] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0113] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0114] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0115] R₁₀ is —H or —(C₁-C₄)alkyl;

[0116] each -halo is —F, —Cl, —Br,— or —I;

[0117] n is an integer ranging from 0 to 3;

[0118] p is an integer ranging from 0 to 2; and

[0119] m is 0 or 1.

[0120] The present invention encompasses compounds having the formula (IIb):

[0121] and pharmaceutically acceptable salts thereof, wherein

[0122] Ar₁ is

[0123] A is

[0124] R₁ is —H, -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0125] each R² is independently:

[0126] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0127] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0128] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0129] each R₃ is independently:

[0130] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0131] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0132] (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0133] R₄ is —H or —(C₁-C₆)alkyl;

[0134] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0135] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0136] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0137] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0138] R₁₀ is —H or —(C₁-C₄)alkyl;

[0139] each -halo is —F, —Cl, —Br,— or —I;

[0140] p is an integer ranging from 0 to 2;

[0141] m is 0 or 1; and

[0142] x is 0 or 1.

[0143] The present invention encompasses compounds having the formula (IIIa):

[0144] and pharmaceutically acceptable salts thereof, wherein

[0145] Ar₁ is

[0146] A is

[0147] R₁is —Cl, —Br, —I, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0148] each R² is independently:

[0149] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0150] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0151] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0152] each R₃ is independently:

[0153] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0154] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0155] (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0156] R₄ is —H or —(C₁-C₆)alkyl;

[0157] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0158] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0159] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0160] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH2(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0161] each -halo is —F, —Cl, —Br,— or —I;

[0162] n is an integer ranging from 0 to 3;

[0163] p is an integer ranging from 0 to 2;

[0164] m is 0 or 1; and

[0165] x is 0 or 1.

[0166] The present invention encompasses compounds having the formula (IIIb):

[0167] and pharmaceutically acceptable salts thereof, wherein

[0168] Ar₁ is

[0169] A is

[0170] R₁ is —H, -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0171] each R² is independently:

[0172] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0173] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0174] (c) -phenyl, -naphthyl, or —(C₁₄)aryl each of which is unsubstituted or substituted with one or more R₆ groups;

[0175] each R₃ is independently:

[0176] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0177] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0178] (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0179] R₄ is —H or —(C₁-C₆)alkyl;

[0180] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0181] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0182] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0183] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0184] each -halo is —F, —Cl, —Br,— or —I;

[0185] p is an integer ranging from 0 to 2;

[0186] m is 0 or 1; and

[0187] x is 0 or 1.

[0188] The present invention also encompasses compounds having the formula (IVa):

[0189] and pharmaceutically acceptable salts thereof, wherein

[0190] Ar₁ is

[0191] Ar₂ is

[0192] R₁ is -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0193] each R² is independently:

[0194] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0195] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0196] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0197] R₃ is —H or —CH₃:

[0198] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0199] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0200] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0201] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0202] each -halo is —F, —Cl, —Br,— or —I;

[0203] n is an integer ranging from 0 to 3; and

[0204] p is an integer ranging from 0 to 2.

[0205] The present invention also encompasses compounds having the formula (IVb):

[0206] and pharmaceutically acceptable salts thereof, wherein

[0207] Ar₁ is

[0208] Ar₂ is

[0209] A is

[0210] R₁ is -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0211] each R² is independently:

[0212] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0213] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0214] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0215] R₃ is —CH₃;

[0216] R₄ is —H or —(C₁-C₆)alkyl;

[0217] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0218] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0219] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0220] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0221] each -halo is —F, —Cl, —Br,— or —I;

[0222] n is an integer ranging from 0 to 3;

[0223] p is an integer ranging from 0 to 2; and

[0224] x is 0 or 1.

[0225] The present invention also encompasses compounds having the formula (V):

[0226] and pharmaceutically acceptable salts thereof, wherein

[0227] Ar₁ is

[0228] Ar₂ is

[0229] R₁ is -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo);

[0230] each R² is independently:

[0231] (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂;

[0232] (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,—(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or

[0233] (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0234] R₃ is —H or —CH₃:

[0235] each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0236] each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0237] each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂;

[0238] R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇;

[0239] each -halo is —F, —Cl, —Br,— or —I;

[0240] n is an integer ranging from 0 to 3; and

[0241] p is an integer ranging from 0 to 2.

[0242] A compound of formula (Ia), (Ib), (IIa), (IIb), (IIIa), (IIIb), (IVa), (IVb), and (V) or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”) is useful for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal.

[0243] The invention also relates to compositions comprising an effective amount of a Benzoazolylpiperazine Compound and a pharmaceutically acceptable carrier or excipient. The compositions are useful for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal.

[0244] The invention further relates to methods for treating pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound.

[0245] The invention further relates to methods for preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound.

[0246] The invention still further relates to methods for inhibiting Vanilloid Receptor 1 (“VR1”) function in a cell, comprising contacting a cell capable of expressing VR1 with an effective amount of a Benzoazolylpiperazine Compound.

[0247] The invention still further relates to methods for inhibiting mGluR₅ function in a cell, comprising contacting a cell capable of expressing mGluR₅ with an effective amount of a Benzoazolylpiperazine Compound.

[0248] The invention still further relates to methods for inhibiting metabotropic glutamate receptor 1 (“mGluR1”) function in a cell, comprising contacting a cell capable of expressing mGluR1 with an effective amount of a Benzoazolylpiperazine Compound.

[0249] The invention still further relates to a method for preparing a composition comprising the step of admixing a Benzoazolylpiperazine Compound and a pharmaceutically acceptable carrier or excipient.

[0250] The invention still further relates to a kit comprising a container containing an effective amount of a Benzoazolylpiperazine Compound.

[0251] The present invention still further relates to a compound selected from the group consisting of

[0252] and pharmaceutically acceptable salts thereof.

[0253] The present invention still further relates to a compound selected from the group consisting of

[0254] and pharmaceutically acceptable salts thereof.

[0255] The present invention still further relates to a compound selected from the group consisting of

[0256] and pharmaceutically acceptable salts thereof.

[0257] The present invention can be understood more fully by reference to the following detailed description and illustrative examples, which are intended to exemplify non-limiting embodiments of the invention.

4. DETAILED DESCRIPTION OF THE INVENTION 4.1 The Compounds of Formula (Ia)

[0258] As stated above, the present invention encompasses compounds of Formula (Ia)

[0259] and pharmaceutically acceptable salts thereof, where Ar₁, R₃, R₈, R₉, A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (Ia).

[0260] In one embodiment, Ar₁ is a pyridyl group.

[0261] In another embodiment, Ar₁ is a pyrimidinyl group.

[0262] In another embodiment, x is 1 and A is —C(O)—N(R₄)—.

[0263] In another embodiment, x is 1 and A is —C(S)—N(R₄)—.

[0264] In another embodiment x is 0.

[0265] In another embodiment, n or p is 0.

[0266] In another embodiment, n or p is 1.

[0267] In another embodiment, m is 0.

[0268] In another embodiment, m is 1.

[0269] In another embodiment, R₄ is —H.

[0270] In another embodiment, R₄ is —(C₁-C₆)alkyl.

[0271] In another embodiment, Ar₁ is a pyridyl group, x is 1, and A is —C(O)N(R₄)—.

[0272] In another embodiment, Ar₁ is a pyridyl group, x is 1, and A is —C(S)N(R₄)—.

[0273] In another embodiment, Ar₁ is a pyrimidinyl group, x is 1, and A is —(O)N(R₄)—.

[0274] In another embodiment, Ar₁ is a pyrimidinyl group, x is 1, and A is —C(S)N(R₄)—.

[0275] In another embodiment, R₁ is —Cl.

[0276] In another embodiment, R₁ is —Br.

[0277] In another embodiment, R₁ is —I.

[0278] In another embodiment, R₁ is —(C₁-C₆)alkyl.

[0279] In another embodiment, R₁ is —CH₃.

[0280] In another embodiment, R₁ is —NO₂.

[0281] In another embodiment, R₁ is —CN.

[0282] In another embodiment, R₁ is —OH.

[0283] In another embodiment, R₁ is —OCH₃.

[0284] In another embodiment, R₁ is —NH₂.

[0285] In another embodiment, R₁ is —C(halo)₃.

[0286] In another embodiment, R₁ is —CH(halo)₂.

[0287] In another embodiment, R₁ is —CH₂(halo).

[0288] In another embodiment, n and p are 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[0289] In another embodiment, n and p are 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0290] In another embodiment, n and p are 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0291] In another embodiment, m is 1 and R₃ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[0292] In another embodiment, m is 1 and R₃ is —(C₁-C₁₀)alkyl, —(C₂—C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,—(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0293] In another embodiment, m is 1 and R₃ is -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups.

[0294] In another embodiment, R₈ and R₉ are each independently —H, -halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[0295] In another embodiment, at least one of R₈ and R₉ is —H.

[0296] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; and R₈ and R₉ are —H.

[0297] In another embodiment, n, p, and m are 0; R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄is —H, and R₈ and R₉ are —H.

[0298] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; is —H; R₈ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₁ is —Cl. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0299] In another embodiment, n, p, and m are 0; R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₁ is —Cl. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0300] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₁ is —Cl. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0301] In another embodiment, n, p, and m are 0; R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₁ is —Cl. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0302] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0303] In another embodiment, n, p, and m are 0; R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₁ is —CH₃.

[0304] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0305] In another embodiment, n, p, and m are 0; R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0306] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0307] In another embodiment, n, p, and m are 0; R₁ is —Cl x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0308] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0309] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0310] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0311] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0312] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0313] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0314] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; and R₈ and R₉ are —H.

[0315] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0316] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0317] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0318] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0319] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0320] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0321] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0322] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0323] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; and R₈ and R₉ are —H.

[0324] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0325] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0326] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0327] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0328] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0329] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0330] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0331] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0332] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0333] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0334] In another embodiment, n, p, and m are 0; R₁ is R₁ is —Cl —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0335] In another embodiment, n, p, and m are 0; R₁ is R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0336] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0337] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0338] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CH₃; and R₉ is —CH₃.

[0339] In another embodiment, n is 0, Ar₁ is -2-(3-nitropyridyl)-, m is 0, x is 0, and R₈ and R₉ are —H.

[0340] In another embodiment, n is 0, Ar₁ is -2-(3-chloropyridyl)-, x is 1, A is —C(S)—N(R₄)—, m is 1, R₃ is —CH₃, R₃ is attached to the carbon atom adjacent to the nitrogen attached to the —C(SO)—N(R₄)— group, the carbon atom to which the R₃ group is attached has the R configuration, R₈ is —H, and R₉ is —CH₃.

[0341] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0342] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0343] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0344] In another embodiment, n and p are 0, m is 1, R₁ is —Cl x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0345] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0346] In another embodiment, n and p are 0, m is 1, R₁ is —Cl x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0347] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0348] In another embodiment, n and p are 0, m is 1, R₁ is —Cl x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0349] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0350] In another embodiment, n and p are 0, m is 1, R₁ is —Cl x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0351] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0352] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0353] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0354] In another embodiment, n and p are 0, m is 1, R₁ is —Cl x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0355] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0356] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0357] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0358] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0359] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0360] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0361] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0362] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0363] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0364] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0365] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0366] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₉ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0367] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0368] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0369] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0370] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0371] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0372] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0373] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[0374] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0375] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0376] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0377] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0378] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₁ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0379] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0380] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0381] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0382] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0383] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0384] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; and R₈ and R₉ are —H.

[0385] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; and R₈ and R₉ are —H.

[0386] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0387] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0388] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0389] In another embodiment, n, p, and m are 0; R₁ is -C_(1;) x is 0; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0390] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0391] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0392] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0393] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0394] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0395] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0396] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0397] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0398] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0399] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0400] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0401] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0402] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; and R₈ and R₉ are —H.

[0403] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0404] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0405] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0406] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0407] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0408] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0409] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0410] In another embodiment, n, p, and m are 0, R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0411] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; and R₈ and R₉ are —H.

[0412] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₈ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0413] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0414] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0415] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0416] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0417] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; R₈ is —CF₃; and and R₉ is —H.

[0418] In another embodiment, n, p, and m are 0; R₁ is —CF₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0419] In another embodiment, n, p, and m are 0, R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0420] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0421] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0422] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or, —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0423] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0424] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0425] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0426] In another embodiment, n, p, and m are 0; R₁ is —CH₃; x is 0; R₄ is —H; R₈ is —CH₃; and R₉ is —CH₃.

[0427] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0428] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0429] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0430] In another embodiment, n and pare 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0431] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0432] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benxothiazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0433] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazxolyl group; R₈ is —H; and R₉ is —C₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[0434] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazxolyl group; R₈ is —H; and R₉ is —C₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[0435] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0436] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0437] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0438] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0439] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0440] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0441] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0442] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0443] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0444] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0445] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0446] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0447] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0448] In another embodiment, n and p are 0, m is 1, R,is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0449] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0450] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0451] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CF₃, and R is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0452] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0453] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0454] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0455] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0456] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0457] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0458] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0459] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0460] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0461] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0462] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0463] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₄ is —H; R₈ is -tert-butyl; and R is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0464] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0465] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or, —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0466] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0467] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0468] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0469] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0470] In another embodiment, Ar₁ is a pyridyl group, n is 0; m is 1; R is —CH₃, —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0471] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0472] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0473] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0474] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0475] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R is —CH₃, —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0476] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0477] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0478] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0479] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0480] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0481] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0482] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0483] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0484] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0485] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₄ is —H; R₁ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0486] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0487] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0488] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0489] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0490] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[0491] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[0492] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[0493] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[0494] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0495] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0496] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, im is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the S configuration.

[0497] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the S configuration.

4.2 The Compounds of Formula (Ib)

[0498] The present invention also encompasses compounds of formula (Ib):

[0499] and pharmaceutically acceptable salts thereof, where Ar₁, R₃, R₈, R₉, A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (Ib).

[0500] In one embodiment, Ar₁ is a pyrazinyl group.

[0501] In another embodiment, Ar₁ is a pyridazinyl group.

[0502] In another embodiment, Ar₁ is a thiazanyl group.

[0503] In another embodiment, x is 1 and A is —C(O)—N(R₄)—.

[0504] In another embodiment, x is 1 and A is —C(S)—N(R₄)—.

[0505] In another embodiment x is 0.

[0506] In another embodiment, p is 0.

[0507] In another embodiment, p is 1.

[0508] In another embodiment, m is 0.

[0509] In another embodiment, m is 1.

[0510] In another embodiment, R₄ is —H.

[0511] In another embodiment, R₄ is —(C₁-C₆)alkyl.

[0512] In another embodiment, Ar₁ is a pyrazinyl group, x is 1, and A is —C(O)N(R₄)—.

[0513] In another embodiment, Ar₁ is a pyrazinyl group, x is 1, and A is —C(S)N(R₄)—.

[0514] In another embodiment, Ar₁ is a pyridazinyl group, x is 1, and A is —C(O)N(R₄)—.

[0515] In another embodiment, Ar₁ is a pyridazinyl group, x is 1, and A is —C(S)N(R₄)—.

[0516] In another embodiment, Ar₁ is a thiazanyl group, x is 1, and A is —C(O)N(R₄)—.

[0517] In another embodiment, Ar₁ is a thiazanyl group, x is 1, and A is —C(S)N(R₄)—.

[0518] In another embodiment, R₁ is —H.

[0519] In another embodiment, R₁ is —Cl.

[0520] In another embodiment, R₁ is —Br.

[0521] In another embodiment, R₁ is —I.

[0522] In another embodiment, R₁ is —F.

[0523] In another embodiment, R₁ is —(C₁-C₆)alkyl.

[0524] In another embodiment, R₁ is —CH₃.

[0525] In another embodiment, R₁ is —NO₂.

[0526] In another embodiment, R₁ is —CN.

[0527] In another embodiment, R₁ is —OH.

[0528] In another embodiment, R₁ is —OCH₃.

[0529] In another embodiment, R₁ is —NH₂.

[0530] In another embodiment, R₁ is —C(halo)₃.

[0531] In another embodiment, R₁ is —CH(halo)₂.

[0532] In another embodiment, R₁ is —CH₂(halo).

[0533] In another embodiment, p is 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH2.

[0534] In another embodiment, p is 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,—(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0535] In another embodiment, p is 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups.

[0536] In another embodiment, m is 1 and R₃ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[0537] In another embodiment, m is 1 and R₃ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0538] In another embodiment, m is 1 and R₃ is -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups.

[0539] In another embodiment, R₈ and R₉ are each independently —H, halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[0540] In another embodiment, at least one of R₈ or R₉ is —H.

[0541] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[0542] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[0543] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0544] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0545] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₁ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0546] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0547] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0548] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0549] In another embodiment, p and m are 0, R₁ is -halo x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0550] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH3, and R₉ is —H.

[0551] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0552] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0553] In another embodiment, p and m are 0, R₁ is -halo x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0554] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0555] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0556] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0557] In another embodiment, p and m are 0, R₁ is -halo x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0558] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0559] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈and R₉ are —H.

[0560] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0561] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0562] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0563] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0564] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0565] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0566] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0567] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0568] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[0569] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0570] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0571] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0572] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0573] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0574] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0575] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0576] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0577] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0578] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0579] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0580] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0581] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0582] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0583] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃.

[0584] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0585] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0586] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0587] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0588] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0589] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0590] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₁ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0591] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₁ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0592] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0593] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0594] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0595] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0596] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0597] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0598] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0599] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0600] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0601] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0602] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0603] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0604] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0605] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0606] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0607] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0608] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0609] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0610] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0611] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0612] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0613] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0614] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0615] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0616] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0617] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0618] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0619] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom o which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0620] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon tom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0621] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon tom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0622] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon tom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0623] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon tom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0624] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon tom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0625] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0626] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0627] In another embodiment, p and m are 0, R₁ is -halo x is 0, R₄ is —H, and R₈ and R₉ are —H.

[0628] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[0629] In another embodiment, p and m are 0, R₁ is -halo x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0630] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0631] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0632] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0633] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0634] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0635] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0636] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0637] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0638] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0639] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0640] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0641] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0642] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0643] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0644] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0645] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[0646] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0647] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0648] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0649] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0650] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0651] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0652] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0653] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0654] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[0655] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0656] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0657] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0658] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0659] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0660] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0661] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0662] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0663] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0664] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0665] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0666] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0667] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0668] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0669] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃.

[0670] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0671] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0672] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0673] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0674] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0675] In another embodiment, p is 0, m is 1, R_(1 is —Cl, x is) 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0676] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0677] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0678] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0679] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0680] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0681] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0682] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0683] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0684] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0685] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0686] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0687] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0688] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0689] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0690] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0691] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0692] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0693] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0694] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0695] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0696] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0697] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0698] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0699] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In one embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0700] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0701] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0702] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0703] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0704] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0705] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0706] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0707] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0708] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0709] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0710] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0711] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0712] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0713] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0714] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0715] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0716] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0717] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0718] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0719] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0720] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0721] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0722] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0723] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0724] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0725] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0726] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0727] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0728] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0729] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0730] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0731] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0732] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0733] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0734] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0735] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0736] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0737] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0738] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0739] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0740] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0741] In another embodiment, Ar₁ is a thiazanyl group, p is 0,m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0742] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzothiazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0743] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[0744] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[0745] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[0746] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[0747] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or a thiazanyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or a thiazanyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0748] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0749] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R₃ group is attached is in the S configuration.

[0750] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R₃ group is attached is in the S configuration.

[0751] The present invention also encompasses compounds of formula (Iia):

4.3 The Compounds of Formula (IIa)

[0752]

[0753] and pharmaceutically acceptable salts thereof, where Ar₁, R₃, R₈, R₉, R₁₀ and m, are defined above for the Benzoazolylpiperazine Compounds of formula (IIa).

[0754] In one embodiment, Ar₁ is a pyridyl group.

[0755] In another embodiment, Ar₁ is a pyrimidinyl group.

[0756] In another embodiment, Ar₁ is a pyrazinyl group.

[0757] In another embodiment, n or p is 0.

[0758] In another embodiment, n or p is 1.

[0759] In another embodiment, m is 0.

[0760] In another embodiment, m is 1.

[0761] In another embodiment, R₁₀ is —H.

[0762] In another embodiment, R₁₀ is —(C₁-C₄)alkyl.

[0763] In another embodiment, R₁₀ is —CH₃.

[0764] In another embodiment, R₁ is —Cl.

[0765] In another embodiment, R₁ is —Br.

[0766] In another embodiment, R₁ is —I.

[0767] In another embodiment, R₁ is —(C₁-C₆)alkyl.

[0768] In another embodiment, R₁ is —CH₃.

[0769] In another embodiment, R₁ is —NO₂.

[0770] In another embodiment, R₁ is —CN.

[0771] In another embodiment, R₁ is —OH.

[0772] In another embodiment, R₁ is —OCH₃.

[0773] In another embodiment, R₁ is —NH₂.

[0774] In another embodiment, R₁ is —C(halo)₃.

[0775] In another embodiment, R₁ is —CH(halo)₂.

[0776] In another embodiment, R₁ is —CH₂(halo).

[0777] In another embodiment, n and p are 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[0778] In another embodiment, n and p are 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0779] In another embodiment, n and p are 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0780] In another embodiment, m is 1 and R₃ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂,

[0781] In another embodiment, m is 1 and R₃ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0782] In another embodiment, m is 1 and R₃ is -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups.

[0783] In another embodiment, R₈ and R₉ are each independently —H, halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[0784] In another embodiment, at least one of R₈ or R₉ is —H.

[0785] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; and R₈ and R₉ are —H.

[0786] In another embodiment, n, p, and m are 0; R₁ is —Cl, R₄ is —H; and R₈ and R₉ are —H.

[0787] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is -halo H; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0788] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0789] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is —H; and R₉ is —CH₃. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0790] In another embodiment, n, p, and m are 0; R₁ is —Cl, R₄ is —H; R₈ is —H; and R₉ is —CH₃. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0791] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is —CH₃; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0792] In another embodiment, n, p, and m are 0; R₁ is —Cl, R₄ is —H; R₈ is —CH₃; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0793] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is —H; and R₉ is —CF₃. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0794] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —H; and R₉ is —CF₃. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0795] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is —CF₃; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0796] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —CF₃; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0797] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0798] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0799] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0800] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0801] In another embodiment, n, p, and m are 0; R₁ is —Cl, Br, or —I; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0802] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0803] In another embodiment, n, p, and m are 0; R₁ is —Cl, Br, or —I; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0804] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0805] In another embodiment, n, p, and m are 0; R₁ is —Cl, Br, or —I; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0806] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0807] In another embodiment, n, p, and m are 0; R₁ is —Cl, Br, or —I; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0808] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0809] In another embodiment, n, p, and m are 0; R₁ is —Cl, Br, or —I; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0810] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0811] In another embodiment, n, p, and m are 0; R₁ is —Cl, Br, or —I; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0812] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0813] In another embodiment, n, p, and m are 0, R₁ is —CH₃, R₄ is —H, and R₈and R₉ are —H.

[0814] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0815] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0816] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0817] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0818] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0819] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₁ is —CF₃; and R₉ is —H.

[0820] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0821] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0822] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; and R₈ and R₉ are —H.

[0823] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0824] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0825] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[0826] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[0827] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[0828] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[0829] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[0830] In another embodiment, n, p, and m are 0; R₁ is —CF₃; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[0831] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0832] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0833] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0834] In another embodiment, n, p, and m are 0; R₁ is —Cl; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0835] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[0836] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[0837] In another embodiment, n, p, and m are 0; R₁ is —CH₃; R₄ is —H; R₈ is —CH₃; and R₉ is —CH₃.

[0838] In another embodiment, n is 0, Ar₁ is -2-(3-chloropyridyl)-, m is 1, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, the carbon atom to which the R₃ group is attached has the R configuration, R₁₀ is —H, R₈ is methyl, and R₉ is iso-propyl.

[0839] In another embodiment, n is 0, Ar₁ is -2-(3-chloropyridyl)-, m is 1, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, the carbon atom to which the R₃ group is attached has the R configuration, R₁₀ is —H, R₈ is iso-propyl, and R₉ is methyl.

[0840] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0841] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0842] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0843] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0844] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0845] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0846] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0847] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0848] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0849] In another embodiment, n and p are 0; m is 1; R₁ is —Cl,;R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0850] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0851] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0852] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0853] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0854] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the -benzoimidazole group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0855] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the -benzoimidazole group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0856] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0857] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0858] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0859] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0860] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0861] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0862] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0863] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0864] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[0865] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0866] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0867] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0868] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0869] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0870] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0871] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0872] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0873] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0874] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0875] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0876] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0877] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0878] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0879] In another embodiment, n and p are 0, m is 1, R₁ is —Cl, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0880] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0881] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0882] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazole group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0883] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0884] In another embodiment, Ar₁ is a pyridyl group n is 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0885] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0886] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₉ is —Cl, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0887] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0888] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0889] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group, R₄ is —H, R₁ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0890] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0891] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —Cl, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0892] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0893] In another embodiment, Ar₁ is a pyrazinyl group; p is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0894] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0895] In another embodiment, Ar₁ is a pyrazinyl group; p is 0; m is 1; R₁ is —Cl, —Br, or —I; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0896] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —Cl, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group, R₄ is —H, R₁ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0897] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0898] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0899] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0900] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group and the carbon to which the R₃ group is attached is in the S configuration.

[0901] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzothiazolyl group and the carbon to which the R₃ group is attached is in the S configuration.

[0902] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0903] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R₃ group is attached is in the R configuration.

[0904] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R₃ group is attached is in the S configuration.

[0905] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R₃ group is attached is in the S configuration.

4.4 The Compounds of Formula (IIb)

[0906] The present invention also encompasses compounds of formula (IIb):

[0907] and pharmaceutically acceptable salts thereof, where Ar₁, R₃, R₈, R₉ , A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (Iib).

[0908] In one embodiment, Ar₁ is a pyridazinyl group.

[0909] In another embodiment, Ar₁ is a thiazanyl group.

[0910] In another embodiment, x is 1 and A is —C(O)—N(R₄)—.

[0911] In another embodiment, x is 1 and A is —C(S)—N(R₄)—.

[0912] In another embodiment x is 0.

[0913] In another embodiment, x is 1.

[0914] In another embodiment p is 0.

[0915] In another embodiment, p is 1.

[0916] In another embodiment m is 0.

[0917] In another embodiment, m is 1.

[0918] In another embodiment, R₄ is —H.

[0919] In another embodiment, R₄ is —(C₁-C₆)alkyl.

[0920] In another embodiment, R₁₀ is —H.

[0921] In another embodiment, R₁₀ is —(C₁-C₄)alkyl.

[0922] In another embodiment, R₁₀ is —CH₃.

[0923] In another embodiment, Ar₁ is a pyrazinyl group, x is 1, and A is —C(O)N(R₄)—.

[0924] In another embodiment, Ar₁ is a pyrazinyl group, x is 1, and A is —C(S)N(R₄)—.

[0925] In another embodiment, Ar₁ is a thiazanyl group, x is 1, and A is —C(O)N(R₄)—.

[0926] In another embodiment, Ar₁ is a thiazanyl group, x is 1, and A is —C(S)N(R₄)—.

[0927] In another embodiment, R₁ is —H.

[0928] In another embodiment, R₁ is —Cl.

[0929] In another embodiment, R₁ is —Br.

[0930] In another embodiment, R₁ is —I.

[0931] In another embodiment, R₁ is —F.

[0932] In another embodiment, R₁ is —(C₁-C₆)alkyl.

[0933] In another embodiment, R₁ is —CH₃.

[0934] In another embodiment, R₁ is —NO₂.

[0935] In another embodiment, R₁ is —CN.

[0936] In another embodiment, R₁ is —OH.

[0937] In another embodiment, R₁ is —OCH₃.

[0938] In another embodiment, R₁ is —NH₂.

[0939] In another embodiment, R₁ is —C(halo)₃.

[0940] In another embodiment, R₁ is —CH(halo)₂.

[0941] In another embodiment, R₁ is —CH₂(halo).

[0942] In another embodiment, p is 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[0943] In another embodiment, p is 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0944] In another embodiment, p is 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[0945] In another embodiment, m is 1 and R₃ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[0946] In another embodiment, m is 1 and R₃ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[0947] In another embodiment, m is 1 and R₃ is -phenyl, -naphthyl, -—C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups.

[0948] In another embodiment, R₈ and R₉ are each independently —H, halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[0949] In another embodiment, at least one of R₈ or R₉ is —H.

[0950] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[0951] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[0952] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0953] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0954] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0955] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0956] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0957] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0958] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0959] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0960] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0961] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0962] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0963] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0964] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0965] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0966] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0967] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0968] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[0969] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0970] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₁ is —Br. In another embodiment, R₈ is —F.

[0971] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0972] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0973] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0974] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0975] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0976] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0977] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[0978] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[0979] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[0980] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[0981] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[0982] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[0983] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[0984] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[0985] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[0986] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0987] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0988] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0989] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0990] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[0991] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[0992] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃.

[0993] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0994] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0995] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0996] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0997] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0998] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[0999] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1000] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1001] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1002] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1003] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1004] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1005] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1006] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1007] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1008] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1009] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1010] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1011] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1012] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1013] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1014] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1015] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1016] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1017] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1018] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1019] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1020] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1021] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1022] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₁ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1023] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1024] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1025] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1026] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1027] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1028] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1029] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1030] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1031] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1032] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1033] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1034] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1035] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1036] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1037] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, and R₉ and R₉ are —H.

[1038] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1039] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1040] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1041] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1042] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1043] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1044] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1045] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1046] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1047] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1048] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1049] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1050] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1051] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1052] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1053] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1054] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1055] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1056] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1057] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1058] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1059] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1060] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1061] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1062] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1063] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1064] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1065] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1066] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1067] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1068] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1069] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1070] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1071] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1072] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1073] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1074] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1075] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1076] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1077] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1078] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃.

[1079] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1080] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1081] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1082] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1083] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1084] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1085] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1086] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1087] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1088] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1089] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1090] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1091] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1092] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1093] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1094] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1095] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1096] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1097] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1098] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1099] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1100] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1101] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1102] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₁ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1103] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1104] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1105] In another embodiment, p is 0, m is 1, R_(1 is —CH) ₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1106] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1107] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1108] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1109] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1110] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1111] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1112] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1113] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1114] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1115] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1116] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1117] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1118] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1119] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1120] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1121] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1122] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1123] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1124] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1125] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1126] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1127] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1128] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1129] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1130] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1131] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1132] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1133] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1134] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1135] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1136] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1137] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1138] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1139] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1140] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1141] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzoimidazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1142] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[1143] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[1144] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[1145] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzoimidazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[1146] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1147] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1148] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group and the carbon to which the R₃ group is attached is in the S configuration.

[1149] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridazinyl group or thiazanyl group and the carbon to which the R₃ group is attached is in the S configuration.

4.5 The Compounds of Formula (IIIa)

[1150] The present invention encompasses compounds of Formula (IIIa)

[1151] and pharmaceutically acceptable salts thereof, where Ar₁, R₃, R_(8,) R₉, A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (IIIa).

[1152] In one embodiment, Ar₁ is a pyridyl group.

[1153] In another embodiment, Ar₁ is a pyrimidinyl group.

[1154] In another embodiment, x is 1 and A is —C(O)—N(R₄)—.

[1155] In another embodiment, x is 1 and A is —C(S)—N(R₄)—.

[1156] In another embodiment x is 0.

[1157] In another embodiment x is 1.

[1158] In another embodiment n or p is 0.

[1159] In another embodiment n or p is 1.

[1160] In another embodiment m is 0.

[1161] In another embodiment m is 1.

[1162] In another embodiment, Ar₁ is a pyridyl group, x is 1, and A is —C(O)N(R₄)—.

[1163] In another embodiment, Ar₁ is a pyridyl group, x is 1, and A is —C(S)N(R₄)—.

[1164] In another embodiment, Ar₁ is a pyrimidinyl group, x is 1, and A is —C(O)N(R₄)—.

[1165] In another embodiment, Ar₁ is a pyrimidinyl group, x is 1, and A is —C(S)N(R₄)—.

[1166] In another embodiment, R₁ is —Cl.

[1167] In another embodiment, R₁ is —Br.

[1168] In another embodiment, R₁ is —I.

[1169] In another embodiment, R₁ is —(C₁-C₆)alkyl.

[1170] In another embodiment, R₁ is —CH₃.

[1171] In another embodiment, R₁ is —NO₂.

[1172] In another embodiment, R₁ is —CN.

[1173] In another embodiment, R₁ is —OH.

[1174] In another embodiment, R₁ is —OCH₃.

[1175] In another embodiment, R₁ is —NH₂.

[1176] In another embodiment, R₁ is —C(halo)₃.

[1177] In another embodiment, R₁ is —CH(halo)₂.

[1178] In another embodiment, R₁ is —CH₂(halo).

[1179] In another embodiment, n and p are 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[1180] In another embodiment, n and p are 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[1181] In another embodiment, n and p are 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[1182] In another embodiment, m is 1 and R₃ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[1183] In another embodiment, m is 1 and R₃ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[1184] In another embodiment, m is 1 and R₃ is -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups.

[1185] In another embodiment, R₄ is —H.

[1186] In another embodiment, R₄ is —(C₁-C₆)alkyl.

[1187] In another embodiment, R₈ and R₉ are each independently —H, halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[1188] In another embodiment, at least one of R₈ or R₉ is —H.

[1189] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; and R₈ and R₉ are —H.

[1190] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; and R₈ and R₉ are —H.

[1191] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1192] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1193] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1194] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1195] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[1196] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[1197] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[1198] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[1199] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H, R₈ is —H; and R₉ is —CF₃.

[1200] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[1201] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[1202] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₁ is —CF₃; and R₉ is —H.

[1203] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[1204] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[1205] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[1206] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[1207] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[1208] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₁ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1209] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1210] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1211] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1212] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1213] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1214] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1215] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1216] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[1217] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1218] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1219] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1220] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H. R₈ is —CH₃, and R₉ is —H.

[1221] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1222] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1223] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1224] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1225] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[1226] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[1227] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[1228] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[1229] In another embodiment, n, p, and m are 0; R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1230] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1231] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃.

[1232] In another embodiment, n is 0, Ar₁ is -2-(3-nitropyridyl)-, m is 0, x is 0, and R₈ and R₉ are —H.

[1233] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1234] In another embodiment, n and p are 0; m is 1, R₁ is —Cl; x is 1, A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1235] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1236] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1237] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1238] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1239] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1240] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1241] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1242] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1243] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1244] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1245] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1246] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1247] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1248] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1249] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1250] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1251] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1252] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1253] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1254] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₁ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1255] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1256] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1257] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1258] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1259] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1260] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1261] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1262] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1263] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1264] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1265] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1266] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1267] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1268] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1269] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1270] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1271] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1272] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1273] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1274] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1275] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1276] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; and R₈and R₉ are —H.

[1277] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; and R₈ and R₉ are —H.

[1278] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1279] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1280] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1281] In another embodiment, n, p, and m are 0; R₁ is —Cl, x is 0; R₄ is —H; R₈ is -halo; and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1282] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[1283] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CH₃.

[1284] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[1285] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —CH₃; and R₉ is —H.

[1286] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[1287] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is —CF₃.

[1288] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[1289] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —CF₃; and R₉ is —H.

[1290] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[1291] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is —OCH₂CH₃.

[1292] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[1293] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —OCH₂CH₃; and R₉ is —H.

[1294] In another embodiment, n, p, and m are 0; R₁ is —CH₃, x is 0; R₄ is —H, and R₈ and R₉ are —H.

[1295] In another embodiment, n, p, and m are 0; R₁ is —CH₃, x is 0; R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1296] In another embodiment, n, p, and m are 0; R₁ is —CH₃, x is 0; R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1297] In another embodiment, n, p, and m are 0; R₁ is —CH₃, x is 0; R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1298] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1299] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1300] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1301] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1302] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1303] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1304] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1305] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1306] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1307] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1308] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1309] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1310] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1311] In another embodiment, n, p, and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1312] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[1313] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H.

[1314] In another embodiment, n, p, and m are 0; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[1315] In another embodiment, n, p, and m are 0; R₁ is —Cl; x is 0; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl.

[1316] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1317] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1318] In another embodiment, n, p, and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃.

[1319] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1320] In another embodiment, n and p are 0; m is 1, R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1321] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1322] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1323] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1324] In another embodiment, n and p are 0; m is 1, R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1325] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1326] In another embodiment, n and p are 0; m is 1, R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1327] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1328] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is O; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1329] In another embodiment, n and p 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1330] In another embodiment, n and p 0; m is 1; R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1331] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1332] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1333] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1334] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1335] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1336] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 0; R₄ is —H; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1337] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1338] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1339] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1340] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1341] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1342] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1343] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1344] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1345] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1346] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1347] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1348] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1349] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1350] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1351] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1352] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1353] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1354] In another embodiment, n and p are 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1355] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1356] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1357] In another embodiment, n and p are 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1358] In another embodiment, n and p are 0; m is 1; R₁ is —Cl; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1359] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1360] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1361] In another embodiment, n and p are 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1362] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1363] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1364] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1365] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1366] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1367] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —CH₃, —Cl, —Br, —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1368] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1369] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 1; A is —C(O)—N(R₄)—; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1370] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1371] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1372] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1373] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1374] In another embodiment, Ar₁ is a pyridyl group; n is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1375] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1376] In another embodiment, Ar₁ is a pyridyl group, n is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1377] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —CH₃, —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1378] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1379] In another embodiment, Ar₁ is a pyrimidinyl group; p is 0; m is 1; R₁ is —Cl, —Br, or —I; x is 0; R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group; R₄ is —H; R₈ is —H; and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1380] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1381] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration.

[1382] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1383] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1384] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group and the carbon to which the R₃ group is attached is in the S configuration.

[1385] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— or the benzooxazolyl group and the carbon to which the R₃ group is attached is in the S configuration.

[1386] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1387] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1388] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the S configuration.

[1389] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R₃ group is attached is in the S configuration.

4.6 The Compounds of Formula (IIIb)

[1390] The present invention also encompasses compounds of formula (IIIb):

[1391] and pharmaceutically acceptable salts thereof, where Ar₁, R₃, R₈, R₉, A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (IIIb).

[1392] In one embodiment, Ar₁ is a pyrazinyl group.

[1393] In another embodiment, Ar₁ is a pyridazinyl group.

[1394] In another embodiment, Ar₁ is a thiazanyl group.

[1395] In another embodiment, x is 1 and A is —C(O)—N(R₄)—.

[1396] In another embodiment, x is 1 and A is —C(S)—N(R₄)—.

[1397] In another embodiment x is 0.

[1398] In another embodiment, x is 1.

[1399] In another embodiment, p is 0.

[1400] In another embodiment, p is 1.

[1401] In another embodiment, m is 0.

[1402] In another embodiment, m is 1.

[1403] In another embodiment, Ar₁ is a pyrazinyl group, x is 1, and A is —C(O)N(R₄)—.

[1404] In another embodiment, Ar₁ is a pyrazinyl group, x is 1, and A is —C(S)N(R₄)—.

[1405] In another embodiment, Ar₁ is a pyridazinyl group, x is 1, and A is —C(O)N(R₄)—.

[1406] In another embodiment, Ar₁ is a pyridazinyl group, x is 1, and A is —C(S)N(R₄)—.

[1407] In another embodiment, Ar₁ is a thiazanyl group, x is 1, and A is —C(O)N(R₄)—.

[1408] In another embodiment, Ar₁ is a thiazanyl group, x is 1, and A is —C(S)N(R₄)—.

[1409] In another embodiment, R₁ is —H.

[1410] In another embodiment, R₁ is —Cl.

[1411] In another embodiment, R₁ is —Br.

[1412] In another embodiment, R₁ is —I.

[1413] In another embodiment, R₁ is —F.

[1414] In another embodiment, R₁ is —(C₁-C₆)alkyl.

[1415] In another embodiment, R₁ is —CH₃.

[1416] In another embodiment, R₁ is —NO₂.

[1417] In another embodiment, R₁ is —CN.

[1418] In another embodiment, R₁ is —OH.

[1419] In another embodiment, R₁ is —OCH₃.

[1420] In another embodiment, R₁ is —NH₂.

[1421] In another embodiment, R₁ is —C(halo)₃.

[1422] In another embodiment, R₁ is —CH(halo)₂.

[1423] In another embodiment, R₁ is —CH₂(halo).

[1424] In another embodiment, p is 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[1425] In another embodiment, p is 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[1426] In another embodiment, p is 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[1427] In another embodiment, m is 1 and R₃ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[1428] In another embodiment, m is 1 and R₃ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl, —(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[1429] In another embodiment, m is 1 and R₃ is -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups.

[1430] In another embodiment, R₄ is —H.

[1431] In another embodiment, R₄ is —(C₁-C₆)alkyl.

[1432] In another embodiment, R₈ and R₉ are each independently —H, halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[1433] In another embodiment, at least one of R₈ or R₉ is —H.

[1434] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[1435] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[1436] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1437] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1438] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1439] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1440] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1441] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1442] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1443] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1444] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1445] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1446] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1447] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1448] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1449] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1450] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1451] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1452] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈and R₉ are —H.

[1453] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1454] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1455] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1456] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1457] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1458] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1459] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1460] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1461] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, and R₈ and R₉ are —H.

[1462] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1463] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1464] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1465] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1466] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1467] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1468] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1469] In another embodiment, p and m are 0, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1470] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1471] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1472] In another embodiment, p and m are 0, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1473] In another embodiment, p and m are 0, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1474] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1475] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl.

[1476] In another embodiment, p and m are 0, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃.

[1477] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1478] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1479] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1480] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1481] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1482] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1483] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1484] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1485] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1486] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1487] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1488] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1489] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1490] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1491] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1492] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1493] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1494] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1495] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1496] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1497] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1498] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1499] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1500] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1501] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1502] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1503] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1504] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1505] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1506] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1507] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1508] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1509] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1510] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1511] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1512] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 1, A is —C(O)—N(R₄)—, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₁ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1513] In another embodiment, p is 0, m is 1, R₁ is halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1514] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1515] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1516] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1517] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1518] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1519] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1520] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1521] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1522] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1523] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1524] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1525] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1526] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1527] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1528] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1529] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1530] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1531] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1532] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1533] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1534] In another embodiment, p and m are 0, R₉ is -halo, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1535] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1536] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1537] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1538] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1539] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1540] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F.

[1541] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1542] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1543] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1544] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1545] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1546] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1547] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, and R₈ and R₉ are —H.

[1548] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F.

[1549] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈is —F.

[1550] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CH₃.

[1551] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CH₃, and R₉ is —H.

[1552] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —CF₃.

[1553] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —CF₃, and R₉ is —H.

[1554] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —H, and R₉ is —OCH₂CH₃.

[1555] In another embodiment, p and m are 0, R₁ is —CF₃, x is 0, R₄ is —H, R₈ is —OCH₂CH₃, and R₉ is —H.

[1556] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1557] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H.

[1558] In another embodiment, p and m are 0, R₁ is -halo, x is 0, R₄is —H, R₈ is —H, and R₉ is -tert-butyl.

[1559] In another embodiment, p and m are 0, R₁ is —Cl, x is 0, R₄is —H, R₈is —H, and R₉ is -tert-butyl.

[1560] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄is —H, R₈ is -tert-butyl, and R₉ is —H.

[1561] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄is —H, R₈ is —H, and R₉ is -tert-butyl.

[1562] In another embodiment, p and m are 0, R₁ is —CH₃, x is 0, R₄is —H, R₈ is —CH₃, and R₉ is—CH₃.

[1563] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1564] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄is —H, R₃is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1565] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1566] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment, R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1567] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1568] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment, R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1569] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1570] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1571] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1572] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1573] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1574] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1575] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1576] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1577] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1578] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄is —H, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1579] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1580] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₄is —H, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1581] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1582] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1583] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1584] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1585] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1586] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1587] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1588] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1589] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1590] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1591] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is -halo. In another embodiment R₉ is —Cl. In another embodiment, R₉ is —Br. In another embodiment, R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1592] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is -halo, and R₉ is —H. In another embodiment R₈ is —Cl. In another embodiment, R₈ is —Br. In another embodiment, R₈ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1593] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1594] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which he R₃ group is attached has the S configuration.

[1595] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1596] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —CF₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1597] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —H, and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1598] In another embodiment, p is 0, m is 1, R₁ is —CF₃, x is 0, R₄ is —H, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₈ is —OCH₂CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1599] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1600] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1601] In another embodiment, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration

[1602] In another embodiment, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1603] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is -tert-butyl, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1604] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈is —H, and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1605] In another embodiment, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —CH₃, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1606] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1607] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄is —H, R₈is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1608] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1609] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄is —H, R₈is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1610] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)‘group, R₄is —H, R₈is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1611] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃or -halo, x is 1, A is —C(O)—N(R₄)—, R₃is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1612] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1613] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1614] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1615] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1616] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1617] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1618] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is -halo, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1619] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —Cl, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1620] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 1, A is —C(O)—N(R₄)—, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1621] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1622] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1623] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1624] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1625] In another embodiment, Ar₁ is a pyrazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1626] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1627] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1628] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1629] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R8 is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1630] In another embodiment, Ar₁ is a pyridazinyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1631] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃ or -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1632] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Cl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1633] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is -halo, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1634] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —Cl, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —Br. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1635] In another embodiment, Ar₁ is a thiazanyl group, p is 0, m is 1, R₁ is —CH₃, x is 0, R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the benzooxazolyl group, R₄ is —H, R₈ is —H, and R₉ is —F. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1636] In another embodiment, m is 1 and R₃ is -(C ₁—C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[1637] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the R configuration.

[1638] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[1639] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the —C(O)—N(R₄)— when x is 1 or the benzooxazolyl group when x is 0 and the carbon to which the R₃ group is attached is in the S configuration.

[1640] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1641] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R₃ group is attached is in the R configuration.

[1642] In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R₃ is —(C₁-C₄)alkyl and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R₃ group is attached is in the S configuration.

[1643] In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R₃ is —CH₃ and is attached to the carbon atom adjacent to the nitrogen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R₃ group is attached is in the S configuration.

4.7 The Compounds of Formula (IVa)

[1644] The present invention also encompasses compounds of formula (IVa):

[1645] and pharmaceutically acceptable salts thereof, where Ar₁, Ar₂, and R₃, are defined above for the Benzoazolylpiperazine Compounds of formula (IVa).

[1646] In one embodiment, Ar₁ is a pyridyl group.

[1647] In another embodiment, Ar₁ is a pyrimidinyl group.

[1648] In another embodiment, Ar₂ is a benzothiazolyl group.

[1649] In another embodiment, Ar₂ is a benzooxazolyl group.

[1650] In another embodiment, Ar₂ is a benzoimidazolyl group.

[1651] In another embodiment, n or p is 0.

[1652] In another embodiment, n or p is 1.

[1653] In another embodiment, R₁ is —Cl.

[1654] In another embodiment, R₁ is —Br.

[1655] In another embodiment, R₁ is —I.

[1656] In another embodiment, R₁ is —F.

[1657] In another embodiment, R₁ is —(C₁-C₆)allyl.

[1658] In another embodiment, R₁ is —CH₃.

[1659] In another embodiment, R₁ is —NO₂.

[1660] In another embodiment, R₁ is —CN.

[1661] In another embodiment, R₁ is —OH.

[1662] In another embodiment, R₁ is —OCH₃.

[1663] In another embodiment, R₁ is —NH₂.

[1664] In another embodiment, R₁ is —C(halo)₃.

[1665] In another embodiment, R₁ is —CH(halo)₂.

[1666] In another embodiment, R₁ is —CH₂(halo).

[1667] In another embodiment, n and p are 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[1668] In another embodiment, n and p are 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[1669] In another embodiment, n and p are 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[1670] In another embodiment, R₃ is —H.

[1671] In another embodiment, R₃ is —CH₃.

[1672] In another embodiment, R₈ and R₉ are each independently —H, halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[1673] In another embodiment, at least one of R₈ and R₉ is —H.

[1674] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H.

[1675] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H.

[1676] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo.

[1677] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro.

[1678] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo.

[1679] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro.

[1680] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo.

[1681] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H.

[1682] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H.

[1683] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H.

[1684] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H.

[1685] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H.

[1686] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -halo, and R₉ is —H.

[1687] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro, and R₉ is —H.

[1688] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo, and R₉ is —H.

[1689] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro, and R₉ is —H.

[1690] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo, and R₉ is —H.

[1691] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃.

[1692] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H, and R₉ is —CH₃.

[1693] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H.

[1694] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃, and R₉ is —H.

[1695] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃.

[1696] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃.

[1697] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H.

[1698] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H.

[1699] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1700] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1701] In another embodiment Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1702] In another embodiment, Ar₁ Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1703] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1704] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1705] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1706] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1707] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1708] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1709] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1710] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1711] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1712] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1713] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1714] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1715] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1716] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1717] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1718] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1719] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -halo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1720] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1721] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1722] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1723] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1724] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1725] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1726] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1727] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1728] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1729] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1730] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1731] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1732] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1733] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1734] In another embodiment Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1735] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1736] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1737] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1738] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃is —CH₃; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1739] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃is —CH₃; R₁ is R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1740] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H.

[1741] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H.

[1742] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo.

[1743] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro.

[1744] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo.

[1745] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro.

[1746] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo.

[1747] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H.

[1748] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H.

[1749] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H.

[1750] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H.

[1751] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H.

[1752] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -halo, and R₉ is —H.

[1753] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro, and R₉ is —H.

[1754] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo, and R₉ is —H.

[1755] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro, and R₉ is —H.

[1756] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo, and R₉ is —H.

[1757] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃.

[1758] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H, and R₉ is —CH₃.

[1759] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H.

[1760] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃, and R₉ is —H.

[1761] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃.

[1762] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃.

[1763] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H.

[1764] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H.

[1765] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1766] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1767] In another embodiment Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₉ is —OCH₂CH₃; and R₉ is —H.

[1768] In another embodiment, Ar₁ Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1769] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1770] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1771] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1772] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1773] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1774] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1775] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1776] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1777] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1778] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1779] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1780] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1781] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1782] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1783] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1784] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1785] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -halo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1786] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1787] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1788] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1789] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1790] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1791] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1792] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1793] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1794] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1795] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1796] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1797] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1798] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1799] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₉ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1800] In another embodiment Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1801] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzothiazolyl group; R₁ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1802] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1803] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1804] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1805] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1806] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H.

[1807] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H.

[1808] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo.

[1809] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro.

[1810] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo.

[1811] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro.

[1812] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo.

[1813] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H.

[1814] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H.

[1815] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H.

[1816] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H.

[1817] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H.

[1818] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo, and R₉ is —H.

[1819] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro, and R₉ is —H.

[1820] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo, and R₉ is —H.

[1821] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro, and R₉ is —H.

[1822] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo, and R₉ is —H.

[1823] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃.

[1824] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H, and R₉ is —CH₃.

[1825] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H.

[1826] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃, and R₉ is —H.

[1827] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃.

[1828] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃.

[1829] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H.

[1830] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H.

[1831] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1832] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1833] In another embodiment Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1834] In another embodiment, Ar₁ Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1835] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1836] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1837] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1838] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1839] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1840] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1841] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1842] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1843] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1844] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1845] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1846] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1847] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1848] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1849] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1850] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1851] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1852] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1853] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1854] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1855] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1856] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1857] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1858] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1859] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1860] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1861] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1862] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1863] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1864] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1865] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1866] In another embodiment Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1867] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1868] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1869] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1870] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1871] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is-CH₃; R₁ is R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1872] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H.

[1873] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H.

[1874] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo.

[1875] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro.

[1876] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo.

[1877] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro.

[1878] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo.

[1879] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H.

[1880] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H.

[1881] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H.

[1882] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H.

[1883] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H.

[1884] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo, and R₉ is —H.

[1885] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro, and R₉ is —H.

[1886] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo, and R₉ is —H.

[1887] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro, and R₉ is —H.

[1888] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo, and R₉ is —H.

[1889] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃.

[1890] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H, and R₉ is —CH₃.

[1891] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H.

[1892] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃, and R₉ is —H.

[1893] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃.

[1894] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃.

[1895] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H.

[1896] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H.

[1897] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1898] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1899] In another embodiment Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1900] In another embodiment, Ar₁ Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1901] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1902] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1903] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1904] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1905] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1906] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1907] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1908] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1909] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1910] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1911] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzoimidazolyl group; Rs is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1912] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1913] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1914] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1915] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1916] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1917] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1918] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1919] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1920] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1921] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1922] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1923] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1924] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1925] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1926] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1927] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1928] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1929] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1930] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1931] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1932] In another embodiment Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1933] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1934] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1935] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1936] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1937] In another embodiment, Ar₁ is a pyriidinyl group, p is 0; R₃ is-CH₃; R₁ is R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1938] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H.

[1939] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H.

[1940] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo.

[1941] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro.

[1942] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo.

[1943] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro.

[1944] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo.

[1945] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H.

[1946] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H.

[1947] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H.

[1948] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H.

[1949] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H.

[1950] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo, and R₉ is —H.

[1951] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro, and R₉ is —H.

[1952] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -bromo, and R₉ is —H.

[1953] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro, and R₉ is —H.

[1954] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo, and R₉ is —H.

[1955] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃.

[1956] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H, and R₉ is —CH₃.

[1957] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H.

[1958] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CH₃, and R₉ is —H.

[1959] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃.

[1960] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃.

[1961] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H.

[1962] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H.

[1963] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1964] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[1965] In another embodiment Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1966] In another embodiment, Ar₁ Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[1967] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1968] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[1969] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1970] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —H; R₁ is R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[1971] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1972] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1973] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1974] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1975] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1976] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1977] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon tom to which the R₃ group is attached has the S configuration.

[1978] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1979] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1980] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1981] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1982] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1983] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1984] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1985] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -bromo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1986] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1987] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1988] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1989] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1990] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1991] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1992] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1993] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1994] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1995] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1996] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1997] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1998] In another embodiment Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[1999] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2000] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2001] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is —F; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2002] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2003] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₃ is —CH₃; R₁ is R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2004] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H.

[2005] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H.

[2006] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo.

[2007] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro.

[2008] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo.

[2009] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro.

[2010] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo.

[2011] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H.

[2012] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H.

[2013] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H.

[2014] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H.

[2015] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H.

[2016] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo, and R₉ is —H.

[2017] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro, and R₉ is —H.

[2018] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -bromo, and R₉ is —H.

[2019] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro, and R₉ is —H.

[2020] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo, and R₉ is —H.

[2021] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃.

[2022] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H, and R₉ is —CH₃.

[2023] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H.

[2024] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CH₃, and R₉ is —H.

[2025] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃.

[2026] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃.

[2027] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H.

[2028] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H.

[2029] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[2030] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃.

[2031] In another embodiment Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[2032] In another embodiment, Ar₁ Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H.

[2033] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[2034] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H.

[2035] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[2036] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —H; R₁ is R₁ is —F.; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl.

[2037] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or, —I; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2038] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2039] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2040] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2041] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2042] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2043] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2044] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2045] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2046] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2047] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2048] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2049] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2050] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2051] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2052] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2053] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2054] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2055] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; 25 Ar₂ is a benzooxazolyl group; R₈ is -bromo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2056] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2057] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2058] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2059] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H, and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2060] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2061] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CH₃, and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2062] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2063] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2064] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2065] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2066] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2067] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2068] In another embodiment Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2069] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2070] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2071] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is —F; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2072] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2073] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₃ is —CH₃; R₁ is R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

4.8 The Compounds of Formula (IVb)

[2074] The present invention also encompasses compounds of formula (IVb):

[2075] and pharmaceutically acceptable salts thereof, where Ar₁, Ar₂, A, R₃ and x are defined above for the Benzoazolylpiperazine Compounds of formula (IVb).

[2076] In one embodiment, Ar₁ is a pyridyl group.

[2077] In another embodiment, Ar₁ is a pyrimidinyl group.

[2078] In another embodiment, n or p is 0.

[2079] In another embodiment, n or p is 1.

[2080] In another embodiment, x is 0.

[2081] In another embodiment, x is 1.

[2082] In another embodiment, R₁ is —F.

[2083] In another embodiment, R₁ is —Cl.

[2084] In another embodiment, R₁ is —Br.

[2085] In another embodiment, R₁ is —I.

[2086] In another embodiment, R₁ is —(C₁-C₆)alkyl.

[2087] In another embodiment, R₁ is —CH₃.

[2088] In another embodiment, R₁ is —NO₂.

[2089] In another embodiment, R₁ is —CN.

[2090] In another embodiment, R₁ is —OH.

[2091] In another embodiment, R₁ is —OCH₃.

[2092] In another embodiment, R₁ is —NH2.

[2093] In another embodiment, R₁ is —C(halo)₃.

[2094] In another embodiment, R₁ is —CH(halo)₂.

[2095] In another embodiment, R₁ is —CH₂(halo).

[2096] In another embodiment, n and p are 1 and R₂ is -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂.

[2097] In another embodiment, n and p are 1 and R₂ is —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups.

[2098] In another embodiment, n and p are 1 and R₂ is -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups;

[2099] In another embodiment, x is 1 and A is —C(O)N(R₄)—.

[2100] In another embodiment, x is 1, A is —C(O)N(R₄)—, and R₄ is —H.

[2101] In another embodiment, x is 1, A is —C(O)N(R₄)—, and R₄ is —CH₃.

[2102] In another embodiment, x is 1 and A is —C(S)N(R₄)—.

[2103] In another embodiment, x is 1, A is —C(S)N(R₄)—, and R₄ is —H.

[2104] In another embodiment, x is 1, A is —C(S)N(R₄)—, and R₄ is —CH₃.

[2105] In another embodiment, Ar₂ is a benzothiazolyl group.

[2106] In another embodiment, Ar₂ is a benzoimidazolyl group.

[2107] In another embodiment, Ar₂ is a benzooxazolyl group.

[2108] In another embodiment, R₈ and R₉ are each independently —H, halo, —(C₁-C₆)alkyl, —O(C₁-C₆)alkyl, —C(halo)₃, —CH(halo)₂, or —CH₂(halo).

[2109] In another embodiment, at least one of R₈ or R₉ is —H.

[2110] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2111] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzothiazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2112] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2113] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2114] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2115] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2116] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2117] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2118] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2119] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2120] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2121] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2122] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —C1, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2123] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H.

[2124] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2125] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2126] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2127] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2128] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2129] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2130] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2131] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2132] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2133] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2134] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2135] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2136] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2137] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2138] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2139] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2140] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2141] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2142] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2143] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2144] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2145] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2146] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2147] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2148] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2149] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2150] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2151] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2152] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2153] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2154] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2155] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2156] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2157] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2158] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2159] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2160] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2161] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2162] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2163] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2164] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2165] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2166] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2167] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2168] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2169] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2170] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2171] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2172] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2173] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2174] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2175] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2176] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2177] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2178] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2179] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2180] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2181] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2182] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2183] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2184] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2185] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzothiazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2186] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2187] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2188] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2189] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2190] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2191] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2192] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2193] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2194] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2195] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2196] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2197] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2198] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2199] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2200] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2201] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2202] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2203] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2204] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2205] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2206] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2207] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2208] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2209] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2210] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2211] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2212] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2213] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2214] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2215] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2216] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2217] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2218] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2219] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2220] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2221] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2222] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2223] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2224] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2225] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2226] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2227] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2228] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2229] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2230] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2231] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2232] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2233] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2234] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2235] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2236] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2237] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2238] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2239] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2240] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2241] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2242] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2243] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2244] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2245] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2246] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2247] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2248] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2249] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2250] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2251] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2252] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2253] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2254] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₉ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2255] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2256] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2257] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2258] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2259] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzoimidazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2260] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2261] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2262] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2263] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2264] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2265] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2266] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2267] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2268] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2269] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2270] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2271] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2272] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2273] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2274] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2275] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2276] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2277] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2278] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2279] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2280] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2281] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2282] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2283] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2284] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2285] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2286] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2287] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2288] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2289] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2290] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2291] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2292] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2293] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2294] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2295] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2296] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2297] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2298] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2299] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2300] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2301] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2302] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2303] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2304] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2305] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2306] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2307] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2308] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2309] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2310] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2311] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2312] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2313] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2314] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2315] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2316] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2317] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2318] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2319] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2320] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF_(3;) Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2321] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2322] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2323] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2324] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2325] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2326] In another embodiment, Art is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2327] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2328] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2329] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2330] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2331] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2332] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2333] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; R₄is —H; Ar₂ is a benzoimidazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2334] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2335] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2336] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2337] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2338] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2339] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2340] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2341] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2342] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2343] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2344] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2345] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H.

[2346] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2347] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2348] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2349] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2350] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2351] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2352] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2353] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2354] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2355] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2356] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2357] In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2358] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2359] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2360] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2361] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2362] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2363] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2364] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2365] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2366] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2367] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2368] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2369] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2370] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2371] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2372] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2373] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2374] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2375] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2376] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2377] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₁ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2378] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2379] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2380] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2381] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2382] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2383] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2384] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2385] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2386] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2387] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2388] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2389] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2390] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2391] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2392] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2393] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2394] In another embodiment, Ar¹ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2395] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2396] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2397] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2398] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2399] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2400] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2401] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2402] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2403] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2404] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2405] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2406] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2407] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzooxazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2408] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2409] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2410] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2411] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2412] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2413] In another embodiment, Ar¹ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2414] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2415] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2416] In another embodiment, Ar₁is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2417] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2418] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2419] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H.

[2420] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2421] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2422] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2423] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2424] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2425] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2426] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2427] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2428] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2429] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2430] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2431] In another embodiment, Ar1 is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2432] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2433] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2434] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2435] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2436] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2437] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2438] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2439] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2440] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2441] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2442] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2443] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2444] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2445] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2446] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2447] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2448] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2449] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2450] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2451] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2452] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2453] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2454] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2455] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2456] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2457] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2458] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another. embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2459] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2460] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2461] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2462] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2463] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2464] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2465] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2466] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2467] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2468] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2469] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2470] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2471] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2472] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2473] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2474] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2475] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2476] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2477] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2478] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2479] In another embodiment, Ar₁ is a pyridyl group, n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2480] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2481] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzooxazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2482] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2483] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2484] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2485] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2486] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2487] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2488] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2489] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2490] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2491] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2492] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2493] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H.

[2494] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2495] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2496] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2497] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2498] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2499] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2500] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2501] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2502] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2503] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2504] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2505] In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2506] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2507] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2508] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2509] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2510] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2511] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2512] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2513] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2514] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2515] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2516] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2517] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2518] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₁ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2519] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2520] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₁ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2521] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2522] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2523] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2524] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2525] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2526] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2527] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2528] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2529] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2530] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2531] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2532] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2533] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2534] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2535] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2536] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2537] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2538] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2539] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2540] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2541] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2542] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2543] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2544] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2545] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2546] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2547] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2548] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2549] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2550] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2551] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2552] In another embodiment, Ar₁ is a pyrimidinyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2553] In another embodiment, Ar₁ is a pyrimidinyl, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2554] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2555] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzothiazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2556] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2557] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2558] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2559] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2560] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2561] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2562] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2563] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2564] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2565] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2566] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2567] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2568] In another embodiment, Ar₁ _(i)s a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2569] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2570] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration. benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2571] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2572] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2573] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2574] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2575] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2576] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2577] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2578] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2579] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2580] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2581] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2582] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2583] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2584] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2585] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2586] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2587] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2588] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2589] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2590] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2591] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2592] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2593] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2594] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2595] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2596] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2597] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2598] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2599] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2600] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2601] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₁ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2602] In another embodiment, Ar₁ _(i)s a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2603] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2604] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2605] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2606] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2607] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2608] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2609] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2610] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2611] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2612] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2613] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2614] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2615] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2616] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2617] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2618] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2619] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2620] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2621] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2622] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2623] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2624] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2625] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2626] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2627] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2628] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzothiazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2629] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2630] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2631] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2632] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2633] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2634] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2635] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2636] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2637] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2638] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2639] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2640] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2641] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2642] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2643] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2644] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2645] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2646] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2647] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2648] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2649] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2650] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₁ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2651] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2652] In another embodiment, Ar1 is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2653] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2654] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2655] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2656] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2657] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2658] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2659] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2660] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2661] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2662] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2663] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2664] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2665] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2666] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2667] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2668] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2669] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2670] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2671] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2672] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2673] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2674] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2675] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2676] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2677] In another embodiment, Ar₁ _(i)s a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2678] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2679] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2680] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2681] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2682] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2683] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2684] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2685] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2686] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2687] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2688] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2689] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2690] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2691] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2692] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2693] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzothiazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2694] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2695] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2696] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2697] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2698] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2699] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2700] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzothiazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2701] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2702] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzoimidazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2703] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2704] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2705] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2706] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2707] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2708] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyi group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2709] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2710] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2711] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2712] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2713] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2714] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2715] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2716] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2717] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2718] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration. In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2719] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2720] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2721] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2722] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2723] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2724] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2725] In another embodiment, Ar1 is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2726] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2727] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2728] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2729] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2730] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₁ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2731] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2732] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2733] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2734] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2735] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2736] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2737] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2738] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2739] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2740] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2741] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2742] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2743] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2744] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2745] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2746] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2747] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2748] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2749] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2750] In another embodiment, Ar₁ is a pyridyl.group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2751] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2752] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2753] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2754] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2755] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2756] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2757] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2758] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2759] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2760] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2761] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2762] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2763] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2764] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2765] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2766] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2767] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2768] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2769] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2770] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2771] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2772] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2773] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2774] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2775] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzoimidazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2776] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2777] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2778] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2779] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2780] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2781] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2782] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2783] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2784] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2785] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2786] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2787] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2788] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2789] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2790] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2791] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2792] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2793] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₁ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2794] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2795] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2796] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2797] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2798] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2799] In another embodiment, Ar1 is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2800] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2801] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2802] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2803] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2804] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2805] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2806] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2807] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2808] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2809] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2810] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2811] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2812] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2813] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2814] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2815] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2816] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2817] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2818] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2819] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2820] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2821] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2822] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2823] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2824] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2825] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2826] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2827] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2828] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₁ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2829] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2830] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2831] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2832] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2833] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2834] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2835] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2836] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2837] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2838] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2839] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2840] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzoimidazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2841] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2842] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2843] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzoimidazolyl group; R₁ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2844] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2845] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2846] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2847] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzoimidazolyl group; R₉ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2848] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2849] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzooxazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2850] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2851] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2852] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2853] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2854] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2855] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2856] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2857] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2858] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2859] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2860] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2861] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H.

[2862] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2863] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2864] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2865] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2866] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2867] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2868] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2869] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2870] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2871] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2872] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2873] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₁ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2874] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2875] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₁ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2876] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2877] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2878] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2879] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2880] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has.the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2881] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2882] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2883] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2884] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2885] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2886] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2887] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2888] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2889] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2890] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2891] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2892] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2893] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2894] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2895] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2896] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₁ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2897] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2898] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2899] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₉ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2900] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2901] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2902] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2903] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2904] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2905] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2906] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2907] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2908] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2909] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2910] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2911] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2912] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2913] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2914] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2915] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2916] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2917] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2918] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2919] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2920] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2921] In another embodiment, Ar₁ is a pyridyl group and n is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2922] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; R₄ is —H; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2923] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; R₄ is —H; Ar₂ is a benzooxazolyl group and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2924] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2925] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2926] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2927] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2928] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2929] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2930] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2931] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2932] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2933] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —Cl; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2934] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2935] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2936] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2937] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2938] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2939] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2940] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2941] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2942] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2943] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2944] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2945] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2946] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2947] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2948] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2949] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2950] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2951] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2952] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2953] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2954] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2955] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2956] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2957] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2958] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2959] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2960] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2961] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2962] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2963] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2964] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2965] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₁ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2966] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2967] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2968] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2969] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2970] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2971] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2972] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; and R₈ and R₉ are —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2973] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -halo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2974] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -chloro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2975] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -bromo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2976] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -fluoro. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2977] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -iodo. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2978] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -halo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2979] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -chloro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2980] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -bromo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2981] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -fluoro; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2982] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is -iodo; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2983] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2984] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2985] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —CF₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2986] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —CF₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2987] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is —OCH₂CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2988] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CF₃; Ar₂ is a benzooxazolyl group; R₈ is —OCH₂CH₃; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2989] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2990] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2991] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F, —Cl, —Br, or —I; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2992] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —F; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2993] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is -tert-butyl; and R₉ is —H. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2994] In another embodiment, Ar₁ is a pyriminidyl group and p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —H; and R₉ is -tert-butyl. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2995] In another embodiment, Ar₁ is a pyriminidyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2996] In another embodiment, Ar₁ is a pyriminidyl group, p is 0; R₁ is —CH₃; Ar₂ is a benzooxazolyl group; R₈ is —CH₃; and R₉ is —CH₃. In another embodiment, the carbon atom to which the R₃ group is attached has the R configuration. In another embodiment, the carbon atom to which the R₃ group is attached has the S configuration.

[2997] In the Benzoazolylpiperazine Compounds the R₃ group can be on any carbon of the piperazine ring. In one embodiment, the R₃ group is attached to a carbon atom adjacent to the nitrogen atom attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, the R₃ group is attached to a carbon atom adjacent to the nitrogen atom attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0.

[2998] In one embodiment, wherein the Benzoazolylpiperazine Compound has an R₃ group, the carbon atom to which the R₃ group is attached has the (R) configuration. In another embodiment, wherein the Benzoazolylpiperazine Compound has an R₃ group, the carbon atom to which the R₃ group is attached has the (S) configuration.

[2999] In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen atom attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; and the carbon to which the R₃ group is attached is in the (R) configuration. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃ is —(C₁-C₄)alkyl unsubstituted or substituted with one or more halo groups. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃ is —CH₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃ is —CF₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃is —CH₂CH₃.

[3000] In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen atom attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group when x is 0; and the carbon to which the R₃ group is attached is in the (R) configuration. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃ is —(C₁-C₄)alkyl unsubstituted or substituted with one or more halo groups. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group when x is 0; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃ is —CH₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃ is —CF₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (R) configuration; and R₃ is —CH₂CH₃.

[3001] In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen atom attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; and the carbon to which the R₃ group is attached is in the (S) configuration. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —(C₁-C₄)alkyl unsubstituted or substituted with one or more halo groups. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —CH₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —CF₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —CH₂CH₃.

[3002] In another embodiment, the Benzoazolylpiperazine Compound has an R₃ groups; the R₃ group is attached to a carbon atom adjacent to a nitrogen atom attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the carbon to which the R₃ group is attached is in the (S) configuration. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —(C₁-C₄)alkyl unsubstituted or substituted with one or more halo groups. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —CH₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —CF₃. In another embodiment, the Benzoazolylpiperazine Compound has an R₃ group; the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (S) configuration; and R₃ is —CH₂CH₃.

[3003] In a preferred embodiment, the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the R₃ group is a —CH₃. In another preferred embodiment, the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0 and the R₃ group is a —CF₃. In another preferred embodiment, the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the R₃ group is a —CH₂CH₃. In another preferred embodiment, the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the carbon to which the R₃ group is attached is in the (R) configuration. In another preferred embodiment, the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (R) configuration; and the R₃ group is a —CH₃. In another preferred embodiment, the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (R) configuration; and the R₃ group is a —CF₃. In another preferred embodiment, the R₃ group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R₃ group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R₃ group is attached is in the (R) configuration; and the R₃ group is a —CH₂CH₃.

[3004] Illustrative Benzoazolylpiperazine Compounds are listed below in Tables I-XXII: TABLE I

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ AAA -2-(3-chloropyridyl) —Cl —H AAB -2-(3-chloropyridyl) —Br —H AAC -2-(3-chloropyridyl) —F —H AAD -2-(3-chloropyridyl) —CH₃ —H AAE -2-(3-chloropyridyl) —CF₃ —H AAF -2-(3-chloropyridyl) —OCH₃ —H AAG -2-(3-chloropyridyl) —OCH₂CH₃ —H AAH -2-(3-chloropyridyl) —OCF₃ —H AAI -2-(3-chloropyridyl) -tert-butyl —H AAJ -2-(3-chloropyridyl) -iso-propyl —H AAK -2-(3-chloropyridyl) —CH₃ —CH₃ AAL -2-(3-chloropyridyl) —H —H AAM -2-(3-chloropyridyl) —H —Cl AAN -2-(3-chloropyridyl) —H —Br AAO -2-(3-chloropyridyl) —H —F AAP -2-(3-chloropyridyl) —H —CH₃ AAQ -2-(3-chloropyridyl) —H —CF₃ AAR -2-(3-chloropyridyl) —H —OCH₃ AAS -2-(3-chloropyridyl) —H —OCH₂CH₃ AAT -2-(3-chloropyridyl) —H —OCF₃ AAU -2-(3-chloropyridyl) —H -tert-butyl AAV -2-(3-chloropyridyl) —H -iso-propyl AAW -2-(3-methylpyridyl) —Cl —H AAX -2-(3-methylpyridyl) —Br —H AAY -2-(3-methylpyridyl) —F —H AAZ -2-(3-methylpyridyl) —CH₃ —H ABA -2-(3-methylpyridyl) —CF₃ —H ABB -2-(3-methylpyridyl) —OCH₃ —H ABC -2-(3-methylpyridyl) —OCH₂CH₃ —H ABD -2-(3-methylpyridyl) —OCF₃ —H ABE -2-(3-methylpyridyl) -tert-butyl —H ABF -2-(3-methylpyridyl) -iso-propyl —H ABG -2-(3-methylpyridyl) —CH₃ —CH₃ ABH -2-(3-methylpyridyl) —H —H ABI -2-(3-methylpyridyl) —H —Cl ABJ -2-(3-methylpyridyl) —H —Br ABK -2-(3-methylpyridyl) —H —F ABL -2-(3-methylpyridyl) —H —CH₃ ABM -2-(3-methylpyridyl) —H —CF₃ ABN -2-(3-methylpyridyl) —H —OCH₃ ABO -2-(3-methylpyridyl) —H —OCH₂CH₃ ABP -2-(3-methylpyridyl) —H —OCF₃ ABQ -2-(3-methylpyridyl) —H -tert-butyl ABR -2-(3-methylpyridyl) —H -iso-propyl ABS -2-(3-CF₃-pyridyl) —Cl —H ABT -2-(3-CF₃-pyridyl) —Br —H ABU -2-(3-CF₃-pyridyl) —F —H ABV -2-(3-CF₃-pyridyl) —CH₃ —H ABW -2-(3-CF₃-pyridyl) —CF₃ —H ABX -2-(3-CF₃-pyridyl) —OCH₃ —H ABY -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H ABZ -2-(3-CF₃-pyridyl) —OCF₃ —H ACA -2-(3-CF₃-pyridyl) -tert-butyl —H ACB -2-(3-CF₃-pyridyl) -iso-propyl —H ACC -2-(3-CF₃-pyridyl) —CH₃ —CH₃ ACD -2-(3-CF₃-pyridyl) —H —H ACE -2-(3-CF₃-pyridyl) —H —Cl ACF -2-(3-CF₃-pyridyl) —H —Br ACG -2-(3-CF₃-pyridyl) —H —F ACH -2-(3-CF₃-pyridyl) —H —CH₃ ACI -2-(3-CF₃-pyridyl) —H —CF₃ ACJ -2-(3-CF₃-pyridyl) —H —OCH₃ ACK -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ ACL -2-(3-CF₃-pyridyl) —H —OCF₃ ACM -2-(3-CF₃-pyridyl) —H -tert-butyl ACN -2-(3-CF₃-pyridyl) —H -iso-propyl ACO -4-(5-chloropyrimidinyl) —Cl —H ACP -4-(5-chloropyrimidinyl) —Br —H ACQ -4-(5-chloropyrimidinyl) —F —H ACR -4-(5-chloropyrimidinyl) —CH₃ —H ACS -4-(5-chloropyrimidinyl) —CF₃ —H ACT -4-(5-chloropyrimidinyl) —OCH₃ —H ACU -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H ACV -4-(5-chloropyrimidinyl) —OCF₃ —H ACW -4-(5-chloropyrimidinyl) -tert-butyl —H ACX -4-(5-chloropyrimidinyl) -iso-propyl —H ACY -4-(5-chloropyrimidinyl) —CH₃ —CH₃ ACZ -4-(5-chloropyrimidinyl) —H —H ADA -4-(5-chloropyrimidinyl) —H —Cl ADB -4-(5-chloropyrimidinyl) —H —Br ADC -4-(5-chloropyrimidinyl) —H —F ADD -4-(5-chloropyrimidinyl) —H —CH₃ ADE -4-(5-chloropyrimidinyl) —H —CF₃ ADF -4-(5-chloropyrimidinyl) —H —OCH₃ ADG -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ ADH -4-(5-chloropyrimidinyl) —H —OCF₃ ADI -4-(5-chloropyrimidinyl) —H -tert-butyl ADJ -4-(5-chloropyrimidinyl) —H -iso-propyl ADK -4-(5-methylpyrimidinyl) —Cl —H ADL -4-(5-methylpyrimidinyl) —Br —H ADM -4-(5-methylpyrimidinyl) —F —H ADN -4-(5-methylpyrimidinyl) —CH₃ —H ADO -4-(5-methylpyrimidinyl) —CF₃ —H ADP -4-(5-methylpyrimidinyl) —OCH₃ —H ADQ -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H ADR -4-(5-methylpyrimidinyl) —OCF₃ —H ADS -4-(5-methylpyrimidinyl) -tert-butyl —H ADT -4-(5-methylpyrimidinyl) -iso-propyl —H ADU -4-(5-methylpyrimidinyl) —CH₃ —CH₃ ADV -4-(5-methylpyrimidinyl) —H —H ADW -4-(5-methylpyrimidinyl) —H —Cl ADX -4-(5-methylpyrimidinyl) —H —Br ADY -4-(5-methylpyrimidinyl) —H —F ADZ -4-(5-methylpyrimidinyl) —H —CH₃ AEA -4-(5-methylpyrimidinyl) —H —CF₃ AEB -4-(5-methylpyrimidinyl) —H —OCH₃ AEC -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ AED -4-(5-methylpyrimidinyl) —H —OCF₃ AEE -4-(5-methylpyrimidinyl) —H -tert-butyl AEF -4-(5-methylpyrimidinyl) —H -iso-propyl AEG -2-pyrazinyl —Cl —H AEH -2-pyrazinyl —Br —H AEI -2-pyrazinyl —F —H AEJ -2-pyrazinyl —CH₃ —H AEK -2-pyrazinyl —CF₃ —H AEL -2-pyrazinyl —OCH₃ —H AEM -2-pyrazinyl —OCH₂CH₃ —H AEN -2-pyrazinyl —OCF₃ —H AEO -2-pyrazinyl -tert-butyl —H AEP -2-pyrazinyl -iso-propyl —H AEQ -2-pyrazinyl —CH₃ —CH₃ AER -2-pyrazinyl —H —H AES -2-pyrazinyl —H —Cl AET -2-pyrazinyl —H —Br AEU -2-pyrazinyl —H —F AEV -2-pyrazinyl —H —CH₃ AEW -2-pyrazinyl —H —CF₃ AEX -2-pyrazinyl —H —OCH₃ AEY -2-pyrazinyl —H —OCH₂CH₃ AEZ -2-pyrazinyl —H —OCF₃ AFA -2-pyrazinyl —H -tert-butyl AFB -2-pyrazinyl —H -iso-propyl AFC -2-(3-chloropyrazinyl) —Cl —H AFD -2-(3-chloropyrazinyl) —Br —H AFE -2-(3-chloropyrazinyl) —F —H AFF -2-(3-chloropyrazinyl) —CH₃ —H AFG -2-(3-chloropyrazinyl) —CF₃ —H AFH -2-(3-chloropyrazinyl) —OCH₃ —H AFI -2-(3-chloropyrazinyl) —OCH₂CH₃ —H AFJ -2-(3-chloropyrazinyl) —OCF₃ —H AFK -2-(3-chloropyrazinyl) -tert-butyl —H AFL -2-(3-chloropyrazinyl) -iso-propyl —H AFM -2-(3-chloropyrazinyl) —CH₃ —CH₃ AFN -2-(3-chloropyrazinyl) —H —H AFO -2-(3-chloropyrazinyl) —H —Cl AFP -2-(3-chloropyrazinyl) —H —Br AFQ -2-(3-chloropyrazinyl) —H —F AFR -2-(3-chloropyrazinyl) —H —CH₃ AFS -2-(3-chloropyrazinyl) —H —CF₃ AFT -2-(3-chloropyrazinyl) —H —OCH₃ AFU -2-(3-chloropyrazinyl) —H —OCH₂CH₃ AFV -2-(3-chloropyrazinyl) —H —OCF₃ AFW -2-(3-chloropyrazinyl) —H -tert-butyl AFX -2-(3-chloropyrazinyl) —H -iso-propyl AFY -2-(3-methylpyrazinyl) —Cl —H AFZ -2-(3-methylpyrazinyl) —Br —H AGA -2-(3-methylpyrazinyl) —F —H AGB -2-(3-methylpyrazinyl) —CH₃ —H AGC -2-(3-methylpyrazinyl) —CF₃ —H AGD -2-(3-methylpyrazinyl) —OCH₃ —H AGE -2-(3-methylpyrazinyl) —OCH₂CH₃ —H AGF -2-(3-methylpyrazinyl) —OCF₃ —H AGG -2-(3-methylpyrazinyl) -tert-butyl —H AGH -2-(3-methylpyrazinyl) -iso-propyl —H AGI -2-(3-methylpyrazinyl) —CH₃ —CH₃ AGJ -2-(3-methylpyrazinyl) —H —H AGK -2-(3-methylpyrazinyl) —H —Cl AGL -2-(3-methylpyrazinyl) —H —Br AGM -2-(3-methylpyrazinyl) —H —F AGN -2-(3-methylpyrazinyl) —H —CH₃ AGO -2-(3-methylpyrazinyl) —H —CF₃ AGP -2-(3-methylpyrazinyl) —H —OCH₃ AGQ -2-(3-methylpyrazinyl) —H —OCH₂CH₃ AGR -2-(3-methylpyrazinyl) —H —OCF₃ AGS -2-(3-methylpyrazinyl) —H -tert-butyl AGT -2-(3-methylpyrazinyl) —H -iso-propyl AGU -2-pyridazinyl —Cl —H AGV -2-pyridazinyl —Br —H AGW -2-pyridazinyl —F —H AGX -2-pyridazinyl —CH₃ —H AGY -2-pyridazinyl —CF₃ —H AGZ -2-pyridazinyl —OCH₃ —H AHA -2-pyridazinyl —OCH₂CH₃ —H AHB -2-pyridazinyl —OCF₃ —H AHC -2-pyridazinyl -tert-butyl —H AHD -2-pyridazinyl -iso-propyl —H AHE -2-pyridazinyl —CH₃ —CH₃ AHF -2-pyridazinyl —H —H AHG -2-pyridazinyl —H —Cl AHH -2-pyridazinyl —H —Br AHI -2-pyridazinyl —H —F AHJ -2-pyridazinyl —H —CH₃ AHK -2-pyridazinyl —H —CF₃ AHL -2-pyridazinyl —H —OCH₃ AHM -2-pyridazinyl —H —OCH₂CH₃ AHN -2-pyridazinyl —H —OCF₃ AHO -2-pyridazinyl —H -tert-butyl AHP -2-pyridazinyl —H -iso-propyl AHQ -3-(4-chloropyridazinyl) —Cl —H AHR -3-(4-chloropyridazinyl) —Br —H AHS -3-(4-chloropyridazinyl) —F —H AHT -3-(4-chloropyridazinyl) —CH₃ —H AHU -3-(4-chloropyridazinyl) —CF₃ —H AHV -3-(4-chloropyridazinyl) —OCH₃ —H AHW -3-(4-chloropyridazinyl) —OCH₂CH₃ —H AHX -3-(4-chloropyridazinyl) —OCF₃ —H AHY -3-(4-chloropyridazinyl) -tert-butyl —H AHZ -3-(4-chloropyridazinyl) -iso-propyl —H AIA -3-(4-chloropyridazinyl) —CH₃ —CH₃ AIB -3-(4-chloropyridazinyl) —H —H AIC -3-(4-chloropyridazinyl) —H —Cl AID -3-(4-chloropyridazinyl) —H —Br AIE -3-(4-chloropyridazinyl) —H —F AIF -3-(4-chloropyridazinyl) —H —CH₃ AIG -3-(4-chloropyridazinyl) —H —CF₃ AIH -3-(4-chloropyridazinyl) —H —OCH₃ AII -3-(4-chloropyridazinyl) —H —OCH₂CH₃ AIJ -3-(4-chloropyridazinyl) —H —OCF₃ AIK -3-(4-chloropyridazinyl) —H -tert-butyl AIL -3-(4-chloropyridazinyl) —H -iso-propyl AIM -3-(4-methylpyridazinyl) —Cl —H AIN -3-(4-methylpyridazinyl) —Br —H AIO -3-(4-methylpyridazinyl) —F —H AIP -3-(4-methylpyridazinyl) —CH₃ —H AIQ -3-(4-methylpyridazinyl) —CF₃ —H AIR -3-(4-methylpyridazinyl) —OCH₃ —H AIS -3-(4-methylpyridazinyl) —OCH₂CH₃ —H AIT -3-(4-methylpyridazinyl) —OCF₃ —H AIU -3-(4-methylpyridazinyl) -tert-butyl —H AIV -3-(4-methylpyridazinyl) -iso-propyl —H AIW -3-(4-methylpyridazinyl) —CH₃ —CH₃ AIX -3-(4-methylpyridazinyl) —H —H AIY -3-(4-methylpyridazinyl) —H —Cl AIZ -3-(4-methylpyridazinyl) —H —Br AJA -3-(4-methylpyridazinyl) —H —F AJB -3-(4-methylpyridazinyl) —H —CH₃ AJC -3-(4-methylpyridazinyl) —H —CF₃ AJD -3-(4-methylpyridazinyl) —H —OCH₃ AJE -3-(4-methylpyridazinyl) —H —OCH₂CH₃ AJF -3-(4-methylpyridazinyl) —H —OCF₃ AJG -3-(4-methylpyridazinyl) —H -tert-butyl AJH -3-(4-methylpyridazinyl) —H -iso-propyl AJI -4-thiazanyl —Cl —H AJJ -4-thiazanyl —Br —H AJK -4-thiazanyl —F —H AJL -4-thiazanyl —CH₃ —H AJM -4-thiazanyl —CF₃ —H AJN -4-thiazanyl —OCH₃ —H AJO -4-thiazanyl —OCH₂CH₃ —H AJP -4-thiazanyl —OCF₃ —H AJQ -4-thiazanyl -tert-butyl —H AJR -4-thiazanyl -iso-propyl —H AJS -4-thiazanyl —CH₃ —CH₃ AJT -4-thiazanyl —H —H AJU -4-thiazanyl —H —Cl AJV -4-thiazanyl —H —Br AJW -4-thiazanyl —H —F AJX -4-thiazanyl —H —CH₃ AJY -4-thiazanyl —H —CF₃ AJZ -4-thiazanyl —H —OCH₃ AKA -4-thiazanyl —H —OCH₂CH₃ AKB -4-thiazanyl —H —OCF₃ AKC -4-thiazanyl —H -tert-butyl AKD -4-thiazanyl —H -iso-propyl AKE -5-(4-chlorothiazanyl) —Cl —H AKF -5-(4-chlorothiazanyl) —Br —H AKG -5-(4-chlorothiazanyl) —F —H AKH -5-(4-chlorothiazanyl) —CH₃ —H AKI -5-(4-chlorothiazanyl) —CF₃ —H AKJ -5-(4-chlorothiazanyl) —OCH₃ —H AKK -5-(4-chlorothiazanyl) —OCH₂CH₃ —H AKL -5-(4-chlorothiazanyl) —OCF₃ —H AKM -5-(4-chlorothiazanyl) -tert-butyl —H AKN -5-(4-chlorothiazanyl) -iso-propyl —H AKO -5-(4-chlorothiazanyl) —CH₃ —CH₃ AKP -5-(4-chlorothiazanyl) —H —H AKQ -5-(4-chlorothiazanyl) —H —Cl AKR -5-(4-chlorothiazanyl) —H —Br AKS -5-(4-chlorothiazanyl) —H —F AKT -5-(4-chlorothiazanyl) —H —CH₃ AKU -5-(4-chlorothiazanyl) —H —CF₃ AKV -5-(4-chlorothiazanyl) —H —OCH₃ AKW -5-(4-chlorothiazanyl) —H —OCH₂CH₃ AKX -5-(4-chlorothiazanyl) —H —OCF₃ AKY -5-(4-chlorothiazanyl) —H -tert-butyl AKZ -5-(4-chlorothiazanyl) —H -iso-propyl ALA -5-(4-methylthiazanyl) —Cl —H ALB -5-(4-methylthiazanyl) —Br —H ALC -5-(4-methylthiazanyl) —F —H ALD -5-(4-methylthiazanyl) —CH₃ —H ALE -5-(4-methylthiazanyl) —CF₃ —H ALF -5-(4-methylthiazanyl) —OCH₃ —H ALG -5-(4-methylthiazanyl) —OCH₂CH₃ —H ALH -5-(4-methylthiazanyl) —OCF₃ —H ALI -5-(4-methylthiazanyl) -tert-butyl —H ALJ -5-(4-methylthiazanyl) -iso-propyl —H ALK -5-(4-methylthiazanyl) —CH₃ —CH₃ ALL -5-(4-methylthiazanyl) —H —H ALM -5-(4-methylthiazanyl) —H —Cl ALN -5-(4-methylthiazanyl) —H —Br ALO -5-(4-methylthiazanyl) —H —F ALP -5-(4-methylthiazanyl) —H —CH₃ ALQ -5-(4-methylthiazanyl) —H —CF₃ ALR -5-(4-methylthiazanyl) —H —OCH₃ ALS -5-(4-methylthiazanyl) —H —OCH₂CH₃ ALT -5-(4-methylthiazanyl) —H —OCF₃ ALU -5-(4-methylthiazanyl) —H -tert-butyl ALV -5-(4-methylthiazanyl) —H -iso-propyl

[3005] TABLE II

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ ALW -2-(3-chloropyridyl) —Cl —H ALX -2-(3-chloropyridyl) —Br —H ALY -2-(3-chloropyridyl) —F —H ALZ -2-(3-chloropyridyl) —CH₃ —H AMA -2-(3-chloropyridyl) —CF₃ —H AMB -2-(3-chloropyridyl) —OCH₃ —H AMC -2-(3-chloropyridyl) —OCH₂CH₃ —H AMD -2-(3-chloropyridyl) —OCF₃ —H AME -2-(3-chloropyridyl) -tert-butyl —H AMF -2-(3-chloropyridyl) -iso-propyl —H AMG -2-(3-chloropyridyl) —CH₃ —CH₃ AMH -2-(3-chloropyridyl) —H —H AMI -2-(3-chloropyridyl) —H —Cl AMJ -2-(3-chloropyridyl) —H —Br AMK -2-(3-chloropyridyl) —H —F AML -2-(3-chloropyridyl) —H —CH₃ AMM -2-(3-chloropyridyl) —H —CF₃ AMN -2-(3-chloropyridyl) —H —OCH₃ AMO -2-(3-chloropyridyl) —H —OCH₂CH₃ AMP -2-(3-chloropyridyl) —H —OCF₃ AMQ -2-(3-chloropyridyl) —H -tert-butyl AMR -2-(3-chloropyridyl) —H -iso-propyl AMS -2-(3-methylpyridyl) —Cl —H AMT -2-(3-methylpyridyl) —Br —H AMU -2-(3-methylpyridyl) —F —H AMV -2-(3-methylpyridyl) —CH₃ —H AMW -2-(3-methylpyridyl) —CF₃ —H AMX -2-(3-methylpyridyl) —OCH₃ —H AMY -2-(3-methylpyridyl) —OCH₂CH₃ —H AMZ -2-(3-methylpyridyl) —OCF₃ —H ANA -2-(3-methylpyridyl) -tert-butyl —H ANB -2-(3-methylpyridyl) -iso-propyl —H ANC -2-(3-methylpyridyl) —CH₃ —CH₃ AND -2-(3-methylpyridyl) —H —H ANE -2-(3-methylpyridyl) —H —Cl ANF -2-(3-methylpyridyl) —H —Br ANG -2-(3-methylpyridyl) —H —F ANH -2-(3-methylpyridyl) —H —CH₃ ANI -2-(3-methylpyridyl) —H —CF₃ ANJ -2-(3-methylpyridyl) —H —OCH₃ ANK -2-(3-methylpyridyl) —H —OCH₂CH₃ ANL -2-(3-methylpyridyl) —H —OCF₃ ANM -2-(3-methylpyridyl) —H -tert-butyl ANN -2-(3-methylpyridyl) —H -iso-propyl ANO -2-(3-CF₃-pyridyl) —Cl —H ANP -2-(3-CF₃-pyridyl) —Br —H ANQ -2-(3-CF₃-pyridyl) —F —H ANR -2-(3-CF₃-pyridyl) —CH₃ —H ANS -2-(3-CF₃-pyridyl) —CF₃ —H ANT -2-(3-CF₃-pyridyl) —OCH₃ —H ANU -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H ANV -2-(3-CF₃-pyridyl) —OCF₃ —H ANW -2-(3-CF₃-pyridyl) -tert-butyl —H ANX -2-(3-CF₃-pyridyl) -iso-propyl —H ANY -2-(3-CF₃-pyridyl) —CH₃ —CH₃ ANZ -2-(3-CF₃-pyridyl) —H —H AOA -2-(3-CF₃-pyridyl) —H —Cl AOB -2-(3-CF₃-pyridyl) —H —Br AOC -2-(3-CF₃-pyridyl) —H —F AOD -2-(3-CF₃-pyridyl) —H —CH₃ AOE -2-(3-CF₃-pyridyl) —H —CF₃ AOF -2-(3-CF₃-pyridyl) —H —OCH₃ AOG -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ AOH -2-(3-CF₃-pyridyl) —H —OCF₃ AOI -2-(3-CF₃-pyridyl) —H -tert-butyl AOJ -2-(3-CF₃-pyridyl) —H -iso-propyl AOK -4-(5-chloropyrimidinyl) —Cl —H AOL -4-(5-chloropyrimidinyl) —Br —H AOM -4-(5-chloropyrimidinyl) —F —H AON -4-(5-chloropyrimidinyl) —CH₃ —H AOO -4-(5-chloropyrimidinyl) —CF₃ —H AOP -4-(5-chloropyrimidinyl) —OCH₃ —H AOQ -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H AOR -4-(5-chloropyrimidinyl) —OCF₃ —H AOS -4-(5-chloropyrimidinyl) -tert-butyl —H AOT -4-(5-chloropyrimidinyl) -iso-propyl —H AOU -4-(5-chloropyrimidinyl) —CH₃ —CH₃ AOV -4-(5-chloropyrimidinyl) —H —H AOW -4-(5-chloropyrimidinyl) —H —Cl AOX -4-(5-chloropyrimidinyl) —H —Br AOY -4-(5-chloropyrimidinyl) —H —F AOZ -4-(5-chloropyrimidinyl) —H —CH₃ APA -4-(5-chloropyrimidinyl) —H —CF₃ APB -4-(5-chloropyrimidinyl) —H —OCH₃ APC -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ APD -4-(5-chloropyrimidinyl) —H —OCF₃ APE -4-(5-chloropyrimidinyl) —H -tert-butyl APF -4-(5-chloropyrimidinyl) —H -iso-propyl APG -4-(5-methylpyrimidinyl) —Cl —H APH -4-(5-methylpyrimidinyl) —Br —H API -4-(5-methylpyrimidinyl) —F —H APJ -4-(5-methylpyrimidinyl) —CH₃ —H APK -4-(5-methylpyrimidinyl) —CF₃ —H APL -4-(5-methylpyrimidinyl) —OCH₃ —H APM -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H APN -4-(5-methylpyrimidinyl) —OCF₃ —H APO -4-(5-methylpyrimidinyl) -tert-butyl —H APP -4-(5-methylpyrimidinyl) -iso-propyl —H APQ -4-(5-methylpyrimidinyl) —CH₃ —CH₃ APR -4-(5-methylpyrimidinyl) —H —H APS -4-(5-methylpyrimidinyl) —H —Cl APT -4-(5-methylpyrimidinyl) —H —Br APU -4-(5-methylpyrimidinyl) —H —F APV -4-(5-methylpyrimidinyl) —H —CH₃ APW -4-(5-methylpyrimidinyl) —H —CF₃ APX -4-(5-methylpyrimidinyl) —H —OCH₃ APY -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ APZ -4-(5-methylpyrimidinyl) —H —OCF₃ AQA -4-(5-methylpyrimidinyl) —H -tert-butyl AQB -4-(5-methylpyrimidinyl) —H -iso-propyl AQC -2-pyrazinyl —Cl —H AQD -2-pyrazinyl —Br —H AQE -2-pyrazinyl —F —H AQF -2-pyrazinyl —CH₃ —H AQG -2-pyrazinyl —CF₃ —H AQH -2-pyrazinyl —OCH₃ —H AQI -2-pyrazinyl —OCH₂CH₃ —H AQJ -2-pyrazinyl —OCF₃ —H AQK -2-pyrazinyl -tert-butyl —H AQL -2-pyrazinyl -iso-propyl —H AQM -2-pyrazinyl —CH₃ —CH₃ AQN -2-pyrazinyl —H —H AQO -2-pyrazinyl —H —Cl AQP -2-pyrazinyl —H —Br AQQ -2-pyrazinyl —H —F AQR -2-pyrazinyl —H —CH₃ AQS -2-pyrazinyl —H —CF₃ AQT -2-pyrazinyl —H —OCH₃ AQU -2-pyrazinyl —H —OCH₂CH₃ AQV -2-pyrazinyl —H —OCF₃ AQW -2-pyrazinyl —H -tert-butyl AQX -2-pyrazinyl —H -iso-propyl AQY -2-(3-chloropyrazinyl) —Cl —H AQZ -2-(3-chloropyrazinyl) —Br —H ARA -2-(3-chloropyrazinyl) —F —H ARB -2-(3-chloropyrazinyl) —CH₃ —H ARC -2-(3-chloropyrazinyl) —CF₃ —H ARD -2-(3-chloropyrazinyl) —OCH₃ —H ARE -2-(3-chloropyrazinyl) —OCH₂CH₃ —H ARF -2-(3-chloropyrazinyl) —OCF₃ —H ARG -2-(3-chloropyrazinyl) -tert-butyl —H ARH -2-(3-chloropyrazinyl) -iso-propyl —H ARI -2-(3-chloropyrazinyl) —CH₃ —CH₃ ARJ -2-(3-chloropyrazinyl) —H —H ARK -2-(3-chloropyrazinyl) —H —Cl ARL -2-(3-chloropyrazinyl) —H —Br ARM -2-(3-chloropyrazinyl) —H —F ARN -2-(3-chloropyrazinyl) —H —CH₃ ARO -2-(3-chloropyrazinyl) —H —CF₃ ARP -2-(3-chloropyrazinyl) —H —OCH₃ ARQ -2-(3-chloropyrazinyl) —H —OCH₂CH₃ ARR -2-(3-chloropyrazinyl) —H —OCF₃ ARS -2-(3-chloropyrazinyl) —H -tert-butyl ART -2-(3-chloropyrazinyl) —H -iso-propyl ARU -2-(3-methylpyrazinyl) —Cl —H ARV -2-(3-methylpyrazinyl) —Br —H ARW -2-(3-methylpyrazinyl) —F —H ARX -2-(3-methylpyrazinyl) —CH₃ —H ARY -2-(3-methylpyrazinyl) —CF₃ —H ARZ -2-(3-methylpyrazinyl) —OCH₃ —H ASA -2-(3-methylpyrazinyl) —OCH₂CH₃ —H ASB -2-(3-methylpyrazinyl) —OCF₃ —H ASC -2-(3-methylpyrazinyl) -tert-butyl —H ASD -2-(3-methylpyrazinyl) -iso-propyl —H ASE -2-(3-methylpyrazinyl) —CH₃ —CH₃ ASF -2-(3-methylpyrazinyl) —H —H ASG -2-(3-methylpyrazinyl) —H —Cl ASH -2-(3-methylpyrazinyl) —H —Br ASI -2-(3-methylpyrazinyl) —H —F ASJ -2-(3-methylpyrazinyl) —H —CH₃ ASK -2-(3-methylpyrazinyl) —H —CF₃ ASL -2-(3-methylpyrazinyl) —H —OCH₃ ASM -2-(3-methylpyrazinyl) —H —OCH₂CH₃ ASN -2-(3-methylpyrazinyl) —H —OCF₃ ASO -2-(3-methylpyrazinyl) —H -tert-butyl ASP -2-(3-methylpyrazinyl) —H -iso-propyl ASQ -2-pyridazinyl —Cl —H ASR -2-pyridazinyl —Br —H ASS -2-pyridazinyl —F —H AST -2-pyridazinyl —CH₃ —H ASU -2-pyridazinyl —CF₃ —H ASV -2-pyridazinyl —OCH₃ —H ASW -2-pyridazinyl —OCH₂CH₃ —H ASX -2-pyridazinyl —OCF₃ —H ASY -2-pyridazinyl -tert-butyl —H ASZ -2-pyridazinyl -iso-propyl —H ATA -2-pyridazinyl —CH₃ —CH₃ ATB -2-pyridazinyl —H —H ATC -2-pyridazinyl —H —Cl ATD -2-pyridazinyl —H —Br ATE -2-pyridazinyl —H —F ATF -2-pyridazinyl —H —CH₃ ATG -2-pyridazinyl —H —CF₃ ATH -2-pyridazinyl —H —OCH₃ ATI -2-pyridazinyl —H —OCH₂CH₃ ATJ -2-pyridazinyl —H —OCF₃ ATK -2-pyridazinyl —H -tert-butyl ATL -2-pyridazinyl —H -iso-propyl ATM -3-(4-chloropyridazinyl) —Cl —H ATN -3-(4-chloropyridazinyl) —Br —H ATO -3-(4-chloropyridazinyl) —F —H ATP -3-(4-chloropyridazinyl) —CH₃ —H ATQ -3-(4-chloropyridazinyl) —CF₃ —H ATR -3-(4-chloropyridazinyl) —OCH₃ —H ATS -3-(4-chloropyridazinyl) —OCH₂CH₃ —H ATT -3-(4-chloropyridazinyl) —OCF₃ —H ATU -3-(4-chloropyridazinyl) -tert-butyl —H ATV -3-(4-chloropyridazinyl) -iso-propyl —H ATW -3-(4-chloropyridazinyl) —CH₃ —CH₃ ATX -3-(4-chloropyridazinyl) —H —H ATY -3-(4-chloropyridazinyl) —H —Cl ATZ -3-(4-chloropyridazinyl) —H —Br AUA -3-(4-chloropyridazinyl) —H —F AUB -3-(4-chloropyridazinyl) —H —CH₃ AUG -3-(4-chloropyridazinyl) —H —CF₃ AUD -3-(4-chloropyridazinyl) —H —OCH₃ AUE -3-(4-chloropyridazinyl) —H —OCH₂CH₃ AUF -3-(4-chloropyridazinyl) —H —OCF₃ AUG -3-(4-chloropyridazinyl) —H -tert-butyl AUH -3-(4-chloropyridazinyl) —H -iso-propyl AUI -3-(4-methylpyridazinyl) —Cl —H AUJ -3-(4-methylpyridazinyl) —Br —H AUK -3-(4-methylpyridazinyl) —F —H AUL -3-(4-methylpyridazinyl) —CH₃ —H AUM -3-(4-methylpyridazinyl) —CF₃ —H AUN -3-(4-methylpyridazinyl) —OCH₃ —H AUO -3-(4-methylpyridazinyl) —OCH₂CH₃ —H AUP -3-(4-methylpyridazinyl) —OCF₃ —H AUQ -3-(4-methylpyridazinyl) -tert-butyl —H AUR -3-(4-methylpyridazinyl) -iso-propyl —H AUS -3-(4-methylpyridazinyl) —CH₃ —CH₃ AUT -3-(4-methylpyridazinyl) —H —H AUU -3-(4-methylpyridazinyl) —H —Cl AUV -3-(4-methylpyridazinyl) —H —Br AUW -3-(4-methylpyridazinyl) —H —F AUX -3-(4-methylpyridazinyl) —H —CH₃ AUY -3-(4-methylpyridazinyl) —H —CF₃ AUZ -3-(4-methylpyridazinyl) —H —OCH₃ AVA -3-(4-methylpyridazinyl) —H —OCH₂CH₃ AVB -3-(4-methylpyridazinyl) —H —OCF₃ AVC -3-(4-methylpyridazinyl) —H -tert-butyl AVD -3-(4-methylpyridazinyl) —H -iso-propyl AVE -4-thiazanyl —Cl —H AVF -4-thiazanyl —Br —H AVG -4-thiazanyl —F —H AVH -4-thiazanyl —CH₃ —H AVI -4-thiazanyl —CF₃ —H AVJ -4-thiazanyl —OCH₃ —H AVK -4-thiazanyl —OCH₂CH₃ —H AVL -4-thiazanyl —OCF₃ —H AVM -4-thiazanyl -tert-butyl —H AVN -4-thiazanyl -iso-propyl —H AVO -4-thiazanyl —CH₃ —CH₃ AVP -4-thiazanyl —H —H AVQ -4-thiazanyl —H —Cl AVR -4-thiazanyl —H —Br AVS -4-thiazanyl —H —F AVT -4-thiazanyl —H —CH₃ AVU -4-thiazanyl —H —CF₃ AVV -4-thiazanyl —H —OCH₃ AVW -4-thiazanyl —H —OCH₂CH₃ AVX -4-thiazanyl —H —OCF₃ AVY -4-thiazanyl —H -tert-butyl AVZ -4-thiazanyl —H -iso-propyl AWA -5-(4-chlorothiazanyl) —Cl —H AWB -5-(4-chlorothiazanyl) —Br —H AWC -5-(4-chlorothiazanyl) —F —H AWD -5-(4-chlorothiazanyl) —CH₃ —H AWE -5-(4-chlorothiazanyl) —CF₃ —H AWF -5-(4-chlorothiazanyl) —OCH₃ —H AWG -5-(4-chlorothiazanyl) —OCH₂CH₃ —H AWH -5-(4-chlorothiazanyl) —OCF₃ —H AWI -5-(4-chlorothiazanyl) -tert-butyl —H AWJ -5-(4-chlorothiazanyl) -iso-propyl —H AWK -5-(4-chlorothiazanyl) —CH₃ —CH₃ AWL -5-(4-chlorothiazanyl) —H —H AWM -5-(4-chlorothiazanyl) —H —Cl AWN -5-(4-chlorothiazanyl) —H —Br AWO -5-(4-chlorothiazanyl) —H —F AWP -5-(4-chlorothiazanyl) —H —CH₃ AWQ -5-(4-chlorothiazanyl) —H —CF₃ AWR -5-(4-chlorothiazanyl) —H —OCH₃ AWS -5-(4-chlorothiazanyl) —H —OCH₂CH₃ AWT -5-(4-chlorothiazanyl) —H —OCF₃ AWU -5-(4-chlorothiazanyl) —H -tert-butyl AWV -5-(4-chlorothiazanyl) —H -iso-propyl AWW -5-(4-methylthiazanyl) —Cl —H AWX -5-(4-methylthiazanyl) —Br —H AWY -5-(4-methylthiazanyl) —F —H AWZ -5-(4-methylthiazanyl) —CH₃ —H AXA -5-(4-methylthiazanyl) —CF₃ —H AXB -5-(4-methylthiazanyl) —OCH₃ —H AXC -5-(4-methylthiazanyl) —OCH₂CH₃ —H AXD -5-(4-methylthiazanyl) —OCF₃ —H AXE -5-(4-methylthiazanyl) -tert-butyl —H AXF -5-(4-methylthiazanyl) -iso-propyl —H AXG -5-(4-methylthiazanyl) —CH₃ —CH₃ AXH -5-(4-methylthiazanyl) —H —H AXI -5-(4-methylthiazanyl) —H —Cl AXJ -5-(4-methylthiazanyl) —H —Br AXK -5-(4-methylthiazanyl) —H —F AXL -5-(4-methylthiazanyl) —H —CH₃ AXM -5-(4-methylthiazanyl) —H —CF₃ AXN -5-(4-methylthiazanyl) —H —OCH₃ AXO -5-(4-methylthiazanyl) —H —OCH₂CH₃ AXP -5-(4-methylthiazanyl) —H —OCF₃ AXQ -5-(4-methylthiazanyl) —H -tert-butyl AXR -5-(4-methylthiazanyl) —H -iso-propyl

[3006] TABLE III

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ AXS (a, b, and c) -2-(3-chloropyridyl) —Cl —H AXT (a, b, and c) -2-(3-chloropyridyl) —Br —H AXU (a, b, and c) -2-(3-chloropyridyl) —F —H AXV (a, b, and c) -2-(3-chloropyridyl) —CH₃ —H AXW -2-(3-chloropyridyl) —CF₃ —H (a, b, and c) AXX (a, b, and c) -2-(3-chloropyridyl) —OCH₃ —H AXY (a, b, and c) -2-(3-chloropyridyl) —OCH₂CH₃ —H AXZ (a, b, and c) -2-(3-chloropyridyl) —OCF₃ —H AYA (a, b, and c) -2-(3-chloropyridyl) -tert-butyl —H AYB (a, b, and c) -2-(3-chloropyridyl) -iso-propyl —H AYC (a, b, and c) -2-(3-chloropyridyl) —CH₃ —CH₃ AYD (a, b, and c) -2-(3-chloropyridyl) —H —H AYE (a, b, and c) -2-(3-chloropyridyl) —H —Cl AYF (a, b, and c) -2-(3-chloropyridyl) —H —Br AYG (a, b, and c) -2-(3-chloropyridyl) —H —F AYH (a, b, and c) -2-(3-chloropyridyl) —H —CH₃ AYI (a, b, and c) -2-(3-chloropyridyl) —H —CF₃ AYJ (a, b, and c) -2-(3-chloropyridyl) —H —OCH₃ AYK (a, b, and c) -2-(3-chloropyridyl) —H —OCH₂CH₃ AYL (a, b, and c) -2-(3-chloropyridyl) —H —OCF₃ AYM -2-(3-chloropyridyl) —H -tert-butyl (a, b, and c) AYN (a, b, and c) -2-(3-chloropyridyl) —H -iso-propyl AYO (a, b, and c) -2-(3-methylpyridyl) —Cl —H AYP (a, b, and c) -2-(3-methylpyridyl) —Br —H AYQ (a, b, and c) -2-(3-methylpyridyl) —F —H AYR (a, b, and c) -2-(3-methylpyridyl) —CH₃ —H AYS (a, b, and c) -2-(3-methylpyridyl) —CF₃ —H AYT (a, b, and c) -2-(3-methylpyridyl) —OCH₃ —H AYU (a, b, and c) -2-(3-methylpyridyl) —OCH₂CH₃ —H AYV (a, b, and c) -2-(3-methylpyridyl) —OCF₃ —H AYW -2-(3-methylpyridyl) -tert-butyl —H (a, b, and c) AYX (a, b, and c) -2-(3-methylpyridyl) -iso-propyl —H AYY (a, b, and c) -2-(3-methylpyridyl) —CH₃ —CH₃ AYZ (a, b, and c) -2-(3-methylpyridyl) —H —H AZA (a, b, and c) -2-(3-methylpyridyl) —H —Cl AZB (a, b, and c) -2-(3-methylpyridyl) —H —Br AZC (a, b, and c) -2-(3-methylpyridyl) —H —F AZD (a, b, and c) -2-(3-methylpyridyl) —H —CH₃ AZE (a, b, and c) -2-(3-methylpyridyl) —H —CF₃ AZF (a, b, and c) -2-(3-methylpyridyl) —H —OCH₃ AZG (a, b, and c) -2-(3-methylpyridyl) —H —OCH₂CH₃ AZH (a, b, and c) -2-(3-methylpyridyl) —H —OCF₃ AZI (a, b, and c) -2-(3-methylpyridyl) —H -tert-butyl AZJ (a, b, and c) -2-(3-methylpyridyl) —H -iso-propyl AZK (a, b, and c) -2-(3-CF₃-pyridyl) —Cl —H AZL (a, b, and c) -2-(3-CF₃-pyridyl) —Br —H AZM (a, b, and c) -2-(3-CF₃-pyridyl) —F —H AZN (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —H AZO (a, b, and c) -2-(3-CF₃-pyridyl) —CF₃ —H AZP (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₃ —H AZQ (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H AZR (a, b, and c) -2-(3-CF₃-pyridyl) —OCF₃ —H AZS (a, b, and c) -2-(3-CF₃-pyridyl) -tert-butyl —H AZT (a, b, and c) -2-(3-CF₃-pyridyl) -iso-propyl —H AZU (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —CH₃ AZV (a, b, and c) -2-(3-CF₃-pyridyl) —H —H AZW -2-(3-CF₃-pyridyl) —H —Cl (a, b, and c) AZX (a, b, and c) -2-(3-CF₃-pyridyl) —H —Br AZY (a, b, and c) -2-(3-CF₃-pyridyl) —H —F AZZ (a, b, and c) -2-(3-CF₃-pyridyl) —H —CH₃ BAA (a, b, and c) -2-(3-CF₃-pyridyl) —H —CF₃ BAB (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₃ BAC (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ BAD (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCF₃ BAE (a, b, and c) -2-(3-CF₃-pyridyl) —H -tert-butyl BAF (a, b, and c) -2-(3-CF₃-pyridyl) —H -iso-propyl BAG (a, b, and c) -4-(5-chloropyrimidinyl) —Cl —H BAH (a, b, and c) -4-(5-chloropyrimidinyl) —Br —H BAI (a, b, and c) -4-(5-chloropyrimidinyl) —F —H BAJ (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —H BAK (a, b, and c) -4-(5-chloropyrimidinyl) —CF₃ —H BAL (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₃ —H BAM -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H (a, b, and c) BAN (a, b, and c) -4-(5-chloropyrimidinyl) —OCF₃ —H BAO (a, b, and c) -4-(5-chloropyrimidinyl) -tert-butyl —H BAP (a, b, and c) -4-(5-chloropyrimidinyl) -iso-propyl —H BAQ (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —CH₃ BAR (a, b, and c) -4-(5-chloropyrimidinyl) —H —H BAS (a, b, and c) -4-(5-chloropyrimidinyl) —H —Cl BAT (a, b, and c) -4-(5-chloropyrimidinyl) —H —Br BAU (a, b, and c) -4-(5-chloropyrimidinyl) —H —F BAV (a, b, and c) -4-(5-chloropyrimidinyl) —H —CH₃ BAW -4-(5-chloropyrimidinyl) —H —CF₃ (a, b, and c) BAX (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₃ BAY (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ BAZ (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCF₃ BBA (a, b, and c) -4-(5-chloropyrimidinyl) —H -tert-butyl BBB (a, b, and c) -4-(5-chloropyrimidinyl) —H -iso-propyl BBC (a, b, and c) -4-(5-methylpyrimidinyl) —Cl —H BBD (a, b, and c) -4-(5-methylpyrimidinyl) —Br —H BBE (a, b, and c) -4-(5-methylpyrimidinyl) —F —H BBF (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —H BBG (a, b, and c) -4-(5-methylpyrimidinyl) —CF₃ —H BBH (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₃ —H BBI (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H BBJ (a, b, and c) -4-(5-methylpyrimidinyl) —OCF₃ —H BBK (a, b, and c) -4-(5-methylpyrimidinyl) -tert-butyl —H BBL (a, b, and c) -4-(5-methylpyrimidinyl) -iso-propyl —H BBM (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —CH₃ BBN (a, b, and c) -4-(5-methylpyrimidinyl) —H —H BBO (a, b, and c) -4-(5-methylpyrimidinyl) —H —Cl BBP (a, b, and c) -4-(5-methylpyrimidinyl) —H —Br BBQ (a, b, and c) -4-(5-methylpyrimidinyl) —H —F BBR (a, b, and c) -4-(5-methylpyrimidinyl) —H —CH₃ BBS (a, b, and c) -4-(5-methylpyrimidinyl) —H —CF₃ BBT (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₃ BBU (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ BBV (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCF₃ BBW -4-(5-methylpyrimidinyl) —H -tert-butyl (a, b, and c) BBX (a, b, and c) -4-(5-methylpyrimidinyl) —H -iso-propyl BBY (a, b, and c) -2-pyrazinyl —Cl —H BBZ (a, b, and c) -2-pyrazinyl —Br —H BCA (a, b, and c) -2-pyrazinyl —F —H BCB (a, b, and c) -2-pyrazinyl —CH₃ —H BCC (a, b, and c) -2-pyrazinyl —CF₃ —H BCD (a, b, and c) -2-pyrazinyl —OCH₃ —H BCE (a, b, and c) -2-pyrazinyl —OCH₂CH₃ —H BCF (a, b, and c) -2-pyrazinyl —OCF₃ —H BCG (a, b, and c) -2-pyrazinyl -tert-butyl —H BCH (a, b, and c) -2-pyrazinyl -iso-propyl —H BCI (a, b, and c) -2-pyrazinyl —CH₃ —CH₃ BCJ (a, b, and c) -2-pyrazinyl —H —H BCK (a, b, and c) -2-pyrazinyl —H —Cl BCL (a, b, and c) -2-pyrazinyl —H —Br BCM (a, b, and c) -2-pyrazinyl —H —F BCN (a, b, and c) -2-pyrazinyl —H —CH₃ BCO (a, b, and c) -2-pyrazinyl —H —CF₃ BCP (a, b, and c) -2-pyrazinyl —H —OCH₃ BCQ (a, b, and c) -2-pyrazinyl —H —OCH₂CH₃ BCR (a, b, and c) -2-pyrazinyl —H —OCF₃ BCS (a, b, and c) -2-pyrazinyl —H -tert-butyl BCT (a, b, and c) -2-pyrazinyl —H -iso-propyl BCU (a, b, and c) -2-(3-chloropyrazinyl) —Cl —H BCV (a, b, and c) -2-(3-chloropyrazinyl) —Br —H BCW -2-(3-chloropyrazinyl) —F —H (a, b, and c) BCX (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —H BCY (a, b, and c) -2-(3-chloropyrazinyl) —CF₃ —H BCZ (a, b, and c) -2-(3-chloropyrazinyl) —OCH₃ —H BDA (a, b, and c) -2-(3-chloropyrazinyl) —OCH₂CH₃ —H BDB (a, b, and c) -2-(3-chloropyrazinyl) —OCF₃ —H BDC (a, b, and c) -2-(3-chloropyrazinyl) -tert-butyl —H BDD (a, b, and c) -2-(3-chloropyrazinyl) -iso-propyl —H BDE (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —CH₃ BDF (a, b, and c) -2-(3-chloropyrazinyl) —H —H BDG (a, b, and c) -2-(3-chloropyrazinyl) —H —Cl BDH (a, b, and c) -2-(3-chloropyrazinyl) —H —Br BDI (a, b, and c) -2-(3-chloropyrazinyl) —H —F BDJ (a, b, and c) -2-(3-chloropyrazinyl) —H —CH₃ BDK (a, b, and c) -2-(3-chloropyrazinyl) —H —CF₃ BDL (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₃ BDM -2-(3-chloropyrazinyl) —H —OCH₂CH₃ (a, b, and c) BDN (a, b, and c) -2-(3-chloropyrazinyl) —H —OCF₃ BDO (a, b, and c) -2-(3-chloropyrazinyl) —H -tert-butyl BDP (a, b, and c) -2-(3-chloropyrazinyl) —H -iso-propyl BDQ (a, b, and c) -2-(3-methylpyrazinyl) —Cl —H BDR (a, b, and c) -2-(3-methylpyrazinyl) —Br —H BDS (a, b, and c) -2-(3-methylpyrazinyl) —F —H BDT (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —H BDU (a, b, and c) -2-(3-methylpyrazinyl) —CF₃ —H BDV (a, b, and c) -2-(3-methylpyrazinyl) —OCH₃ —H BDW -2-(3-methylpyrazinyl) —OCH₂CH₃ —H (a, b, and c) BDX (a, b, and c) -2-(3-methylpyrazinyl) —OCF₃ —H BDY (a, b, and c) -2-(3-methylpyrazinyl) -tert-butyl —H BDZ (a, b, and c) -2-(3-methylpyrazinyl) -iso-propyl —H BEA (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —CH₃ BEB (a, b, and c) -2-(3-methylpyrazinyl) —H —H BEC (a, b, and c) -2-(3-methylpyrazinyl) —H —Cl BED (a, b, and c) -2-(3-methylpyrazinyl) —H —Br BEE (a, b, and c) -2-(3-methylpyrazinyl) —H —F BEF (a, b, and c) -2-(3-methylpyrazinyl) —H —CH₃ BEG (a, b, and c) -2-(3-methylpyrazinyl) —H —CF₃ BEH (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₃ BEI (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₂CH₃ BEJ (a, b, and c) -2-(3-methylpyrazinyl) —H —OCF₃ BEK (a, b, and c) -2-(3-methylpyrazinyl) —H -tert-butyl BEL (a, b, and c) -2-(3-methylpyrazinyl) —H -iso-propyl BEM (a, b, and c) -2-pyridazinyl —Cl —H BEN (a, b, and c) -2-pyridazinyl —Br —H BEO (a, b, and c) -2-pyridazinyl —F —H BEP (a, b, and c) -2-pyridazinyl —CH₃ —H BEQ (a, b, and c) -2-pyridazinyl —CF₃ —H BER (a, b, and c) -2-pyridazinyl —OCH₃ —H BES (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H BET (a, b, and c) -2-pyridazinyl —OCF₃ —H BEU (a, b, and c) -2-pyridazinyl -tert-butyl —H BEV (a, b, and c) -2-pyridazinyl -iso-propyl —H BEW (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ BEX (a, b, and c) -2-pyridazinyl —H —H BEY (a, b, and c) -2-pyridazinyl —H —Cl BEZ (a, b, and c) -2-pyridazinyl —H —Br BFA (a, b, and c) -2-pyridazinyl —H —F BFB (a, b, and c) -2-pyridazinyl —H —CH₃ BFC (a, b, and c) -2-pyridazinyl —H —CF₃ BFD (a, b, and c) -2-pyridazinyl —H —OCH₃ BFE (a, b, and c) -2-pyridazinyl —H —OCH₂CH₃ BFF (a, b, and c) -2-pyridazinyl —H —OCF₃ BFG (a, b, and c) -2-pyridazinyl —H -tert-butyl BFH (a, b, and c) -2-pyridazinyl —H -iso-propyl BFI (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H BFJ (a, b, and c) -3-(4-chloropyridazinyl) —Br —H BFK (a, b, and c) -3-(4-chloropyridazinyl) —F —H BFL (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H BFM (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H BFN (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H BFO (a, b, and c) -3-(4-chloropyridazinyl) —OCH₂CH₃ —H BFP (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H BFQ (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H BFR (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H BFS (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ BFT (a, b, and c) -3-(4-chloropyridazinyl) —H —H BFU (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl BFV (a, b, and c) -3-(4-chloropyridazinyl) —H —Br BFW (a, b, and c) -3-(4-chloropyridazinyl) —H —F BFX (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ BFY (a, b, and c) -3-(4-chloropyridazinyl) —H —CF₃ BFZ (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ BGA (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₃ BGB (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ BGC (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl BGD (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl BGE (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H BGF (a, b, and c) -3-(4-methylpyridazinyl) —Br —H BGG (a, b, and c) -3-(4-methylpyridazinyl) —F —H BGH (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H BGI (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H BGJ (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H BGK (a, b, and c) -3-(4-methylpyridazinyl) —OCH₂CH₃ —H BGL (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H BGM -3-(4-methylpyridazinyl) -tert-butyl —H (a, b, and c) BGN (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H BGO (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —CH₃ BGP (a, b, and c) -3-(4-methylpyridazinyl) —H —H BGQ (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl BGR (a, b, and c) -3-(4-methylpyridazinyl) —H —Br BGS (a, b, and c) -3-(4-methylpyridazinyl) —H —F BGT (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ BGU (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ BGV (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ BGW -3-(4-methylpyridazinyl) —H —OCH₂CH₃ (a, b, and c) BGX (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ BGY (a, b, and c) -3-(4-methylpyridazinyl) —H -tert-butyl BGZ (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl BHA (a, b, and c) -4-thiazanyl —Cl —H BHB (a, b, and c) -4-thiazanyl —Br —H BHC (a, b, and c) -4-thiazanyl —F —H BHD (a, b, and c) -4-thiazanyl —CH₃ —H BHE (a, b, and c) -4-thiazanyl —CF₃ —H BHF (a, b, and c) -4-thiazanyl —OCH₃ —H BHG (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H BHH (a, b, and c) -4-thiazanyl —OCF₃ —H BHI (a, b, and c) -4-thiazanyl -tert-butyl —H BHJ (a, b, and c) -4-thiazanyl -iso-propyl —H BHK (a, b, and c) -4-thiazanyl —CH₃ —CH₃ BHL (a, b, and c) -4-thiazanyl —H —H BHM -4-thiazanyl —H —Cl (a, b, and c) BHN (a, b, and c) -4-thiazanyl —H —Br BHO (a, b, and c) -4-thiazanyl —H —F BHP (a, b, and c) -4-thiazanyl —H —CH₃ BHQ (a, b, and c) -4-thiazanyl —H —CF₃ BHR (a, b, and c) -4-thiazanyl —H —OCH₃ BHS (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ BHT (a, b, and c) -4-thiazanyl —H —OCF₃ BHU (a, b, and c) -4-thiazanyl —H -tert-butyl BHV (a, b, and c) -4-thiazanyl —H -iso-propyl BHW -5-(4-chlorothiazanyl) —Cl —H (a, b, and c) BHX (a, b, and c) -5-(4-chlorothiazanyl) —Br —H BHY (a, b, and c) -5-(4-chlorothiazanyl) —F —H BHZ (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H BIA (a, b, and c) -5-(4-chlorothiazanyl) —CF₃ —H BIB (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H BIC (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H BID (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H BIE (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H BIF (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H BIG (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ BIH (a, b, and c) -5-(4-chlorothiazanyl) —H —H BII (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl BIJ (a, b, and c) -5-(4-chlorothiazanyl) —H —Br BIK (a, b, and c) -5-(4-chlorothiazanyl) —H —F BIL (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ BIM (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ BIN (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ BIO (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ BIP (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ BIQ (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl BIR (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl BIS (a, b, and c) -5-(4-methylthiazanyl) —Cl —H BIT (a, b, and c) -5-(4-methylthiazanyl) —Br —H BIU (a, b, and c) -5-(4-methylthiazanyl) —F —H BIV (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H BIW (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H BIX (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H BIY (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H BIZ (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H BJA (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H BJB (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H BJC (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ BJD (a, b, and c) -5-(4-methylthiazanyl) —H —H BJE (a, b, and c) -5-(4-methylthiazanyl) —H —Cl BJF (a, b, and c) -5-(4-methylthiazanyl) —H —Br BJG (a, b, and c) -5-(4-methylthiazanyl) —H —F BJH (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ BJI (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ BJJ (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ BJK (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ BJL (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ BJM (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl BJN (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3007] TABLE IV

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ BJO (a, b, and c) -2-(3-chloropyridyl) —Cl —H BJP (a, b, and c) -2-(3-chloropyridyl) —Br —H BJQ (a, b, and c) -2-(3-chloropyridyl) —F —H BJR (a, b, and c) -2-(3-chloropyridyl) —CH₃ —H BJS (a, b, and c) -2-(3-chloropyridyl) —CF₃ —H BJT (a, b, and c) -2-(3-chloropyridyl) —OCH3 —H BJU (a, b, and c) -2-(3-chloropyridyl) —OCH₂CH₃ —H BJV (a, b, and c) -2-(3-chloropyridyl) —OCF₃ —H BJW (a, b, and c) -2-(3-chloropyridyl) -tert-butyl —H BJX (a, b, and c) -2-(3-chloropyridyl) -iso-propyl —H BJY (a, b, and c) -2-(3-chloropyridyl) —CH₃ —CH₃ BJZ (a, b, and c) -2-(3-chloropyridyl) —H —H BKA (a, b, and c) -2-(3-chloropyridyl) —H —Cl BKB (a, b, and c) -2-(3-chloropyridyl) —H —Br BKC (a, b, and c) -2-(3-chloropyridyl) —H —F BKD (a, b, and c) -2-(3-chloropyridyl) —H —CH₃ BKE (a, b, and c) -2-(3-chloropyridyl) —H —CF₃ BKF (a, b, and c) -2-(3-chloropyridyl) —H —OCH₃ BKG (a, b, and c) -2-(3-chloropyridyl) —H —OCH₂CH₃ BKH (a, b, and c) -2-(3-chloropyridyl) —H —OCF₃ BKI (a, b, and c) -2-(3-chloropyridyl) —H -tert-butyl BKJ (a, b, and c) -2-(3-chloropyridyl) —H -iso-propyl BKK (a, b, and c) -2-(3-methylpyridyl) —Cl —H BKL (a, b, and c) -2-(3-methylpyridyl) —Br —H BKM (a, b, and c) -2-(3-methylpyridyl) —F —H BKN (a, b, and c) -2-(3-methylpyridyl) —CH₃ —H BKO (a, b, and c) -2-(3-methylpyridyl) —CF₃ —H BKP (a, b, and c) -2-(3-methylpyridyl) —OCH₃ —H BKQ (a, b, and c) -2-(3-methylpyridyl) —OCH₂CH₃ —H BKR (a, b, and c) -2-(3-methylpyridyl) —OCF₃ —H BKS (a, b, and c) -2-(3-methylpyridyl) -tert-butyl —H BKT (a, b, and c) -2-(3-methylpyridyl) -iso-propyl —H BKU (a, b, and c) -2-(3-methylpyridyl) —CH₃ —CH₃ BKV (a, b, and c) -2-(3-methylpyridyl) —H —H BKW (a, b, and c) -2-(3-methylpyridyl) —H —Cl BKX (a, b, and c) -2-(3-methylpyridyl) —H —Br BKY (a, b, and c) -2-(3-methylpyridyl) —H —F BKZ (a, b, and c) -2-(3-methylpyridyl) —H —CH₃ BLA (a, b, and c) -2-(3-methylpyridyl) —H —CF₃ BLB (a, b, and c) -2-(3-methylpyridyl) —H —OCH₃ BLC (a, b, and c) -2-(3-methylpyridyl) —H —OCH₂CH₃ BLD (a, b, and c) -2-(3-methylpyridyl) —H —OCF₃ BLE (a, b, and c) -2-(3-methylpyridyl) —H -tert-butyl BLF (a, b, and c) -2-(3-methylpyridyl) —H -iso-propyl BLG (a, b, and c) -2-(3—CF₃-pyridyl) —Cl —H BLH (a, b, and c) -2-(3—CF₃-pyridyl) —Br —H BLI (a, b, and c) -2-(3—CF₃-pyridyl) —F —H BLJ (a, b, and c) -2-(3—CF₃-pyridyl) —CH₃ —H BLK (a, b, and c) -2-(3—CF₃-pyridyl) —CF₃ —H BLL (a, b, and c) -2-(3—CF₃-pyridyl) —OCH₃ —H BLM (a, b, and c) -2-(3—CF₃-pyridyl) —OCH₂CH₃ —H BLN (a, b, and c) -2-(3—CF₃-pyridyl) —OCF₃ —H BLO (a, b, and c) -2-(3—CF₃-pyridyl) -tert-butyl —H BLP (a, b, and c) -2-(3—CF₃-pyridyl) -iso-propyl —H BLQ (a, b, and c) -2-(3—CF₃-pyridyl) —CH₃ —CH₃ BLR (a, b, and c) -2-(3—CF₃-pyridyl) —H —H BLS (a, b, and c) -2-(3—CF₃-pyridyl) —H —Cl BLT (a, b, and c) -2-(3—CF₃-pyridyl) —H —Br BLU (a, b, and c) -2-(3—CF₃-pyridyl) —H —F BLV (a, b, and c) -2-(3—CF₃-pyridyl) —H —CH₃ BLW (a, b, and c) -2-(3—CF₃-pyridyl) —H —CF₃ BLX (a, b, and c) -2-(3—CF₃-pyridyl) —H —OCH₃ BLY (a, b, and c) -2-(3—CF₃-pyridyl) —H —OCH₂CH₃ BLZ (a, b, and c) -2-(3—CF₃-pyridyl) —H —OCF₃ BMA (a, b, and c) -2-(3—CF₃-pyridyl) —H -tert-butyl BMB (a, b, and c) -2-(3—CF₃-pyridyl) —H -iso-propyl BMC (a, b, and c) -4-(5-chloropyrimidinyl) —Cl —H BMD (a, b, and c) -4-(5-chloropyrimidinyl) —Br —H BME (a, b, and c) -4-(5-chloropyrimidinyl) —F —H BMF (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —H BMG (a, b, and c) -4-(5-chloropyrimidinyl) —CF₃ —H BMH (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₃ —H BMI (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H BMJ (a, b, and c) -4-(5-chloropyrimidinyl) —OCF₃ —H BMK (a, b, and c) -4-(5-chloropyrimidinyl) -tert-butyl —H BML (a, b, and c) -4-(5-chloropyrimidinyl) -iso-propyl —H BMM (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —CH₃ BMN (a, b, and c) -4-(5-chloropyrimidinyl) —H —H BMO (a, b, and c) -4-(5-chloropyrimidinyl) —H —Cl BMP (a, b, and c) -4-(5-chloropyrimidinyl) —H —Br BMQ (a, b, and c) -4-(5-chloropyrimidinyl) —H —F BMR (a, b, and c) -4-(5-chloropyrimidinyl) —H —CH₃ BMS (a, b, and c) -4-(5-chloropyrimidinyl) —H —CF₃ BMT (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₃ BMU (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ BMV (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCF₃ BMW (a, b, and c) -4-(5-chloropyrimidinyl) —H -tert-butyl BMX (a, b, and c) -4-(5-chloropyrimidinyl) —H -iso-propyl BMY (a, b, and c) -4-(5-methylpyrimidinyl) —Cl —H BMZ (a, b, and c) -4-(5-methylpyrimidinyl) —Br —H BNA (a, b, and c) -4-(5-methylpyrimidinyl) —F —H BNB (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —H BNC (a, b, and c) -4-(5-methylpyrimidinyl) —CF₃ —H BND (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₃ —H BNE (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H BNF (a, b, and c) -4-(5-methylpyrimidinyl) —OCF₃ —H BNG (a, b, and c) -4-(5-methylpyrimidinyl) -tert-butyl —H BNH (a, b, and c) -4-(5-methylpyrimidinyl) -iso-propyl —H BNI (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —CH₃ BNJ (a, b, and c) -4-(5-methylpyrimidinyl) —H —H BNK (a, b, and c) -4-(5-methylpyrimidinyl) —H —Cl BNL (a, b, and c) -4-(5-methylpyrimidinyl) —H —Br BNM (a, b, and c) -4-(5-methylpyrimidinyl) —H —F BNN (a, b, and c) -4-(5-methylpyrimidinyl) —H —CH₃ BNO (a, b, and c) -4-(5-methylpyrimidinyl) —H —CF₃ BNP (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₃ BNQ (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ BNR (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCF₃ BNS (a, b, and c) -4-(5-methylpyrimidinyl) —H -tert-butyl BNT (a, b, and c) -4-(5-methylpyrimidinyl) —H -iso-propyl BNU (a, b, and c) -2-pyrazinyl —Cl —H BNV (a, b, and c) -2-pyrazinyl —Br —H BNW (a, b, and c) -2-pyrazinyl —F —H BNX (a, b, and c) -2-pyrazinyl —CH₃ —H BNY (a, b, and c) -2-pyrazinyl —CF₃ —H BNZ (a, b, and c) -2-pyrazinyl —OCH₃ —H BOA (a, b, and c) -2-pyrazinyl —OCH₂CH₃ —H BOB (a, b, and c) -2-pyrazinyl —OCF₃ —H BOC (a, b, and c) -2-pyrazinyl -tert-butyl —H BOD (a, b, and c) -2-pyrazinyl -iso-propyl —H BOE (a, b, and c) -2-pyrazinyl —CH₃ —CH₃ BOF (a, b, and c) -2-pyrazinyl —H —H BOG (a, b, and c) -2-pyrazinyl —H —Cl BOH (a, b, and c) -2-pyrazinyl —H —Br BOI (a, b, and c) -2-pyrazinyl —H —F BOJ (a, b, and c) -2-pyrazinyl —H —CH₃ BOK (a, b, and c) -2-pyrazinyl —H —CF₃ BOL (a, b, and c) -2-pyrazinyl —H —OCH₃ BOM (a, b, and c) -2-pyrazinyl —H —OCH₂CH₃ BON (a, b, and c) -2-pyrazinyl —H —OCF₃ BOO (a, b, and c) -2-pyrazinyl —H -tert-butyl BOP (a, b, and c) -2-pyrazinyl —H -iso-propyl BOQ (a, b, and c) -2-(3-chloropyrazinyl) —Cl —H BOR (a, b, and c) -2-(3-chloropyrazinyl) —Br —H BOS (a, b, and c) -2-(3-chloropyrazinyl) —F —H BOT (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —H BOU (a, b, and c) -2-(3-chloropyrazinyl) —CF₃ —H BOV (a, b, and c) -2-(3-chloropyrazinyl) —OCH₃ —H BOW (a, b, and c) -2-(3-chloropyrazinyl) —OCH₂CH₃ —H BOX (a, b, and c) -2-(3-chloropyrazinyl) —OCF₃ —H BOY (a, b, and c) -2-(3-chloropyrazinyl) -tert-butyl —H BOZ (a, b, and c) -2-(3-chloropyrazinyl) -iso-propyl —H BPA (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —CH₃ BPB (a, b, and c) -2-(3-chloropyrazinyl) —H —H BPC (a, b, and c) -2-(3-chloropyrazinyl) —H —Cl BPD (a, b, and c) -2-(3-chloropyrazinyl) —H —Br BPE (a, b, and c) -2-(3-chloropyrazinyl) —H —F BPF (a, b, and c) -2-(3-chloropyrazinyl) —H —CH₃ BPG (a, b, and c) -2-(3-chloropyrazinyl) —H —CF₃ BPH (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₃ BPI (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₂CH₃ BPJ (a, b, and c) -2-(3-chloropyrazinyl) —H —OCF₃ BPK (a, b, and c) -2-(3-chloropyrazinyl) —H -tert-butyl BPL (a, b, and c) -2-(3-chloropyrazinyl) —H -iso-propyl BPM (a, b, and c) -2-(3-methylpyrazinyl) —Cl —H BPN (a, b, and c) -2-(3-methylpyrazinyl) —Br —H BPO (a, b, and c) -2-(3-methylpyrazinyl) —F —H BPP (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —H BPQ (a, b, and c) -2-(3-methylpyrazinyl) —CF₃ —H BPR (a, b, and c) -2-(3-methylpyrazinyl) —OCH₃ —H BPS (a, b, and c) -2-(3-methylpyrazinyl) —OCH₂CH₃ —H BPT (a, b, and c) -2-(3-methylpyrazinyl) —OCF₃ —H BPU (a, b, and c) -2-(3-methylpyrazinyl) -tert-butyl —H BPV (a, b, and c) -2-(3-methylpyrazinyl) -iso-propyl —H BPW (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —CH₃ BPX (a, b, and c) -2-(3-methylpyrazinyl) —H —H BPY (a, b, and c) -2-(3-methylpyrazinyl) —H —Cl BPZ (a, b, and c) -2-(3-methylpyrazinyl) —H —Br BQA (a, b, and c) -2-(3-methylpyrazinyl) —H —F BQB (a, b, and c) -2-(3-methylpyrazinyl) —H —CH₃ BQC (a, b, and c) -2-(3-methylpyrazinyl) —H —CF₃ BQD (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₃ BQE (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₂CH₃ BQF (a, b, and c) -2-(3-methylpyrazinyl) —H —OCF₃ BQG (a, b, and c) -2-(3-methylpyrazinyl) —H -tert-butyl BQH (a, b, and c) -2-(3-methylpyrazinyl) —H -iso-propyl BQI (a, b, and c) -2-pyridazinyl —Cl —H BQJ (a, b, and c) -2-pyridazinyl —Br —H BQK (a, b, and c) -2-pyridazinyl —F —H BQL (a, b, and c) -2-pyridazinyl —CH₃ —H BQM (a, b, and c) -2-pyridazinyl —CF₃ —H BQN (a, b, and c) -2-pyridazinyl —OCH₃ —H BQO (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H BQP (a, b, and c) -2-pyridazinyl —OCF₃ —H BQQ (a, b, and c) -2-pyridazinyl -tert-butyl —H BQR (a, b, and c) -2-pyridazinyl -iso-propyl —H BQS (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ BQT (a, b, and c) -2-pyridazinyl —H —H BQU (a, b, and c) -2-pyridazinyl —H —Cl BQV (a, b, and c) -2-pyridazinyl —H —Br BQW (a, b, and c) -2-pyridazinyl —H —F BQX (a, b, and c) -2-pyridazinyl —H —CH₃ BQY (a, b, and c) -2-pyridazinyl —H —CF₃ BQZ (a, b, and c) -2-pyridazinyl —H —OCH₃ BRA (a, b, and c) -2-pyridazinyl —H —OCH₂CH₃ BRB (a, b, and c) -2-pyridazinyl —H —OCF₃ BRC (a, b, and c) -2-pyridazinyl —H -tert-butyl BRD (a, b, and c) -2-pyridazinyl —H -iso-propyl BRE (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H BRF (a, b, and c) -3-(4-chloropyridazinyl) —Br —H BRG (a, b, and c) -3-(4-chloropyridazinyl) —F —H BRH (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H BRI (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H BRJ (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H BRK (a, b, and c) -3-(4-chloropyridazinyl) —OCH₂CH₃ —H BRL (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H BRM (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H BRN (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H BRO (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ BRP (a, b, and c) -3-(4-chloropyridazinyl) —H —H BRQ (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl BRR (a, b, and c) -3-(4-chloropyridazinyl) —H —Br BRS (a, b, and c) -3-(4-chloropyridazinyl) —H —F BRT (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ BRU (a, b, and c) -3-(4-chloropyridazinyl) —H —CF₃ BRV (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ BRW (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₃ BRX (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ BRY (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl BRZ (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl BSA (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H BSB (a, b, and c) -3-(4-methylpyridazinyl) —Br —H BSC (a, b, and c) -3-(4-methylpyridazinyl) —F —H BSD (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H BSE (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H BSF (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H BSG (a, b, and c) -3-(4-methylpyridazinyl) —OCH₂CH₃ —H BSH (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H BSI (a, b, and c) -3-(4-methylpyridazinyl) -tert-butyl —H BSJ (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H BSK (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —CH₃ BSL (a, b, and c) -3-(4-methylpyridazinyl) —H —H BSM (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl BSN (a, b, and c) -3-(4-methylpyridazinyl) —H —Br BSO (a, b, and c) -3-(4-methylpyridazinyl) —H —F BSP (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ BSQ (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ BSR (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ BSS (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₂CH₃ BST (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ BSU (a, b, and c) -3-(4-methylpyridazinyl) —H -tert-butyl BSV (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl BSW (a, b, and c) -4-thiazanyl —Cl —H BSX (a, b, and c) -4-thiazanyl —Br —H BSY (a, b, and c) -4-thiazanyl —F —H BSZ (a, b, and c) -4-thiazanyl —CH₃ —H BTA (a, b, and c) -4-thiazanyl —CF₃ —H BTB (a, b, and c) -4-thiazanyl —OCH₃ —H BTC (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H BTD (a, b, and c) -4-thiazanyl —OCF₃ —H BTE (a, b, and c) -4-thiazanyl -tert-butyl —H BTF (a, b, and c) -4-thiazanyl -iso-propyl —H BTG (a, b, and c) -4-thiazanyl —CH₃ —CH₃ BTH (a, b, and c) -4-thiazanyl —H —H BTI (a, b, and c) -4-thiazanyl —H —Cl BTJ (a, b, and c) -4-thiazanyl —H —Br BTK (a, b, and c) -4-thiazanyl —H —F BTL (a, b, and c) -4-thiazanyl —H —CH₃ BTM (a, b, and c) -4-thiazanyl —H —CF₃ BTN (a, b, and c) -4-thiazanyl —H —OCH₃ BTO (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ BTP (a, b, and c) -4-thiazanyl —H —OCF₃ BTQ (a, b, and c) -4-thiazanyl —H -tert-butyl BTR (a, b, and c) -4-thiazanyl —H -iso-propyl BTS (a, b, and c) -5-(4-chlorothiazanyl) —Cl —H BTT (a, b, and c) -5-(4-chlorothiazanyl) —Br —H BTU (a, b, and c) -5-(4-chlorothiazanyl) —F —H BTV (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H BTW (a, b, and c) -5-(4-chlorothiazanyl) —CF₃ —H BTX (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H BTY (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H BTZ (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H BUA (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H BUB (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H BUC (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ BUD (a, b, and c) -5-(4-chlorothiazanyl) —H —H BUE (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl BUF (a, b, and c) -5-(4-chlorothiazanyl) —H —Br BUG (a, b, and c) -5-(4-chlorothiazanyl) —H —F BUH (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ BUI (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ BUJ (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ BUK (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ BUL (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ BUM (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl BUN (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl BUO (a, b, and c) -5-(4-methylthiazanyl) —Cl —H BUP (a, b, and c) -5-(4-methylthiazanyl) —Br —H BUQ (a, b, and c) -5-(4-methylthiazanyl) —F —H BUR (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H BUS (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H BUT (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H BUU (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H BUV (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H BUW (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H BUX (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H BUY (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ BUZ (a, b, and c) -5-(4-methylthiazanyl) —H —H BVA (a, b, and c) -5-(4-methylthiazanyl) —H —Cl BVB (a, b, and c) -5-(4-methylthiazanyl) —H —Br BVC (a, b, and c) -5-(4-methylthiazanyl) —H —F BVD (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ BVE (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ BVF (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ BVG (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ BVH (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ BVI (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl BVJ (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3008] TABLE V

and pharmaceutically acceptable salts thereof, wherein: Compound AR₁ R₈ R₉ BVK -2-pyridazinyl —Cl —H BVL -2-pyridazinyl —Br —H BVM -2-pyridazinyl —F —H BVN -2-pyridazinyl —CH₃ —H BVO -2-pyridazinyl —CF₃ —H BVP -2-pyridazinyl —OCH₃ —H BVQ -2-pyridazinyl —OCH₂CH₃ —H BVR -2-pyridazinyl —OCF₃ —H BVS -2-pyridazinyl -tert-butyl —H BVT -2-pyridazinyl -iso-propyl —H BVU -2-pyridazinyl —CH₃ —CH₃ BVV -2-pyridazinyl —H —H BVW -2-pyridazinyl —H —Cl BVX -2-pyridazinyl —H —Br BVY -2-pyridazinyl —H —F BVZ -2-pyridazinyl —H —CH₃ BWA -2-pyridazinyl —H —CF₃ BWB -2-pyridazinyl —H —OCH₃ BWC -2-pyridazinyl —H —OCH₂CH₃ BWD -2-pyridazinyl —H —OCF₃ BWE -2-pyridazinyl —H -tert-butyl BWF -2-pyridazinyl —H -iso-propyl BWG -3-(4-chloropyridazinyl) —Cl —H BWH -3-(4-chloropyridazinyl) —Br —H BWI -3-(4-chloropyridazinyl) —F —H BWJ -3-(4-chloropyridazinyl) —CH₃ —H BWK -3-(4-chloropyridazinyl) —CF₃ —H BWL -3-(4-chloropyridazinyl) —OCH₃ —H BWM -3-(4-chloropyridazinyl) —OCH₂CH₃ —H BWN -3-(4-chloropyridazinyl) —OCF₃ —H BWO -3-(4-chloropyridazinyl) -tert-butyl —H BWP -3-(4-chloropyridazinyl) -iso-propyl —H BWQ -3-(4-chloropyridazinyl) —CH₃ —CH₃ BWR -3-(4-chloropyridazinyl) —H —H BWS -3-(4-chloropyridazinyl) —H —Cl BWT -3-(4-chloropyridazinyl) —H —Br BWU -3-(4-chloropyridazinyl) —H —F BWV -3-(4-chloropyridazinyl) —H —CH₃ BWW -3-(4-chloropyridazinyl) —H —CF₃ BWX -3-(4-chloropyridazinyl) —H —OCH₃ BWY -3-(4-chloropyridazinyl) —H —OCH₂CH₃ BWZ -3-(4-chloropyridazinyl) —H —OCF₃ BXA -3-(4-chloropyridazinyl) —H -tert-butyl BXB -3-(4-chloropyridazinyl) —H -iso-propyl BXC -3-(4-methylpyridazinyl) —Cl —H BXD -3-(4-methylpyridazinyl) —Br —H BXE -3-(4-methylpyridazinyl) —F —H BXF -3-(4-methylpyridazinyl) —CH₃ —H BXG -3-(4-methylpyridazinyl) —CF₃ —H BXH -3-(4-methylpyridazinyl) —OCH₃ —H BXI -3-(4-methylpyridazinyl) —OCH₂CH₃ —H BXJ -3-(4-methylpyridazinyl) —OCF₃ —H BXK -3-(4-methylpyridazinyl) -tert-butyl —H BXL -3-(4-methylpyridazinyl) -iso-propyl —H BXM -3-(4-methylpyridazinyl) —CH₃ —CH₃ BXN -3-(4-methylpyridazinyl) —H —H BXO -3-(4-methylpyridazinyl) —H —Cl BXP -3-(4-methylpyridazinyl) —H —Br BXQ -3-(4-methylpyridazinyl) —H —F BXR -3-(4-methylpyridazinyl) —H —CH₃ BXS -3-(4-methylpyridazinyl) —H —CF₃ BXT -3-(4-methylpyridazinyl) —H —OCH₃ BXU -3-(4-methylpyridazinyl) —H —OCH₂CH₃ BXV -3-(4-methylpyridazinyl) —H —OCF₃ BXW -3-(4-methylpyridazinyl) —H -tert-butyl BXX -3-(4-methylpyridazinyl) —H -iso-propyl BXY -4-thiazanyl —Cl —H BXZ -4-thiazanyl —Br —H BYA -4-thiazanyl —F —H BYB -4-thiazanyl —CH₃ —H BYC -4-thiazanyl —CF₃ —H BYD -4-thiazanyl —OCH₃ —H BYE -4-thiazanyl —OCH₂CH₃ —H BYF -4-thiazanyl —OCF₃ —H BYG -4-thiazanyl -tert-butyl —H BYH -4-thiazanyl -iso-propyl —H BYL -4-thiazanyl —CH₃ —CH₃ BYJ -4-thiazanyl —H —H BYK -4-thiazanyl —H —Cl BYL -4-thiazanyl —H —Br BYM -4-thiazanyl —H —F BYN -4-thiazanyl —H —CH₃ BYO -4-thiazanyl —H —CF₃ BYP -4-thiazanyl —H —OCH₃ BYQ -4-thiazanyl —H —OCH₂CH₃ BYR -4-thiazanyl —H —OCF₃ BYS -4-thiazanyl —H -tert-butyl BYT -4-thiazanyl —H -iso-propyl BYU -5-(4-chlorothiazanyl) —Cl —H BYV -5-(4-chlorothiazanyl) —Br —H BYW -5-(4-chlorothiazanyl) —F —H BYX -5-(4-chlorothiazanyl) —CH₃ —H BYY -5-(4-chlorothiazanyl) —CF₃ —H BYZ -5-(4-chlorothiazanyl) —OCH₃ —H BZA -5-(4-chlorothiazanyl) —OCH₂CH₃ —H BZB -5-(4-chlorothiazanyl) —OCF₃ —H BZC -5-(4-chlorothiazanyl) -tert-butyl —H BZD -5-(4-chlorothiazanyl) -iso-propyl —H BZE -5-(4-chlorothiazanyl) —CH₃ —CH₃ BZF -5-(4-chlorothiazanyl) —H —H BZG -5-(4-chlorothiazanyl) —H —Cl BZH -5-(4-chlorothiazanyl) —H —Br BZI -5-(4-chlorothiazanyl) —H —F BZJ -5-(4-chlorothiazanyl) —H —CH₃ BZK -5-(4-chlorothiazanyl) —H —CF₃ BZL -5-(4-chlorothiazanyl) —H —OCH₃ BZM -5-(4-chlorothiazanyl) —H —OCH₂CH₃ BZN -5-(4-chlorothiazanyl) —H —OCF₃ BZO -5-(4-chlorothiazanyl) —H -tert-butyl BZP -5-(4-chlorothiazanyl) —H -iso-propyl BZQ -5-(4-methylthiazanyl) —Cl —H BZR -5-(4-methylthiazanyl) —Br —H BZS -5-(4-methylthiazanyl) —F —H BZT -5-(4-methylthiazanyl) —CH₃ —H BZU -5-(4-methylthiazanyl) —CF₃ —H BZV -5-(4-methylthiazanyl) —OCH₃ —H BZW -5-(4-methylthiazanyl) —OCH₂CH₃ —H BZX -5-(4-methylthiazanyl) —OCF₃ —H BZY -5-(4-methylthiazanyl) -tert-butyl —H BZZ -5-(4-methylthiazanyl) -iso-propyl —H CAA -5-(4-methylthiazanyl) —CH₃ —CH₃ CAB -5-(4-methylthiazanyl) —H —H CAC -5-(4-methylthiazanyl) —H —Cl CAD -5-(4-methylthiazanyl) —H —Br CAE -5-(4-methylthiazanyl) —H —F CAF -5-(4-methylthiazanyl) —H —CH₃ CAG -5-(4-methylthiazanyl) —H —CF₃ CAH -5-(4-methylthiazanyl) —H —OCH₃ CAI -5-(4-methylthia.zanyl) —H —OCH₂CH₃ CAJ -5-(4-methylthiazanyl) —H —OCF₃ CAK -5-(4-methylthiazanyl) —H -tert-butyl CAL -5-(4-methyltbiazanyl) —H -iso-propyl

[3009] TABLE VI

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ CAM -2-(3-chloropyridyl) —Cl —H CAN -2-(3-chloropyridyl) —Br —H CAO -2-(3-chloropyridyl) —F —H CAP -2-(3-chloropyridyl) —CH₃ —H CAQ -2-(3-chloropyridyl) —CF₃ —H CAR -2-(3-chloropyridyl) —OCH₃ —H CAS -2-(3-chloropyridyl) —CH₂CH₃ —H CAT -2-(3-chloropyridyl) —OCF₃ —H CAU -2-(3-chloropyridyl) -tert-butyl —H CAV -2-(3-chloropyridyl) -iso-propyl —H CAW -2-(3-chloropyridyl) —CH₃ —CH₃ CAX -2-(3-chloropyridyl) —H —H CAY -2-(3-chloropyridyl) —H —Cl CAZ -2-(3-chloropyridyl) —H —Br CBA -2-(3-chloropyridyl) —H —F CBB -2-(3-chloropyridyl) —H —CH₃ CBC -2-(3-chloropyridyl) —H —CF₃ CBD -2-(3-chloropyridyl) —H —OCH₃ CBE -2-(3-chloropyridyl) —H —CH₂CH₃ CBF -2-(3-chloropyridyl) —H —OCF₃ CBG -2-(3-chloropyridyl) —H -tert-butyl CBH -2-(3-chloropyridyl) —H -iso-propyl CBI -2-(3-methylpyridyl) —Cl —H CBJ -2-(3-methylpyridyl) —Br —H CBK -2-(3-methylpyridyl) —F —H CBL -2-(3-methylpyridyl) —CH₃ —H CBM -2-(3-methylpyridyl) —CF₃ —H CBN -2-(3-methylpyridyl) —OCH₃ —H CBO -2-(3-methylpyridyl) —CH₂CH₃ —H CBP -2-(3-methylpyridyl) —OCF₃ —H CBQ -2-(3-methylpyridyl) -tert-butyl —H CBR -2-(3-methylpyridyl) -iso-propyl —H CBS -2-(3-methylpyridyl) —CH₃ —CH₃ CBT -2-(3-methylpyridyl) —H —H CBU -2-(3-methylpyridyl) —H —Cl CBV -2-(3-methylpyridyl) —H —Br CBW -2-(3-methylpyridyl) —H —F CBX -2-(3-methylpyridyl) —H —CH₃ CBY -2-(3-methylpyridyl) —H —CF₃ CBZ -2-(3-methylpyridyl) —H —OCH₃ CCA -2-(3-methylpyridyl) —H —CH₂CH₃ CCB -2-(3-methylpyridyl) —H —OCF₃ CCC -2-(3-methylpyridyl) —H -tert-butyl CCD -2-(3-methylpyridyl) —H -iso-propyl CCE -2-(3—CF₃-pyridyl) —Cl —H CCF -2-(3—CF₃-pyridyl) —Br —H CCG -2-(3—CF₃-pyridyl) —F —H CCH -2-(3—CF₃-pyridyl) —CH₃ —H CCI -2-(3—CF₃-pyridyl) —CF₃ —H CCJ -2-(3—CF₃-pyridyl) —OCH₃ —H CCK -2-(3—CF₃-pyridyl) —CH₂CH₃ —H CCL -2-(3—CF₃-pyridyl) —OCF₃ —H CCM -2-(3—CF₃-pyridyl) -tert-butyl —H CCN -2-(3—CF₃-pyridyl) -iso-propyl —H CCO -2-(3—CF₃-pyridyl) —CH₃ —CH₃ CCP -2-(3—CF₃-pyridyl) —H —H CCQ -2-(3—CF₃-pyridyl) —H —Cl CCR -2-(3—CF₃-pyridyl) —H —Br CCS -2-(3—CF₃-pyridyl) —H —F CCT -2-(3—CF₃-pyridyl) —H —CH₃ CCU -2-(3—CF₃-pyridyl) —H —CF₃ CCV -2-(3—CF₃-pyridyl) —H —OCH₃ CCW -2-(3—CF₃-pyridyl) —H —CH₂CH₃ CCX -2-(3—CF₃-pyridyl) —H —OCF₃ CCY -2-(3—CF₃-pyridyl) —H -tert-butyl CCZ -2-(3—CF₃-pyridyl) —H -iso-propyl CDA -4-(5-chloropyrimidinyl) —Cl —H CDB -4-(5-chloropyrimidinyl) —Br —H CDC -4-(5-chloropyrimidinyl) —F —H CDD -4-(5-chloropyrimidinyl) —CH₃ —H CDE -4-(5-chloropyrimidinyl) —CF₃ —H CDF -4-(5-chloropyrimidinyl) —OCH₃ —H CDG -4-(5-chloropyrimidinyl) —CH₂CH₃ —H CDH -4-(5-chloropyrimidinyl) —OCF₃ —H CDI -4-(5-chloropyrimidinyl) -tert-butyl —H CDJ -4-(5-chloropyrimidinyl) -iso-propyl —H CDK -4-(5-chloropyrimidinyl) —CH₃ —CH₃ CDL -4-(5-chloropyrimidinyl) —H —H CDM -4-(5-chloropyrimidinyl) —H —Cl CDN -4-(5-chloropyrimidinyl) —H —Br CDO -4-(5-chloropyrimidinyl) —H —F CDP -4-(5-chloropyrimidinyl) —H —CH₃ CDQ -4-(5-chloropyrimidinyl) —H —CF₃ CDR -4-(5-chloropyrimidinyl) —H —OCH₃ CDS -4-(5-chloropyrimidinyl) —H —CH₂CH₃ CDT -4-(5-chloropyrimidinyl) —H —OCF₃ CDU -4-(5-chloropyrimidinyl) —H -tert-butyl CDV -4-(5-chloropyrimidinyl) —H -iso-propyl CDW -4-(5-methylpyrimidinyl) —Cl —H CDX -4-(5-methylpyrimidinyl) —Br —H CDY -4-(5-methylpyrimidinyl) —F —H CDZ -4-(5-methylpyrimidinyl) —CH₃ —H CEA -4-(5-methylpyrimidinyl) —CF₃ —H CEB -4-(5-methylpyrimidinyl) —OCH₃ —H CEC -4-(5-methylpyrimidinyl) —CH₂CH₃ —H CED -4-(5-methylpyrimidinyl) —OCF₃ —H CEE -4-(5-methylpyrimidinyl) -tert-butyl —H CEF -4-(5-methylpyrimidinyl) -iso-propyl —H CEG -4-(5-methylpyrimidinyl) —CH₃ —CH₃ CEH -4-(5-methylpyrimidinyl) —H —H CEI -4-(5-methylpyrimidinyl) —H —Cl CEJ -4-(5-methylpyrimidinyl) —H —Br CEK -4-(5-methylpyrimidinyl) —H —F CEL -4-(5-methylpyrimidinyl) —H —CH₃ CEM -4-(5-methylpyrimidinyl) —H —CF₃ CEN -4-(5-methylpyrimidinyl) —H —OCH₃ CEO -4-(5-methylpyrimidinyl) —H —CH₂CH₃ CEP -4-(5-methylpyrimidinyl) —H —OCF₃ CEQ -4-(5-methylpyrimidinyl) —H -tert-butyl CER -4-(5-methylpyrimidinyl) —H -iso-propyl CES -2-pyrazinyl —Cl —H CET -2-pyrazinyl —Br —H CEU -2-pyrazinyl —F —H CEV -2-pyrazinyl —CH₃ —H CEW -2-pyrazinyl —CF₃ —H CEX -2-pyrazinyl —OCH₃ —H CEY -2-pyrazinyl —CH₂CH₃ —H CEZ -2-pyrazinyl —OCF₃ —H CFA -2-pyrazinyl -tert-butyl —H CFB -2-pyrazinyl -iso-propyl —H CFC -2-pyrazinyl —CH₃ —CH₃ CFD -2-pyrazinyl —H —H CFE -2-pyrazinyl —H —Cl CFF -2-pyrazinyl —H —Br CFG -2-pyrazinyl —H —F CFH -2-pyrazinyl —H —CH₃ CFI -2-pyrazinyl —H —CF₃ CFJ -2-pyrazinyl —H —OCH₃ CFK -2-pyrazinyl —H —CH₂CH₃ CFL -2-pyrazinyl —H —OCF₃ CFM -2-pyrazinyl —H -tert-butyl CFN -2-pyrazinyl —H -iso-propyl CFO -2-(3-chloropyrazinyl) —Cl —H CFP -2-(3-chloropyrazinyl) —Br —H CFQ -2-(3-chloropyrazinyl) —F —H CFR -2-(3-chloropyrazinyl) —CH₃ —H CFS -2-(3-chloropyrazinyl) —CF₃ —H CFT -2-(3-chloropyrazinyl) —OCH₃ —H CFU -2-(3-chloropyrazinyl) —CH₂CH₃ —H CFV -2-(3-chloropyrazinyl) —OCF₃ —H CFW -2-(3-chloropyrazinyl) -tert-butyl —H CFX -2-(3-chloropyrazinyl) -iso-propyl —H CFY -2-(3-chloropyrazinyl) —CH₃ —CH₃ CFZ -2-(3-chloropyrazinyl) —H —H CGA -2-(3-chloropyrazinyl) —H —Cl CGB -2-(3-chloropyrazinyl) —H —Br CGC -2-(3-chloropyrazinyl) —H —F CGD -2-(3-chloropyrazinyl) —H —CH₃ CGE -2-(3-chloropyrazinyl) —H —CF₃ CGF -2-(3-chloropyrazinyl) —H —OCH₃ CGG -2-(3-chloropyrazinyl) —H —CH₂CH₃ CGH -2-(3-chloropyrazinyl) —H —OCF₃ CGI -2-(3-chloropyrazinyl) —H -tert-butyl CGJ -2-(3-chloropyrazinyl) —H -iso-propyl CGK -2-(3-methylpyrazinyl) —Cl —H CGL -2-(3-methylpyrazinyl) —Br —H CGM -2-(3-methylpyrazinyl) —F —H CGN -2-(3-methylpyrazinyl) —CH₃ —H CGO -2-(3-methylpyrazinyl) —CF₃ —H CGP -2-(3-methylpyrazinyl) —OCH₃ —H CGQ -2-(3-methylpyrazinyl) —CH₂CH₃ —H CGR -2-(3-methylpyrazinyl) —OCF₃ —H CGS -2-(3-methylpyrazinyl) -tert-butyl —H CGT -2-(3-methylpyrazinyl) -iso-propyl —H CGU -2-(3-methylpyrazinyl) —CH₃ —CH₃ CGV -2-(3-methylpyrazinyl) —H —H CGW -2-(3-methylpyrazinyl) —H —Cl CGX -2-(3-methylpyrazinyl) —H —Br CGY -2-(3-methylpyrazinyl) —H —F CGZ -2-(3-methylpyrazinyl) —H —CH₃ CHA -2-(3-methylpyrazinyl) —H —CF₃ CHB -2-(3-methylpyrazinyl) —H —OCH₃ CHC -2-(3-methylpyrazinyl) —H —CH₂CH₃ CHD -2-(3-methylpyrazinyl) —H —OCF₃ CHE -2-(3-methylpyrazinyl) —H -tert-butyl CHF -2-(3-methylpyrazinyl) —H -iso-propyl CHG -2-pyridazinyl —Cl —H CHH -2-pyridazinyl —Br —H CHI -2-pyridazinyl —F —H CHJ -2-pyridazinyl —CH₃ —H CHK -2-pyridazinyl —CF₃ —H CHL -2-pyridazinyl —OCH₃ —H CHM -2-pyridazinyl —CH₂CH₃ —H CHN -2-pyridazinyl —OCF₃ —H CHO -2-pyridazinyl -tert-butyl —H CHP -2-pyridazinyl -iso-propyl —H CHQ -2-pyridazinyl —CH₃ —CH₃ CHR -2-pyridazinyl —H —H CHS -2-pyridazinyl —H —Cl CHT -2-pyridazinyl —H —Br CHU -2-pyridazinyl —H —F CHV -2-pyridazinyl —H —CH₃ CHW -2-pyridazinyl —H —CF₃ CHX -2-pyridazinyl —H —OCH₃ CHY -2-pyridazinyl —H —CH₂CH₃ CHZ -2-pyridazinyl —H —OCF₃ CIA -2-pyridazinyl —H -tert-butyl CIB -2-pyridazinyl —H -iso-propyl CIC -3-(4-chloropyridazinyl) —Cl —H CID -3-(4-chloropyridazinyl) —Br —H CIE -3-(4-chloropyridazinyl) —F —H CLF -3-(4-chloropyridazinyl) —CH₃ —H CIG -3-(4-chloropyridazinyl) —CF₃ —H CIH -3-(4-chloropyridazinyl) —OCH₃ —H CII -3-(4-chloropyridazinyl) —CH₂CH₃ —H CIJ -3-(4-chloropyridazinyl) —OCF₃ —H CIK -3-(4-chloropyridazinyl) -tert-butyl —H CIL -3-(4-chloropyridazinyl) -iso-propyl —H CIM -3-(4-chloropyridazinyl) —CH₃ —CH₃ CIN -3-(4-chloropyridazinyl) —H —H CIO -3-(4-chloropyridazinyl) —H —Cl CIP -3-(4-chloropyridazinyl) —H —Br CIQ -3-(4-chloropyridazinyl) —H —F CIR -3-(4-chloropyridazinyl) —H —CH₃ CIS -3-(4-chloropyridazinyl) —H —CF₃ CIT -3-(4-chloropyridazinyl) —H —OCH₃ CIU -3-(4-chloropyridazinyl) —H —CH₂CH₃ CIV -3-(4-chloropyridazinyl) —H —OCF₃ CIW -3-(4-chloropyridazinyl) —H -tert-butyl CIX -3-(4-chloropyridazinyl) —H -iso-propyl CIY -3-(4-methylpyridazinyl) —Cl —H CIZ -3-(4-methylpyridazinyl) —Br —H CJA -3-(4-methylpyridazinyl) —F —H CJB -3-(4-methylpyridazinyl) —CH₃ —H CJC -3-(4-methylpyridazinyl) —CF₃ —H CJD -3-(4-methylpyridazinyl) —OCH₃ —H CJE -3-(4-methylpyridazinyl) —CH₂CH₃ —H CJF -3-(4-methylpyridazinyl) —OCF₃ —H CJG -3-(4-methylpyridazinyl) -tert-butyl —H CJH -3-(4-methylpyridazinyl) -iso-propyl —H CJI -3-(4-methylpyridazinyl) —CH₃ —CH₃ CJJ -3-(4-methylpyridazinyl) —H —H CJK -3-(4-methylpyridazinyl) —H —Cl CJL -3-(4-methylpyridazinyl) —H —Br CJM -3-(4-methylpyridazinyl) —H —F CJN -3-(4-methylpyridazinyl) —H —CH₃ CJO -3-(4-methylpyridazinyl) —H —CF₃ CJP -3-(4-methylpyridazinyl) —H —OCH₃ CJQ -3-(4-methylpyridazinyl) —H —CH₂CH₃ CJR -3-(4-methylpyridazinyl) —H —OCF₃ CJS -3-(4-methylpyridazinyl) —H -tert-butyl CJT -3-(4-methylpyridazinyl) —H -iso-propyl CJU -4-thiazanyl —Cl —H CJV -4-thiazanyl —Br —H CJW -4-thiazanyl —F —H CJX -4-thiazanyl —CH₃ —H CJY -4-thiazanyl —CF₃ —H CJZ -4-thiazanyl —OCH₃ —H CKA -4-thiazanyl —CH₂CH₃ —H CKB -4-thiazanyl —OCF₃ —H CKC -4-thiazanyl -tert-butyl —H CKD -4-thiazanyl -iso-propyl —H CKE -4-thiazanyl —CH₃ —CH₃ CKF -4-thiazanyl —H —H CKG -4-thiazanyl —H —Cl CKH -4-thiazanyl —H —Br CKI -4-thiazanyl —H —F CKJ -4-thiazanyl —H —CH₃ CKK -4-thiazanyl —H —CF₃ CKL -4-thiazanyl —H —OCH₃ CKM -4-thiazanyl —H —CH₂CH₃ CKN -4-thiazanyl —H —OCF₃ CKO -4-thiazanyl —H -tert-butyl CKP -4-thiazanyl —H -iso-propyl CKQ -5-(4-chlorothiazanyl) —Cl —H CKR -5-(4-chlorothiazanyl) —Br —H CKS -5-(4-chlorothiazanyl) —F —H CKT -5-(4-chlorothiazanyl) —CH₃ —H CKU -5-(4-chlorothiazanyl) —CF₃ —H CKV -5-(4-chlorothiazanyl) —OCH_(3 —H) CKW -5-(4-chlorothiazanyl) —CH₂CH₃ —H CKX -5-(4-chlorothiazanyl) —OCF_(3 —H) CKY -5-(4-chlorothiazanyl) -tert-butyl —H CKZ -5-(4-chlorothiazanyl) -iso-propyl —H CLA -5-(4-chlorothiazanyl) —CH₃ —CH₃ CLB -5-(4-chlorothiazanyl) —H —H CLC -5-(4-chlorothiazanyl) —H —Cl CLD -5-(4-chlorothiazanyl) —H —Br CLE -5-(4-chlorothiazanyl) —H —F CLF -5-(4-chlorothiazanyl) —H —CH₃ CLG -5-(4-chlorothiazanyl) —H —CF₃ CLH -5-(4-chlorothiazanyl) —H —OCH₃ CLI -5-(4-chlorothiazanyl) —H —CH₂CH₃ CLJ -5-(4-chlorothiazanyl) —H —OCF₃ CLK -5-(4-chlorotbiazanyl) —H -tert-butyl CLL -5-(4-chlorothiazanyl) —H -iso-propyl CLM -5-(4-methylthiazanyl) —Cl —H CLN -5-(4-methylthiazanyl) —Br —H CLO -5-(4-methylthiazanyl) —F —H CLP -5-(4-methylthiazanyl) —CH₃ —H CLQ -5-(4-methylthiazanyl) —CF₃ —H CLR -5-(4-methylthiazanyl) —OCH₃ —H CLS -5-(4-methylthiazanyl) —CH₂CH₃ —H CLT -5-(4-methylthiazanyl) —OCF₃ —H CLU -5-(4-methylthiazanyl) -tert-butyl —H CLV -5-(4-methylthiazanyl) -iso-propyl —H CLW -5-(4-methylthiazanyl) —CH₃ —CH₃ CLX -5-(4-methylthiazanyl) —H —H CLY -5-(4-methylthiazanyl) —H —Cl CLZ -5-(4-methylthiazanyl) —H —Br CMA -5-(4-methylthiazanyl) —H —F CMB -5-(4-methylthiazanyl) —H —CH₃ CMC -5-(4-methylthiazanyl) —H —CF₃ CMD -5-(4-methylthiazanyl) —H —OCH₃ CME -5-(4-methylthiazanyl) —H —CH₂CH₃ CMF -5-(4-methylthiazanyl) —H —OCF₃ CMG -5-(4-methylthiazanyl) —H -tert-butyl CMH -5-(4-methylthiazanyl) —H -iso-propyl

[3010] TABLE VII

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ CMI (a, b, and c) -2-pyridazinyl —Cl —H CMJ (a, b, and c) -2-pyridazinyl —Br —H CMK (a, b, and c) -2-pyridazinyl —F —H CML (a, b, and c) -2-pyridazinyl —CH₃ —H CMM (a, b, and c) -2-pyridazinyl —CF₃ —H CMN (a, b, and c) -2-pyridazinyl —OCH₃ —H CMO (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H CMP (a, b, and c) -2-pyridazinyl —OCF₃ —H CMQ (a, b, and c) -2-pyridazinyl -tert-butyl —H CMR (a, b, and c) -2-pyridazinyl -iso-propyl —H CMS (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ CMT (a, b, and c) -2-pyridazinyl —H —H CMU (a, b, and c) -2-pyridazinyl —H —Cl CMV (a, b, and c) -2-pyridazinyl —H —Br CMW (a, b, and c) -2-pyridazinyl —H —F CMX (a, b, and c) -2-pyridazinyl —H —CH₃ CMY (a, b, and c) -2-pyridazinyl —H —CF₃ CMZ (a, b, and c) -2-pyridazinyl —H —OCH₃ CNA (a, b, and c) -2-pyridazinyl —H —OCH₂CH₃ CNB (a, b, and c) -2-pyridazinyl —H —OCF₃ CNC (a, b, and c) -2-pyridazinyl —H -tert-butyl CND (a, b, and c) -2-pyridazinyl —H -iso-propyl CNE (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H CNF (a, b, and c) -3-(4-chloropyridazinyl) —Br —H CNG (a, b, and c) -3-(4-chloropyridazinyl) —F —H CNH (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H CNI (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H CNJ (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H CNK (a, b, and c) -3-(4-chloropyridazinyl) —OCH₂CH₃ —H CNL (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H CNM (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H CNN (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H CNO (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ CNP (a, b, and c) -3-(4-chloropyridazinyl) —H —H CNQ (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl CNR (a, b, and c) -3-(4-chloropyridazinyl) —H —Br CNS (a, b, and c) -3-(4-chloropyridazinyl) —H —F CNT (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ CNU (a, b, and c) -3-(4-chloropyridazinyl) —H —CF₃ CNV (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ CNW (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₃ CNX (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ CNY (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl CNZ (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl COA (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H COB (a, b, and c) -3-(4-methylpyridazinyl) —Br —H COC (a, b, and c) -3-(4-methylpyridazinyl) —F —H COD (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H COE (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H COF (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H COG (a, b, and c) 3-(4-methylpyridazinyl) —OCH₂CH₃ —H COH (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H COI (a, b, and c) -3-(4-methylpyridazinyl) -tert-butyl —H COJ (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H COK (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —CH₃ COL (a, b, and c) -3-(4-methylpyridazinyl) —H —H COM (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl CON (a, b, and c) -3-(4-methylpyridazinyl) —H —Br COO (a, b, and c) -3-(4-methylpyridazinyl) —H —F COP (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ COQ (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ COR (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ COS (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₂CH₃ COT (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ COU (a, b, and c) -3-(4-methylpyridazinyl) —H -tert-butyl COV (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl COW (a, b, and c) -4-thiazanyl —Cl —H COX (a, b, and c) -4-thiazanyl —Br —H COY (a, b, and c) -4-thiazanyl —F —H COZ (a, b, and c) -4-thiazanyl —CH₃ —H CPA (a, b, and c) -4-thiazanyl —CF₃ —H CPB (a, b, and c) -4-thiazanyl —OCH₃ —H CPC (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H CPD (a, b, and c) -4-thiazanyl —OCF₃ —H CPE (a, b, and c) -4-thiazanyl -tert-butyl —H CPF (a, b, and c) -4-thiazanyl -iso-propyl —H CPG (a, b, and c) -4-thiazanyl —CH₃ —CH₃ CPH (a, b, and c) -4-thiazanyl —H —H CPI (a, b, and c) -4-thiazanyl —H —Cl CPJ (a, b, and c) -4-thiazanyl —H —Br CPK (a, b, and c) -4-thiazanyl —H —F CPL (a, b, and c) -4-thiazanyl —H —CH₃ CPM (a, b, and c) -4-thiazanyl —H —CF₃ CPN (a, b, and c) -4-thiazanyl —H —OCH₃ CPO (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ CPP (a, b, and c) -4-thiazanyl —H —OCF₃ CPQ (a, b, and c) -4-thiazanyl —H -tert-butyl CPR (a, b, and c) -4-thiazanyl —H -iso-propyl CPS (a, b, and c) -5-(4-chlorothiazanyl) —Cl —H CPT (a, b, and c) -5-(4-chlorothiazanyl) —Br —H CPU (a, b, and c) -5-(4-chlorothiazanyl) —F —H CPV (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H CPW (a, b, and c) -5-(4-chlorothiazanyl) —CF₃ —H CPX (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H CPY (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H CPZ (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H CQA (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H CQB (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H CQC (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ CQD (a, b, and c) -5-(4-chlorothiazanyl) —H —H CQE (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl CQF (a, b, and c) -5-(4-chlorothiazanyl) —H —Br CQG (a, b, and c) -5-(4-chlorothiazanyl) —H —F CQH (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ CQI (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ CQJ (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ CQK (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ CQL (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ CQM (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl CQN (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl CQO (a, b, and c) -5-(4-methylthiazanyl) —Cl —H CQP (a, b, and c) -5-(4-methylthiazanyl) —Br —H CQQ (a, b, and c) -5-(4-methylthiazanyl) —F —H CQR (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H CQS (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H CQT (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H CQU (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H CQV (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H CQW (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H CQX (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H CQY (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ CQZ (a, b, and c) -5-(4-methylthiazanyl) —H —H CRA (a, b, and c) -5-(4-methylthiazanyl) —H —Cl CRB (a, b, and c) -5-(4-methylthiazanyl) —H —Br CRC (a, b, and c) -5-(4-methylthiazanyl) —H —F CRD (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ CRE (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ CRF (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ CRG (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ CRH (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ CRI (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl CRJ (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3011] TABLE VIII

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ CRK (a, b, and c) -2-(3-chloropyridyl) —Cl —H CRL (a, b, and c) -2-(3-chloropyridyl) —Br —H CRM (a, b, and c) -2-(3-chloropyridyl) —F —H CRN (a, b, and c) -2-(3-chloropyridyl) —CH₃ —H CRO (a, b, and c) -2-(3-chloropyridyl) —CF₃ —H CRP (a, b, and c) -2-(3-chloropyridyl) —OCH₃ —H CRQ (a, b, and c) -2-(3-chloropyridyl) —OCH₂CH₃ —H CRR (a, b, and c) -2-(3-chloropyridyl) —OCF₃ —H CRS (a, b, and c) -2-(3-chloropyridyl) -tert-butyl —H CRT (a, b, and c) -2-(3-chloropyridyl) -iso-propyl —H CRU (a, b, and c) -2-(3-chloropyridyl) —CH_(3 —CH) ₃ CRV (a, b, and c) -2-(3-chloropyridyl) —H —H CRW (a, b, and c) -2-(3-chloropyridyl) —H —Cl CRX (a, b, and c) -2-(3-chloropyridyl) —H —Br CRY (a, b, and c) -2-(3-chloropyridyl) —H —F CRZ (a, b, and c) -2-(3-chloropyridyl) —H —CH₃ CSA (a, b, and c) -2-(3-chloropyridyl) —H —CF₃ CSB (a, b, and c) -2-(3-chloropyridyl) —H —OCH₃ CSC (a, b, and c) -2-(3-chloropyridyl) —H —OCH₂CH₃ CSD (a, b, and c) -2-(3-chloropyridyl) —H —OCF₃ CSE (a, b, and c) -2-(3-chloropyridyl) —H -tert-butyl CSF (a, b, and c) -2-(3-chloropyridyl) —H -iso-propyl CSG (a, b, and c) -2-(3-methylpyridyl) —Cl —H CSH (a, b, and c) -2-(3-methylpyridyl) —Br —H CSI (a, b, and c) -2-(3-methylpyridyl) —F —H CSJ (a, b, and c) -2-(3-methylpyridyl) —CH₃ —H CSK (a, b, and c) -2-(3-methylpyridyl) —CF₃ —H CSL (a, b, and c) -2-(3-methylpyridyl) —OCH₃ —H CSM (a, b, and c) -2-(3-methylpyridyl) —OCH₂CH₃ —H CSN (a, b, and c) -2-(3-methylpyridyl) —OCF₃ —H CSO (a, b, and c) -2-(3-methylpyridyl) -tert-butyl —H CSP (a, b, and c) -2-(3-methylpyridyl) -iso-propyl —H CSQ (a, b, and c) -2-(3-methylpyridyl) —CH₃ —CH₃ CSR (a, b, and c) -2-(3-methylpyridyl) —H —H CSS (a, b, and c) -2-(3-methylpyridyl) —H —Cl CST (a, b, and c) -2-(3-methylpyridyl) —H —Br CSU (a, b, and c) -2-(3-methylpyridyl) —H —F CSV (a, b, and c) -2-(3-methylpyridyl) —H —CH₃ CSW (a, b, and c) -2-(3-methylpyridyl) —H —CF₃ CSX (a, b, and c) -2-(3-methylpyridyl) —H —OCH₃ CSY (a, b, and c) -2-(3-methylpyridyl) —H —OCH₂CH₃ CSZ (a, b, and c) -2-(3-methylpyridyl) —H —OCF₃ CTA (a, b, and c) -2-(3-methylpyridyl) —H -tert-butyl CTB (a, b, and c) -2-(3-methylpyridyl) —H -iso-propyl CTC (a, b, and c) -2-(3-CF₃-pyridyl) —Cl —H CTD (a, b, and c) -2-(3-CF₃-pyridyl) —Br —H CTE (a, b, and c) -2-(3-CF₃-pyridyl) —F —H CTF (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —H CTG (a, b, and c) -2-(3-CF₃-pyridyl) —CF₃ —H CTH (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₃ —H CTI (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H CTJ (a, b, and c) -2-(3-CF₃-pyridyl) —OCF₃ —H CTK (a, b, and c) -2-(3-CF₃-pyridyl) -tert-butyl —H CTL (a, b, and c) -2-(3-CF₃-pyridyl) -iso-propyl —H CTM (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —CH₃ CTN (a, b, and c) -2-(3-CF₃-pyridyl) —H —H CTO (a, b, and c) -2-(3-CF₃-pyridyl) —H —Cl CTP (a, b, and c) -2-(3-CF₃-pyridyl) —H —Br CTQ (a, b, and c) -2-(3-CF₃-pyridyl) —H —F CTR (a, b, and c) -2-(3-CF₃-pyridyl) —H —CH₃ CTS (a, b, and c) -2-(3-CF₃-pyridyl) —H —CF₃ CTT (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₃ CTU (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ CTV (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCF₃ CTW (a, b, and c) -2-(3-CF₃-pyridyl) —H -tert-butyl CTX (a, b, and c) -2-(3-CF₃-pyridyl) —H -iso-propyl CTY (a, b, and c) -4-(5-chloropyrimidinyl) —Cl —H CTZ (a, b, and c) -4-(5-chloropyrimidinyl) —Br —H CUA (a, b, and c) -4-(5-chloropyrimidinyl) —F —H CUB (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —H CUC (a, b, and c) -4-(5-chloropyrimidinyl) —CF₃ —H CUD (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₃ —H CUE (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H CUF (a, b, and c) -4-(5-chloropyrimidinyl) —OCF₃ —H CUG (a, b, and c) -4-(5-chloropyrimidinyl) -tert-butyl —H CUH (a, b, and c) -4-(5-chloropyrimidinyl) -iso-propyl —H CUI (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —CH₃ CUJ (a, b, and c) -4-(5-chloropyrimidinyl) —H —H CUK (a, b, and c) -4-(5-chloropyrimidinyl) —H —Cl CUL (a, b, and c) -4-(5-chloropyrimidinyl) —H —Br CUM (a, b, and c) -4-(5-chloropyrimidinyl) —H —F CUN (a, b, and c) -4-(5-chloropyrimidinyl) —H —CH₃ CUO (a, b, and c) -4-(5-chloropyrimidinyl) —H —CF₃ CUP (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₃ CUQ (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ CUR (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCF₃ CUS (a, b, and c) -4-(5-chloropyrimidinyl) —H -tert-butyl CUT (a, b, and c) -4-(5-chloropyrimidinyl) —H -iso-propyl CUU (a, b, and c) -4-(5-methylpyrimidinyl) —Cl —H CUV (a, b, and c) -4-(5-methylpyrimidinyl) —Br —H CUW (a, b, and c) -4-(5-methylpyrimidinyl) —F —H CUX (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —H CUY (a, b, and c) -4-(5-methylpyrimidinyl) —CF₃ —H CUZ (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₃ —H CVA (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H CVB (a, b, and c) -4-(5-methylpyrimidinyl) —OCF₃ —H CVG (a, b, and c) -4-(5-methylpyrimidinyl) -tert-butyl —H CVD (a, b, and c) -4-(5-methylpyrimidinyl) -iso-propyl —H CVE (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —CH₃ CVF (a, b, and c) -4-(5-methylpyrimidinyl) —H —H CVG (a, b, and c) -4-(5-methylpyrimidinyl) —H —Cl CVH (a, b, and c) -4-(5-methylpyrimidinyl) —H —Br CVI (a, b, and c) -4-(5-methylpyrimidinyl) —H —F CVJ (a, b, and c) -4-(5-methylpyrimidinyl) —H —CH₃ CVK (a, b, and c) -4-(5-methylpyrimidinyl) —H —CF₃ CVL (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₃ CVM (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ CVN (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCF₃ CVO (a, b, and c) -4-(5-methylpyrimidinyl) —H -tert-butyl CVP (a, b, and c) -4-(5-methylpyrimidinyl) —H -iso-propyl CVQ (a, b, and c) -2-pyrazinyl —Cl —H CVR (a, b, and c) -2-pyrazinyl —Br —H CVS (a, b, and c) -2-pyrazinyl —F —H CVT (a, b, and c) -2-pyrazinyl —CH₃ —H CVU (a, b, and c) -2-pyrazinyl —CF₃ —H CVV (a, b, and c) -2-pyrazinyl —OCH₃ —H CVW (a, b, and c) -2-pyrazinyl —OCH₂CH₃ —H CVX (a, b, and c) -2-pyrazinyl —OCF₃ —H CVY (a, b, and c) -2-pyrazinyl -tert-butyl —H CVZ (a, b, and c) -2-pyrazinyl -iso-propyl —H CWA (a, b, and c) -2-pyrazinyl —CH₃ —CH₃ CWB (a, b, and c) -2-pyrazinyl —H —H CWC (a, b, and c) -2-pyrazinyl —H —Cl CWD (a, b, and c) -2-pyrazinyl —H —Br CWE (a, b, and c) -2-pyrazinyl —H —F CWF (a, b, and c) -2-pyrazinyl —H —CH₃ CWG (a, b, and c) -2-pyrazinyl —H —CF₃ CWH (a, b, and c) -2-pyrazinyl —H —OCH₃ CWI (a, b, and c) -2-pyrazinyl —H —OCH₂CH₃ CWJ (a, b, and c) -2-pyrazinyl —H —OCF₃ CWK (a, b, and c) -2-pyrazinyl —H -tert-butyl CWL (a, b, and c) -2-pyrazinyl —H -iso-propyl CWM (a, b, and c) -2-(3-chloropyrazinyl) —Cl —H CWN (a, b, and c) -2-(3-chloropyrazinyl) —Br —H CWO (a, b, and c) -2-(3-chloropyrazinyl) —F —H CWP (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —H CWQ (a, b, and c) -2-(3-chloropyrazinyl) —CF₃ —H CWR (a, b, and c) -2-(3-chloropyrazinyl) —OCH₃ —H CWS (a, b, and c) -2-(3-chloropyrazinyl) —OCH₂CH₃ —H CWT (a, b, and c) -2-(3-chloropyrazinyl) —OCF₃ —H CWU (a, b, and c) -2-(3-chloropyrazinyl) -tert-butyl —H CWV (a, b, and c) -2-(3-chloropyrazinyl) -iso-propyl —H CWW (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —CH₃ CWX (a, b, and c) -2-(3-chloropyrazinyl) —H —H CWY (a, b, and c) -2-(3-chloropyrazinyl) —H —Cl CWZ (a, b, and c) -2-(3-chloropyrazinyl) —H —Br CXA (a, b, and c) -2-(3-chloropyrazinyl) —H —F CXB (a, b, and c) -2-(3-chloropyrazinyl) —H —CH₃ CXC (a, b, and c) -2-(3-chloropyrazinyl) —H —CF₃ CXD (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₃ CXE (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₂CH₃ CXF (a, b, and c) -2-(3-chloropyrazinyl) —H —OCF₃ CXG (a, b, and c) -2-(3-chloropyrazinyl) —H -tert-butyl CXH (a, b, and c) -2-(3-chloropyrazinyl) —H -iso-propyl CXI (a, b, and c) -2-(3-methylpyrazinyl) —Cl —H CXJ (a, b, and c) -2-(3-methylpyrazinyl) —Br —H CXK (a, b, and c) -2-(3-methylpyrazinyl) —F —H CXL (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —H CXM (a, b, and c) -2-(3-methylpyrazinyl) —CF₃ —H CXN (a, b, and c) -2-(3-methylpyrazinyl) —OCH₃ —H CXO (a, b, and c) -2-(3-methylpyrazinyl) —OCH₂CH₃ —H CXP (a, b, and c) -2-(3-methylpyrazinyl) —OCF₃ —H CXQ (a, b, and c) -2-(3-methylpyrazinyl) -tert-butyl —H CXR (a, b, and c) -2-(3-methylpyrazinyl) -iso-propyl —H CXS (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —CH₃ CXT (a, b, and c) -2-(3-methylpyrazinyl) —H —H CXU (a, b, and c) -2-(3-methylpyrazinyl) —H —Cl CXV (a, b, and c) -2-(3-methylpyrazinyl) —H —Br CXW (a, b, and c) -2-(3-methylpyrazinyl) —H —F CXX (a, b, and c) -2-(3-methylpyrazinyl) —H —CH₃ CXY (a, b, and c) -2-(3-methylpyrazinyl) —H —CF₃ CXZ (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₃ CYA (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₂CH₃ CYB (a, b, and c) -2-(3-methylpyrazinyl) —H —OCF₃ CYC (a, b, and c) -2-(3-methylpyrazinyl) —H -tert-butyl CYD (a, b, and c) -2-(3-methylpyrazinyl) —H -iso-propyl CYE (a, b, and c) -2-pyridazinyl —Cl —H CYF (a, b, and c) -2-pyridazinyl —Br —H CYG (a, b, and c) -2-pyridazinyl —F —H CYH (a, b, and c) -2-pyridazinyl —CH₃ —H CYI (a, b, and c) -2-pyridazinyl —CF₃ —H CYJ (a, b, and c) -2-pyridazinyl —OCH₃ —H CYK (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H CYL (a, b, and c) -2-pyridazinyl —OCF₃ —H CYM (a, b, and c) -2-pyridazinyl -tert-butyl —H CYN (a, b, and c) -2-pyridazinyl -iso-propyl —H CYO (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ CYP (a, b, and c) -2-pyridazinyl —H —H CYQ (a, b, and c) -2-pyridazinyl —H —Cl CYR (a, b, and c) -2-pyridazinyl —H —Br CYS (a, b, and c) -2-pyridazinyl —H —F CYT (a, b, and c) -2-pyridazinyl —H —CH₃ CYU (a, b, and c) -2-pyridazinyl —H —CF₃ CYV (a, b, and c) -2-pyridazinyl —H —OCH₃ CYW (a, b, and c) -2-pyridazinyl —H —OCH₂CH₂ CYX (a, b, and c) -2-pyridazinyl —H —OCF₃ CYY (a, b, and c) -2-pyridazinyl —H -tert-butyl CYZ (a, b, and c) -2-pyridazinyl —H -iso-propyl CZA (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H CZB (a, b, and c) -3-(4-chloropyridazinyl) —Br —H CZC (a, b, and c) -3-(4-chloropyridazinyl) —F —H CZD (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H CZE (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H CZF (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H CZG (a, b, and c) -3-(4-chloropyridazinyl) —OCH₂CH₃ —H CZH (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H CZI (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H CZJ (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H CZK (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ CZL (a, b, and c) -3-(4-chloropyridazinyl) —H —H CZM (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl CZN (a, b, and c) -3-(4-chloropyridazinyl) —H —Br CZO (a, b, and c) -3-(4-chloropyridazinyl) —H —F CZP (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ CZQ (a, b, and c) -3-(4-chloropyridazinyl) —H —CF₃ CZR (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ CZS (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₂ CZT (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ CZU (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl CZV (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl CZW (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H CZX (a, b, and c) -3-(4-methylpyridazinyl) —Br —H CZY (a, b, and c) -3-(4-methylpyridazinyl) —F —H CZZ (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H DAA (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H DAB (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H DAC (a, b, and c) -3-(4-methylpyridazinyl) —OCH₂CH₃ —H DAD (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H DAE (a, b, and c) -3-(4-methylpyridazinyl) -tert-butyl —H DAF (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H DAG (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —CH₃ DAH (a, b, and c) -3-(4-methylpyridazinyl) —H —H DAI (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl DAJ (a, b, and c) -3-(4-methylpyridazinyl) —H —Br DAK (a, b, and c) -3-(4-methylpyridazinyl) —H —F DAL (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ DAM (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ DAN (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ DAO (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₂CH₃ DAP (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ DAQ (a, b, and c) -3-(4-methylpyridazinyl) —H -tert-butyl DAR (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl DAS (a, b, and c) -4-thiazanyl —Cl —H DAT (a, b, and c) -4-thiazanyl —Br —H DAU (a, b, and c) -4-thiazanyl —F —H DAV (a, b, and c) -4-thiazanyl —CH₃ —H DAW (a, b, and c) -4-thiazanyl —CF₃ —H DAX (a, b, and c) -4-thiazanyl —OCH₃ —H DAY (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H DAZ (a, b, and c) -4-thiazanyl —OCF₃ —H DBA (a,, b, and c) -4-thiazanyl -tert-butyl —H DBB (a, b, and c) -4-thiazanyl -iso-propyl —H DBC (a, b, and c) -4-thiazanyl —CH₃ —CH₃ DBD (a, b, and c) -4-thiazanyl —H —H DBE (a, b, and c) -4-thiazanyl —H —Cl DBF (a, b, and c) -4-thiazanyl —H —Br DBG (a, b, and c) -4-thiazanyl —H —F DBH (a, b, and c) -4-thiazanyl —H —CH₃ DBI (a, b, and c) -4-thiazanyl —H —CF₃ DBJ (a, b, and c) -4-thiazanyl —H —OCH₃ DBK (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ DBL (a, b, and c) -4-thiazanyl —H —OCF₃ DBM (a, b, and c) -4-thiazanyl —H -tert-butyl DBN (a, b, and c) -4-thiazanyl —H -iso-propyl DBO (a, b, and c) -5-(4-chlorothiazanyl) —Cl —H DBP (a, b, and c) -5-(4-chlorothiazanyl) —Br —H DBQ (a, b, and c) -5-(4-chlorothiazanyl) —F —H DBR (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H DBS (a, b, and c) -5-(4-chlorothiazanyl) —CF₃ —H DBT (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H DBU (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H DBV (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H DBW (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H DBX (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H DBY (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ DBZ (a, b, and c) -5-(4-chlorothiazanyl) —H —H DCA (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl DCB (a, b, and c) -5-(4-chlorothiazanyl) —H —Br DCC (a, b, and c) -5-(4-chlorothiazanyl) —H —F DCD (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ DCE (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ DCF (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ DCG (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ DCH (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ DCI (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl DCJ (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl DCK (a, b, and c) -5-(4-methylthiazanyl) —Cl —H DCL (a, b, and c) -5-(4-methylthiazanyl) —Br —H DCM (a, b, and c) -5-(4-methylthiazanyl) —F —H DCN (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H DCO (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H DCP (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H DCQ (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H DCR (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H DCS (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H DCT (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H DCU (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ DCV (a, b, and c) -5-(4-methylthiazanyl) —H —H DCW (a, b, and c) -5-(4-methylthiazanyl) —H —Cl DCX (a, b, and c) -5-(4-methylthiazanyl) —H —Br DCY (a, b, and c) -5-(4-methylthiazanyl) —H —F DCZ (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ DDA (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ DDB (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ DDC (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ DDD (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ DDE (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl DDF (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3012] TABLE IX

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ DDG -2-pyridazinyl —Cl —H DDH -2-pyridazinyl —Br —H DDI -2-pyridazinyl —F —H DDJ -2-pyridazinyl —CH₃ —H DDK -2-pyridazinyl —CF₃ —H DDL -2-pyridazinyl —OCH₃ —H DDM -2-pyridazinyl —OCH₂CH₃ —H DDN -2-pyridazinyl —OCF₃ —H DDO -2-pyridazinyl -tert-butyl —H DDP -2-pyridazinyl -iso-propyl —H DDQ -2-pyridazinyl —CH₃ —CH₃ DDR -2-pyridazinyl —H —H DDS -2-pyridazinyl —H —Cl DDT -2-pyridazinyl —H —Br DDU -2-pyridazinyl —H —F DDV -2-pyridazinyl —H —CH₃ DDW -2-pyridazinyl —H —CF₃ DDX -2-pyridazinyl —H —OCH₃ DDY -2-pyridazinyl —H —OCH₂CH₃ DDZ -2-pyridazinyl —H —OCF₃ DEA -2-pyridazinyl —H -tert-butyl DEB -2-pyridazinyl —H -iso-propyl DEC -3-(4-chloropyridazinyl) —Cl —H DED -3-(4-chloropyridazinyl) —Br —H DEE -3-(4-chloropyridazinyl) —F —H DEF -3-(4-chloropyridazinyl) —CH₃ —H DEG -3-(4-chloropyridazinyl) —CF₃ —H DEH -3-(4-chloropyridazinyl) —OCH₃ —H DEI -3-(4-chloropyridazinyl) —OCH₂CH₃ —H DEJ -3-(4-chloropyridazinyl) —OCF₃ —H DEK -3-(4-chloropyridazinyl) -tert-butyl —H DEL -3-(4-chloropyridazinyl) -iso-propyl —H DEM -3-(4-chloropyridazinyl) —CH₃ —CH₃ DEN -3-(4-chloropyridazinyl) —H —H DEO -3-(4-chloropyridazinyl) —H —Cl DEP -3-(4-chloropyridazinyl) —H —Br DEQ -3-(4-chloropyridazinyl) —H —F DER -3-(4-chloropyridazinyl) —H —CH₃ DES -3-(4-chloropyridazinyl) —H —CF₃ DET -3-(4-chloropyridazinyl) —H —OCH₃ DEU -3-(4-chloropyridazinyl) —H —OCH₂CH₃ DEV -3-(4-chloropyridazinyl) —H —OCF₃ DEW -3-(4-chloropyridazinyl) —H -tert-butyl DEX -3-(4-chloropyridazinyl) —H -iso-propyl DEY -3-(4-methylpyridazinyl) —Cl —H DEZ -3-(4-methylpyridazinyl) —Br —H DFA -3-(4-methylpyridazinyl) —F —H DFB -3-(4-methylpyridazinyl) —CH₃ —H DFC -3-(4-methylpyridazinyl) —CF₃ —H DFD -3-(4-methylpyridazinyl) —OCH_(3 —H) DFE -3-(4-methylpyridazinyl) —OCH₂CH₃ —H DFF -3-(4-methylpyridazinyl) —OCF₃ —H DFG -3-(4-methylpyridazinyl) -tert-butyl —H DFH -3-(4-methylpyridazinyl) -iso-propyl —H DFI -3-(4-methylpyridazinyl) —CH₃ —CH₃ DFJ -3-(4-methylpyridazinyl) —H —H DFK -3-(4-methylpyridazinyl) —H —Cl DFL -3-(4-methylpyridazinyl) —H —Br DFM -3-(4-methylpyridazinyl) —H —F DFN -3-(4-methylpyridazinyl) —H —CH₃ DFO -3-(4-methylpyridazinyl) —H —CF₃ DEP -3-(4-methylpyridazinyl) —H —OCH₃ DFQ -3-(4-methylpyridazinyl) —H —OCH₂CH₃ DFR -3-(4-methylpyridazinyl) —H —OCF₃ DFS -3-(4-methylpyridazinyl) —H -tert-butyl DFT -3-(4-methylpyridazinyl) —H -iso-propyl DFU -4-thiazanyl —Cl —H DFV -4-thiazanyl —Br —H DFW -4-thiazanyl —F —H DFX -4-thiazanyl —CH₃ —H DFY -4-thiazanyl —CF₃ —H DFZ -4-thiazanyl —OCH₃ —H DGA -4-thiazanyl —OCH₂CH₃ —H DGB -4-thiazanyl —OCF₃ —H DGC -4-thiazanyl -tert-butyl —H DGD -4-thiazanyl -iso-propyl —H DGE -4-thiazanyl —CH₃ —CH₃ DGF -4-thiazanyl —H —H DGG -4-thiazanyl —H —Cl DGH -4-thiazanyl —H —Br DGI -4-thiazanyl —H —F DGJ -4-thiazanyl —H —CH₃ DGK -4-thiazanyl —H —CF₃ DGL -4-thiazanyl —H —OCH₃ DGM -4-thiazanyl —H —OCH₂CH₃ DGN -4-thiazanyl —H —OCF₃ DGO -4-thiazanyl —H -tert-butyl DGP -4-thiazanyl —H -iso-propyl DGQ -5-(4-chlorothiazanyl) —Cl —H DGR -5-(4-chlorothiazanyl) —Br —H DGS -5-(4-chlorothiazanyl) —F —H DGT -5-(4-chlorothiazanyl) —CH₃ —H DGU -5-(4-chlorothiazanyl) —CF₃ —H DGV -5-(4-chlorothiazanyl) —OCH₃ —H DGW -5-(4-chlorothiazanyl) —OCH₂CH₃ —H DGX -5-(4-chlorothiazanyl) —OCF₃ —H DGY -5-(4-chlorothiazanyl) -tert-butyl —H DGZ -5-(4-chlorothiazanyl) -iso-propyl —H DHA -5-(4-chlorothiazanyl) —CH₃ —CH₃ DHB -5-(4-chlorothiazanyl) —H —H DHC -5-(4-chlorothiazanyl) —H —Cl DHD -5-(4-chlorothiazanyl) —H —Br DHE -5-(4-chlorothiazanyl) —H —F DHF -5-(4-chlorothiazanyl) —H —CH₃ DHG -5-(4-chlorothiazanyl) —H —CF₃ DHH -5-(4-chlorothiazanyl) —H —OCH₃ DHI -5-(4-chlorothiazanyl) —H —OCH₂CH₃ DHJ -5-(4-chlorothiazanyl) —H —OCF₃ DHK -5-(4-chlorothiazanyl) —H -tert-butyl DHL -5-(4-chlorothiazanyl) —H -iso-propyl DHM -5-(4-methylthiazanyl) —Cl —H DHN -5-(4-methylthiazanyl) —Br —H DHO -5-(4-methylthiazanyl) —F —H DHP -5-(4-methylthiazanyl) —CH₃ —H DHQ -5-(4-methylthiazanyl) —CF₃ —H DHR -5-(4-methylthiazanyl) —OCH₃ —H DHS -5-(4-methylthiazanyl) —OCH₂CH₃ —H DHT -5-(4-methylthiazanyl) —OCF₃ —H DHU -5-(4-methylthiazanyl) -tert-butyl —H DHV -5-(4-methylthiazanyl) -iso-propyl —H DHW -5-(4-methylthiazanyl) —CH₃ —CH₃ DHX -5-(4-methylthiazanyl) —H —H DHY -5-(4-methylthiazanyl) —H —Cl DHZ -5-(4-methylthiazanyl) —H —Br DIA -5-(4-methylthiazanyl) —H —F DIB -5-(4-methylthiazanyl) —H —CH₃ DIC -5-(4-methylthiazanyl) —H —CF₃ DID -5-(4-methylthiazanyl) —H —OCH₃ DIE -5-(4-methylthiazanyl) —H —OCH₂CH₃ DIF -5-(4-methylthiazanyl) —H —OCF₃ DIG -5-(4-methylthiazanyl) —H -tert-butyl DIH -5-(4-methylthiazanyl) —H -iso-propyl

[3013] TABLE X

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ DII -2-(3-chloropyridyl) —Cl —H DIJ -2-(3-chloropyridyl) —Br —H DIK -2-(3-chloropyridyl) —F —H DIL -2-(3-chloropyridyl) —CH₃ —H DIM -2-(3-chloropyridyl) —CF₃ —H DIN -2-(3-chloropyridyl) —OCH₃ —H DIO -2-(3-chloropyridyl) —OCH₂CH₃ —H DIP -2-(3-chloropyridyl) —OCF₃ —H DIQ -2-(3-chloropyridyl) -tert-butyl —H DIR -2-(3-chloropyridyl) -iso-propyl —H DIS -2-(3-chloropyridyl) —CH₃ —CH₃ DIT -2-(3-chloropyridyl) —H —H DIU -2-(3-chloropyridyl) —H —Cl DIV -2-(3-chloropyridyl) —H —Br DIW -2-(3-chloropyridyl) —H —F DIX -2-(3-chloropyridyl) —H —CH₃ DIY -2-(3-chloropyridyl) —H —CF₃ DIZ -2-(3-chloropyridyl) —H —OCH₃ DJA -2-(3-chloropyridyl) —H —OCH₂CH₃ DJB -2-(3-chloropyridyl) —H —OCF₃ DJC -2-(3-chloropyridyl) —H -tert-butyl DJD -2-(3-chloropyridyl) —H -iso-propyl DJE -2-(3-methylpyridyl) —Cl —H DJF -2-(3-methylpyridyl) —Br —H DJG -2-(3-methylpyridyl) —F —H DJH -2-(3-methylpyridyl) —CH₃ —H DJI -2-(3-methylpyridyl) —CF₃ —H DJJ -2-(3-methylpyridyl) —OCH₃ —H DJK -2-(3-methylpyridyl) —OCH₂CH₃ —H DJL -2-(3-methylpyridyl) —OCF₃ —H DJM -2-(3-methylpyridyl) -tert-butyl —H DJN -2-(3-methylpyridyl) -iso-propyl —H DJO -2-(3-methylpyridyl) —CH₃ —CH₃ DJP -2-(3-methylpyridyl) —H —H DJQ -2-(3-methylpyridyl) —H —Cl DJR -2-(3-methylpyridyl) —H —Br DJS -2-(3-methylpyridyl) —H —F DJT -2-(3-methylpyridyl) —H —CH₃ DJU -2-(3-methylpyridyl) —H —CF₃ DJV -2-(3-methylpyridyl) —H —OCH₃ DJW -2-(3-methylpyridyl) —H —OCH₂CH₃ DJX -2-(3-methylpyridyl) —H —OCF₃ DJY -2-(3-methylpyridyl) —H -tert-butyl DJZ -2-(3-methylpyridyl) —H -iso-propyl DKA -2-(3-CF₃-pyridyl) —Cl —H DKB -2-(3-CF₃-pyridyl) —Br —H DKC -2-(3-CF₃-pyridyl) —F —H DKD -2-(3-CF₃-pyridyl) —CH₃ —H DKE -2-(3-CF₃-pyridyl) —CF₃ —H DKF -2-(3-CF₃-pyridyl) —OCH₃ —H DKG -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H DKH -2-(3-CF₃-pyridyl) —OCF₃ —H DKI -2-(3-CF₃-pyridyl) -tert-butyl —H DKJ -2-(3-CF₃-pyridyl) -iso-propyl —H DKK -2-(3-CF₃-pyridyl) —CH₃ —CH₃ DKL -2-(3-CF₃-pyridyl) —H —H DKM -2-(3-CF₃-pyridyl) —H —Cl DKN -2-(3-CF₃-pyridyl) —H —Br DKO -2-(3-CF₃-pyridyl) —H —F DKP -2-(3-CF₃-pyridyl) —H —CH₃ DKQ -2-(3-CF₃-pyridyl) —H —CF₃ DKR -2-(3-CF₃-pyridyl) —H —OCH₃ DKS -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ DKT -2-(3-CF₃-pyridyl) —H —OCF₃ DKU -2-(3-CF₃-pyridyl) —H -tert-butyl DKV -2-(3-CF₃-pyridyl) —H -iso-propyl DKW -4-(5-chloropyrimidinyl) —Cl —H DKX -4-(5-chloropyrimidinyl) —Br —H DKY -4-(5-chloropyrimidinyl) —F —H DKZ -4-(5-chloropyrimidinyl) —CH₃ —H DLA -4-(5-chloropyrimidinyl) —CF₃ —H DLB -4-(5-chloropyrimidinyl) —OCH₃ —H DLC -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H DLD -4-(5-chloropyrimidinyl) —OCF₃ —H DLE -4-(5-chloropyrimidinyl) -tert-butyl —H DLF -4-(5-chloropyrimidinyl) -iso-propyl —H DLG -4-(5-chloropyrimidinyl) —CH₃ —CH₃ DLH -4-(5-chloropyrimidinyl) —H —H DLI -4-(5-chloropyrimidinyl) —H —Cl DLJ -4-(5-chloropyrimidinyl) —H —Br DLK -4-(5-chloropyrimidinyl) —H —F DLL -4-(5-chloropyrimidinyl) —H —CH₃ DLM -4-(5-chloropyrimidinyl) —H —CF₃ DLN -4-(5-chloropyrimidinyl) —H —OCH₃ DLO -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ DLP -4-(5-chloropyrimidinyl) —H —OCF₃ DLQ -4-(5-chloropyrimidinyl) —H -tert-butyl DLR -4-(5-chloropyrimidinyl) —H -iso-propyl DLS -4-(5-methylpyrimidinyl) —Cl —H DLT -4-(5-methylpyrimidinyl) —Br —H DLU -4-(5-methylpyrimidinyl) —F —H DLV -4-(5-methylpyrimidinyl) —CH₃ —H DLW -4-(5-methylpyrimidinyl) —CF₃ —H DLX -4-(5-methylpyrimidinyl) —OCH₃ —H DLY -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H DLZ -4-(5-methylpyrimidinyl) —OCF₃ —H DMA -4-(5-methylpyrimidinyl) -tert-butyl —H DMB -4-(5-methylpyrimidinyl) -iso-propyl —H DMC -4-(5-methylpyrimidinyl) —CH₃ —CH₃ DMD -4-(5-methylpyrimidinyl) —H —H DME -4-(5-methylpyrimidinyl) —H —Cl DMF -4-(5-methylpyrimidinyl) —H —Br DMG -4-(5-methylpyrimidinyl) —H —F DMH -4-(5-methylpyrimidinyl) —H —CH₃ DMI -4-(5-methylpyrimidinyl) —H —CF₃ DMJ -4-(5-methylpyrimidinyl) —H —OCH₃ DMK -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ DML -4-(5-methylpyrimidinyl) —H —OCF₃ DMM -4-(5-methylpyrimidinyl) —H -tert-butyl DIN -4-(5-methylpyrimidinyl) —H -iso-propyl DMO -2-pyrazinyl —Cl —H DMP -2-pyrazinyl —Br —H DMQ -2-pyrazinyl —F —H DMR -2-pyrazinyl —CH₃ —H DMS -2-pyrazinyl —CF₃ —H DMT -2-pyrazinyl —OCH₃ —H DMU -2-pyrazinyl —OCH₂CH₃ —H DMV -2-pyrazinyl —OCF₃ —H DMW -2-pyrazinyl -tert-butyl —H DMX -2-pyrazinyl -iso-propyl —H DMY -2-pyrazinyl —CH₃ —CH₃ DMZ -2-pyrazinyl —H —H DNA -2-pyrazinyl —H —Cl DNB -2-pyrazinyl —H —Br DNC -2-pyrazinyl —H —F DND -2-pyrazinyl —H —CH₃ DNE -2-pyrazinyl —H —CF₃ DNF -2-pyrazinyl —H —OCH₃ DNG -2-pyrazinyl —H —OCH₂CH₃ DNH -2-pyrazinyl —H —OCF₃ DNI -2-pyrazinyl —H -tert-butyl DNJ -2-pyrazinyl —H -iso-propyl DNK -2-(3-chloropyrazinyl) —Cl —H DNL -2-(3-chloropyrazinyl) —Br —H DNM -2-(3-chloropyrazinyl) —F —H DNN -2-(3-chloropyrazinyl) —CH₃ —H DNO -2-(3-chloropyrazinyl) —CF₃ —H DNP -2-(3-chloropyrazinyl) —OCH₃ —H DNQ -2-(3-chloropyrazinyl) —OCH₂CH₃ —H DNR -2-(3-chloropyrazinyl) —OCF₃ —H DNS -2-(3-chloropyrazinyl) -tert-butyl —H DNT -2-(3-chloropyrazinyl) -iso-propyl —H DNU -2-(3-chloropyrazinyl) —CH₃ —CH₃ DNV -2-(3-chloropyrazinyl) —H —H DNW -2-(3-chloropyrazinyl) —H —Cl DNX -2-(3-chloropyrazinyl) —H —Br DNY -2-(3-chloropyrazinyl) —H —F DNZ -2-(3-chloropyrazinyl) —H —CH₃ DOA -2-(3-chloropyrazinyl) —H —CF₃ DOB -2-(3-chloropyrazinyl) —H —OCH₃ DOC -2-(3-chloropyrazinyl) —H —OCH₂CH₃ DOD -2-(3-chloropyrazinyl) —H —OCF₃ DOE -2-(3-chloropyrazinyl) —H -tert-butyl DOF -2-(3-chloropyrazinyl) —H -iso-propyl DOG -2-(3-methylpyrazinyl) —Cl —H DOH -2-(3-methylpyrazinyl) —Br —H DOI -2-(3-methylpyrazinyl) —F —H DOJ -2-(3-methylpyrazinyl) —CH₃ —H DOK -2-(3-methylpyrazinyl) —CF₃ —H DOL -2-(3-methylpyrazinyl) —OCH₃ —H DOM -2-(3-methylpyrazinyl) —OCH₂CH₃ —H DON -2-(3-methylpyrazinyl) —OCF₃ —H DOO -2-(3-methylpyrazinyl) -tert-butyl —H DOP -2-(3-methylpyrazinyl) -iso-propyl —H DOQ -2-(3-methylpyrazinyl) —CH₃ —CH₃ DOR -2-(3-methylpyrazinyl) —H —H DOS -2-(3-methylpyrazinyl) —H —Cl DOT -2-(3-methylpyrazinyl) —H —Br DOU -2-(3-methylpyrazinyl) —H —F DOV -2-(3-methylpyrazinyl) —H —CH₃ DOW -2-(3-methylpyrazinyl) —H —CF₃ DOX -2-(3-methylpyrazinyl) —H —OCH₃ DOY -2-(3-methylpyrazinyl) —H —OCH₂CH₃ DOZ -2-(3-methylpyrazinyl) —H —OCF₃ DPA -2-(3-methylpyrazinyl) —H -tert-butyl DPB -2-(3-methylpyrazinyl) —H -iso-propyl DPC -2-pyridazinyl —Cl —H DPD -2-pyridazinyl —Br —H DPE -2-pyridazinyl —F —H DPF -2-pyridazinyl —CH₃ —H DPG -2-pyridazinyl —CF₃ —H DPH -2-pyridazinyl —OCH₃ —H DPI -2-pyridazinyl —OCH₂CH₃ —H DPJ -2-pyridazinyl —OCF₃ —H DPK -2-pyridazinyl -tert-butyl —H DPL -2-pyridazinyl -iso-propyl —H DPM -2-pyridazinyl —CH₃ —CH₃ DPN -2-pyridazinyl —H —H DPO -2-pyridazinyl —H —Cl DPP -2-pyridazinyl —H —Br DPQ -2-pyridazinyl —H —F DPR -2-pyridazinyl —H —CH₃ DPS -2-pyridazinyl —H —CF₃ DPT -2-pyridazinyl —H —OCH₃ DPU -2-pyridazinyl —H —OCH₂CH₃ DPV -2-pyridazinyl —H —OCF₃ DPW -2-pyridazinyl —H -tert-butyl DPX -2-pyridazinyl —H -iso-propyl DPY -3-(4-chloropyridazinyl) —Cl —H DPZ -3-(4-chloropyridazinyl) —Br —H DQA -3-(4-chloropyridazinyl) —F —H DQB -3-(4-chloropyridazinyl) —CH₃ —H DQC -3-(4-chloropyridazinyl) —CF₃ —H DQD -3-(4-chloropyridazinyl) —OCH₃ —H DQE -3-(4-chloropyridazinyl) —OCH₂CH₃ —H DQF -3-(4-chloropyridazinyl) —OCF₃ —H DQG -3-(4-chloropyridazinyl) -tert-butyl —H DQH -3-(4-chloropyridazinyl) -iso-propyl —H DQI -3-(4-chloropyridazinyl) —CH₃ —CH₃ DQJ -3-(4-chloropyridazinyl) —H —H DQK -3-(4-chloropyridazinyl) —H —Cl DQL -3-(4-chloropyridazinyl) —H —Br DQM -3-(4-chloropyridazinyl) —H —F DQN -3-(4-chloropyridazinyl) —H —CH₃ DQO -3-(4-chloropyridazinyl) —H —CF₃ DQP -3-(4-chloropyridazinyl) —H —OCH₃ DQQ -3-(4-chloropyridazinyl) —H —OCH₂CH₃ DQR -3-(4-chloropyridazinyl) —H —OCF₃ DQS -3-(4-chloropyridazinyl) —H -tert-butyl DQT -3-(4-chloropyridazinyl) —H -iso-propyl DQU -3-(4-methylpyridazinyl) —Cl —H DQV -3-(4-methylpyridazinyl) —Br —H DQW -3-(4-methylpyridazinyl) —F —H DQX -3-(4-methylpyridazinyl) —CH₃ —H DQY -3-(4-methylpyridazinyl) —CF₃ —H DQZ -3-(4-methylpyridazinyl) —OCH₃ —H DRA -3-(4-methylpyridazinyl) —OCH₂CH₃ —H DRB -3-(4-methylpyridazinyl) —OCF₃ —H DRC -3-(4-methylpyridazinyl) -tert-butyl —H DRD -3-(4-methylpyridazinyl) -iso-propyl —H DRE -3-(4-methylpyridazinyl) —CH₃ —CH₃ DRF -3-(4-methylpyridazinyl) —H —H DRG -3-(4-methylpyridazinyl) —H —Cl DRH -3-(4-methylpyridazinyl) —H —Br DRI -3-(4-methylpyridazinyl) —H —F DRJ -3-(4-methylpyridazinyl) —H —CH₃ DRK -3-(4-methylpyridazinyl) —H —CF₃ DRL -3-(4-methylpyridazinyl) —H —OCH₃ DRM -3-(4-methylpyridazinyl) —H —OCH₂CH₃ DRN -3-(4-methylpyridazinyl) —H —OCF₃ DRO -3-(4-methylpyridazinyl) —H -tert-butyl DRP -3-(4-methylpyridazinyl) —H -iso-propyl DRQ -4-thiazanyl —Cl —H DRR -4-thiazanyl —Br —H DRS -4-thiazanyl —F —H DRT -4-thiazanyl —CH₃ —H DRU -4-thiazanyl —CF₃ —H DRV -4-thiazanyl —OCH₃ —H DRW -4-thiazanyl —OCH₂CH₃ —H DRX -4-thiazanyl —OCF₃ —H DRY -4-thiazanyl -tert-butyl —H DRZ -4-thiazanyl -iso-propyl —H DSA -4-thiazanyl —CH₃ —CH₃ DSB -4-thiazanyl —H —H DSC -4-thiazanyl —H —Cl DSD -4-thiazanyl —H —Br DSE -4-thiazanyl —H —F DSF -4-thiazanyl —H —CH₃ DSG -4-thiazanyl —H —CF₃ DSH -4-thiazanyl —H —OCH₃ DSI -4-thiazanyl —H —OCH₂CH₃ DSJ -4-thiazanyl —H —OCF₃ DSK -4-thiazanyl —H -tert-butyl DSL -4-thiazanyl —H -iso-propyl DSM -5-(4-chlorothiazanyl) —Cl —H DSN -5-(4-chlorothiazanyl) —Br —H DSO -5-(4-chlorothiazanyl) —F —H DSP -5-(4-chlorothiazanyl) —CH₃ —H DSQ -5-(4-chlorothiazanyl) —CF₃ —H DSR -5-(4-chlorothiazanyl) —OCH₃ —H DSS -5-(4-chlorothiazanyl) —OCH₂CH₃ —H DST -5-(4-chlorothiazanyl) —OCF₃ —H DSU -5-(4-chlorothiazanyl) -tert-butyl —H DSV -5-(4-chlorothiazanyl) -iso-propyl —H DSW -5-(4-chlorothiazanyl) —CH₃ —CH₃ DSX -5-(4-chlorothiazanyl) —H —H DSY -5-(4-chlorothiazanyl) —H —Cl DSZ -5-(4-chlorothiazanyl) —H —Br DTA -5-(4-chlorothiazanyl) —H —F DTB -5-(4-chlorothiazanyl) —H —CH₃ DTC -5-(4-chlorothiazanyl) —H —CF₃ DTD -5-(4-chlorothiazanyl) —H —OCH₃ DTE -5-(4-chlorothiazanyl) —H —OCH₂CH₃ DTF -5-(4-chlorothiazanyl) —H —OCF₃ DTG -5-(4-chlorothiazanyl) —H -tert-butyl DTH -5-(4-chlorothiazanyl) —H -iso-propyl DTI -5-(4-methylthiazanyl) —Cl —H DTJ -5-(4-methylthiazanyl) —Br —H DTK -5-(4-methylthiazanyl) —F —H DTL -5-(4-methylthiazanyl) —CH₃ —H DTM -5-(4-methylthiazanyl) —CF₃ —H DTN -5-(4-methylthiazanyl) —OCH₃ —H DTO -5-(4-methylthiazanyl) —OCH₂CH₃ —H DTP -5-(4-methylthiazanyl) —OCF₃ —H DTQ -5-(4-methylthiazanyl) -tert-butyl —H DTR -5-(4-methylthiazanyl) -iso-propyl —H DTS -5-(4-methylthiazanyl) —CH₃ —CH₃ DTT -5-(4-methylthiazanyl) —H —H DTU -5-(4-methylthiazanyl) —H —Cl DTV -5-(4-methylthiazanyl) —H —Br DTW -5-(4-methylthiazanyl) —H —F DTX -5-(4-methylthiazanyl) —H —CH₃ DTY -5-(4-methylthiazanyl) —H —CF₃ DTZ -5-(4-methylthiazanyl) —H —OCH₃ DUA -5-(4-methylthiazanyl) —H —OCH₂CH₃ DUB -5-(4-methylthiazanyl) —H —OCF₃ DUC -5-(4-methylthiazanyl) —H -tert-butyl DUD -5-(4-methylthiazanyl) —H -iso-propyl

[3014] TABLE XI

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ DUE (a, b, and c) -2-pyridazinyl —Cl —H DUF (a, b, and c) -2-pyridazinyl —Br —H DUG (a, b, and c) -2-pyridazinyl —F —H DUH (a, b, and c) -2-pyridazinyl —CH₃ —H DUI (a, b, and c) -2-pyridazinyl —CF₃ —H DUJ (a, b, and c) -2-pyridazinyl —OCH₃ —H DUK (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H DUL (a, b, and c) -2-pyridazinyl —OCF₃ —H DUM (a, b, and c) -2-pyridazinyl -tert-butyl —H DUN (a, b, and c) -2-pyridazinyl -iso-propyl —H DUO (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ DUP (a, b, and c) -2-pyridazinyl —H —H DUQ (a, b, and c) -2-pyridazinyl —H —Cl DUR (a, b, and c) -2-pyridazinyl —H —Br DUS (a, b, and c) -2-pyridazinyl —H —F DUT (a, b, and c) -2-pyridazinyl —H —CH₃ DUU (a, b, and c) -2-pyridazinyl —H —CF₃ DUV (a, b, and c) -2-pyridazinyl —H —OCH₃ DUW (a, b, and c) -2-pyridazinyl —H —OCH₂CH₃ DUX (a, b, and c) -2-pyridazinyl —H —OCF₃ DUY (a, b, and c) -2-pyridazinyl —H -tert-butyl DUZ (a, b, and c) -2-pyridazinyl —H -iso-propyl DVA (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H DVB (a, b, and c) -3-(4-chloropyridazinyl) —Br —H DVC (a, b, and c) -3-(4-chloropyridazinyl) —F —H DVD (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H DVE (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H DVF (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H DVG (a, b, and c) -3-(4-chloropyridazinyl) —OCH₂CH₃ —H DVH (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H DVI (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H DVJ (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H DVK (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ DVL (a, b, and c) -3-(4-chloropyridazinyl) —H —H DVM (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl DVN (a, b, and c) -3-(4-chloropyridazinyl) —H —Br DVO (a, b, and c) -3-(4-chloropyridazinyl) —H —F DVP (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ DVQ (a, b, and c) -3-(4-chloropyridazinyl) —H —CF₃ DVR (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ DVS (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₃ DVT (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ DVU (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl DVV (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl DVW (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H DVX (a, b, and c) -3-(4-methylpyridazinyl) —Br —H DVY (a, b, and c) -3-(4-methylpyridazinyl) —F —H DVZ (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H DWA (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H DWB (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H DWC (a, b, and c) -3-(4-methylpyridazinyl) —OCH₂CH₃ —H DWD (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H DWE (a, b, and c) -3-(4-methylpyridazinyl) -tert-butyl —H DWF (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H DWG (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —CH₃ DWH (a, b, and c) -3-(4-methylpyridazinyl) —H —H DWI (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl DWJ (a, b, and c) -3-(4-methylpyridazinyl) —H —Br DWK (a, b, and c) -3-(4-methylpyridazinyl) —H —F DWL (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ DWM (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ DWN (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ DWO (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₂CH₃ DWP (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ DWQ (a, b, and c) -3-(4-methylpyridazinyl) —H -tert-butyl DWR (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl DWS (a, b, and c) -4-thiazanyl —Cl —H DWT (a, b, and c) -4-thiazanyl —Br —H DWU (a, b, and c) -4-thiazanyl —F —H DWV (a, b, and c) -4-thiazanyl —CH₃ —H DWW (a, b, and c) -4-thiazanyl —CF₃ —H DWX (a, b, and c) -4-thiazanyl —OCH₃ —H DWY (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H DWZ (a, b, and c) -4-thiazanyl —OCF₃ —H DXA (a, b, and c) -4-thiazanyl -tert-butyl —H DXB (a, b, and c) -4-thiazanyl -iso-propyl —H DXC (a, b, and c) -4-thiazanyl —CH₃ —CH₃ DXD (a, b, and c) -4-thiazanyl —H —H DXE (a, b, and c) -4-thiazanyl —H —Cl DXF (a, b, and c) -4-thiazanyl —H —Br DXG (a, b, and c) -4-thiazanyl —H —F DXH (a, b, and c) -4-thiazanyl —H —CH₃ DXI (a, b, and c) -4-thiazanyl —H —CF₃ DXJ (a, b, and c) -4-thiazanyl —H —OCH₃ DXK (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ DXL (a, b, and c) -4-thiazanyl —H —OCF₃ DXM (a, b, and c) -4-thiazanyl —H -tert-butyl DXN (a, b, and c) -4-thiazanyl —H -iso-propyl DXO (a, b, and c) -5-(4-chlorothiazanyl) —Cl —H DXP (a, b, and c) -5-(4-chlorothiazanyl) —Br —H DXQ (a, b, and c) -5-(4-chlorothiazanyl) —F —H DXR (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H DXS (a, b, and c) -5-(4-chlorothiazanyl) —CF₃ —H DXT (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H DXU (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H DXV (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H DXW (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H DXX (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H DXY (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ DXZ (a, b, and c) -5-(4-chlorothiazanyl) —H —H DYA (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl DYB (a, b, and c) -5-(4-chlorothiazanyl) —H —Br DYC (a, b, and c) -5-(4-chlorothiazanyl) —H —F DYD (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ DYE (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ DYE (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ DYG (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ DYH (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ DYI (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl DYJ (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl DYK (a, b, and c) -5-(4-methylthiazanyl) —Cl —H DYL (a, b, and c) -5-(4-methylthiazanyl) —Br —H DYM (a, b, and c) -5-(4-methylthiazanyl) —F —H DYN (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H DYO (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H DYP (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H DYQ (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H DYR (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H DYS (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H DYT (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H DYU (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ DYV (a, b, and c) -5-(4-methylthiazanyl) —H —H DYW (a, b, and c) -5-(4-methylthiazanyl) —H —Cl DYX (a, b, and c) -5-(4-methylthiazanyl) —H —Br DYY (a, b, and c) -5-(4-methylthiazanyl) —H —F DYZ (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ DZA (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ DZB (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ DZC (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ DZD (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ DZE (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl DZF (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3015] TABLE XII

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ DZG (a, b, and c) -2-(3-chloropyridyl) —Cl —H DZH (a, b, and c) -2-(3-chloropyridyl) —Br —H DZI (a, b, and c) -2-(3-chloropyridyl) —F —H DZJ (a, b, and c) -2-(3-chloropyridyl) —CH₃ —H DZK (a, b, and c) -2-(3-chloropyridyl) —CF₃ —H DZL (a, b, and c) -2-(3-chloropyridyl) —OCH₃ —H DZM (a, b, and c) -2-(3-chloropyridyl) —OCH₂CH₃ —H DZN (a, b, and c) -2-(3-chloropyridyl) —OCF₃ —H DZO (a, b, and c) -2-(3-chloropyridyl) -tert-butyl —H DZP (a, b, and c) -2-(3-chloropyridyl) -iso-propyl —H DZQ (a, b, and c) -2-(3-chloropyridyl) —CH₃ —CH₃ DZR (a, b, and c) -2-(3-chloropyridyl) —H —H DZS (a, b, and c) -2-(3-chloropyridyl) —H —Cl DZT (a, b, and c) -2-(3-chloropyridyl) —H —Br DZU (a, b, and c) -2-(3-chloropyridyl) —H —F DZV (a, b, and c) -2-(3-chloropyridyl) —H —CH₃ DZW (a, b, and c) -2-(3-chloropyridyl) —H —CF₃ DZX (a, b, and c) -2-(3-chloropyridyl) —H —OCH₃ DZY (a, b, and c) -2-(3-chloropyridyl) —H —OCH₂CH₃ DZZ (a, b, and c) -2-(3-chloropyridyl) —H —OCF₃ EAA (a, b, and c) -2-(3-chloropyridyl) —H -tert-butyl EAB (a, b, and c) -2-(3-chloropyridyl) —H -iso-propyl EAC (a, b, and c) -2-(3-methylpyridyl) —Cl —H EAD (a, b, and c) -2-(3-methylpyridyl) —Br —H EAB (a, b, and c) -2-(3-methylpyridyl) —F —H EAF (a, b, and c) -2-(3-methylpyridyl) —CH₃ —H EAG (a, b, and c) -2-(3-methylpyridyl) —CF₃ —H EAH (a, b, and c) -2-(3-methylpyridyl) —OCH₃ —H EMI (a, b, and c) -2-(3-methylpyridyl) —OCH₂CH₃ —H EMJ (a, b, and c) -2-(3-methylpyridyl) —OCF₃ —H EAK (a, b, and c) -2-(3-methylpyridyl) -tert-butyl —H EAL (a, b, and c) -2-(3-methylpyridyl) -iso-propyl —H EAM (a, b, and c) -2-(3-methylpyridyl) —CH₃ —CH₃ EAN (a, b, and c) -2-(3-methylpyridyl) —H —H EAO (a, b, and c) -2-(3-methylpyridyl) —H —Cl EAP (a, b, and c) -2-(3-methylpyridyl) —H —Br EAQ (a, b, and c) -2-(3-methylpyridyl) —H —F EAR (a, b, and c) -2-(3-methylpyridyl) —H —CH₃ EAS (a, b, and c) -2-(3-methylpyridyl) —H —CF₃ EAT (a, b, and c) -2-(3-methylpyridyl) —H —OCH₃ EAU (a, b, and c) -2-(3-methylpyridyl) —H —OCH₂CH₃ EAV (a, b, and c) -2-(3-methylpyridyl) —H —OCF₃ EAW (a, b, and c) -2-(3-methylpyridyl) —H -tert-butyl EAX (a, b, and c) -2-(3-methylpyridyl) —H -iso-propyl EAY (a, b, and c) -2-(3—CF₃-pyridyl) —Cl —H EAZ (a, b, and c) -2-(3—CF₃-pyridyl) —Br —H EBA (a, b, and c) -2-(3—CF₃-pyridyl) —F —H EBB (a, b, and c) -2-(3—CF₃-pyridyl) —CH₃ —H EBC (a, b, and c) -2-(3—CF₃-pyridyl) —CF₃ —H EBD (a, b, and c) -2-(3—CF₃-pyridyl) —OCH₃ —H EBE (a, b, and c) -2-(3—CF₃-pyridyl) —OCH₂CH₃ —H EBF (a, b, and c) -2-(3—CF₃-pyridyl) —OCF₃ —H EBG (a, b, and c) -2-(3—CF₃-pyridyl) -tert-butyl —H EBH (a, b, and c) -2-(3—CF₃-pyridyl) -iso-propyl —H EBI (a, b, and c) -2-(3—CF₃-pyridyl) —CH₃ —CH₃ EBJ (a, b, and c) -2-(3—CF₃-pyridyl) —H —H EBK (a, b, and c) -2-(3—CF₃-pyridyl) —H —Cl EBL (a, b, and c) -2-(3—CF₃-pyridyl) —H —Br EBM (a, b, and c) -2-(3—CF₃-pyridyl) —H —F EBN (a, b, and c) -2-(3—CF₃-pyridyl) —H —CH₃ EBO (a, b, and c) -2-(3—CF₃-pyridyl) —H —CF₃ EBP (a, b, and c) -2-(3—CF₃-pyridyl) —H —OCH₃ EBQ (a, b, and c) -2-(3—CF₃-pyridyl) —H —OCH₂CH₃ EBR (a, b, and c) -2-(3—CF₃-pyridyl) —H —OCF₃ EBS (a, b, and c) -2-(3—CF₃-pyridyl) —H -tert-butyl EBT (a, b, and c) -2-(3—CF₃-pyridyl) —H -iso-propyl EBU (a, b, and c) -4-(5-chloropyrimidinyl) —Cl —H EBV (a, b, and c) -4-(5-chloropyrimidinyl) —Br —H EBW (a, b, and c) -4-(5-chloropyrimidinyl) —F —H EBX (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —H EBY (a, b, and c) -4-(5-chloropyrimidinyl) —CF₃ —H EBZ (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₃ —H ECA (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H ECB (a, b, and c) -4-(5-chloropyrimidinyl) —OCF₃ —H ECC (a, b, and c) -4-(5-chloropyrimidinyl) -tert-butyl —H ECD (a, b, and c) -4-(5-chloropyrimidinyl) -iso-propyl —H ECE (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —CH₃ ECF (a, b, and c) -4-(5-chloropyrimidinyl) —H —H ECG (a, b, and c) -4-(5-chloropyrimidinyl) —H —Cl ECH (a, b, and c) -4-(5-chloropyrimidinyl) —H —Br ECI (a, b, and c) -4-(5-chloropyrimidinyl) —H —F ECJ (a, b, and c) -4-(5-chloropyrimidinyl) —H —CH₃ ECK (a, b, and c) -4-(5-chloropyrimidinyl) —H —CF₃ ECL (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₃ ECM (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ ECN (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCF₃ ECO (a, b, and c) -4-(5-chloropyrimidinyl) —H -tert-butyl ECP (a, b, and c) -4-(5-chloropyrimidinyl) —H -iso-propyl ECQ (a, b, and c) -4-(5-methylpyrimidinyl) —Cl —H ECR (a, b, and c) -4-(5-methylpyrimidinyl) —Br —H ECS (a, b, and c) -4-(5-methylpyrimidinyl) —F —H ECT (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —H ECU (a, b, and c) -4-(5-methylpyrimidinyl) —CF₃ —H ECV (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₃ —H ECW (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H ECX (a, b, and c) -4-(5-methylpyrimidinyl) —OCF₃ —H ECY (a, b, and c) -4-(5-methylpyrimidinyl) -tert-butyl —H ECZ (a, b, and c) -4-(5-methylpyrimidinyl) -iso-propyl —H EDA (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —CH₃ EDB (a, b, and c) -4-(5-methylpyrimidinyl) —H —H EDC (a, b, and c) -4-(5-methylpyrimidinyl) —H —Cl EDD (a, b, and c) -4-(5-methylpyrimidinyl) —H —Br EDE (a, b, and c) -4-(5-methylpyrimidinyl) —H —F EDF (a, b, and c) -4-(5-methylpyrimidinyl) —H —CH₃ EDG (a, b, and c) -4-(5-methylpyrimidinyl) —H —CF₃ EDH (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₃ EDI (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ EDJ (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCF₃ EDK (a, b, and c) -4-(5-methylpyrimidinyl) —H -tert-butyl EDL (a, b, and c) -4-(5-methylpyrimidinyl) —H -iso-propyl EDM (a, b, and c) -2-pyrazinyl —Cl —H EDN (a, b, and c) -2-pyrazinyl —Br —H EDO (a, b, and c) -2-pyrazinyl —F —H EDP (a, b, and c) -2-pyrazinyl —CH₃ —H EDQ (a, b, and c) -2-pyrazinyl —CF₃ —H EDR (a, b, and c) -2-pyrazinyl —OCH₃ —H EDS (a, b, and c) -2-pyrazinyl —OCH₂CH₃ —H EDT (a, b, and c) -2-pyrazinyl —OCF₃ —H EDU (a, b, and c) -2-pyrazinyl -tert-butyl —H EDV (a, b, and c) -2-pyrazinyl -iso-propyl —H EDW (a, b, and c) -2-pyrazinyl —CH₃ —CH₃ EDX (a, b, and c) -2-pyrazinyl —H —H EDY (a, b, and c) -2-pyrazinyl —H —Cl EDZ (a, b, and c) -2-pyrazinyl —H —Br EEA (a, b, and c) -2-pyrazinyl —H —F EEB (a, b, and c) -2-pyrazinyl —H —CH₃ EEC (a, b, and c) -2-pyrazinyl —H —CF₃ EED (a, b, and c) -2-pyrazinyl —H —OCH₃ EEE (a, b, and c) -2-pyrazinyl —H —OCH₂CH₃ EEF (a, b, and c) -2-pyrazinyl —H —OCF₃ EEG (a, b, and c) -2-pyrazinyl —H -tert-butyl EEH (a, b, and c) -2-pyrazinyl —H -iso-propyl EEI (a, b, and c) -2-(3-chloropyrazinyl) —Cl —H EEJ (a, b, and c) -2-(3-chloropyrazinyl) —Br —H EEK (a, b, and c) -2-(3-chloropyrazinyl) —F —H EEL (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —H EEM (a, b, and c) -2-(3-chloropyrazinyl) —CF₃ —H EEN (a, b, and c) -2-(3-chloropyrazinyl) —OCH₃ —H EEO (a, b, and c) -2-(3-chloropyrazinyl) —OCH₂CH₃ —H EEP (a, b, and c) -2-(3-chloropyrazinyl) —OCF₃ —H EEQ (a, b, and c) -2-(3-chloropyrazinyl) -tert-butyl —H EER (a, b, and c) -2-(3-chloropyrazinyl) -iso-propyl —H EES (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —CH₃ EET (a, b, and c) -2-(3-chloropyrazinyl) —H —H EEU (a, b, and c) -2-(3-chloropyrazinyl) —H —Cl EEV (a, b, and c) -2-(3-chloropyrazinyl) —H —Br EEW (a, b, and c) -2-(3-chloropyrazinyl) —H —F EEX (a, b, and c) -2-(3-chloropyrazinyl) —H —CH₃ EEY (a, b, and c) -2-(3-chloropyrazinyl) —H —CF₃ EEZ (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₃ EFA (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₂CH₃ EFB (a, b, and c) -2-(3-chloropyrazinyl) —H —OCF₃ EFC (a, b, and c) -2-(3-chloropyrazinyl) —H -tert-butyl EFD (a, b, and c) -2-(3-chloropyrazinyl) —H -iso-propyl EFE (a, b, and c) -2-(3-methylpyrazinyl) —Cl —H EFF (a, b, and c) -2-(3-methylpyrazinyl) —Br —H EFG (a, b, and c) -2-(3-methylpyrazinyl) —F —H EFH (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —H EFI (a, b, and c) -2-(3-methylpyrazinyl) —CF₃ —H EFJ (a, b, and c) -2-(3-methylpyrazinyl) —OCH₃ —H EFK (a, b, and c) -2-(3-methylpyrazinyl) —OCH₂CH₃ —H EFL (a, b, and c) -2-(3-methylpyrazinyl) —OCF₃ —H EFM (a, b, and c) -2-(3-methylpyrazinyl) -tert-butyl —H EFN (a, b, and c) -2-(3-methylpyrazinyl) -iso-propyl —H EFO (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —CH₃ EFP (a, b, and c) -2-(3-methylpyrazinyl) —H —H EFQ (a, b, and c) -2-(3-methylpyrazinyl) —H —Cl EFR (a, b, and c) -2-(3-methylpyrazinyl) —H —Br EFS (a, b, and c) -2-(3-methylpyrazinyl) —H —F EFT (a, b, and c) -2-(3-methylpyrazinyl) —H —CH₃ EFU (a, b, and c) -2-(3-methylpyrazinyl) —H —CF₃ EFV (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₃ EFW (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₂CH₃ EFX (a, b, and c) -2-(3-methylpyrazinyl) —H —OCF₃ EFY (a, b, and c) -2-(3-methylpyrazinyl) —H -tert-butyl EFZ (a, b, and c) -2-(3-methylpyrazinyl) —H -iso-propyl EGA (a, b, and c) -2-pyridazinyl —Cl —H EGB (a, b, and c) -2-pyridazinyl —Br —H EGC (a, b, and c) -2-pyridazinyl —F —H EGD (a, b, and c) -2-pyridazinyl —CH₃ —H EGE (a, b, and c) -2-pyridazinyl —CF₃ —H EGF (a, b, and c) -2-pyridazinyl —OCH₃ —H EGG (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H EGH (a, b, and c) -2-pyridazinyl —OCF₃ —H EGI (a, b, and c) -2-pyridazinyl -tert-butyl —H EGJ (a, b, and c) -2-pyridazinyl -iso-propyl —H EGK (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ EGL (a, b, and c) -2-pyridazinyl —H —H EGM (a, b, and c) -2-pyridazinyl —H —Cl EGN (a, b, and c) -2-pyridazinyl —H —Br EGO (a, b, and c) -2-pyridazinyl —H —F EGP (a, b, and c) -2-pyridazinyl —H —CH₃ EGQ (a, b, and c) -2-pyridazinyl —H —CF₃ EGR (a, b, and c) -2-pyridazinyl —H —OCH₃ EGS (a, b, and c) -2-pyridazinyl —H —OCH₂CH₃ EGT (a, b, and c) -2-pyridazinyl —H —OCF₃ EGU (a, b, and c) -2-pyridazinyl —H -tert-butyl EGV (a, b, and c) -2-pyridazinyl —H -iso-propyl EGW (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H EGX (a, b, and c) -3-(4-chloropyridazinyl) —Br —H EGY (a, b, and c) -3-(4-chloropyridazinyl) —F —H EGZ (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H EHA (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H EHB (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H EHC (a, b, and c) -3-(4-chloropyridazinyl) —OCH₂CH₃ —H EHD (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H EHE (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H EHF (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H EHG (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ EHH (a, b, and c) -3-(4-chloropyridazinyl) —H —H EHI (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl EHJ (a, b, and c) -3-(4-chloropyridazinyl) —H —Br EHK (a, b, and c) -3-(4-chloropyridazinyl) —H —F EHL (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ EHM (a, b, and c) -3-(4-chloropyridazinyl) —H —CF₃ EHN (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ EHO (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₃ EHP (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ EHQ (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl EHR (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl EHS (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H EHT (a, b, and c) -3-(4-methylpyridazinyl) —Br —H EHU (a, b, and c) -3-(4-methylpyridazinyl) —F —H EHV (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H EHW (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H EHX (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H EHY (a, b, and c) -3-(4-methylpyridazinyl) —OCH₂CH₃ —H EHZ (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H EIA (a, b, and c) -3-(4-methylpyridazinyl) -tert-butyl —H EIB (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H EIC (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —CH₃ EID (a, b, and c) -3-(4-methylpyridazinyl) —H —H EIE (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl EIF (a, b, and c) -3-(4-methylpyridazinyl) —H —Br EIG (a, b, and c) -3-(4-methylpyridazinyl) —H —F EIH (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ EII (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ EIJ (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ EIK (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₂CH₃ EIL (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ EIM (a, b, and c) -3-(4-methylpyridazinyl) —H -tert-butyl EIN (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl EIO (a, b, and c) -4-thiazanyl —Cl —H EIP (a, b, and c) -4-thiazanyl —Br —H EIQ (a, b, and c) -4-thiazanyl —F —H EIR (a, b, and c) -4-thiazanyl —CH₃ —H EIS (a, b, and c) -4-thiazanyl —CF_(3 —H) EIT (a, b, and c) -4-thiazanyl —OCH₃ —H EIU (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H EIV (a, b, and c) -4-thiazanyl —OCF₃ —H EIW (a, b, and c) -4-thiazanyl -tert-butyl —H EIX (a, b, and c) -4-thiazanyl -iso-propyl —H EIY (a, b, and c) -4-thiazanyl —CH₃ —CH₃ EIZ (a, b, and c) -4-thiazanyl —H —H EJA (a, b, and c) -4-thiazanyl —H —Cl EJB (a, b, and c) -4-thiazanyl —H —Br EJC (a, b, and c) -4-thiazanyl —H —F EJD (a, b, and c) -4-thiazanyl —H —CH₃ EJE (a, b, and c) -4-thiazanyl —H —CF₃ EJF (a, b, and c) -4-thiazanyl —H —OCH₃ EJG (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ EJH (a, b, and c) -4-thiazanyl —H —OCF₃ EJI (a, b, and c) -4-thiazanyl —H -tert-butyl EJJ (a, b, and c) -4-thiazanyl —H -iso-propyl EJK (a, b, and c) -5-(4-chlorothiazanyl) —Cl —H EJL (a, b, and c) -5-(4-chlorothiazanyl) —Br —H EJM (a, b, and c) -5-(4-chlorothiazanyl) —F —H EJN (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H EJO (a, b, and c) -5-(4-chlorotbiazanyl) —CF₃ —H EJP (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H EJQ (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H EJR (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H EJS (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H EJT (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H EJU (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ EJV (a, b, and c) -5-(4-chlorothiazanyl) —H —H EJW (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl EJX (a, b, and c) -5-(4-chlorothiazanyl) —H —Br EJY (a, b, and c) -5-(4-chlorothiazanyl) —H —F EJZ (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ EKA (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ EKB (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ EKC (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ EKD (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ EKE (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl EKF (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl EKG (a, b, and c) -5-(4-methylthiazanyl) —Cl —H EKH (a, b, and c) -5-(4-methylthiazanyl) —Br —H EKI (a, b, and c) -5-(4-methylthiazanyl) —F —H EKJ (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H EKK (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H EKL (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H EKM (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H EKN (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H EKO (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H EKP (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H EKQ (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ EKR (a, b, and c) -5-(4-methylthiazanyl) —H —H EKS (a, b, and c) -5-(4-methylthiazanyl) —H —Cl EKT (a, b, and c) -5-(4-methylthiazanyl) —H —Br EKU (a, b, and c) -5-(4-methylthiazanyl) —H —F EKV (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ EKW (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ EKX (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ EKY (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ EKZ (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ ELA (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl ELB (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3016] TABLE XIII

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ B₉ ELC -2-(3-chloropyridyl) —Cl —H ELD -2-(3-chloropyridyl) —Br —H ELE -2-(3-chloropyridyl) —F —H ELF -2-(3-chloropyridyl) —CH₃ —H ELG -2-(3-chloropyridyl) —CF₃ —H ELH -2-(3-chloropyridyl) —OCH₃ —H ELI -2-(3-chloropyridyl) —OCH₂CH₃ —H ELJ -2-(3-chloropyridyl) —OCF₃ —H ELK -2-(3-chloropyridyl) -tert-butyl —H ELL -2-(3-chloropyridyl) -iso-propyl —H ELM -2-(3-chloropyridyl) —CH₃ —CH₃ ELN -2-(3-chloropyridyl) —H —H ELO -2-(3-chloropyridyl) —H —Cl ELP -2-(3-chloropyridyl) —H —Br ELQ -2-(3-chloropyridyl) —H —F ELR -2-(3-chloropyridyl) —H —CH₃ ELS -2-(3-chloropyridyl) —H —CF₃ ELT -2-(3-chloropyridyl) —H —OCH₃ ELU -2-(3-chloropyridyl) —H —OCH₂CH₃ ELV -2-(3-chloropyridyl) —H —OCF₃ ELW -2-(3-chloropyridyl) —H -tert-butyl ELX -2-(3-chloropyridyl) —H -iso-propyl ELY -2-(3-methylpyridyl) —Cl —H ELZ -2-(3-methylpyridyl) —Br —H EMA -2-(3-methylpyridyl) —F —H EMB -2-(3-methylpyridyl) —CH₃ —H EMC -2-(3-methylpyridyl) —CF₃ —H EMD -2-(3-methylpyridyl) —OCH₃ —H EME -2-(3-methylpyridyl) —OCH₂CH₃ —H EMF -2-(3-methylpyridyl) —OCF₃ —H EMG -2-(3-methylpyridyl) -tert-butyl —H EMH -2-(3-methylpyridyl) -iso-propyl —H EMI -2-(3-methylpyridyl) —CH₃ —CH₃ EMJ -2-(3-methylpyridyl) —H —H EMK -2-(3-methylpyridyl) —H —Cl EML -2-(3-methylpyridyl) —H —Br EMM -2-(3-methylpyridyl) —H —F EMN -2-(3-methylpyridyl) —H —CH₃ EMO -2-(3-methylpyridyl) —H —CF₃ EMP -2-(3-methylpyridyl) —H —OCH₃ EMQ -2-(3-methylpyridyl) —H —OCH₂CH₃ EMR -2-(3-methylpyridyl) —H —OCF₃ EMS -2-(3-methylpyridyl) —H -tert-butyl EMT -2-(3-methylpyridyl) —H -iso-propyl EMU -2-(3—CF₃-pyridyl) —Cl —H EMV -2-(3—CF₃-pyridyl) —Br —H EMW -2-(3—CF₃-pyridyl) —F —H EMX -2-(3—CF₃-pyridyl) —CH₃ —H EMY -2-(3—CF₃-pyridyl) —CF₃ —H EMZ -2-(3—CF₃-pyridyl) —OCH₃ —H ENA -2-(3—CF₃-pyridyl) —OCH₂CH₃ —H ENB -2-(3—CF₃-pyridyl) —OCF₃ —H ENC -2-(3—CF₃-pyridyl) -tert-butyl —H END -2-(3—CF₃-pyridyl) -iso-propyl —H ENE -2-(3—CF₃-pyridyl) —CH₃ —CH₃ ENF -2-(3—CF₃-pyridyl) —H —H ENG -2-(3—CF₃-pyridyl) —H —Cl ENH -2-(3—CF₃-pyridyl) —H —Br ENI -2-(3—CF₃-pyridyl) —H —F ENJ -2-(3—CF₃-pyridyl) —H —CH₃ ENK -2-(3—CF₃-pyridyl) —H —CF₃ ENL -2-(3—CF₃-pyridyl) —H —OCH₃ ENM -2-(3—CF₃-pyridyl) —H —OCH₂CH₃ ENN -2-(3—CF₃-pyridyl) —H —OCF₃ ENO -2-(3—CF₃-pyridyl) —H -tert-butyl ENP -2-(3—CF₃-pyridyl) —H -zso-propyl ENQ -4-(5-chloropyrimidinyl) —Cl —H ENR -4-(5-chloropyrimidinyl) —Br —H ENS -4-(5-chloropyrimidinyl) —F —H ENT -4-(5-chloropyrimidinyl) —CH₃ —H ENU -4-(5-chloropyrimidinyl) —CF₃ —H ENV -4-(5-chloropyrimidinyl) —OCH₃ —H ENW -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H ENX -4-(5-chloropyrimidinyl) —OCF_(3 —H) ENY -4-(5-chloropyrimidinyl) -tert-butyl —H ENZ -4-(5-chloropyrimidinyl) -iso-propyl —H EOA -4-(5-chloropyrimidinyl) —CH₃ —CH₃ EOB -4-(5-chloropyrimidinyl) —H —H EOC -4-(5-chloropyrimidinyl) —H —Cl EOD -4-(5-chloropyrimidinyl) —H —Br EOE -4-(5-chloropyrimidinyl) —H —F EOF -4-(5-chloropyrimidinyl) —H —CH₃ EOG -4-(5-chloropyrimidinyl) —H —CF₃ EOH -4-(5-chloropyrimidinyl) —H —OCH₃ EOI -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ EOJ -4-(5-chloropyrimidinyl) —H —OCF₃ EOK -4-(5-chloropyrimidinyl) —H -tert-butyl EOL -4-(5-chloropyrimidinyl) —H -iso-propyl EOM -4-(5-methylpyrimidinyl) —Cl —H EON -4-(5-methylpyrimidinyl) —Br —H EOO -4-(5-methylpyrimidinyl) —F —H EOP -4-(5-methylpyrimidinyl) —CH₃ —H EOQ -4-(5-methylpyrimidinyl) —CF₃ —H EOR -4-(5-methylpyrimidinyl) —OCH₃ —H EOS -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H EOT -4-(5-methylpyrimidinyl) —OCF₃ —H EOU -4-(5-methylpyrimidinyl) -tert-butyl —H EOV -4-(5-methylpyrimidinyl) -iso-propyl —H EOW -4-(5-methylpyrimidinyl) —CH₃ —CH₃ EOX -4-(5-methylpyrimidinyl) —H —H EOY -4-(5-methylpyrimidinyl) —H —Cl EOZ -4-(5-methylpyrimidinyl) —H —Br EPA -4-(5-methylpyrimidinyl) —H —F EPB -4-(5-methylpyrimidinyl) —H —CH₃ EPC -4-(5-methylpyrimidinyl) —H —CF₃ EPD -4-(5-methylpyrimidinyl) —H —OCH₃ EPE -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ EPF -4-(5-methylpyrimidinyl) —H —OCF₃ EPG -4-(5-methylpyrimidinyl) —H -tert-butyl EPH -4-(5-methylpyrimidinyl) —H -iso-propyl EPI -2-pyrazinyl —Cl —H EPJ -2-pyrazinyl —Br —H EPK -2-pyrazinyl —F —H EPL -2-pyrazinyl —CH₃ —H EPM -2-pyrazinyl —CF₃ —H EPN -2-pyrazinyl —OCH₃ —H EPO -2-pyrazinyl —OCH₂CH₃ —H EPP -2-pyrazinyl —OCF₃ —H EPQ -2-pyrazinyl -tert-butyl —H EPR -2-pyrazinyl -iso-propyl —H EPS -2-pyrazinyl —CH₃ —CH₃ EPT -2-pyrazrnyl —H —H EPU -2-pyrazinyl —H —Cl EPV -2-pyrazinyl —H —Br EPW -2-pyrazinyl —H —F EPX -2-pyrazinyl —H —CH₃ EPY -2-pyrazinyl —H —CF₃ EPZ -2-pyrazinyl —H —OCH₃ EQA -2-pyrazinyl —H —OCH₂CH₃ EQB -2-pyrazinyl —H —OCF₃ EQC -2-pyrazinyl —H -tert-butyl EQD -2-pyrazinyl —H -iso-propyl EQE -2-(3-chloropyrazinyl) —Cl —H EQF -2-(3-chloropyrazinyl) —Br —H EQG -2-(3-chloropyrazinyl) —F —H EQH -2-(3-chloropyrazinyl) —CH₃ —H EQI -2-(3-chloropyrazinyl) —CF₃ —H EQJ -2-(3-chloropyrazinyl) —OCH₃ —H EQK -2-(3-chloropyrazinyl) —OCH₂CH₃ —H EQL -2-(3-chloropyrazinyl) —OCF₃ —H EQM -2-(3-chloropyrazinyl) -tert-butyl —H EQN -2-(3-chloropyrazinyl) -iso-propyl —H EQO -2-(3-chloropyrazinyl) —CH₃ —CH₃ EQP -2-(3-chloropyrazinyl) —H —H EQQ -2-(3-chloropyrazinyl) —H —Cl EQR -2-(3-chloropyrazinyl) —H —Br EQS -2-(3-chloropyrazinyl) —H —F EQT -2-(3-chloropyrazinyl) —H —CH₃ EQU -2-(3-chloropyrazinyl) —H —CF₃ EQV -2-(3-chloropyrazinyl) —H —OCH₃ EQW -2-(3-chloropyrazinyl) —H —OCH₂CH₃ EQX -2-(3-chloropyrazinyl) —H —OCF₃ EQY -2-(3-chloropyrazinyl) —H -tert-butyl EQZ -2-(3-chloropyrazinyl) —H -iso-propyl ERA -2-(3-methylpyrazinyl) —Cl —H ERB -2-(3-methylpyrazinyl) —Br —H ERC -2-(3-methylpyrazinyl) —F —H ERD -2-(3-methylpyrazinyl) —CH₃ —H ERE -2-(3-methylpyrazinyl) —CF₃ —H ERF -2-(3-methylpyrazinyl) —OCH₃ —H ERG -2-(3-methylpyrazinyl) —OCH₂CH₃ —H ERH -2-(3-methylpyrazinyl) —OCF₃ —H ERI -2-(3-methylpyrazinyl) -tert-butyl —H ERJ -2-(3-methylpyrazinyl) -iso-propyl —H ERK -2-(3-methylpyrazinyl) —CH₃ —CH₃ ERL -2-(3-methylpyrazinyl) —H —H ERM -2-(3-methylpyrazinyl) —H —Cl ERN -2-(3-methylpyrazinyl) —H —Br ERO -2-(3-methylpyrazinyl) —H —F ERP -2-(3-methylpyrazinyl) —H —CH₃ ERQ -2-(3-methylpyrazinyl) —H —CF₃ ERR -2-(3-methylpyrazinyl) —H —OCH₃ ERS -2-(3-methylpyrazinyl) —H —OCH₂CH₃ ERT -2-(3-methylpyrazinyl) —H —OCF₃ ERU -2-(3-methylpyrazinyl) —H -tert-butyl ERV -2-(3-methylpyrazinyl) —H -iso-propyl ERW -2-pyridazinyl —Cl —H ERX -2-pyridazinyl —Br —H ERY -2-pyridazinyl —F —H ERZ -2-pyridazinyl —CH₃ —H ESA -2-pyridazinyl —CF₃ —H ESB -2-pyridazinyl —OCH₃ —H ESC -2-pyridazinyl —OCH₂CH₃ —H ESD -2-pyridazinyl —OCF₃ —H ESE -2-pyridazinyl -tert-butyl —H ESF -2-pyridazinyl -iso-propyl —H ESG -2-pyridazinyl —CH₃ —CH₃ ESH -2-pyridazinyl —H —H ESI -2-pyridazinyl —H —Cl ESJ -2-pyridazinyl —H —Br ESK -2-pyridazinyl —H —F ESL -2-pyridazinyl —H —CH₃ ESM -2-pyridazinyl —H —CF₃ ESN -2-pyridazinyl —H —OCH₃ ESO -2-pyridazinyl —H —OCH₂CH₃ ESP -2-pyridazinyl —H —OCF₃ ESQ -2-pyridazinyl —H -tert-butyl ESR -2-pyridazinyl —H -iso-propyl ESS -3-(4-chloropyridazinyl) —Cl —H EST -3-(4-chloropyridazinyl) —Br —H ESU -3-(4-chloropyridazinyl) —F —H ESV -3-(4-chloropyridazinyl) —CH₃ —H ESW -3-(4-chloropyridazinyl) —CF₃ —H ESX -3-(4-chloropyridazinyl) —OCH_(3 —H) ESY -3-(4-chloropyridazinyl) —OCH₂CH₃ —H ESZ -3-(4-chloropyridazinyl) —OCF_(3 —H) ETA -3-(4-chloropyridazinyl) -tert-butyl —H ETB -3-(4-chloropyridazinyl) -zso-propyl —H ETC -3-(4-chloropyridazinyl) —CH₃ —CH₃ ETD -3-(4-chloropyridazinyl) —H —H ETE -3-(4-chloropyridazinyl) —H —Cl ETF -3-(4-chloropyridazinyl) —H —Br ETG -3-(4-chloropyridazinyl) —H —F ETH -3-(4-chloropyridazinyl) —H —CH₃ ETI -3-(4-chloropyridazinyl) —H —CF₃ ETJ -3-(4-chloropyridazinyl) —H —OCH₃ ETK -3-(4-chloropyridazinyl) —H —OCH₂CH₃ ETL -3-(4-chloropyridazinyl) —H —OCF₃ ETM -3-(4-chloropyridazinyl) —H -tert-butyl ETN -3-(4-chloropyridazinyl) —H -iso-propyl ETO -3-(4-methylpyridazinyl) —Cl —H ETP -3-(4-methylpyridazinyl) —Br —H ETQ -3-(4-methylpyridazinyl) —F —H ETR -3-(4-methylpyridazinyl) —CH₃ —H ETS -3-(4-methylpyridazinyl) —CF₃ —H ETT -3-(4-methylpyridazinyl) —OCH₃ —H ETU -3-(4-methylpyridazinyl) —OCH₂CH₃ —H ETV -3-(4-methylpyridazinyl) —OCF₃ —H ETW -3-(4-methylpyridazinyl) -tert-butyl —H ETX -3-(4-methylpyridazinyl) -iso-propyl —H ETY -3-(4-methylpyridazinyl) —CH₃ —CH₃ ETZ -3-(4-methylpyridazinyl) —H —H EUA -3-(4-methylpyridazinyl) —H —Cl EUB -3-(4-methylpyridazinyl) —H —Br EUC -3-(4-methylpyridazinyl) —H —F EUD -3-(4-methylpyridazinyl) —H —CH₃ EUE -3-(4-methylpyridazinyl) —H —CF₃ EUF -3-(4-methylpyridazinyl) —H —OCH₃ EUG -3-(4-methylpyridazinyl) —H —OCH₂CH₃ EUH -3-(4-methylpyridazinyl) —H —OCF₃ EUI -3-(4-methylpyridazinyl) —H -tert-butyl EUJ -3-(4-methylpyridazinyl) —H -iso-propyl EUK -4-thiazanyl —Cl —H EUL -4-thiazanyl —Br —H EUM -4-thiazanyl —F —H EUN -4-thiazanyl —CH₃ —H EUO -4-thiazanyl —CF₃ —H EUP -4-thiazanyl —OCH₃ —H EUQ -4-thiazanyl —OCH₂CH₃ —H EUR -4-thiazanyl —OCF₃ —H EUS -4-thiazanyl -tert-butyl —H EUT -4-thiazanyl -iso-propyl —H EUU -4-thiazanyl —CH₃ —CH₃ EUV -4-thiazanyl —H —H EUW -4-thiazanyl —H —Cl EUX -4-thiazanyl —H —Br EUY -4-thiazanyl —H —F EUZ -4-thiazanyl —H —CH₃ EVA -4-thiazanyl —H —CF₃ EVB -4-thiazanyl —H —OCH₃ EVC -4-thiazanyl —H —OCH₂CH₃ EVD -4-thiazanyl —H —OCF₃ EVE -4-thiazanyl —H -tert-butyl EVF -4-thiazanyl —H -iso-propyl EVG -5-(4-chlorothiazanyl) —Cl —H EVH -5-(4-chlorothiazanyl) —Br —H EVI -5-(4-chlorothiazanyl) —F —H EVJ -5-(4-chlorothiazanyl) —CH₃ —H EVK -5-(4-chlorothiazanyl) —CF₃ —H EVL -5-(4-chlorothiazanyl) —OCH₃ —H EVM -5-(4-chlorothiazanyl) —OCH₂CH₃ —H EVN -5-(4-chlorothiazanyl) —OCF₃ —H EVO -5-(4-chlorothiazanyl) -tert-butyl —H EVP -5-(4-chlorothiazanyl) -iso-propyl —H EVQ -5-(4-chlorothiazanyl) —CH₃ —CH₃ EVR -5-(4-chlorothiazanyl) —H —H EVS -5-(4-chlorothiazanyl) —H —Cl EVT -5-(4-chlorothiazanyl) —H —Br EVU -5-(4-chlorothiazanyl) —H —F EVV -5-(4-chlorothiazanyl) —H —CH₃ EVW -5-(4-chlorothiazanyl) —H —CF₃ EVX -5-(4-chlorothiazanyl) —H —OCH₃ EVY -5-(4-chlorothiazanyl) —H —OCH₂CH₃ EVZ -5-(4-chlorothiazanyl) —H —OCF₃ EWA -5-(4-chlorothiazanyl) —H -tert-butyl EWB -5-(4-chlorothiazanyl) —H -zso-propyl EWC -5-(4-methylthiazanyl) —Cl —H EWD -5-(4-methylthiazanyl) —Br —H EWE -5-(4-methylthiazanyl) —F —H EWF -5-(4-methylthiazanyl) —CH₃ —H EWG -5-(4-methylthiazanyl) —CF₃ —H EWH -5-(4-methylthiazanyl) —OCH₃ —H EWI -5-(4-methylthiazanyl) —OCH₂CH₃ —H EWJ -5-(4-methylthiazanyl) —OCF₃ —H EWK -5-(4-methylthiazanyl) -tert-butyl —H EWL -5-(4-methylthiazanyl) -iso-propyl —H EWM -5-(4-methylthiazanyl) —CH₃ —CH₃ EWN -5-(4-methylthiazanyl) —H —H EWO -5-(4-methylthiazanyl) —H —Cl EWP -5-(4-methylthiazanyl) —H —Br EWQ -5-(4-methylthiazanyl) —H —F EWR -5-(4-methylthiazanyl) —H —CH₃ EWS -5-(4-methylthiazanyl) —H —CF₃ EWT -5-(4-methylthiazanyl) —H —OCH₃ EWU -5-(4-methylthiazanyl) —H —OCH₂CH₃ EWV -5-(4-methylthiazanyl) —H —OCF₃ EWW -5-(4-methylthiazanyl) —H -tert-butyl EWX -5-(4-methylthiazanyl) —H -iso-propyl

[3017] TABLE XIV

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ EWY -2-(3-chloropyridyl) —Cl —H EWZ -2-(3-chloropyridyl) —Br —H EXA -2-(3-chloropyridyl) —F —H EXB -2-(3-chloropyridyl) —CH₃ —H EXC -2-(3-chloropyridyl) —CF₃ —H EXD -2-(3-chloropyridyl) —OCH₃ —H EXE -2-(3-chloropyridyl) —OCH₂CH₃ —H EXF -2-(3-chloropyridyl) —OCF₃ —H EXG -2-(3-chloropyridyl) -tert-butyl —H EXH -2-(3-chloropyridyl) -iso-propyl —H EXI -2-(3-chloropyridyl) —CH₃ —CH₃ EXJ -2-(3-chloropyridyl) —H —H EXK -2-(3-chloropyridyl) —H —Cl EXL -2-(3-chloropyridyl) —H —Br EXM -2-(3-chloropyridyl) —H —F EXN -2-(3-chloropyridyl) —H —CH₃ EXO -2-(3-chloropyridyl) —H —CF₃ EXP -2-(3-chloropyridyl) —H —OCH₃ EXQ -2-(3-chloropyridyl) —H —OCH₂CH₃ EXR -2-(3-chloropyridyl) —H —OCF₃ EXS -2-(3-chloropyridyl) —H -tert-butyl EXT -2-(3-chloropyridyl) —H -iso-propyl EXU -2-(3-methylpyridyl) —Cl —H EXV -2-(3-methylpyridyl) —Br —H EXW -2-(3-methylpyridyl) —F —H EXX -2-(3-methylpyridyl) —CH₃ —H EXY -2-(3-methylpyridyl) —CF₃ —H EXZ -2-(3-methylpyridyl) —OCH₃ —H EYA -2-(3-methylpyridyl) —OCH₂CH₃ —H EYB -2-(3-methylpyridyl) —OCF₃ —H EYC -2-(3-methylpyridyl) -tert-butyl —H EYD -2-(3-methylpyridyl) -iso-propyl —H EYE -2-(3-methylpyridyl) —CH₃ —CH₃ EXF -2-(3-methylpyridyl) —H —H EYG -2-(3-methylpyridyl) —H —Cl EYH -2-(3-methylpyridyl) —H —Br EYI -2-(3-methylpyridyl) —H —F EYJ -2-(3-methylpyridyl) —H —CH₃ EYK -2-(3-methylpyridyl) —H —CF₃ EYL -2-(3-methylpyridyl) —H —OCH₃ EYM -2-(3-methylpyridyl) —H —OCH₂CH₃ EYN -2-(3-methylpyridyl) —H —OCF₃ EYO -2-(3-methylpyridyl) —H -tert-butyl EYP -2-(3-methylpyridyl) —H -iso-propyl EYQ -2-(3-CF₃-pyridyl) —Cl —H EYR -2-(3-CF₃-pyridyl) —Br —H EYS -2-(3-CF₃-pyridyl) —F —H EYT -2-(3-CF₃-pyridyl) —CH₃ —H EYU -2-(3-CF₃-pyridyl) —CF₃ —H EYV -2-(3-CF₃-pyridyl) —OCH₃ —H EYW -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H EYX -2-(3-CF₃-pyridyl) —OCF₃ —H EYY -2-(3-CF₃-pyridyl) -tert-butyl —H EYZ -2-(3-CF₃-pyridyl) -iso-propyl —H EZA -2-(3-CF₃-pyridyl) —CH₃ —CH₃ EZB -2-(3-CF₃-pyridyl) —H —H EZC -2-(3-CF₃-pyridyl) —H —Cl EZD -2-(3-CF₃-pyridyl) —H —Br EZE -2-(3-CF₃-pyridyl) —H —F EZF -2-(3-CF₃-pyridyl) —H —CH₃ EZG -2-(3-CF₃-pyridyl) —H —CF₃ EZH -2-(3-CF₃-pyridyl) —H —OCH₃ EZI -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ EZJ -2-(3-CF₃-pyridyl) —H —OCF₃ EZK -2-(3-CF₃-pyridyl) —H -tert-butyl EZL -2-(3-CF₃-pyridyl) —H -iso-propyl EZM -4-(5-chloropyrimidinyl) —Cl —H EZN -4-(5-chloropyrimidinyl) —Br —H EZO -4-(5-chloropyrimidinyl) —F —H EZP -4-(5-chloropyrimidinyl) —CH₃ —H EZQ -4-(5-chloropyrimidinyl) —CF₃ —H EZR -4-(5-chloropyrimidinyl) —OCH₃ —H EZS -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H EZT -4-(5-chloropyrimidinyl) —OCF₃ —H EZU -4-(5-chloropyrimidinyl) -tert-butyl —H EZV -4-(5-chloropyrimidinyl) -iso-propyl —H EZW -4-(5-chloropyrimidinyl) —CH₃ —CH₃ EZX -4-(5-chloropyrimidinyl) —H —H EZY -4-(5-chloropyrimidinyl) —H —Cl EZZ -4-(5-chloropyrimidinyl) —H —Br FAA -4-(5-chloropyrimidinyl) —H —F FAB -4-(5-chloropyrimidinyl) —H —CH₃ FAC -4-(5-chloropyrimidinyl) —H —CF₃ FAD -4-(5-chloropyrimidinyl) —H —OCH₃ FAE -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ FAF -4-(5-chloropyrimidinyl) —H —OCF₃ FAG -4-(5-chloropyrimidinyl) —H -tert-butyl FAH -4-(5-chloropyrimidinyl) —H -iso-propyl FAI -4-(5-methylpyrimidinyl) —Cl —H FAJ -4-(5-methylpyrimidinyl) —Br —H FAK -4-(5-methylpyrimidinyl) —F —H FAL -4-(5-methylpyrimidinyl) —CH₃ —H FAM -4-(5-methylpyrimidinyl) —CF₃ —H FAN -4-(5-methylpyrimidinyl) —OCH₃ —H FAO -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H FAP -4-(5-methylpyrimidinyl) —OCF₃ —H FAQ -4-(5-methylpyrimidinyl) -tert-butyl —H FAR -4-(5-methylpyrimidinyl) -iso-propyl —H FAS -4-(5-methylpyrimidinyl) —CH₃ —CH₃ FAT -4-(5-methylpyrimidinyl) —H —H FAU -4-(5-methylpyrimidinyl) —H —Cl FAV -4-(5-methylpyrimidinyl) —H —Br FAW -4-(5-methylpyrimidinyl) —H —F FAX -4-(5-methylpyrimidinyl) —H —CH₃ FAY -4-(5-methylpyrimidinyl) —H —CF₃ FAZ -4-(5-methylpyrimidinyl) —H —OCH₃ FBA -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ FBB -4-(5-methylpyrimidinyl) —H —OCF₃ FBC -4-(5-methylpyrimidinyl) —H -tert-butyl FBD -4-(5-methylpyrimidinyl) —H -iso-propyl FBE -2-pyrazinyl —Cl —H FBF -2-pyrazinyl —Br —H FBG -2-pyrazinyl —F —H FBH -2-pyrazinyl —CH₃ —H FBI -2-pyrazinyl —CF₃ —H FBJ -2-pyrazinyl —OCH₃ —H FBK -2-pyrazinyl —OCH₂CH₃ —H FBL -2-pyrazinyl —OCF₃ —H FBM -2-pyrazinyl -tert-butyl —H FBN -2-pyrazinyl -iso-propyl —H FBO -2-pyrazinyl —CH₃ —CH₃ FBP -2-pyrazinyl —H —H FBQ -2-pyrazinyl —H —Cl FBR -2-pyrazinyl —H —Br FBS -2-pyrazinyl —H —F FBT -2-pyrazinyl —H —CH₃ FBU -2-pyrazinyl —H —CF₃ FBV -2-pyrazinyl —H —OCH₃ FBW -2-pyrazinyl —H —OCH₂CH₃ FBX -2-pyrazinyl —H —OCF₃ FBY -2-pyrazinyl —H -tert-butyl FBZ -2-pyrazinyl —H -iso-propyl FCA -2-(3-chloropyrazinyl) —Cl —H FCB -2-(3-chloropyrazinyl) —Br —H FCC -2-(3-chloropyrazinyl) —F —H FCD -2-(3-chloropyrazinyl) —CH₃ —H FCE -2-(3-chloropyrazinyl) —CF₃ —H FCF -2-(3-chloropyrazinyl) —OCH₃ —H FCG -2-(3-chloropyrazinyl) —OCH₂CH₃ —H FCH -2-(3-chloropyrazinyl) —OCF₃ —H FCI -2-(3-chloropyrazinyl) -tert-butyl —H FCJ -2-(3-chloropyrazinyl) -iso-propyl —H FCK -2-(3-chloropyrazinyl) —CH₃ —CH₃ FCL -2-(3-chloropyrazinyl) —H —H FCM -2-(3-chloropyrazinyl) —H —Cl FCN -2-(3-chloropyrazinyl) —H —Br FCO -2-(3-chloropyrazinyl) —H —F FCP -2-(3-chloropyrazinyl) —H —CH₃ FCQ -2-(3-chloropyrazinyl) —H —CF₃ FCR -2-(3-chloropyrazinyl) —H —OCH₃ FCS -2-(3-chloropyrazinyl) —H —OCH₂CH₃ FCT -2-(3-chloropyrazinyl) —H —OCF₃ FCU -2-(3-chloropyrazinyl) —H -tert-butyl FCV -2-(3-chloropyrazinyl) —H -iso-propyl FCW -2-(3-methylpyrazinyl) —Cl —H FCX -2-(3-methylpyrazinyl) —Br —H FCY -2-(3-methylpyrazinyl) —F —H FCZ -2-(3-methylpyrazinyl) —CH₃ —H FDA -2-(3-methylpyrazinyl) —CF₃ —H FDB -2-(3-methylpyrazinyl) —OCH₃ —H FDC -2-(3-methylpyrazinyl) —OCH₂CH₃ —H FDD -2-(3-methylpyrazinyl) —OCF₃ —H FDE -2-(3-methylpyrazinyl) -tert-butyl —H FDF -2-(3-methylpyrazinyl) -iso-propyl —H FDG -2-(3-methylpyrazinyl) —CH₃ —CH₃ FDH -2-(3-methylpyrazinyl) —H —H FDI -2-(3-methylpyrazinyl) —H —Cl FDJ -2-(3-methylpyrazinyl) —H —Br FDK -2-(3-methylpyrazinyl) —H —F FDL -2-(3-methylpyrazinyl) —H —CH₃ FDM -2-(3-methylpyrazinyl) —H —CF₃ FDN -2-(3-methylpyrazinyl) —H —OCH₃ FDO -2-(3-methylpyrazinyl) —H —OCH₂CH₃ FDP -2-(3-methylpyrazinyl) —H —OCF₃ FDQ -2-(3-methylpyrazinyl) —H -tert-butyl FDR -2-(3-methylpyrazinyl) —H -iso-propyl FDS -2-pyridazinyl —Cl —H FDT -2-pyridazinyl —Br —H FDU -2-pyridazinyl —F —H FDV -2-pyridazinyl —CH₃ —H FDW -2-pyridazinyl —CF₃ —H FDX -2-pyridazinyl —OCH₃ —H FDY -2-pyridazinyl —OCH₂CH₃ —H FDZ -2-pyridazinyl —OCF₃ —H FEA -2-pyridazinyl -tert-butyl —H FEB -2-pyridazinyl -iso-propyl —H FEC -2-pyridazinyl —CH₃ —CH₃ FED -2-pyridazinyl —H —H FEE -2-pyridazinyl —H —Cl FEF -2-pyridazinyl —H —Br FEG -2-pyridazinyl —H —F FEH -2-pyridazinyl —H —CH₃ FEI -2-pyridazinyl —H —CF₃ FEJ -2-pyridazinyl —H —OCH₃ FEK -2-pyridazinyl —H —OCH₂CH₃ FEL -2-pyridazinyl —H —OCF₃ FEM -2-pyridazinyl —H -tert-butyl FEN -2-pyridazinyl —H -iso-propyl FEO -3-(4-chloropyridazinyl) —Cl —H FEP -3-(4-chloropyridazinyl) —Br —H FEQ -3-(4-chloropyridazinyl) —F —H FER -3-(4-chloropyridazinyl) —CH₃ —H FES -3-(4-chloropyridazinyl) —CF₃ —H FET -3-(4-chloropyridazinyl) —OCH₃ —H FEU -3-(4-chloropyridazinyl) —OCH₂CH₃ —H FEV -3-(4-chloropyridazinyl) —OCF₃ —H FEW -3-(4-chloropyridazinyl) -tert-butyl —H FEX -3-(4-chloropyridazinyl) -iso-propyl —H FEY -3-(4-chloropyridazinyl) —CH₃ —CH₃ FEZ -3-(4-chloropyridazinyl) —H —H FFA -3-(4-chloropyridazinyl) —H —Cl FFB -3-(4-chloropyridazinyl) —H —Br FFC -3-(4-chloropyridazinyl) —H —F FFD -3-(4-chloropyridazinyl) —H —CH₃ FFE -3-(4-chloropyridazinyl) —H —CF₃ FFF -3-(4-chloropyridazinyl) —H —OCH₃ FFG -3-(4-chloropyridazinyl) —H —OCH₂CH₃ FFH -3-(4-chloropyridazinyl) —H —OCF₃ FFI -3-(4-chloropyridazinyl) —H -tert-butyl FFJ -3-(4-chloropyridazinyl) —H -iso-propyl FFK -3-(4-methylpyridazinyl) —Cl —H FFL -3-(4-methylpyridazinyl) —Br —H FFM -3-(4-methylpyridazinyl) —F —H FFN -3-(4-methylpyridazinyl) —CH₃ —H FFO -3-(4-methylpyridazinyl) —CF₃ —H FFP -3-(4-methylpyridazinyl) —OCH₃ —H FFQ -3-(4-methylpyridazinyl) —OCH₂CH₃ —H FFR -3-(4-methylpyridazinyl) —OCF₃ —H FFS -3-(4-methylpyridazinyl) -tert-butyl —H FFT -3-(4-methylpyridazinyl) -iso-propyl —H FFU -3-(4-methylpyridazinyl) —CH₃ —CH₃ FFV -3-(4-methylpyridazinyl) —H —H FFW -3-(4-methylpyridazinyl) —H —Cl FFX -3-(4-methylpyridazinyl) —H —Br FFY -3-(4-methylpyridazinyl) —H —F FFZ -3-(4-methylpyridazinyl) —H —CH₃ FGA -3-(4-methylpyridazinyl) —H —CF₃ FGB -3-(4-methylpyridazinyl) —H —OCH₃ FGC -3-(4-methylpyridazinyl) —H —OCH₂CH₃ FGD -3-(4-methylpyridazinyl) —H —OCF₃ FGE -3-(4-methylpyridazinyl) —H -tert-butyl FGF -3-(4-methylpyridazinyl) —H -iso-propyl FGG -4-thiazanyl —Cl —H FGH -4-thiazanyl —Br —H FGI -4-thiazanyl —F —H FGJ -4-thiazanyl —CH₃ —H FGK -4-thiazanyl —CF₃ —H FGL -4-thiazanyl —OCH₃ —H FGM -4-thiazanyl —OCH₂CH₃ —H FGN -4-thiazanyl —OCF₃ —H FGO -4-thiazanyl -tert-butyl —H FGP -4-thiazanyl -iso-propyl —H FGQ -4-thiazanyl —CH₃ —CH₃ FGR -4-thiazanyl —H —H FGS -4-thiazanyl —H —Cl FGT -4-thiazanyl —H —Br FGU -4-thiazanyl —H —F FGV -4-thiazanyl —H —CH₃ FGW -4-thiazanyl —H —CF₃ FGX -4-thiazanyl —H —OCH₃ FGY -4-thiazanyl —H —OCH₂CH₃ FGZ -4-thiazanyl —H —OCF₃ FHA -4-thiazanyl —H -tert-butyl FHB -4-thiazanyl —H -iso-propyl FHC -5-(4-chlorothiazanyl) —Cl —H FHD -5-(4-chlorothiazanyl) —Br —H FHE -5-(4-chlorothiazanyl) —F —H FHF -5-(4-chlorothiazanyl) —CH₃ —H FHG -5-(4-chlorothiazanyl) —CF₃ —H FHH -5-(4-chlorothiazanyl) —OCH₃ —H FHI -5-(4-chlorothiazanyl) —OCH₂CH₃ —H FHJ -5-(4-chlorothiazanyl) —OCF₃ —H FHK -5-(4-chlorothiazanyl) -tert-butyl —H FHL -5-(4-chlorothiazanyl) -iso-propyl —H FHM -5-(4-chlorothiazanyl) —CH₃ —CH₃ FHN -5-(4-chlorothiazanyl) —H —H FHO -5-(4-chlorothiazanyl) —H —Cl FHP -5-(4-chlorothiazanyl) —H —Br FHQ -5-(4-chlorothiazanyl) —H —F FHR -5-(4-chlorothiazanyl) —H —CH₃ FHS -5-(4-chlorothiazanyl) —H —CF₃ FHT -5-(4-chlorothiazanyl) —H —OCH₃ FHU -5-(4-chlorothiazanyl) —H —OCH₂CH₃ FHV -5-(4-chlorothiazanyl) —H —OCF₃ FHW -5-(4-chlorothiazanyl) —H -tert-butyl FHX -5-(4-chlorothiazanyl) —H -iso-propyl FHY -5-(4-methylthiazanyl) —Cl —H FHZ -5-(4-methylthiazanyl) —Br —H FIA -5-(4-methylthiazanyl) —F —H FIB -5-(4-methylthiazanyl) —CH₃ —H FIC -5-(4-methylthiazanyl) —CF₃ —H FID -5-(4-methylthiazanyl) —OCH₃ —H FIE -5-(4-methylthiazanyl) —OCH₂CH₃ —H FIF -5-(4-methylthiazanyl) —OCF₃ —H FIG -5-(4-methylthiazanyl) -tert-butyl —H FIH -5-(4-methylthiazanyl) -iso-propyl —H FII -5-(4-methylthiazanyl) —CH₃ —CH₃ FIJ -5-(4-methylthiazanyl) —H —H FIK -5-(4-methylthiazanyl) —H —Cl FIL -5-(4-methylthiazanyl) —H —Br FIM -5-(4-methylthiazanyl) —H —F FIN -5-(4-methylthiazanyl) —H —CH₃ FIO -5-(4-methylthiazanyl) —H —CF₃ FIP -5-(4-methylthiazanyl) —H —OCH₃ FIQ -5-(4-methylthiazanyl) —H —OCH₂CH₃ FIR -5-(4-methylthiazanyl) —H —OCF₃ FIS -5-(4-methylthiazanyl) —H -tert-butyl FIT -5-(4-methylthiazanyl) —H -iso-propyl

[3018] TABLE XV

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ FIU (a, b, and c) -2-(3-chloropyridyl) —Cl —H FIV (a, b, and c) -2-(3-chloropyridyl) —Br —H FIW (a, b, and c) -2-(3-chloropyridyl) —F —H FIX (a, b, and c) -2-(3-chloropyridyl) —CH₃ —H FLY (a, b, and c) -2-(3-chloropyridyl) —CF₃ —H FIZ (a, b, and c) -2-(3-chloropyridyl) —OCH₃ —H FJA (a, b, and c) -2-(3-chloropyridyl) —OCH₂CH₃ —H FJB (a, b, and c) -2-(3-chloropyridyl) —OCF₃ —H FJC (a, b, and c) -2-(3-chloropyridyl) -tert-butyl —H FJD (a, b, and c) -2-(3-chloropyridyl) -iso-propyl —H FJE (a, b, and c) -2-(3-chloropyridyl) —CH₃ —CH₃ FJF (a, b, and c) -2-(3-chloropyridyl) —H —H FJG (a, b, and c) -2-(3-chloropyridyl) —H —Cl FJH (a, b, and c) -2-(3-chloropyridyl) —H —Br FJI (a, b, and c) -2-(3-chloropyridyl) —H —F FJJ (a, b, and c) -2-(3-chloropyridyl) —H —CH₃ FJK (a, b, and c) -2-(3-chloropyridyl) —H —CF₃ FJL (a, b, and c) -2-(3-chloropyridyl) —H —OCH₃ FJM (a, b, and c) -2-(3-chloropyridyl) —H —OCH₂CH₃ FJN (a, b, and c) -2-(3-chloropyridyl) —H —OCF₃ FJO (a, b, and c) -2-(3-chloropyridyl) —H -tert-butyl FJP (a, b, and c) -2-(3-chloropyridyl) —H -iso-propyl FJQ (a, b, and c) -2-(3-methylpyridyl) —Cl —H FJR (a, b, and c) -2-(3-methylpyridyl) —Br —H FJS (a, b, and c) -2-(3-methylpyridyl) —F —H FJT (a, b, and c) -2-(3-methylpyridyl) —CH₃ —H FJU (a, b, and c) -2-(3-methylpyridyl) —CF₃ —H FJV (a, b, and c) -2-(3-methylpyridyl) —OCH₃ —H FJW (a, b, and c) -2-(3-methylpyridyl) —OCH₂CH₃ —H FJX (a, b, and c) -2-(3-methylpyridyl) —OCF₃ —H FJY (a, b, and c) -2-(3-methylpyridyl) -tert-butyl —H FJZ (a, b, and c) -2-(3-methylpyridyl) -iso-propyl —H FKA (a, b, and c) -2-(3-methylpyridyl) —CH₃ —CH₃ FKB (a, b, and c) -2-(3-methylpyridyl) —H —H FKC (a, b, and c) -2-(3-methylpyridyl) —H —Cl FKD (a, b, and c) -2-(3-methylpyridyl) —H —Br FKE (a, b, and c) -2-(3-methylpyridyl) —H —F FKF (a, b, and c) -2-(3-methylpyridyl) —H —CH₃ FKG (a, b, and c) -2-(3-methylpyridyl) —H —CF₃ FKH (a, b, and c) -2-(3-methylpyridyl) —H —OCH₃ FKI (a, b, and c) -2-(3-methylpyridyl) —H —OCH₂CH₃ FKJ (a, b, and c) -2-(3-methylpyridyl) —H —OCF₃ FKK (a, b, and c) -2-(3-methylpyridyl) —H -tert-butyl FKL (a, b, and c) -2-(3-methylpyridyl) —H -iso-propyl FKM (a, b, and c) -2-(3-CF₃-pyridyl) —Cl —H FKN (a, b, and c) -2-(3-CF₃-pyridyl) —Br —H FKO (a, b, and c) -2-(3-CF₃-pyridyl) —F —H FKP (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —H FKQ (a, b, and c) -2-(3-CF₃-pyridyl) —CF₃ —H FKR (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₃ —H FKS (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H FKT (a, b, and c) -2-(3-CF₃-pyridyl) —OCF₃ —H FKU (a, b, and c) -2-(3-CF₃-pyridyl) -tert-butyl —H FKV (a, b, and c) -2-(3-CF₃-pyridyl) -iso-propyl —H FKW (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —CH₃ FKX (a, b, and c) -2-(3-CF₃-pyridyl) —H —H FKY (a, b, and c) -2-(3-CF₃-pyridyl) —H —Cl FKZ (a, b, and c) -2-(3-CF₃-pyridyl) —H —Br FLA (a, b, and c) -2-(3-CF₃-pyridyl) —H —F FLB (a, b, and c) -2-(3-CF₃-pyridyl) —H —CH₃ FLC (a, b, and c) -2-(3-CF₃-pyridyl) —H —CF₃ FLD (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₃ FLE (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ FLF (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCF₃ FLG (a, b, and c) -2-(3-CF₃-pyridyl) —H -tert-butyl FLH (a, b, and c) -2-(3-CF₃-pyridyl) —H -iso-propyl FLI (a, b, and c) -4-(5-chloropyrimidinyl) —Cl —H FLJ (a, b, and c) -4-(5-chloropyrimidinyl) —Br —H FLK (a, b, and c) -4-(5-chloropyrimidinyl) —F —H FLL (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —H FLM (a, b, and c) -4-(5-chloropyrimidinyl) —CF₃ —H FLN (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₃ —H FLO (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H FLP (a, b, and c) -4-(5-chloropyrimidinyl) —OCF₃ —H FLQ (a, b, and c) -4-(5-chloropyrimidinyl) -tert-butyl —H FLR (a, b, and c) -4-(5-chloropyrimidinyl) -iso-propyl —H FLS (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —CH₃ FLT (a, b, and c) -4-(5-chloropyrimidinyl) —H —H FLU (a, b, and c) -4-(5-chloropyrimidinyl) —H —Cl FLV (a, b, and c) -4-(5-chloropyrimidinyl) —H —Br FLW (a, b, and c) -4-(5-chloropyrimidinyl) —H —F FLX (a, b, and c) -4-(5-chloropyrimidinyl) —H —CH₃ FLY (a, b, and c) -4-(5-chloropyrimidinyl) —H —CF₃ FLZ (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₃ FMA (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ FMB (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCF₃ FMC (a, b, and c) -4-(5-chloropyrimidinyl) —H -tert-butyl FMD (a, b, and c) -4-(5-chloropyrimidinyl) —H -iso-propyl FME (a, b, and c) -4-(5-methylpyrimidinyl) —Cl —H FMF (a, b, and c) -4-(5-methylpyrimidinyl) —Br —H FMG (a, b, and c) -4-(5-methylpyrimidinyl) —F —H FMH (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —H FMI (a, b, and c) -4-(5-methylpyrimidinyl) —CF₃ —H FMJ (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₃ —H FMK (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H FML (a, b, and c) -4-(5-methylpyrimidinyl) —OCF₃ —H FMM -4-(5-methylpyrimidinyl) -tert-butyl —H (a, b, and c) FMN (a, b, and c) -4-(5-methylpyrimidinyl) -iso-propyl —H FMO (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —CH₃ FMP (a, b, and c) -4-(5-methylpyrimidinyl) —H —H FMQ (a, b, and c) -4-(5-methylpyrimidinyl) —H —Cl FMR (a, b, and c) -4-(5-methylpyrimidinyl) —H —Br FMS (a, b, and c) -4-(5-methylpyrimidinyl) —H —F FMT (a, b, and c) -4-(5-methylpyrimidinyl) —H —CH₃ FMU (a, b, and c) -4-(5-methylpyrimidinyl) —H —CF₃ FMV (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₃ FMW -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ (a, b, and c) FMX (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCF₃ FMY (a, b, and c) -4-(5-methylpyrimidinyl) —H -tert-butyl FMZ (a, b, and c) -4-(5-methylpyrimidinyl) —H -iso-propyl FNA (a, b, and c) -2-pyrazinyl —Cl —H FNB (a, b, and c) -2-pyrazinyl —Br —H FNC (a, b, and c) -2-pyrazinyl —F —H FND (a, b, and c) -2-pyrazinyl —CH₃ —H FNE (a, b, and c) -2-pyrazinyl —CF₃ —H FNF (a, b, and c) -2-pyrazinyl —OCH₃ —H FNG (a, b, and c) -2-pyrazinyl —OCH₂CH₃ —H FNH (a, b, and c) -2-pyrazinyl —OCF₃ —H FNI (a, b, and c) -2-pyrazinyl -tert-butyl —H FNJ (a, b, and c) -2-pyrazinyl -iso-propyl —H FNK (a, b, and c) -2-pyrazinyl —CH₃ —CH₃ FNL (a, b, and c) -2-pyrazinyl —H —H FNM (a, b, and c) -2-pyrazinyl —H —Cl FNN (a, b, and c) -2-pyrazinyl —H —Br FNO (a, b, and c) -2-pyrazinyl —H —F FNP (a, b, and c) -2-pyrazinyl —H —CH₃ FNQ (a, b, and c) -2-pyrazinyl —H —CF₃ FNR (a, b, and c) -2-pyrazinyl —H —OCH₃ FNS (a, b, and c) -2-pyrazinyl —H —OCH₂CH₃ FNT (a, b, and c) -2-pyrazinyl —H —OCF₃ FNU (a, b, and c) -2-pyrazinyl —H -tert-butyl FNV (a, b, and c) -2-pyrazinyl —H -iso-propyl FNW (a, b, and c) -2-(3-chloropyrazinyl) —Cl —H FNX (a, b, and c) -2-(3-chloropyrazinyl) —Br —H FNY (a, b, and c) -2-(3-chloropyrazinyl) —F —H FNZ (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —H FOA (a, b, and c) -2-(3-chloropyrazinyl) —CF₃ —H FOB (a, b, and c) -2-(3-chloropyrazinyl) —OCH₃ —H FOC (a, b, and c) -2-(3-chloropyrazinyl) —OCH₂CH₃ —H FOD (a, b, and c) -2-(3-chloropyrazinyl) —OCF₃ —H FOE (a, b, and c) -2-(3-chloropyrazinyl) -tert-butyl —H FOF (a, b, and c) -2-(3-chloropyrazinyl) -iso-propyl —H FOG (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —CH₃ FOH (a, b, and c) -2-(3-chloropyrazinyl) —H —H FOI (a, b, and c) -2-(3-chloropyrazinyl) —H —Cl FOJ (a, b, and c) -2-(3-chloropyrazinyl) —H —Br FOK (a, b, and c) -2-(3-chloropyrazinyl) —H —F FOL (a, b, and c) -2-(3-chloropyrazinyl) —H —CH₃ FOM (a, b, and c) -2-(3-chloropyrazinyl) —H —CF₃ FON (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₃ FOO (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₂CH₃ FOP (a, b, and c) -2-(3-chloropyrazinyl) —H —OCF₃ FOQ (a, b, and c) -2-(3-chloropyrazinyl) —H -tert-butyl FOR (a, b, and c) -2-(3-chloropyrazinyl) —H -iso-propyl FOS (a, b, and c) -2-(3-methylpyrazinyl) —Cl —H FOT (a, b, and c) -2-(3-methylpyrazinyl) —Br —H FOU (a, b, and c) -2-(3-methylpyrazinyl) —F —H FOV (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —H FOW (a, b, and c) -2-(3-methylpyrazinyl) —CF₃ —H FOX (a, b, and c) -2-(3-methylpyrazinyl) —OCH₃ —H FOY (a, b, and c) -2-(3-methylpyrazinyl) —OCH₂CH₃ —H FOZ (a, b, and c) -2-(3-methylpyrazinyl) —OCF₃ —H FPA (a, b, and c) -2-(3-methylpyrazinyl) -tert-butyl —H FPB (a, b, and c) -2-(3-methylpyrazinyl) -iso-propyl —H FPC (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —CH₃ FPD (a, b, and c) -2-(3-methylpyrazinyl) —H —H FPE (a, b, and c) -2-(3-methylpyrazinyl) —H —Cl FPF (a, b, and c) -2-(3-methylpyrazinyl) —H —Br FPG (a, b, and c) -2-(3-methylpyrazinyl) —H —F FPH (a, b, and c) -2-(3-methylpyrazinyl) —H —CH₃ FPI (a, b, and c) -2-(3-methylpyrazinyl) —H —CF₃ FPJ (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₃ FPK (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₂CH₃ FPL (a, b, and c) -2-(3-methylpyrazinyl) —H —OCF₃ FPM (a, b, and c) -2-(3-methylpyrazinyl) —H -tert-butyl FPN (a, b, and c) -2-(3-methylpyrazinyl) —H -iso-propyl FPO (a, b, and c) -2-pyridazinyl —Cl —H FPP (a, b, and c) -2-pyridazinyl —Br —H FPQ (a, b, and c) -2-pyridazinyl —F —H FPR (a, b, and c) -2-pyridazinyl —CH₃ —H FPS (a, b, and c) -2-pyridazinyl —CF₃ —H FPT (a, b, and c) -2-pyridazinyl —OCH₃ —H FPU (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H FPV (a, b, and c) -2-pyridazinyl —OCF₃ —H FPW (a, b, and c) -2-pyridazinyl -tert-butyl —H FPX (a, b, and c) -2-pyridazinyl -iso-propyl —H FPY (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ FPZ (a, b, and c) -2-pyridazinyl —H —H FQA (a, b, and c) -2-pyridazinyl —H —Cl FQB (a, b, and c) -2-pyridazinyl —H —Br FQC (a, b, and c) -2-pyridazinyl —H —F FQD (a, b, and c) -2-pyridazinyl —H —CH₃ FQE (a, b, and c) -2-pyridazinyl —H —CF₃ FQF (a, b, and c) -2-pyridazinyl —H —OCH₃ FQG (a, b, and c) -2-pyridazinyl —H —OCH₂CH₃ FQH (a, b, and c) -2-pyridazinyl —H —OCF₃ FQI (a, b, and c) -2-pyridazinyl —H -tert-butyl FQJ (a, b, and c) -2-pyridazinyl —H -iso-propyl FQK (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H FQL (a, b, and c) -3-(4-chloropyridazinyl) —Br —H FQM (a, b, and c) -3-(4-chloropyridazinyl) —F —H FQN (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H FQO (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H FQP (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H FQQ (a, b, and c) -3-(4-chloropyridazinyl) —OCH₂CH₃ —H FQR (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H FQS (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H FQT (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H FQU (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ FQV (a, b, and c) -3-(4-chloropyridazinyl) —H —H FQW (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl FQX (a, b, and c) -3-(4-chloropyridazinyl) —H —Br FQY (a, b, and c) -3-(4-chloropyridazinyl) —H —F FQZ (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ FRA (a, b, and c) -3-(4-chloropyridazinyl) —H —CF₃ FRB (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ FRC (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₃ FRD (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ FRE (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl FRF (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl FRG (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H FRH (a, b, and c) -3-(4-methylpyridazinyl) —Br —H FRI (a, b, and c) -3-(4-methylpyridazinyl) —F —H FRJ (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H FRK (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H FRL (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H FRM (a, b, and c) -3-(4-methylpyridazinyl) —OCH₂CH₃ —H FRN (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H FRO (a, b, and c) -3-(4-methylpyridazinyl) -tert-butyl —H FRP (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H FRQ (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —CH₃ FRR (a, b, and c) -3-(4-methylpyridazinyl) —H —H FRS (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl FRT (a, b, and c) -3-(4-methylpyridazinyl) —H —Br FRU (a, b, and c) -3-(4-methylpyridazinyl) —H —F FRV (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ FRW (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ FRX (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ FRY (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₂CH₃ FRZ (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ FSA (a, b, and c) -3-(4-methylpyridazinyl) —H -tert-butyl FSB (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl FSC (a, b, and c) -4-thiazanyl —Cl —H FSD (a, b, and c) -4-thiazanyl —Br —H FSE (a, b, and c) -4-thiazanyl —F —H FSF (a, b, and c) -4-thiazanyl —CH₃ —H FSG (a, b, and c) -4-thiazanyl —CF₃ —H FSH (a, b, and c) -4-thiazanyl —OCH₃ —H FSI (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H FSJ (a, b, and c) -4-thiazanyl —OCF₃ —H FSK (a, b, and c) -4-thiazanyl -tert-butyl —H FSL (a, b, and c) -4-thiazanyl -iso-propyl —H FSM (a, b, and c) -4-thiazanyl —CH₃ —CH₃ FSN (a, b, and c) -4-thiazanyl —H —H FSO (a, b, and c) -4-thiazanyl —H —Cl FSP (a, b, and c) -4-thiazanyl —H —Br FSQ (a, b, and c) -4-thiazanyl —H —F FSR (a, b, and c) -4-thiazanyl —H —CH₃ FSS (a, b, and c) -4-thiazanyl —H —CF₃ FST (a, b, and c) -4-thiazanyl —H —OCH₃ FSU (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ FSV (a, b, and c) -4-thiazanyl —H —OCF₃ FSW (a, b, and c) -4-thiazanyl —H -tert-butyl FSX (a, b, and c) -4-thiazanyl —H -iso-propyl FSY (a, b, and c) -5-(4-chlorothiazanyl) —Cl —H FSZ (a, b, and c) -5-(4-chlorothiazanyl) —Br —H FTA (a, b, and c) -5-(4-chlorothiazanyl) —F —H FTB (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H FTC (a, b, and c) -5-(4-chlorothiazanyl) —CF₃ —H FTD (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H FTE (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H FTF (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H FTG (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H FTH (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H FTI (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ FTJ (a, b, and c) -5-(4-chlorothiazanyl) —H —H FTK (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl FTL (a, b, and c) -5-(4-chlorothiazanyl) —H —Br FTM (a, b, and c) -5-(4-chlorothiazanyl) —H —F FTN (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ FTO (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ FTP (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ FTQ (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ FTR (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ FTS (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl FTT (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl FTU (a, b, and c) -5-(4-methylthiazanyl) —Cl —H FTV (a, b, and c) -5-(4-methylthiazanyl) —Br —H FTW (a, b, and c) -5-(4-methylthiazanyl) —F —H FTX (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H FTY (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H FTZ (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H FUA (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H FUB (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H FUC (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H FUD (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H FUE (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ FUF (a, b, and c) -5-(4-methylthiazanyl) —H —H FUG (a, b, and c) -5-(4-methylthiazanyl) —H —Cl FUH (a, b, and c) -5-(4-methylthiazanyl) —H —Br FUI (a, b, and c) -5-(4-methylthiazanyl) —H —F FUJ (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ FUK (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ FUL (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ FUM (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ FUN (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ FUO (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl FUP (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3019] TABLE XVI

and pharmaceutically acceptable salts thereof, wherein: Compound Ar₁ R₈ R₉ FUQ (a, b, and c) -2-(3-chloropyridyl) —Cl —H FUR (a, b, and c) -2-(3-chloropyridyl) —Br —H FUS (a, b, and c) -2-(3-chloropyridyl) —F —H FUT (a, b, and c) -2-(3-chloropyridyl) —CH₃ —H FUU (a, b, and c) -2-(3-chloropyridyl) —CF₃ —H FUV (a, b, and c) -2-(3-chloropyridyl) —OCH₃ —H FUW (a, b, and c) -2-(3-chloropyridyl) —OCH₂CH₃ —H FUX (a, b, and c) -2-(3-chloropyridyl) —OCF₃ —H FUY (a, b, and c) -2-(3-chloropyridyl) -tert-butyl —H FUZ (a, b, and c) -2-(3-chloropyridyl) -iso-propyl —H FVA (a, b, and c) -2-(3-chloropyridyl) —CH₃ —CH₃ FVB (a, b, and c) -2-(3-chloropyridyl) —H —H FVC (a, b, and c) -2-(3-chloropyridyl) —H —Cl FVD (a, b, and c) -2-(3-chloropyridyl) —H —Br FVE (a, b, and c) -2-(3-chloropyridyl) —H —F FVF (a, b, and c) -2-(3-chloropyridyl) —H —CH₃ FVG (a, b, and c) -2-(3-chloropyridyl) —H —CF₃ FVH (a, b, and c) -2-(3-chloropyridyl) —H —OCH₃ FVI (a, b, and c) -2-(3-chloropyridyl) —H —OCH₂CH₃ FVJ (a, b, and c) -2-(3-chloropyridyl) —H —OCF₃ FVK (a, b, and c) -2-(3-chloropyridyl) —H -tert-butyl FVL (a, b, and c) -2-(3-chloropyridyl) —H -iso-propyl FVM (a, b, and c) -2-(3-methylpyridyl) —Cl —H FVN (a, b, and c) -2-(3-methylpyridyl) —Br —H FVO (a, b, and c) -2-(3-methylpyridyl) —F —H FVP (a, b, and c) -2-(3-methylpyridyl) —CH₃ —H FVQ (a, b, and c) -2-(3-methylpyridyl) —CF₃ —H FVR (a, b, and c) -2-(3-methylpyridyl) —OCH₃ —H FVS (a, b, and c) -2-(3-methylpyridyl) —OCH₂CH₃ —H FVT (a, b, and c) -2-(3-methylpyridyl) —OCF₃ —H FVU (a, b, and c) -2-(3-methylpyridyl) -tert-butyl —H FVV (a, b, and c) -2-(3-methylpyridyl) -iso-propyl —H FVW (a, b, and c) -2-(3-methylpyridyl) —CH₃ —CH₃ FVX (a, b, and c) -2-(3-methylpyridyl) —H —H FVY (a, b, and c) -2-(3-methylpyridyl) —H —Cl FVZ (a, b, and c) -2-(3-methylpyridyl) —H —Br FWA (a, b, and c) -2-(3-methylpyridyl) —H —F FWB (a, b, and c) -2-(3-methylpyridyl) —H —CH₃ FWC (a, b, and c) -2-(3-methylpyridyl) —H —CF₃ FWD (a, b, and c) -2-(3-methylpyridyl) —H —OCH₃ FWE (a, b, and c) -2-(3-methylpyridyl) —H —OCH₂CH₃ FWF (a, b, and c) -2-(3-methylpyridyl) —H —OCF₃ FWG (a, b, and c) -2-(3-methylpyridyl) —H -tert-butyl FWH (a, b, and c) -2-(3-methylpyridyl) —H -iso-propyl FWI (a, b, and c) -2-(3-CF₃-pyridyl) —Cl —H FWJ (a, b, and c) -2-(3-CF₃-pyridyl) —Br —H FWK (a, b, and c) -2-(3-CF₃-pyridyl) —F —H FWL (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —H FWM -2-(3-CF₃-pyridyl) —CF₃ —H (a, b, and c) FWN (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₃ —H FWO (a, b, and c) -2-(3-CF₃-pyridyl) —OCH₂CH₃ —H FWP (a, b, and c) -2-(3-CF₃-pyridyl) —OCF₃ —H FWQ (a, b, and c) -2-(3-CF₃-pyridyl) -tert-butyl —H FWR (a, b, and c) -2-(3-CF₃-pyridyl) -iso-propyl —H FWS (a, b, and c) -2-(3-CF₃-pyridyl) —CH₃ —CH₃ FWT (a, b, and c) -2-(3-CF₃-pyridyl) —H —H FWU (a, b, and c) -2-(3-CF₃-pyridyl) —H —Cl FWV (a, b, and c) -2-(3-CF₃-pyridyl) —H —Br FWW -2-(3-CF₃-pyridyl) —H —F (a, b, and c) FWX (a, b, and c) -2-(3-CF₃-pyridyl) —H —CH₃ FWY (a, b, and c) -2-(3-CF₃-pyridyl) —H —CF₃ FWZ (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₃ FXA (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCH₂CH₃ FXB (a, b, and c) -2-(3-CF₃-pyridyl) —H —OCF₃ FXC (a, b, and c) -2-(3-CF₃-pyridyl) —H -tert-butyl FXD (a, b, and c) -2-(3-CF₃-pyridyl) —H -iso-propyl FXE (a, b, and c) -4-(5-chloropyrimidinyl) —Cl —H FXF (a, b, and c) -4-(5-chloropyrimidinyl) —Br —H FXG (a, b, and c) -4-(5-chloropyrimidinyl) —F —H FXH (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —H FXI (a, b, and c) -4-(5-chloropyrimidinyl) —CF₃ —H FXJ (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₃ —H FXK (a, b, and c) -4-(5-chloropyrimidinyl) —OCH₂CH₃ —H FXL (a, b, and c) -4-(5-chloropyrimidinyl) —OCF₃ —H FXM (a, b, and c) -4-(5-chloropyrimidinyl) -tert-butyl —H FXN (a, b, and c) -4-(5-chloropyrimidinyl) -iso-propyl —H FXO (a, b, and c) -4-(5-chloropyrimidinyl) —CH₃ —CH₃ FXP (a, b, and c) -4-(5-chloropyrimidinyl) —H —H FXQ (a, b, and c) -4-(5-chloropyrimidinyl) —H —Cl FXR (a, b, and c) -4-(5-chloropyrimidinyl) —H —Br FXS (a, b, and c) -4-(5-chloropyrimidinyl) —H —F FXT (a, b, and c) -4-(5-chloropyrimidinyl) —H —CH₃ FXU (a, b, and c) -4-(5-chloropyrimidinyl) —H —CF₃ FXV (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₃ FXW (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCH₂CH₃ FXX (a, b, and c) -4-(5-chloropyrimidinyl) —H —OCF₃ FXY (a, b, and c) -4-(5-chloropyrimidinyl) —H -tert-butyl FXZ (a, b, and c) -4-(5-chloropyrimidinyl) —H -iso-propyl FYA (a, b, and c) -4-(5-methylpyrimidinyl) —Cl —H FYB (a, b, and c) -4-(5-methylpyrimidinyl) —Br —H FYC (a, b, and c) -4-(5-methylpyrimidinyl) —F —H FYD (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —H FYE (a, b, and c) -4-(5-methylpyrimidinyl) —CF₃ —H FYF (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₃ —H FYG (a, b, and c) -4-(5-methylpyrimidinyl) —OCH₂CH₃ —H FYH (a, b, and c) -4-(5-methylpyrimidinyl) —OCF₃ —H FYI (a, b, and c) -4-(5-methylpyrimidinyl) -tert-butyl —H FYJ (a, b, and c) -4-(5-methylpyrimidinyl) -iso-propyl —H FYK (a, b, and c) -4-(5-methylpyrimidinyl) —CH₃ —CH₃ FYL (a, b, and c) -4-(5-methylpyrimidinyl) —H —H FYM (a, b, and c) -4-(5-methylpyrimidinyl) —H —Cl FYN (a, b, and c) -4-(5-methylpyrimidinyl) —H —Br FYO (a, b, and c) -4-(5-methylpyrimidinyl) —H —F FYP (a, b, and c) -4-(5-methylpyrimidinyl) —H —CH₃ FYQ (a, b, and c) -4-(5-methylpyrimidinyl) —H —CF₃ FYR (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₃ FYS (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCH₂CH₃ FYT (a, b, and c) -4-(5-methylpyrimidinyl) —H —OCF₃ FYU (a, b, and c) -4-(5-methylpyrimidinyl) —H -tert-butyl FYV (a, b, and c) -4-(5-methylpyrimidinyl) —H -iso-propyl FYW (a, b, and c) -2-pyrazinyl —Cl —H FYX (a, b, and c) -2-pyrazinyl —Br —H FYY (a, b, and c) -2-pyrazinyl —F —H FYZ (a, b, and c) -2-pyrazinyl —CH₃ —H FZA (a, b, and c) -2-pyrazinyl —CF₃ —H FZB (a, b, and c) -2-pyrazinyl —OCH₃ —H FZC (a, b, and c) -2-pyrazinyl —OCH₂CH₃ —H FZD (a, b, and c) -2-pyrazinyl —OCF₃ —H FZE (a, b, and c) -2-pyrazinyl -tert-butyl —H FZF (a, b, and c) -2-pyrazinyl -iso-propyl —H FZG (a, b, and c) -2-pyrazinyl —CH₃ —CH₃ FZH (a, b, and c) -2-pyrazinyl —H —H FZI (a, b, and c) -2-pyrazinyl —H —Cl FZJ (a, b, and c) -2-pyrazinyl —H —Br FZK (a, b, and c) -2-pyrazinyl —H —F FZL (a, b, and c) -2-pyrazinyl —H —CH₃ FZM (a, b, and c) -2-pyrazinyl —H —CF₃ FZN (a, b, and c) -2-pyrazinyl —H —OCH₃ FZO (a, b, and c) -2-pyrazinyl —H —OCH₂CH₃ FZP (a, b, and c) -2-pyrazinyl —H —OCF₃ FZQ (a, b, and c) -2-pyrazinyl —H -tert-butyl FZR (a, b, and c) -2-pyrazinyl —H -iso-propyl FZS (a, b, and c) -2-(3-chloropyrazinyl) —Cl —H FZT (a, b, and c) -2-(3-chloropyrazinyl) —Br —H FZU (a, b, and c) -2-(3-chloropyrazinyl) —F —H FZV (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —H FZW (a, b, and c) -2-(3-chloropyrazinyl) —CF₃ —H FZX (a, b, and c) -2-(3-chloropyrazinyl) —OCH₃ —H FZY (a, b, and c) -2-(3-chloropyrazinyl) —OCH₂CH₃ —H FZZ (a, b, and c) -2-(3-chloropyrazinyl) —OCF₃ —H GAA (a, b, and c) -2-(3-chloropyrazinyl) -tert-butyl —H GAB (a, b, and c) -2-(3-chloropyrazinyl) -iso-propyl —H GAC (a, b, and c) -2-(3-chloropyrazinyl) —CH₃ —CH₃ GAD (a, b, and c) -2-(3-chloropyrazinyl) —H —H GAE (a, b, and c) -2-(3-chloropyrazinyl) —H —Cl GAF (a, b, and c) -2-(3-chloropyrazinyl) —H —Br GAG (a, b, and c) -2-(3-chloropyrazinyl) —H —F GAH (a, b, and c) -2-(3-chloropyrazinyl) —H —CH₃ GAI (a, b, and c) -2-(3-chloropyrazinyl) —H —CF₃ GAJ (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₃ GAK (a, b, and c) -2-(3-chloropyrazinyl) —H —OCH₂CH₃ GAL (a, b, and c) -2-(3-chloropyrazinyl) —H —OCF₃ GAM -2-(3-chloropyrazinyl) —H -tert-butyl (a, b, and c) GAN (a, b, and c) -2-(3-chloropyrazinyl) —H -iso-propyl GAO (a, b, and c) -2-(3-methylpyrazinyl) —Cl —H GAP (a, b, and c) -2-(3-methylpyrazinyl) —Br —H GAQ (a, b, and c) -2-(3-methylpyrazinyl) —F —H GAR (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —H GAS (a, b, and c) -2-(3-methylpyrazinyl) —CF₃ —H GAT (a, b, and c) -2-(3-methylpyrazinyl) —OCH₃ —H GAU (a, b, and c) -2-(3-methylpyrazinyl) —OCH₂CH₃ —H GAV (a, b, and c) -2-(3-methylpyrazinyl) —OCF₃ —H GAW -2-(3-methylpyrazinyl) -tert-butyl —H (a, b, and c) GAX (a, b, and c) -2-(3-methylpyrazinyl) -iso-propyl —H GAY (a, b, and c) -2-(3-methylpyrazinyl) —CH₃ —CH₃ GAZ (a, b, and c) -2-(3-methylpyrazinyl) —H —H GBA (a, b, and c) -2-(3-methylpyrazinyl) —H —Cl GBB (a, b, and c) -2-(3-methylpyrazinyl) —H —Br GBC (a, b, and c) -2-(3-methylpyrazinyl) —H —F GBD (a, b, and c) -2-(3-methylpyrazinyl) —H —CH₃ GBE (a, b, and c) -2-(3-methylpyrazinyl) —H —CF₃ GBF (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₃ GBG (a, b, and c) -2-(3-methylpyrazinyl) —H —OCH₂CH₃ GBH (a, b, and c) -2-(3-methylpyrazinyl) —H —OCF₃ GBI (a, b, and c) -2-(3-methylpyrazinyl) —H -tert-butyl GBJ (a, b, and c) -2-(3-methylpyrazinyl) —H -iso-propyl GBK (a, b, and c) -2-pyridazinyl —Cl —H GBL (a, b, and c) -2-pyridazinyl —Br —H GBM -2-pyridazinyl —F —H (a, b, and c) GBN (a, b, and c) -2-pyridazinyl —CH₃ —H GBO (a, b, and c) -2-pyridazinyl —CF₃ —H GBP (a, b, and c) -2-pyridazinyl —OCH₃ —H GBQ (a, b, and c) -2-pyridazinyl —OCH₂CH₃ —H GBR (a, b, and c) -2-pyridazinyl —OCF₃ —H GBS (a, b, and c) -2-pyridazinyl -tert-butyl —H GBT (a, b, and c) -2-pyridazinyl -iso-propyl —H GBU (a, b, and c) -2-pyridazinyl —CH₃ —CH₃ GBV (a, b, and c) -2-pyridazinyl —H —H GBW -2-pyridazinyl —H —Cl (a, b, and c) GBX (a, b, and c) -2-pyridazinyl —H —Br GBY (a, b, and c) -2-pyridazinyl —H —F GBZ (a, b, and c) -2-pyridazinyl —H —CH₃ GCA (a, b, and c) -2-pyridazinyl —H —CF₃ GCB (a, b, and c) -2-pyridazinyl —H —OCH₃ GCC (a, b, and c) -2-pyridazinyl —H —OCH₂CH₃ GCD (a, b, and c) -2-pyridazinyl —H —OCF₃ GCE (a, b, and c) -2-pyridazinyl —H -tert-butyl GCF (a, b, and c) -2-pyridazinyl —H -iso-propyl GCG (a, b, and c) -3-(4-chloropyridazinyl) —Cl —H GCH (a, b, and c) -3-(4-chloropyridazinyl) —Br —H GCI (a, b, and c) -3-(4-chloropyridazinyl) —F —H GCJ (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —H GCK (a, b, and c) -3-(4-chloropyridazinyl) —CF₃ —H GCL (a, b, and c) -3-(4-chloropyridazinyl) —OCH₃ —H GCM -3-(4-chloropyridazinyl) —OCH₂CH₃ —H (a, b, and c) GCN (a, b, and c) -3-(4-chloropyridazinyl) —OCF₃ —H GCO (a, b, and c) -3-(4-chloropyridazinyl) -tert-butyl —H GCP (a, b, and c) -3-(4-chloropyridazinyl) -iso-propyl —H GCQ (a, b, and c) -3-(4-chloropyridazinyl) —CH₃ —CH₃ GCR (a, b, and c) -3-(4-chloropyridazinyl) —H —H GCS (a, b, and c) -3-(4-chloropyridazinyl) —H —Cl GCT (a, b, and c) -3-(4-chloropyridazinyl) —H —Br GCU (a, b, and c) -3-(4-chloropyridazinyl) —H —F GCV (a, b, and c) -3-(4-chloropyridazinyl) —H —CH₃ GCW -3-(4-chloropyridazinyl) —H —CF₃ (a, b, and c) GCX (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₃ GCY (a, b, and c) -3-(4-chloropyridazinyl) —H —OCH₂CH₃ GCZ (a, b, and c) -3-(4-chloropyridazinyl) —H —OCF₃ GDA (a, b, and c) -3-(4-chloropyridazinyl) —H -tert-butyl GDB (a, b, and c) -3-(4-chloropyridazinyl) —H -iso-propyl GDC (a, b, and c) -3-(4-methylpyridazinyl) —Cl —H GDD (a, b, and c) -3-(4-methylpyridazinyl) —Br —H GDE (a, b, and c) -3-(4-methylpyridazinyl) —F —H GDF (a, b, and c) -3-(4-methylpyridazinyl) —CH₃ —H GDG (a, b, and c) -3-(4-methylpyridazinyl) —CF₃ —H GDH (a, b, and c) -3-(4-methylpyridazinyl) —OCH₃ —H GDI (a, b, and c) -3-(4-methylpyridazinyl) —OCH₂CH₃ —H GDJ (a, b, and c) -3-(4-methylpyridazinyl) —OCF₃ —H GDK (a, b, and c) -3-(4-methylpyridazinyl) -tert-butyl —H GDL (a, b, and c) -3-(4-methylpyridazinyl) -iso-propyl —H GDM -3-(4-methylpyridazinyl) —CH₃ —CH₃ (a, b, and c) GDN (a, b, and c) -3-(4-methylpyridazinyl) —H —H GDO (a, b, and c) -3-(4-methylpyridazinyl) —H —Cl GDP (a, b, and c) -3-(4-methylpyridazinyl) —H —Br GDQ (a, b, and c) -3-(4-methylpyridazinyl) —H —F GDR (a, b, and c) -3-(4-methylpyridazinyl) —H —CH₃ GDS (a, b, and c) -3-(4-methylpyridazinyl) —H —CF₃ GDT (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₃ GDU (a, b, and c) -3-(4-methylpyridazinyl) —H —OCH₂CH₃ GDV (a, b, and c) -3-(4-methylpyridazinyl) —H —OCF₃ GDW -3-(4-methylpyridazinyl) —H -tert-butyl (a, b, and c) GDX (a, b, and c) -3-(4-methylpyridazinyl) —H -iso-propyl GDY (a, b, and c) -4-thiazanyl —Cl —H GDZ (a, b, and c) -4-thiazanyl —Br —H GEA (a, b, and c) -4-thiazanyl —F —H GEB (a, b, and c) -4-thiazanyl —CH₃ —H GEC (a, b, and c) -4-thiazanyl —CF₃ —H GED (a, b, and c) -4-thiazanyl —OCH₃ —H GEE (a, b, and c) -4-thiazanyl —OCH₂CH₃ —H GEF (a, b, and c) -4-thiazanyl —OCF₃ —H GEG (a, b, and c) -4-thiazanyl -tert-butyl —H GEH (a, b, and c) -4-thiazanyl -iso-propyl —H GEI (a, b, and c) -4-thiazanyl —CH₃ —CH₃ GEJ (a, b, and c) -4-thiazanyl —H —H GEK (a, b, and c) -4-thiazanyl —H —Cl GEL (a, b, and c) -4-thiazanyl —H —Br GEM (a, b, and c) -4-thiazanyl —H —F GEN (a, b, and c) -4-thiazanyl —H —CH₃ GEO (a, b, and c) -4-thiazanyl —H —CF₃ GEP (a, b, and c) -4-thiazanyl —H —OCH₃ GEQ (a, b, and c) -4-thiazanyl —H —OCH₂CH₃ GER (a, b, and c) -4-thiazanyl —H —OCF₃ GES (a, b, and c) -4-thiazanyl —H -tert-butyl GET (a, b, and c) -4-thiazanyl —H -iso-propyl GEU (a, b, and c) -5-(4-chlorothiazanyl) —Cl —H GEV (a, b, and c) -5-(4-chlorothiazanyl) —Br —H GEW -5-(4-chlorothiazanyl) —F —H (a, b, and c) GEX (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —H GEY (a, b, and c) -5-(4-chlorothiazanyl) —CF₃ —H GEZ (a, b, and c) -5-(4-chlorothiazanyl) —OCH₃ —H GFA (a, b, and c) -5-(4-chlorothiazanyl) —OCH₂CH₃ —H GFB (a, b, and c) -5-(4-chlorothiazanyl) —OCF₃ —H GFC (a, b, and c) -5-(4-chlorothiazanyl) -tert-butyl —H GFD (a, b, and c) -5-(4-chlorothiazanyl) -iso-propyl —H GFE (a, b, and c) -5-(4-chlorothiazanyl) —CH₃ —CH₃ GFF (a, b, and c) -5-(4-chlorothiazanyl) —H —H GFG (a, b, and c) -5-(4-chlorothiazanyl) —H —Cl GFH (a, b, and c) -5-(4-chlorothiazanyl) —H —Br GFI (a, b, and c) -5-(4-chlorothiazanyl) —H —F GFJ (a, b, and c) -5-(4-chlorothiazanyl) —H —CH₃ GFK (a, b, and c) -5-(4-chlorothiazanyl) —H —CF₃ GFL (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₃ GFM (a, b, and c) -5-(4-chlorothiazanyl) —H —OCH₂CH₃ GFN (a, b, and c) -5-(4-chlorothiazanyl) —H —OCF₃ GFO (a, b, and c) -5-(4-chlorothiazanyl) —H -tert-butyl GFP (a, b, and c) -5-(4-chlorothiazanyl) —H -iso-propyl GFQ (a, b, and c) -5-(4-methylthiazanyl) —Cl —H GFR (a, b, and c) -5-(4-methylthiazanyl) —Br —H GFS (a, b, and c) -5-(4-methylthiazanyl) —F —H GFT (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —H GFU (a, b, and c) -5-(4-methylthiazanyl) —CF₃ —H GFV (a, b, and c) -5-(4-methylthiazanyl) —OCH₃ —H GFW (a, b, and c) -5-(4-methylthiazanyl) —OCH₂CH₃ —H GFX (a, b, and c) -5-(4-methylthiazanyl) —OCF₃ —H GFY (a, b, and c) -5-(4-methylthiazanyl) -tert-butyl —H GFZ (a, b, and c) -5-(4-methylthiazanyl) -iso-propyl —H GGA (a, b, and c) -5-(4-methylthiazanyl) —CH₃ —CH₃ GGB (a, b, and c) -5-(4-methylthiazanyl) —H —H GGC (a, b, and c) -5-(4-methylthiazanyl) —H —Cl GGD (a, b, and c) -5-(4-methylthiazanyl) —H —Br GGE (a, b, and c) -5-(4-methylthiazanyl) —H —F GGF (a, b, and c) -5-(4-methylthiazanyl) —H —CH₃ GGG (a, b, and c) -5-(4-methylthiazanyl) —H —CF₃ GGH (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₃ GGI (a, b, and c) -5-(4-methylthiazanyl) —H —OCH₂CH₃ GGJ (a, b, and c) -5-(4-methylthiazanyl) —H —OCF₃ GGK (a, b, and c) -5-(4-methylthiazanyl) —H -tert-butyl GGL (a, b, and c) -5-(4-methylthiazanyl) —H -iso-propyl

[3020] TABLE XIX

and pharmaceutically acceptable salts thereof, wherein: Compound X R₈ R₉ GGM S —Cl —H GGN S —Br —H GGO S —F —H GGP S —CH₃ —H GGQ S —CF₃ —H GGR S —OCH₃ —H GGS S —OCH₂CH₃ —H GGT S —OCF₃ —H GGU S -tert-butyl —H GGV S -iso-propyl —H GGW S —CH₃ —CH₃ GGX S —H —H GGY S —H —Cl GGZ S —H —Br GHA S —H —F GHB S —H —CH₃ GHC S —H —CF₃ GHD S —H —OCH₃ GHE S —H —OCH₂CH₃ GHF S —H —OCF₃ GHG S —H -tert-butyl GHH S —H -iso-propyl GHI O —Cl —H GHJ O —Br —H GHK O —F —H GHL O —CH₃ —H GHM O —CF₃ —H GHN O —OCH₃ —H GHO O —OCH₂CH₃ —H GHP O —OCF₃ —H GHQ O -tert-butyl —H GHR O -iso-propyl —H GHS O —CH₃ —CH₃ GHT O —H —H GHU O —H —Cl GHV O —H —Br GHW O —H —F GHX O —H —CH₃ GHY O —H —CF₃ GHZ O —H —OCH₃ GIA O —H —OCH₂CH₃ GIB O —H —OCF₃ GIC O —H -tert-butyl GID O —H -iso-propyl GIE NH —Cl —H GIF NH —Br —H GIG NH —F —H GIH NH —CH₃ —H GII NH —CF₃ —H GIJ NH —OCH₃ —H GIK NH —OCH₂CH₃ —H GIL NH —OCF₃ —H GIM NH -tert-butyl —H GIN NH -iso-propyl —H GIO NH —CH₃ —CH₃ GIP NH —H —H GIQ NH —H —Cl GIR NH —H —Br GIS NH —H —F GIT NH —H —CH₃ GIU NH —H —CF₃ GIV NH —H —OCH₃ GIW NH —H —OCH₂CH₃ GIX NH —H —OCF₃ GIY NH —H -tert-butyl GIZ NH —H -iso-propyl

[3021] TABLE XX

and pharmaceutically acceptable salts thereof, wherein: Compound X R₈ R₉ GJA S —Cl —H GJB S —Br —H GJC S —F —H GJD S —CH₃ —H GJE S —CF₃ —H GJF S —OCH₃ —H GJG S —OCH₂CH₃ —H GJH S —OCF₃ —H GJI S -tert-butyl —H GJJ S -iso-propyl —H GJK S —CH₃ —CH₃ GJL S —H —H GJM S —H —Cl GJN S —H —Br GJO S —H —F GJP S —H —CH₃ GJQ S —H —CF₃ GJR S —H —OCH₃ GJS S —H —OCH₂CH₃ GJT S —H —OCF₃ GJU S —H -tert-butyl GJV S —H -iso-propyl GJW O —Cl —H GJX O —Br —H GJY O —F —H GJZ O —CH₃ —H GKA O —CF₃ —H GKB O —OCH₃ —H GKC O —OCH₂CH₃ —H GKD O —OCF₃ —H GKE O -tert-butyl —H GKF O -iso-propyl —H GKG O —CH₃ —CH₃ GKH O —H —H GKJ O —H —Cl GKJ O —H —Br GKK O —H —F GKL O —H —CH₃ GKM O —H —CF₃ GKN O —H —OCH₃ GKO O —H —OCH₂CH₃ GKP O —H —OCF₃ GKQ O —H -tert-butyl GKR O —H -iso-propyl GKS N —Cl —H GKT N —Br —H GKU N —F —H GKV N —CH₃ —H GKW N —CF₃ —H GKX N —OCH₃ —H GKY N —OCH₂CH₃ —H GKZ N —OCF₃ —H GLA N -tert-butyl —H GLB N -iso-propyl —H GLC N —CH₃ —CH₃ GLD N —H —H GLE N —H —Cl GLF N —H —Br GLG N —H —F GLH N —H —CH₃ GLI N —H —CF₃ GLJ N —H —OCH₃ GLK N —H —OCH₂CH₃ GLL N —H —OCF₃ GLM N —H -tert-butyl GLN N —H -iso-propyl

[3022] TABLE XXI

and pharmaceutically acceptable salts thereof, wherein: Compound X R₁ R₂ R₉ GLO S —CH₃ —Cl —F GLP S —CH₃ —Cl —Cl GLQ S —CH₃ —Cl —CH₃ GLR S —CH₃ —F —F GLS S —CH₃ —F —Cl GLT S —CH₃ —F —CH₃ GLU S —CF₃ —Cl —F GLV S —CF₃ —Cl —Cl GLW S —CF₃ —Cl —CH₃ GLX S —CF₃ —F —F GLY S —CF₃ —F —Cl GLZ S —CF₃ —F —CH₃ GMA S —Cl —Cl —F GMB S —Cl —Cl —Cl GMC S —Cl —Cl —CH₃ GMD S —Cl —F —F GME S —Cl —F —Cl GMF S —Cl —F —CH₃ GMG NH —CH₃ —Cl —F GMH NH —CH₃ —Cl —Cl GMI NH —CH₃ —Cl —CH₃ GMJ NH —CH₃ —F —F GMK NH —CH₃ —F —Cl GML NH —CH₃ —F —CH₃ GMM NH —CF₃ —Cl —F GMN NH —CF₃ —Cl —Cl GMO NH —CF₃ —Cl —CH₃ GMP NH —CF₃ —F —F GMQ NH —CF₃ —F —Cl GMR NH —CF₃ —F —CH₃ GMS NH —Cl —Cl —F GMT NH —Cl —Cl —Cl GMU NH —Cl —Cl —CH₃ GMV NH —Cl —F —F GMW NH —Cl —F —Cl GMX NH —Cl —F —CH₃ GMY O —CH₃ —Cl —F GMZ O —CH₃ —Cl —Cl GNA O —CH₃ —Cl —CH₃ GNB O —CH₃ —F —F GNC O —CH₃ —F —Cl GND O —CH₃ —F —CH₃ GNE O —CF₃ —Cl —F GNF O —CF₃ —Cl —Cl GNG O —CF₃ —Cl —CH₃ GNH O —CF₃ —F —F GNI O —CF₃ —F —Cl GNJ O —CF₃ —F —CH₃ GNK O —Cl —Cl —F GNL O —Cl —Cl —Cl GNM O —Cl —Cl —CH₃ GNN O —Cl —F —F GNO O —Cl —F —Cl GNP O —Cl —F —CH₃

[3023] TABLE XXII

and pharmaceutically acceptable salts thereof, wherein: Compound X R₁ R₂ R₉ GNQ S —CH₃ —Cl —F GNR S —CH₃ —Cl —Cl GNS S —CH₃ —Cl —CH₃ GNT S —CH₃ —F —F GNU S —CH₃ —F —Cl GNV S —CH₃ —F —CH₃ GNW S —CF₃ —Cl —F GNX S —CF₃ —Cl —Cl GNY S —CF₃ —Cl —CH₃ GNZ S —CF₃ —F —F GOA S —CF₃ —F —Cl GOB S —CF₃ —F —CH₃ GOC S —Cl —Cl —F GOD S —Cl —Cl —Cl GOE S —Cl —Cl —CH₃ GOF S —Cl —F —F GOG S —Cl —F —Cl GOH S —Cl —F —CH₃ GOI NH —CH₃ —Cl —F GOJ NH —CH₃ —Cl —Cl GOK NH —CH₃ —Cl —CH₃ GOL NH —CH₃ —F —F GOM NH —CH₃ —F —Cl GON NH —CH₃ —F —CH₃ GOO NH —CF₃ —Cl —F GOP NH —CF₃ —Cl —Cl GOQ NH —CF₃ —Cl —CH₃ GOR NH —CF₃ —F —F GOS NH —CF₃ —F —Cl GOT NH —CF₃ —F —CH₃ GOU NH —Cl —Cl —F GOV NH —Cl —Cl —Cl GOW NH —Cl —Cl —CH₃ GOX NH —Cl —F —F GOY NH —Cl —F —Cl GOZ NH —Cl —F —CH₃ GPA O —CH₃ —Cl —F GPB O —CH₃ —Cl —Cl GPC O —CH₃ —Cl —CH₃ GPD O —CH₃ —F —F GPE O —CH₃ —F —Cl GPF O —CH₃ —F —CH₃ GPG O —CF₃ —Cl —F GPH O —CF₃ —Cl —Cl GPI O —CF₃ —Cl —CH₃ GPJ O —CF₃ —F —F GPK O —CF₃ —F —Cl GPL O —CF₃ —F —CH₃ GPM O —Cl —Cl —F GPN O —Cl —Cl —Cl GPO O —Cl —Cl —CH₃ GPP O —Cl —F —F GPQ O —Cl —F —Cl GPR O —Cl —F —CH₃

4.1 Definitions

[3024] As used herein, the terms used above having following meaning:

[3025] “—(C₁-C₁₀)alkyl” means a straight chain or branched non-cyclic hydrocarbon having from 1 to 10 carbon atoms. Representative straight chain —(C₁-C₁₀)alkyls include -methyl, -ethyl, -n-propyl, -n-butyl, -n-pentyl, -n-hexyl, -n-heptyl, -n-octyl, -n-nonyl, and -n-decyl. Representative branched —(C₁-C₁₀)alkyls include -isopropyl, -sec-butyl, -isobutyl, -tert-butyl, -isopentyl, -neopentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1-ethylbutyl, 2-ethylbutyl, 3-ethylbutyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-methylhexyl, 2-methylhexyl, 3-methylhexyl, 4-methylhexyl, 5-methylhexyl, 1,2-dimethylpentyl,-1,3-dimethylpentyl, 1,2-dimethylhexyl, 1,3-dimethylhexyl, 3,3-dimethylhexyl, 1,2-dimethylheptyl, 1,3-dimethylheptyl, and 3,3-dimethylheptyl.

[3026] “—(C₁-C₆)alkyl” means a straight chain or branched non-cyclic hydrocarbon having from 1 to 6 carbon atoms. Representative straight chain —(C₁-C₆)alkyls include -methyl, -ethyl, -n-propyl, -n-butyl, -n-pentyl, and -n-hexyl. Representative branched —(C₁-C₆)alkyls include -isopropyl, -sec-butyl, -isobutyl, -tert-butyl, -isopentyl, -neopentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1-ethylbutyl, 2-ethylbutyl, 3-ethylbutyl, 1,1-dimethtylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, and 3,3-dimethylbutyl.

[3027] “—(C₁-C₄)alkyl” means a straight chain or branched non-cyclic hydrocarbon having from 1 to 4 carbon atoms. Representative straight chain —(C₁-C₄)alkyls include -methyl, -ethyl, -n-propyl, and -n-butyl. Representative branched —(C₁-C₄)alkyls include -isopropyl, -sec-butyl, -isobutyl, and -tert-butyl.

[3028] “—(C₂-C₁₀)alkenyl” means a straight chain or branched non-cyclic hydrocarbon having from 2 to 10 carbon atoms and including at least one carbon-carbon double bond. Representative straight chain and branched (C₂-C₁₀)alkenyls include -vinyl, -allyl, -1-butenyl, -2-butenyl, -isobutylenyl, -1-pentenyl, -2-pentenyl, -3-methyl-1-butenyl, -2-methyl-2-butenyl, -2,3-dimethyl-2-butenyl, -1-hexenyl, -2-hexenyl, -3-hexenyl, -1-heptenyl, -2-heptenyl, -3-heptenyl, -1-octenyl, -2-octenyl, -3-octenyl, -1-nonenyl, -2-nonenyl, -3-nonenyl, -1-decenyl, -2-decenyl, -3-decenyl and the like.

[3029] “—(C₂-C₆)alkenyl” means a straight chain or branched non-cyclic hydrocarbon having from 2 to 6 carbon atoms and including at least one carbon-carbon double bond. Representative straight chain and branched (C₂-C₆)alkenyls include -vinyl, -allyl, -1-butenyl, -2-butenyl, -isobutylenyl, -1-pentenyl, -2-pentenyl, -3-methyl-1-butenyl, -2-methyl-2-butenyl, -2,3-dimethyl-2-butenyl, -1-hexenyl, 2-hexenyl, 3-hexenyl and the like.

[3030] “—(C₂-C₁₀)alkynyl” means a straight chain or branched non-cyclic hydrocarbon having from 2 to 10 carbon atoms and including at least one carbon-carbon triple bond. Representative straight chain and branched —(C₂-C₁₀)alkynyls include -acetylenyl, -propynyl, -1-butynyl, -2-butynyl, -1-pentynyl, -2-pentynyl, -3-methyl-1-butynyl, -4-pentynyl, -1-hexynyl, -2-hexynyl, -5-hexynyl, -1-heptynyl, -2-heptynyl, -6-heptynyl, -1-octynyl, -2-octynyl, -7-octynyl, -1-nonynyl, -2-nonynyl, -8-nonynyl, -1-decynyl, -2-decynyl, -9-decynyl and the like.

[3031] “—(C₂-C₆)alkynyl” means a straight chain or branched non-cyclic hydrocarbon having from 2 to 6 carbon atoms and including at least one carbon-carbon triple bond. Representative straight chain and branched (C₂-C₆)alkynyls include -acetylenyl, -propynyl, -1-butynyl, -2-butynyl, -1-pentynyl, -2-pentynyl, -3-methyl-1-butynyl, -4-pentynyl, -1-hexynyl, -2-hexynyl, -5-hexynyl and the like.

[3032] “—(C₃-C₁₀)cycloalkyl” means a saturated cyclic hydrocarbon having from 3 to 10 carbon atoms. Representative (C₃-C₁₀ )cycloalkyls are -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, -cycloheptyl, -cyclooctyl, -cyclononyl, and -cyclodecyl.

[3033] “—(C₃-C₈)cycloalkyl” means a saturated cyclic hydrocarbon having from 3 to 8 carbon atoms. Representative (C₃-C₈)cycloalkyls include -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, -cycloheptyl, and -cyclooctyl. “—(C₈-C₁₄)bicycloalkyl” means a bi-cyclic hydrocarbon ring system having from 8 to 14 carbon atoms and at least one saturated cyclic alkyl ring. Representative —(C₈-C₁₄)bicycloalkyls include -indanyl, -1,2,3,4-tetrahydronaphthyl, -5,6,7,8-tetrahydronaphthyl, -perhydronaphthyl, and the like.

[3034] “—(C₈-C₄)tricycloalkyl” means a tri-cyclic hydrocarbon ring system having from 8 to 14 carbon atoms and at least one saturated ring. Representative —(C₈-C₁₄)tricycloalkyls include -pyrenyl, -1,2,3,4-tetrahydroanthracenyl, -perhydroanthracenyl -aceanthreneyl, -1,2,3,4-tetrahydropenanthrenyl, -5,6,7,8-tetrahydrophenanthrenyl, -perhydrophenanthrenyl and the like.

[3035] “—(C₅-C₁₀)cycloalkenyl” means a cyclic non-aromatic hydrocarbon having at least one carbon-carbon double bond in the cyclic system and from 5 to 10 carbon atoms. Representative (C₅-C₁₀)cycloalkenyls include -cyclopentenyl, -cyclopentadienyl, -cyclohexenyl, -cyclohexadienyl,-cycloheptenyl, -cycloheptadienyl, -cycloheptatrienyl, -cyclooctenyl, -cyclooctadienyl, -cyclooctatrienyl, -cyclooctatetraenyl, -cyclononenyl -cyclononadienyl, -cyclodecenyl, -cyclodecadienyl and the like.

[3036] “—(C₅-C₈)cycloalkenyl” means a cyclic non-aromatic hydrocarbon having at least one carbon-carbon double bond in the cyclic system and from 5 to 8 carbon atoms. Representative (C₅-C₈)cycloalkenyls include -cyclopentenyl, -cyclopentadienyl, -cyclohexenyl, -cyclohexadienyl, -cycloheptenyl, -cycloheptadienyl, -cycloheptatrienyl, -cyclooctenyl, -cyclooctadienyl, -cyclooctatrienyl, -cyclooctatetraenyl and the like.

[3037] “—(C₈-C₁₄)bicycloalkenyl” means a bi-cyclic hydrocarbon ring system having at least one carbon-carbon double bond in each ring and from 8 to 14 carbon atoms. Representative —(C₈-C₁₄)bicycloalkenyls include -indenyl, -pentalenyl, -naphthalenyl, -azulenyl, -heptalenyl, -1,2,7,8-tetrahydronaphthalenyl and the like.

[3038] “—(C₈-C₁₄)tricycloalkenyl” means a tri-cyclic hydrocarbon ring system having at least one carbon-carbon double bond in each ring and from 8 to 14 carbon atoms. Representative —(C₈-C₁₄)tricycloalkenyls include -anthracenyl, -phenanthrenyl, -phenalenyl, -acenaphthalenyl, as-indacenyl, s-indacenyl and the like.

[3039] “-(3-to 7-membered)heterocycle” or “-(3-to 7-membered)heterocyclo” means a 3-to 7-membered monocyclic heterocyclic ring which is either saturated, unsaturated non-aromatic, or aromatic. A 3-membered -heterocycle can contain up to 3 heteroatoms, and a 4-to 7-memberedheterocycle can contain up to 4 heteroatoms. Each heteroatom is independently selected from nitrogen, which can be quaternized; oxygen; and sulfur, including sulfoxide and sulfone. The -(3-to 7-membered)heterocycle can be attached via a nitrogen or carbon atom. Representative -(3-to 7-membered)heterocycles include pyridyl, furyl, thiophenyl, pyrrolyl, oxazolyl, imidazolyl, thiazolyl, thiadiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl, pyrrolidinonyl, yrrolidinyl, piperidinyl, piperazinyl, hydantoinyl, valerolactamyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydropyrindinyl, tetrahydropyrimidinyl, tetrahydrothiophenyl, tetrahydrothiopyranyl and the like.

[3040] “-(3-to 5-membered)heterocycle” or “-(3-to 5-membered)heterocyclo” means a 3-to 5-membered monocyclic heterocyclic ring which is either saturated, unsaturated non-aromatic, or aromatic. A 3-membered heterocycle can contain up to 3 heteroatoms, and a 4-to 5-membered heterocycle can contain up to 4 heteroatoms. Each heteroatom is independently selected from nitrogen, which can be quaternized; oxygen; and sulfur, including sulfoxide and sulfone. The -(3-to 5-membered)heterocycle can be attached via a nitrogen or carbon atom. Representative -(3-to 5-membered)heterocycles include furyl, thiophenyl, pyrrolyl, oxazolyl, imidazolyl, thiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, triazinyl, pyrrolidinonyl, pyrrolidinyl, hydantoinyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydrothiophenyl and the like.

[3041] “-(7-to 10-membered)bicycloheterocycle” or “-(7-to 10-membered)bicycloheterocyclo” means a 7-to 10-membered bicyclic, heterocyclic ring which is either saturated, unsaturated non-aromatic, or aromatic. A -(7-to 10-membered)bicycloheterocycle contains from 1 to 4 heteroatoms independently selected from nitrogen, which can be quaternized; oxygen; and sulfur, including sulfoxide and sulfone. The -(7-to 10-membered)bicycloheterocycle can be attached via a nitrogen or carbon atom. Representative -(7-to 10-membered)bicycloheterocycles include -quinolinyl, -isoquinolinyl, -chromonyl, -coumarinyl, -indolyl, -indolizinyl, -benzo[b]furanyl, -benzo[b]thiophenyl, -indazolyl, -purinyl, -4H-quinolizinyl, -isoquinolyl, -quinolyl, -phthalazinyl, -naphthyridinyl, -carbazolyl, -, β-carbolinyl and the like.

[3042] “—(C₁₄)aryl” means a 14-membered aromatic carbocyclic moiety such as-anthryl or -phenanthryl.

[3043] “-(5-to 10-membered)heteroaryl” means an aromatic heterocycle ring of 5 to 10 members, including both mono-and bicyclic ring systems, wherein at least one carbon atom of one or both of the rings is replaced with a heteroatom independently selected from nitrogen, oxygen, and sulfur. One or both of the -(5-to 10-membered)heteroaryl's rings contain at least one carbon atom. Representative -(5-to 10-membered)heteroaryls include pyridyl, furyl, benzofuranyl, thiophenyl, benzothiophenyl, quinolinyl, pyrrolyl, indolyl, oxazolyl, benzoxazolyl, imidazolyl, benzimidazolyl, thiazolyl, benzothiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiadiazolyl, triazinyl, cinnolinyl, phthalazinyl, and quinazolinyl.

[3044] “—CH₂(halo)” means a methyl group wherein one of the hydrogens of the methyl group has been replaced with a halogen. Representative —CH₂(halo) groups include —CH₂F, —CH₂Cl, —CH₂Br, and —CH₂I.

[3045] “—CH(halo)₂” means a methyl group wherein two of the hydrogens of the methyl group have been replaced with a halogen. Representative —CH(halo)₂ groups include —CHF₂, —CHCl₂, —CHBr₂, CHBrCl, CHClI, and —CHI_(2.)

[3046] “—C(halo)₃” means a methyl group wherein each of the hydrogens of the methyl group has been replaced with a halogen. Representative —C(halo)₃ groups include —CF₃, —CCl₃, —CBr₃, and —CI₃.

[3047] “-Halogen” or “-Halo” means —F, —Cl, —Br, or —I.

[3048] The phrase “pyridyl group” means

[3049] wherein R₁, R₂, and n are defined above for the Benzoazolylpiperazine Compounds of formula (Ia, IIa, and IIIa).

[3050] The phrase “pyrazinyl group” means,

[3051] wherein R₁, R₂, and p are defined above for the Benzoazolylpiperazine Compounds of formula (Ib, IIa, and IIIb).

[3052] The phrase “pyrimidinyl group” means

[3053] wherein R₁, R₂, and p are defined above for the Benzoazolylpiperazine Compounds of formula (Ia), (IIa), and (IIIa).

[3054] The phrase “pyridazinyl group” means

[3055] wherein R₁, R₂, and p are defined above for the Benzoazolylpiperazine Compounds of formula (Ib), (Ilb), and (IIIb).

[3056] The phrase “thiazanyl group” means

[3057] wherein R₁ is defined above for the Benzoazolylpiperazine Compounds of formula (Ib), (IIb), and (IIIb).

[3058] The phrase “2-(3-chloropyridyl)” means

[3059] The phrase “2-(3-methylpyridyl)” means

[3060] The phrase “2-(3-CF₃-pyridyl)” means

[3061] The phrase “2-(3-CHF₂-pyridyl)” means

[3062] The phrase “2-(3-hydroxypyridyl)” means

[3063] The phrase “2-(3-nitropyridyl)” means

[3064] The phrase “2-(3-cyanopyridyl)” means

[3065] The phrase “2-(3-bromopyridyl)” means

[3066] The phrase “2-(3-iodopyridyl)” means

[3067] The phrase “4-(5-chloropyrimidinyl)” means

[3068] The phrase “4-(5-methylpyrimidinyl)” means

[3069] The phrase “4-(5-fluoropyrimidinyl)” means

[3070] The phrase “2-(3-chloropyrazinyl)” means

[3071] The phrase “2-(3-methylpyrazinyl)” means

[3072] The phrase “2-(3-fluoropyrazinyl)” means

[3073] The phrase “3-(4-chloropyridazinyl)” means

[3074] The phrase “3-(4-methylpyridazinyl)” means

[3075] The phrase “3-(4-fluoropyridazinyl)” means

[3076] The phrase “5-(4-chlorothiazanyl)” means

[3077] The phrase “5-(4-methylthiazanyl)” means

[3078] The phrase “2-pyrazinyl” means

[3079] The phrase “2-pyridazinyl” means

[3080] The phrase “4-thiazanyl” means

[3081] The phrase “5-(4-fluorothiazanyl)” means

[3082] The phrase “benzoimidiazolyl group” means

[3083] wherein R₈, R₉ and R₁₀ are defined above for the Benzoazolylpiperazine Compounds of formula (IIa) and (IIb).

[3084] The phrase “benzothiazolyl group” means

[3085] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib).

[3086] The phrase “benzooxazolyl group” means

[3087] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb).

[3088] The term “animal,” includes, but is not limited to, a cow, monkey, baboon, chimpanzee, horse, sheep, pig, chicken, turkey, quail, cat, dog, mouse, rat, rabbit, guinea pig, and human.

[3089] The phrase “pharmaceutically acceptable salt,” as used herein, includes a salt formed from an acid and a basic nitrogen group of one of the Benzoazolylpiperazine Compounds. Illustrative salts include, but are not limited, to sulfate, citrate, acetate, oxalate, chloride, bromide, iodide, nitrate, bisulfate, phosphate, acid phosphate, isonicotinate, lactate, salicylate, acid citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, and pamoate (i.e., 1,1′-methylene-bis-(2-hydroxy-3-naphthoate)) salts. The term “pharmaceutically acceptable salt” also includes a salt prepared from a Benzoazolylpiperazine Compound having an acidic finctional group, such as a carboxylic acid finctional group, and a pharmaceutically acceptable inorganic or organic base. Suitable bases include, but are not limited to, hydroxides of alkali metals such as sodium, potassium, and lithium; hydroxides of alkaline earth metal such as calcium and magnesium; hydroxides of other metals, such as aluminum and zinc; ammonia and organic amines, such as unsubstituted or hydroxy-substituted mono-, di-, or trialkylamines; dicyclohexylamine; tributyl amine; pyridine; N-methyl,N-ethylamine; diethylamine; triethylamine; mono-, bis-, or tris-(2-hydroxy-lower alkyl amines), such as mono-, bis-, or tris-(2-hydroxyethyl)amine, 2-hydroxy-tert-butylamine, or tris-(hydroxymethyl)methylamine, N,N,-di-lower alkyl-N-(hydroxy lower alkyl)-amines, such as N,N,-dimethyl-N-(2-hydroxyethyl)amine, or tri-(2-hydroxyethyl)amine; N-methyl-D-glucamine; and amino acids such as arginine, lysine and the like.

[3090] The phrase “effective amount,” when used in connection with a Benzoazolylpiperazine Compound means an amount effective for: (a) treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression; or (b) inhibiting VR1, mGluR1, or mGluR5 function in a cell.

[3091] The phrase “effective amount,” when used in connection with the another therapeutic agent means an amount for providing the therapeutic effect of the therapeutic agent.

[3092] When a first group is “substituted with one or more” second groups, one or more hydrogen atoms of the first group is replaced with a corresponding number of second groups. When the number of second groups is two or greater, each second group can be the same or different. In one embodiment, the number of second groups is one or two. In another embodiment, the number of second groups is one.

[3093] The term “DMSO” means dimethyl sulfoxide.

[3094] The term “DCM” means dichloromethane.

[3095] The term “UI” means urinary incontinence.

[3096] The term “IBD” means inflammatory-bowel disease.

[3097] The term “IBS” means irritable-bowel syndrome.

[3098] The term “ALS” means amyotrophic lateral sclerosis.

[3099] The phrase “treatment of” and “treating” includes the amelioration or cessation of pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression, or a symptom thereof.

[3100] The phrase “prevention of” and “preventing” includes the avoidance of the onset of pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression, or a symptom thereof.

4.2 Methods for Making the Benzoazolylpiperazine Compounds

[3101] The Benzoazolylpiperazine Compounds can be made using conventional organic synthesis or by the following illustrative methods shown in the schemes below.

4.2.1 Methods for Making the Benzoazolypiperazine Compounds of Formula (IA) and (IB) wherein X is 1 and A is —C(O)—NR₄

[3102] The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H, can be obtained by the following illustrative method shown in Scheme A:

[3103] A compound of formula B (about 2 mmol) is dissolved in an aprotic organic solvent (about 3 mL). To the resulting solution is added a compound of formula A (about 2 mmol) and the resulting reaction mixture allowed to stir for about 10 min. The solvent is then removed under reduced pressure to provide the Benzoazolylpiperazine Compound of formula (Ia) or (Ib) wherein x is 1, A is —(O)—NR₄—, and R₄ is —H. The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) can be purified on a silica column eluted with 5:95 ethyl acetate/hexane.

[3104] The compound of formula B can be obtained as shown below in Scheme B:

[3105] A compound of formula D (about 0.75 eq.) in an aprotic organic solvent (about 0.04 M) is cooled to about 0° C. To the cooled solution is slowly added a solution of a compound of formula C (about 0.75 eq.) in an aprotic organic solvent (about 0.4 M). The resulting reaction mixture is stirred at 0° C. for about 5 min. and about 0.75 eq. of triethylamine are added to the reaction mixture. The reaction mixture is then allowed to warm to room temperature and the solvent is then removed under reduced pressure to provide the compound of formula B. The compound of formula D is commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com). Compounds of formula C are commercially available or can be prepared by the following illustrative method shown below in Scheme C.

[3106] To a stirred solution of aniline U (about 74 mmol) and potassium thiocyanate (about 148 mmol) in about 100 mL of glacial acetic acid is added dropwise a solution of bromine (about 74 mmol) in about 25 mL of glacial acetic acid. The flask containing the bromine in acetic acid is then rinsed with about 15 mL of acetic acid which is combined with the solution of aniline U. The resulting reaction mixture is vigorously stirred at room temperature for between about 2 h and about 24 h. The reaction mixture is then poured over crushed ice (about 500 mL) and the pH of the resulting mixture adjusted to a value of about 10 using ammonium hydroxide to provide a precipitate. The resulting precipitate is collected by filtration and recrystallized from toluene to provide the compound of formula C. Compounds of formula U are commercially available or can be prepared by methods well known to those skilled in the art.

[3107] The compound of formula A can be obtained as shown below in Scheme D:

[3108] A compound of formula F1-F5 (about 20 mmol) is reacted with a compound of formula E (about 27.5 mmol) in about 15 mL of DMSO in the presence of triethylamine (about 30 mmol), optionally with heating, for about 24 h to provide a compound of formula A. The compound of formula A is isolated from the reaction mixture and purified. In one embodiment, the compound of formula A is purified using column chromatography or recrystallization.

[3109] Compounds of formula E and F are commercially available or can be prepared by methods well known to those skilled in the art. The compound of formula E wherein m is 0 and the compound of formula E wherein m is 1 and R₃ is (R) —CH₃ or (S) —CH₃ are commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com). In one embodiment, X is bromide, chloride, or iodide.

[3110] The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl can be obtained by the following illustrative method shown below in Scheme E.

[3111] To a solution of a Benzoazolylpiperazine compound of formula (Ia) or (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H (about 1 eq.), obtained as described above in Scheme A, in DMF at 0° C., is added a DMF solution of NaH (about 2 eq.). The resulting reaction mixture is allowed to warm to room temperature over about 1 h. To the resulting mixture is added about 1.2 eq. of an alkyl halide, R₄X, and the resulting reaction mixture allowed to stir until the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-₆)alkyl is formed. The progress of the reaction can be monitored using conventional analytical techniques including, but not limited to, high pressure liquid chromatography (HPLC), column chromatography, thin-layer chromatography (TLC), column chromatography, gas chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy such as ¹H and ¹³C NMR. The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl is then isolated and purified. In one embodiment, the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl is isolated by removing the solvent under reduced pressure. In another embodiment, the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl is isolated by extraction. The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl can be purified, for example, by column chromatography or recrystallization.

4.2.2 Methods for Making the Benzoazolypiperazine Compounds of Formula (IA) and (IB) wherein X is 1 and A is —(S)—NR₄

[3112] The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(S)—NR₄—, and R₄ is —H can be obtained by the following illustrative method in Scheme F:

[3113] A Compound of Formula C (about 2 mmol), 1,1′-thiocarbonyldiimidazole (about 2 mmol) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)), and 4-dimethylaminopyridine (DMAP) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) are suspended in DMSO (about 3 mL) at room temperature and the resulting mixture is heated at about 100° C. for about 6 h. The resulting reaction mixture is then cooled to room temperature and a compound of Formula A (about 2 mmol) is added to the reaction mixture and the reaction mixture is heated to about 100° C. for about 16 h. The solvent is then removed under reduced pressure to provide the Benzoazolylpiperazine Compound of formula (Ia) or (Ib) wherein x is 1, A is —C(S)—NR₄—, and R₄ is —H. The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) can be purified on a silica column eluted with 5:95 ethyl acetate/hexane.

[3114] The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(S)—NR₄—, and R₄ is —(C₁-C₆)alkyl can be obtained by a method analogous to the method used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl as described in Scheme E except that a Benzoazolylpiperazine Compound of formula (Ia) and (Ib) wherein x is 1, A is —(S)—NR₄—, and R₄ is —H, obtained as described above in Scheme F, is used in place of the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H.

4.2.3 Methods for Making the Benzoazolylpiperazine Compounds of Formula (IA) and (IB) wherein X is 0

[3115] The Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 0 can be obtained by the following illustrative method shown below in Scheme G:

[3116] A compound of Formula A (about 1 mmol) and a compound of Formula G (about 1 mmol) are dissolved in DMSO (about 3 mL) and heated at a temperature of between about 140° C. and 150° C. for about 12 h. The mixture is cooled to room temperature and the solvent removed under reduced pressure to provide a residue that is purified using silica gel flash chromatography (gradient elution from 2:98 methanol:DCM to 6:94 methanol:DCM) to provide the Benzoazolylpiperazine Compound of formula (Ia) or (Ib) wherein x is 0.

[3117] The compound of Formula A can be obtained as shown above in Scheme D.

[3118] The compounds of Formula G are commercially available or can be prepared by procedures well known to those skilled in the art. An illustrative method for preparing compounds of Formula G is shown below in Scheme H.

[3119] A compound of Formula Z (about 5 to about 10 mmol) and carbodiimidazole (CDI) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) (about 2 eq) is dissolved in THF (about 50 to about 70 mL) and the resulting reaction mixture is heated at reflux temperature for about 4 hours. The reaction mixture is then concentrated under reduced pressure to provide a residue. Ethyl acetate (about 50 mL) is added to the residue and the resulting insoluble material is collected by filtration and washed with ethyl acetate to provide a compound of Formula AA. The compound of Formula AA is then reacted with POCl₃ according to the procedure described in J. Med. Chem. 40:586-593 (1997) to provide the compound of Formula BB. The compounds of Formula Z are commercially available or can be prepared by procedures well known to those skilled in the art. An illustrative procedure for obtaining a compound of Formula Z is shown below in Scheme I:

[3120] Thiol CC (about 12 mmol) is dissolved in concentrated sulfuric acid (about 10 mL) at 0° C. and the resulting solution cooled to a temperature of about −13° C. to about −15° C. About 1 mL of 70% nitric acid is added to the resulting solution over a time period of about 30 min. and the resulting reaction mixture allowed to stir for about 2 h at a temperature of between about −13° C. to about −15° C. The reaction mixture is then poured into ice water (about 100 mL), neutralized with 5% to 10% aqueous sodium hydroxide, and extracted with about 50 mL of chloroform. The chloroform layer is separated from the aqueous layer and removed under reduced pressure to provide a residue that is purified using flash chromatography (silica column and chloroform eluant) to provide a compound of Formula DD. The compound of Formula DD is dissolved in ethanol (about 50 mL) and hydrogenated for about 12 h at room temperature using 10% palladium on carbon as a catalyst. The catalyst is removed by filtration and the ethanol is removed under reduced pressure to provide a residue that is purified using flash chromatography (silica gel eluted with 20:1 dichloromethane:methanol) to provide the compound of Formula EE. The compounds of Formula CC are commercially available or can be prepared by procedures well known to those skilled in the art.

4.2.4 Methods for Making the Benzoazolylpiperazine Compounds of Formula (IIA) and (IIB) wherein X is 0

[3121] The Benzoazolylpiperazine Compounds of formula (IIa) wherein R₁₀ is —H and formula (IIb) wherein x is 0 and R₁₀ is —H can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 0 as described above in section 4.2.3, Scheme G except that a compound of Formula H, shown below,

[3122] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (IIa) and (IIb), is used in place of the compound of Formula G as illustrated below in Scheme

[3123] A compound of Formula A (about 1 mmol) and a compound of Formula H (about 1 mmol) are dissolved in toluene or p-xylene in a sealed tube and heated at a temperature of between about 140° C. and 150° C. for about 3 days. The mixture is cooled to room temperature and the solvent removed under reduced pressure to provide a residue that is purified using flash chromatography (silica gel with a gradient elution from 2% methanol:dichloromethane to 6% methanol:dichloromethane) to provide the Benzoazolylpiperazine Compound of formula (IIa) and formula (IIb) wherein x is 0.

[3124] The compound of Formula A can be obtained as shown above in Scheme D.

[3125] The compounds of Formula H are commercially available or can be prepared by procedures well known to those skilled in the art. An illustrative method for preparing the compound of Formula H is shown below in Scheme K:

[3126] A compound of Formula I (about 5 to about 10 mmol) and carbodiimidazole (CDI) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) (about 2 eq) is dissolved in THF (about 50 to about 70 mL) and the resulting reaction mixture is heated at reflux temperature for about 4 hours. The reaction mixture is then concentrated under reduced pressure to provide a residue. Ethyl acetate (about 50 mL) is added to the residue and the resulting insoluble material is collected by filtration and washed with ethyl acetate to provide a compound of Formula J. The compound of Formula J is then reacted with POCl₃ according to the procedure described in J. Med. Chem. 40:586-593 (1997) to provide the compound of Formula H. The compounds of Formula I are commercially available or can be prepared by procedures well known to those skilled in the art. An illustrative procedure for obtaining a compound of Formula I is shown below in Scheme L:

[3127] Aniline hydrochloride V (about 12 mmol) is dissolved in concentrated sulfuric acid (about 10 mL) at 0° C. and the resulting solution cooled to a temperature of about −13° C. to about −15° C. About 1 mL of 70% nitric acid is added to the resulting solution over a time period of about 30 min. and the resulting reaction mixture allowed to stir for about 2 h at a temperature of between about −13° C. to about −15° C. The reaction mixture is then poured into ice water (about 100 mL), neutralized with 5% to 10% aqueous sodium hydroxide and extracted with about 50 mL of chloroform. The chloroform is separated from the aqueous layer and removed under reduced pressure to provide a residue that is purified using flash chromatography (silica column and chloroform eluant) to provide a compound of Formula W. The compound of Formula W is dissolved in ethanol (about 50 mL) and hydrogenated for about 12 h at room temperature using 10% palladium on carbon as a catalyst. The catalyst is removed by filtration and the ethanol is removed under reduced pressure to provide a residue that is purified using flash chromatography (silica gel eluted with 20:1 dichloromethane:methanol) to provide the compound of Formula I. The compounds of Formula V are commercially available or can be prepared by procedures well known to those skilled in the art.

[3128] The Benzoazolylpiperazine Compounds of formula (IIa) wherein R₁₀ is —(C₁-C₄)alkyl and formula (IIb) wherein x is 0 and R₁₀ is —(C₁-C₄)alkyl can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (IIa) and (IIb) wherein x is 0 and R₁₀ is —H, as described above in Scheme J, except that a compound of Formula K, shown below

[3129] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (IIa) and (IIb) and R₁₀ is a —(C₁-C₆)alkyl is used in place of the compound of Formula H. The compound of Formula K can be obtained as described below in Scheme M

[3130] NaH (about 2 eq) is added to a solution of a compound of Formula H in DMF at 0° C. and the resulting mixture is allowed to stir and to warm to room temperature over a period of about one hour. An alkyl halide, R₁₀—X, (about 1.2 eq) is then added to the solution and the resulting reaction mixture allowed to stir until the compound of Formula K is produced. In one embodiment, the alkyl halide is an alkyl iodide. The formation of the compound of Formula K can be monitored by analytical methods well known to those skilled in the art including, but not limited to, liquid chromatography, column chromatography, gas chromatography, thin-layer chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy such as ¹H and ¹³C NMR. Water is then added to the reaction mixture to produce a precipitate of the compound of Formula K which is filtered, collected, and dried.

[3131] The compound of Formula H can be obtained as described above in Scheme K.

4.2.5 Methods for Making the Benzoazolylpiperazine Compounds of Formula (IIB) wherein X is 1 and A is —C(O)—NR₄

[3132] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(O)—NR₄—, R₄ is —H, and R₁₀ is —H can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H as described above in Scheme A except that a compound of Formula L, shown below,

[3133] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (IIb), is used in place of the compound of Formula B.

[3134] The Compound of Formula L can be obtained by a method analogous to that used to obtain the compound of Formula B as described in section 4.2.1, Scheme B, except that a compound of Formula M, shown below,

[3135] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (IIb), is used in place of the compound of Formula C. Compounds of Formula M are commercially available or can be prepared by procedures well known to those skilled in the art. An illustrative procedure for obtaining a compound of Formula M is shown below in Scheme N:

[3136] A compound of Formula H (about 1 mmol), prepared as described above in Scheme K, is dissolved in excess aqueous ammonia in a sealed tube and heated at a temperature of between about 140° C. and 150° C. for about 3 days. The mixture is cooled to room temperature and the solvent removed under reduced pressure to provide a residue. In another embodiment, the mixture is cooled to room temperature, extracted with an organic solvent, the organic phase separated from the aqueous phase, and the organic solvent removed under reduced pressure to provide a residue. The residue is then purified to provide the compound of Formula M. In one embodiment, the residue is purified by recrystallization. In another embodiment, the residue is purified using flash chromatography.

[3137] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(O)—NR₄—, R₄ is —H, and R₁₀ is —(C₁-C₄)alkyl can be obtained by a method analogous to that used to obtain the Benzoazolylpoperazine Compounds of formula (IIb) wherein x is 1, A is —C(O)—NR₄—, R₄ is —H, and R₁₀ is —H except that a compound of Formula N, shown below,

[3138] wherein R₈, R₉, and R₁₀ are defined above for the Benzoazolylpiperazine Compounds of formula (IIb), is used in place of the Compound of Formula L. The compound of Formula N can be obtained by a method analogous to that used to obtain the compound of Formula L except that a compound of Formula O, shown below,

[3139] wherein R₈, R₉, and R₁₀ are defined above for the Benzoazolylpiperazine Compounds of formula (IIb), is used in place of the compound of Formula M. The compound of Formula O can be obtained as shown below in Scheme N:

[3140] NaH (about 2 eq) is added to a solution of a compound of Formula M in DMF at 0° C. and the resulting mixture is allowed to stir and to warm to room temperature over a period of about one hour. An alkyl halide, R₁₀—X, (about 1 eq.) is then added to the solution and the resulting reaction mixture allowed to stir until a mixture of acompound of Formula O and a compound of Formula X is produced. In one embodiment, the alkyl halide is an alkyl iodide. The formation of the compound of Formula O and the compound of Formula X can be monitored by analytical methods well known to those skilled in the art including, but not limited to, those described above. Water is then added to the reaction mixture to produce a precipitate of the compound of Formula O and the compound of Formula X which are collected by filtration. The compound of Formula O and the compound of Formula X are then separated to provide the compound of Formula O. The compound of Formula O and the compound of Formula X can be separated by analytical methods well known to those skilled in the art including, but not limited to, column chromatography, preparative TLC, preparative HPLC, and preparative GC.

[3141] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(O)—NR₄—, R₄ is —(C₁-C₆)alkyl, and R₁₀ is —H can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl as shown above in Scheme E except that the Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(O)—NR₄—, R₄ is —H, and R₁₀ is —H, prepared as described above, is used in place of the Benzoazolylpiperazine compound of formula (Ia) or (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄is —H.

[3142] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(O)—NR₄—, R₄ is —(C₁-C₆)alkyl, and R₁₀ is —(C₁-C₄)alkyl can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl as shown above in Scheme E except that the Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(O)—NR₄—, R₄ is —H, and R₁₀ is —(C₁-C₆)alkyl, prepared as described above, is used in place of the Benzoazolylpiperazine compound of formula (Ia) or (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H.

4.2.6 Methods for Making the Benzoazolylpiperazine Compounds of Formula (IIB) wherein X is 1 and A is —(S)—NR₄—

[3143] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —(S)—NR₄—, R₄ is —H, and R₁₀ is —H can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1 and A is —C(S)—NR₄—, and R₄ is —H as described above in Scheme F except that a compound of Formula M is used in place of the compound of Formula C. The compound of Formula M can be obtained as described above.

[3144] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(S)—NR₄—, R₄ is —H, and R₁₀ is —(C₁-C₄)alkyl can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(S)—NR₄—, and R₄ is —H, as described in section 4.2.2, Scheme F, except that a compound of Formula O is used in place of the compound of Formula C. The compound of Formula O can be obtained as described above.

[3145] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(S)—NR₄—, R₄ is —(C₁-C₆)alkyl, and R₁₀ is —H can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl as described above in Scheme E except that the Benzoylpiperazine Compound of Formula (IIa) wherein A is —C(S)—NR₄—, R₄ is —H, and R₁₀ is —H, prepared as described above, is used in place of the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H.

[3146] The Benzoazolylpiperazine Compounds of formula (IIb) wherein x is 1, A is —C(S)—NR₄—, R₄ is —(C₁-C₆)alkyl, and R₁₀ is —(C₁-C₄)alkyl can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl as described above in Scheme E except that the Benzoylpiperazine Compound of Formula (IIa) wherein A is —C(S)—NR₄—, R₄ is —H, and R₁₀ is —(C₁-C₄)alkyl, prepared as described above, is used in place of the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄is —H.

4.2.7 Methods for Making the Benzoazolylpiperazine Compounds of Formula (IIIA) and (IIIB) wherein X is 1 and A is —C(O)—NR₄

[3147] The Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb) wherein x is 1, A is —C(O)—NR₄—, and R₄is —H can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1 and A is —C(O)—NR₄ as described in section 4.2.1, Scheme A, except that a compound of Formula P, shown below,

[3148] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb), is used in place of the compound of Formula B.

[3149] The Compound of Formula P can be obtained by a method analogous to that used to obtain the compound of Formula B as described above in Scheme B except that a compound of Formula Q, shown below,

[3150] wherein R₈ and R₉ are defined above for the Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb), is used in place of the compound of Formula C. The compounds of Formula Q are commercially available or can be prepared by procedures well known to those skilled in the art. The compounds of Formula Q can be obtained by a method analogous to that used to obtain the compound of Formula BB, as described in Scheme H, except that a compound of Formula HH, shown below,

[3151] is used in place of a compound of Formula Z.

[3152] An illustrative procedure for obtaining a compound of Formula HH is shown below in Scheme O:

[3153] Phenol FF (about 12 mmol) is dissolved in concentrated sulfuric acid (about 10 mL) at 0° C. and the resulting solution cooled to a temperature of about −13° C. to about −15° C. About 1 mL of 70% nitric acid is added to the resulting solution over a time period of about 30 min. and the resulting reaction mixture allowed to stir for about 2 h at a temperature of between about −13° C. to about −15° C. The reaction mixture is then poured into ice water (about 100 mL), neutralized with 5% to 10% aqueous sodium hydroxide, and extracted with about 50 mL of chloroform. The chloroform is separated from the aqueous layer and removed under reduced pressure to provide a residue that is purified using flash chromatography (silica column and chloroform eluant) to provide a compound of Formula GG The compound of Formula GG is dissolved in ethanol (about 50 mL) and hydrogenated for about 12 h at room temperature using 10% palladium on carbon as a catalyst. The catalyst is removed by filtration and the ethanol is removed under reduced pressure to provide a residue that is purified using flash chromatography (silica gel eluted with 20:1 dichloromethane:methanol) to provide the compound of Formula HH The compounds of 30 Formula FF are commercially available or can be prepared by procedures well known to those skilled in the art.

[3154] The Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb) wherein x is 1, A is —C(O)—NR₄—, and R₄is —(C₁-C₆)alkyl can be obtained by a method analogous to the method used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —(C₁-C₆)alkyl as shown above in Scheme E except that the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H is replaced with a Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H, obtained as described above.

4.2.8 Methods for Making the Benzoazolylpiperazine Compounds of Formula (IIIA) and (IIIB) wherein X is 1 and A is —C(S)—NR₄

[3155] The Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb) wherein x is 1, A is —C(S)—NR₄—, and R₄ is —H can be obtained by a method analogous to that used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1 and A is —C(S)—NR₄—, and R₄ is —H as described above in Scheme F except that a compound of Formula Q is used in place of the compound of Formula C. The compound of Formula Q can be obtained as described above.

[3156] The Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb) wherein x is 1, A is —C(S)—NR₄—, and R₄ is —(C₁-C₆)alkyl can be obtained by a method analogous to the method used to obtain the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄is —(C₁-C₆)alkyl as described in Scheme E except that a Benzoazolylpiperazine Compound of formula (IIIa) and (IIIb) wherein x is 1, A is —(S)—NR₄—, and R₄ is —H, obtained as described above, is used in place of the Benzoazolylpiperazine Compounds of formula (Ia) and (Ib) wherein x is 1, A is —C(O)—NR₄—, and R₄ is —H.

4.2.9 Methods for Making the Benzoazolylpiperazine Compounds of Formula (IIIA) and (IIIB) wherein X is 0

[3157] The Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb) wherein x is 0 can be obtained by the following illustrative method shown in Scheme P.

[3158] A compound of Formula S (about 15 to about 20 mmol) and a compound of Formula T (about 1 eq.) are dissolved in ethanol (about 30 to about 40 mL) and the resulting reaction mixture heated at reflux temperature for about 5 h. The reaction mixture is concentrated under reduced pressure to provide a residue that is diluted with water (about 30 mL) and acidified with acetic acid to a pH value of about 6. The aqueous mixture is then extracted with ethyl acetate, the ethyl acetate dried (Na₂SO₄), and the solvent removed under reduced pressure to provide a compound of Formula Y which is used without further purification. The compound of Formula Y (about 1 mmol) and a compound of Formula A (about 1 eq.) are dissolved in toluene or p-xylene (about 0.5. mL to about 1 mL) and the reaction mixture heated in a sealed tube at a temperature of about 150° C. for about 24 h. The reaction mixture is concentrated under reduced pressure to provide a residue. The resulting residue can be purified using flash chromatography (silica gel, 5:95 methanol:DCM) to provide the Benzoazolylpiperazine Compounds of formula (IIIa) and (IIIb) wherein x is 0.

[3159] The compounds of Formula S are commercially available or can be prepared by procedures well known to those skilled in the art. An illustrative procedure for obtaining a compound of Formula S is shown below in Scheme Q:

[3160] Phenol II (about 12 mmol) is dissolved in concentrated sulfiric acid (about 10 mL) at 0° C. and the resulting solution cooled to a temperature of about −13° C. to about −15° C. About 1 mL of 70% nitric acid is added to the resulting solution over a time period of about 30 min. and the resulting reaction mixture allowed to stir for about 2 h at a temperature of between about −13° C. to about −15° C. The reaction mixture is then poured into ice water (about 100 mL), neutralized with 5% to 10% aqueous sodium hydroxide and extracted with about 50 mL of chloroform. The chloroform is separated from the aqueous layer and removed under reduced pressure to provide a residue that is purified using flash chromatography (silica column and chloroform eluant) to provide a compound of Formula JJ. The compound of Formula JJ is dissolved in ethanol (about 50 mL) and hydrogenated for about 12 h at room temperature using 10% palladium on carbon as a catalyst. The catalyst is removed by filtration and the ethanol is removed under reduced pressure to provide a residue that is purified using flash chromatography (silica gel eluted with 20:1 dichloromethane:methanol) to provide the compound of Formula S. The compounds of Formula S are commercially available or can be prepared by procedures well known to those skilled in the art.

[3161] The compound of Formula T is commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com).

[3162] The compounds of Formula A can be obtained as described above.

[3163] Suitable aprotic organic solvents for use in the illustrative methods include, but are not limited to, DCM, DMSO, chloroform, toluene, benzene, acetonitrile, carbon tetrachloride, pentane, hexane, ligroin, and diethylether. In one embodiment, the aprotic organic solvent is DCM.

[3164] Certain Benzoazolylpiperazine Compounds can have one or more asymmetric centers and therefore exist in different enantiomeric and diastereomeric forms. A Benzoazolylpiperazine Compound can be in the form of an optical isomer or a diastereomer. Accordingly, the invention encompasses Benzoazolylpiperazine Compounds and their uses as described herein in the form of their optical isomers, diasteriomers, and mixtures thereof, including a racemic mixture.

[3165] In addition, one or more hydrogen, carbon or other atoms of a Benzoazolylpiperazine Compound can be replaced by an isotope of the hydrogen, carbon or other atoms. Such compounds, which are encompassed by the present invention, are useful as research and diagnostic tools in metabolism pharmacokinetic studies and in binding assays.

4.3 Therapeutic Uses of the Benzoazolypiperazine Compounds

[3166] In accordance with the invention, the Benzoazolylpiperazine Compounds are administered to an animal in need of treatment or prevention of pain, UI, an ulcer, IBD, 113S, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression.

[3167] In one embodiment, an effective amount of a Benzoazolylpiperazine Compound can be used to treat or prevent any condition treatable or preventable by inhibiting VR1. Examples of conditions that are treatable or preventable by inhibiting VR1 include, but are not limited to, pain, UI, an ulcer, IBD, and IBS.

[3168] In another embodiment, an effective amount of a Benzoazolylpiperazine Compound can be used to treat or prevent any condition treatable or preventable by inhibiting mGluR5. Examples of conditions that are treatable or preventable by inhibiting mGluR5 include, but are not limited to, pain, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, a pruritic condition, and psychosis.

[3169] In another embodiment, an effective amount of a Benzoazolylpiperazine Compound can be used to treat or prevent any condition treatable or preventable by inhibiting mGluR1. Examples of conditions that are treatable or preventable by inhibiting mGluR1 include, but are not limited to, pain, UI, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, and depression.

[3170] The Benzoazolylpiperazine Compounds can be used to treat or prevent acute or chronic pain. Examples of pain treatable or preventable using the Benzoazolylpiperazine Compounds include, but are not limited to, cancer pain, central pain, labor pain, myocardial infarction pain, pancreatic pain, colic pain, post-operative pain, headache pain, muscle pain, pain associated with intensive care, arthritic pain, and pain associated with a periodontal disease, including gingivitis and periodontitis.

[3171] The pain to be treated or prevented can be associated with inflammation associated with an inflammatory disease, which can arise where there is an inflammation of the body tissue, and which can be a local inflammatory response and/or a systemic inflammation. For example, the Benzoazolylpiperazine Compounds can be used to treat, or prevent pain associated with inflammatory disease including, but not limited to: organ transplant rejection; reoxygenation injury resulting from organ transplantation (see Grupp et al., J. Mol, Cell Cardiol. 31:297-303 (1999)) including, but not limited to, transplantation of the heart, lung, liver, or kidney; chronic inflammatory diseases of the joints, including arthritis, rheumatoid arthritis, osteoarthritis and bone diseases associated with increased bone resorption; inflammatory bowel diseases, such as ileitis, ulcerative colitis, Barrett's syndrome, and Crohn's disease; inflammatory lung diseases, such as asthma, adult respiratory distress syndrome, and chronic obstructive airway disease; inflammatory diseases of the eye, including corneal dystrophy, trachoma, onchocerciasis, uveitis, sympathetic ophthalmitis and endophthalmitis; chronic inflammatory disease of the gum, including gingivitis and periodontitis; tuberculosis; leprosy; inflammatory diseases of the kidney, including uremic complications, glomerulonephritis and nephrosis; inflammatory disease of the skin, including sclerodermatitis, psoriasis and eczema; inflammatory diseases of the central nervous system, including chronic demyelinating diseases of the nervous system, multiple sclerosis, AIDS-related neurodegeneration and Alzheimer's disease, infectious meningitis, encephalomyelitis, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and viral or autoimmune encephalitis; autoimmune diseases, including Type I and Type II diabetes mellitus; diabetic complications, including, but not limited to, diabetic cataract, glaucoma, retinopathy, nephropathy (such as microaluminuria and progressive diabetic nephropathy), polyneuropathy, mononeuropathies, autonomic neuropathy, gangrene of the feet, atherosclerotic coronary arterial disease, peripheral arterial disease, nonketotic hyperglycemic-hyperosmolar coma, foot ulcers, joint problems, and a skin or mucous membrane complication (such as an infection, a shin spot, a candidal infection or necrobiosis lipoidica diabeticorum); immune-complex vasculitis, and systemic lupus erythematosus (SLE); inflammatory disease of the heart, such as cardiomyopathy, ischemic heart disease hypercholesterolemia, and artherosclerosis; as well as various other diseases that can have significant inflammatory components, including preeclampsia, chronic liver failure, brain and spinal cord trauma, and cancer. The Benzoazolylpiperazine Compounds can also be used for inhibiting, treating, or preventing pain associated with inflammatory disease that can, for example, be a systemic inflammation of the body, exemplified by gram-positive or gram negative shock, hemorrhagic or anaphylactic shock, or shock induced by cancer chemotherapy in response to pro-inflammatory cytokines, e.g., shock associated with pro-inflammatory cytokines. Such shock can be induced, e.g., by a chemotherapeutic agent that is administered as a treatment for cancer.

[3172] The Benzoazolylpiperazine Compounds can be used to treat or prevent UI. Examples of UI treatable or preventable using the Benzoazolylpiperazine Compounds include, but are not limited to, urge incontinence, stress incontinence, overflow incontinence, neurogenic incontinence, and total incontinence.

[3173] The Benzoazolylpiperazine Compounds can be used to treat or prevent an ulcer. Examples of ulcers treatable or preventable using the Benzoazolylpiperazine Compounds include, but are not limited to, a duodenal ulcer, a gastric ulcer, a marginal ulcer, an esophageal ulcer, or a stress ulcer.

[3174] The Benzoazolylpiperazine Compounds can be used to treat or prevent IBD, including Crohn's disease and ulcerative colitis.

[3175] The Benzoazolylpiperazine Compounds can be used to treat or prevent IBS. Examples of IBS treatable or preventable using the Benzoazolylpiperazine Compounds include, but are not limited to, spastic-colon-type IBS and constipation-predominant IBS.

[3176] The Benzoazolylpiperazine Compounds can be used to treat or prevent an addictive disorder, including but not limited to, an eating disorder, an impulse-control disorder, an alcohol-related disorder, a nicotine-related disorder, an amphetamine-related disorder, a cannabis-related disorder, a cocaine-related disorder, an hallucinogen-related disorder, an inhalant-related disorders, and an opioid-related disorder, all of which are further sub-classified as listed below.

[3177] Eating disorders include, but are not limited to, Bulimia Nervosa, Nonpurging Type; Bulimia Nervosa, Purging Type; Anorexia; and Eating Disorder not otherwise specified (NOS).

[3178] Impulse control disorders include, but are not limited to, Intermittent Explosive Disorder, Kleptomania, Pyromania, Pathological Gambling, Trichotillomania, and Impulse Control Disorder not otherwise specified (NOS).

[3179] Alcohol-related disorders include, but are not limited to, Alcohol-Induced Psychotic Disorder with delusions, Alcohol Abuse, Alcohol Intoxication, Alcohol Withdrawal, Alcohol Intoxication Delirium, Alcohol Withdrawal Delirium, Alcohol-Induced Persisting Dementia, Alcohol-Induced Persisting Amnestic Disorder, Alcohol Dependence, Alcohol-Induced Psychotic Disorder with hallucinations, Alcohol-Induced Mood Disorder, Alcohol-Induced Anxiety Disorder, Alcohol-Induced Sexual Dysfunction, Alcohol-Induced Sleep Disorder, Alcohol-Related Disorder not otherwise specified (NOS), Alcohol Intoxication, and Alcohol Withdrawal.

[3180] Nicotine-related disorders include, but are not limited to, Nicotine Dependence, Nicotine Withdrawal, and Nicotine-Related Disorder not otherwise specified (NOS).

[3181] Amphetamine-related disorders include, but are not limited to, Amphetamine Dependence, Amphetamine Abuse, Amphetamine Intoxication, Amphetamine Withdrawal, Amphetamine Intoxication Delirium, Amphetamine-Induced Psychotic Disorder with delusions, Amphetamine-Induced Psychotic Disorders with hallucinations, Amphetamine-Induced Mood Disorder, Amphetamine-Induced Anxiety Disorder, Amphetamine-Induced Sexual Dysfunction, Amphetamine-Induced Sleep Disorder, Amphetamine Related Disorder not otherwise specified (NOS), Amphetamine Intoxication, and Amphetamine Withdrawal.

[3182] Cannabis-related disorders include, but are not limited to, Cannabis Dependence, Cannabis Abuse, Cannabis Intoxication, Cannabis Intoxication Delirium, Cannabis-Induced Psychotic Disorder with delusions, Cannabis-Induced Psychotic Disorder with hallucinations, Cannabis-Induced Anxiety Disorder, Cannabis Related Disorder not otherwise specified (NOS), and Cannabis Intoxication.

[3183] Cocaine-related disorders include, but are not limited to, Cocaine Dependence, Cocaine Abuse, Cocaine Intoxication, Cocaine Withdrawal, Cocaine Intoxication Delirium, Cocaine-Induced Psychotic Disorder with delusions, Cocaine-Induced Psychotic Disorders with hallucinations, Cocaine-Induced Mood Disorder, Cocaine-Induced Anxiety Disorder, Cocaine-Induced Sexual Dysfunction, Cocaine-Induced Sleep Disorder, Cocaine Related Disorder not otherwise specified (NOS), Cocaine Intoxication, and Cocaine Withdrawal.

[3184] Hallucinogen-related disorders include, but are not limited to, Hallucinogen Dependence, Hallucinogen Abuse, Hallucinogen Intoxication, Hallucinogen Withdrawal, Hallucinogen Intoxication Delirium, Hallucinogen-Induced Psychotic Disorder with delusions, Hallucinogen-Induced Psychotic Disorders with hallucinations, Hallucinogen-Induced Mood Disorder, Hallucinogen-Induced Anxiety Disorder, Hallucinogen-Induced Sexual Dysfunction, Hallucinogen-Induced Sleep Disorder, Hallucinogen Related Disorder not otherwise specified (NOS), Hallucinogen Intoxication, and Hallucinogen Persisting Perception Disorder (Flashbacks).

[3185] Inhalant-related disorders include, but are not limited to, Inhalant Dependence, Inhalant Abuse, Inhalant Intoxication, Inhalant Intoxication Delirium, Inhalant-Induced Psychotic Disorder with delusions, Inhalant-Induced Psychotic Disorder with hallucinations, Inhalant-Induced Anxiety Disorder, Inhalant Related Disorder not otherwise specified (NOS), and Inhalant Intoxication.

[3186] Opioid-related disorders include, but are not limited to, Opioid Dependence, Opioid Abuse, Opioid Intoxication, Opioid Intoxication Delirium, Opioid-Induced Psychotic Disorder with delusions, Opioid-Induced Psychotic Disorder with hallucinations, Opioid-Induced Anxiety Disorder, Opioid Related Disorder not otherwise specified (NOS), Opioid Intoxication, and Opioid Withdrawal.

[3187] The Benzoazolylpiperazine Compounds can be used to treat or prevent Parkinson's disease and parkinsonism and the symptoms associated with Parkinson's disease and parkinsonism, including but not limited to, bradykinesia, muscular rigidity, resting tremor, and impairment of postural balance.

[3188] The Benzoazolylpiperazine Compounds can be used to treat or prevent generalized anxiety or severe anxiety and the symptoms associated with anxiety, including but not limited to, restlessness; tension; tachycardia; dyspnea; depression, including chronic “neurotic” depression; panic disorder; agoraphobia and other specific phobias; eating disorders; and personality disorders.

[3189] The Benzoazolylpiperazine Compounds can be used to treat or prevent epilepsy, including but not limited to, partial epilepsy, generalized epilepsy, and the symptoms associated with epilepsy, including but not limited to, simple partial seizures, jacksonian seizures, complex partial (psychomotor) seizures, convulsive seizures (grand mal or tonic-clonic seizures), petit mal (absence) seizures, and status epilepticus.

[3190] The Benzoazolylpiperazine Compounds can be used to treat or prevent strokes, including but not limited to, ischemic strokes and hemorrhagic strokes.

[3191] The Benzoazolylpiperazine Compounds can be used to treat or prevent a seizure, including but not limited to, infantile spasms, febrile seizures, and epileptic seizures.

[3192] The Benzoazolylpiperazine Compounds can be used to treat or prevent a pruritic condition, including but not limited to, pruritus caused by dry skin, scabies, dermatitis, herpetiformis, atopic dermatitis, pruritus vulvae et ani, miliaria, insect bites, pediculosis, contact dermatitis, drug reactions, urticaria, urticarial eruptions of pregnancy, psoriasis, lichen planus, lichen simplex chronicus, exfoliative dermatitis, folliculitis, bullous pemphigoid, or fiberglass dermatitis.

[3193] The Benzoazolylpiperazine Compounds can be used to treat or prevent psychosis, including but not limited to, schizophrenia, including paranoid schizophrenia, hebephrenic or disorganized schizophrenia, catatonic schizophrenia, undifferentiated schizophrenia, negative or deficit subtype schizophrenia, and non-deficit schizophrenia; a delusional disorder, including erotomanic subtype delusional disorder, grandiose subtype delusional disorder, jealous subtype delusional disorder, persecutory subtype delusional disorder, and somatic subtype delusional disorder; and brief psychosis.

[3194] The Benzoazolylpiperazine Compounds can be used to treat or prevent a cognitive disorder, including but not limited to, delirium and dementia such as multi-infarct dementia, dementia pugilistica, dimentia caused by AIDS, and dementia caused by Alzheimer's disease.

[3195] The Benzoazolylpiperazine Compounds can be used to treat or prevent a memory deficiency, including but not limited to, dissociative amnesia and dissociative fugue.

[3196] The Benzoazolylpiperazine Compounds can be used to treat or prevent restricted brain function, including but not limited to, that caused by surgery or an organ transplant, restricted blood supply to the brain, a spinal cord injury, a head injury, hypoxia, cardiac arrest, or hypoglycemia.

[3197] The Benzoazolylpiperazine Compounds can be used to treat or prevent Huntington's chorea.

[3198] The Benzoazolylpiperazine Compounds can be used to treat or prevent ALS.

[3199] The Benzoazolylpiperazine Compounds can be used to treat or prevent retinopathy, including but not limited to, arteriosclerotic retinopathy, diabetic arteriosclerotic retinopathy, hypertensive retinopathy, non-proliferative retinopathy, and proliferative retinopathy.

[3200] The Benzoazolylpiperazine Compounds can be used to treat or prevent a muscle spasm.

[3201] The Benzoazolylpiperazine Compounds can be used to treat or prevent a migraine including, but not limited to, migraine without aura (“common migraine”), migraine with aura (“classic migraine”), migraine without headache, basilar migraine, familial hemiplegic migraine, migrainous infarction, and migraine with prolonged aura.

[3202] The Benzoazolylpiperazine Compounds can be used to treat or prevent vomiting, including but not limited to, nausea vomiting, dry vomiting (retching), and regurgitation.

[3203] The Benzoazolylpiperazine Compounds can be used to treat or prevent dyskinesia, including but not limited to, tardive dyskinesia and biliary dyskinesia.

[3204] The Benzoazolylpiperazine Compounds can be used to treat or prevent depression, including but not limited to, major depression and bipolar disorder.

[3205] Applicants believe that the Benzoazolylpiperazine Compounds are antagonists for VR1.

[3206] The invention also relates to methods for inhibiting VR1 function in a cell comprising contacting a cell capable of expressing VR1 with an effective amount of a Benzoazolylpiperazine Compound. This method can be used in vitro, for example, as an assay to select cells that express VR1 and, accordingly, are useful as part of an assay to select compounds useful for treating or preventing pain, UI, an ulcer, IBD, or IBS. The method is also useful for inhibiting VR1 function in a cell in vivo, in an animal, a human in one embodiment, by contacting a cell, in an animal, with an effective amount of a Benzoazolylpiperazine Compound. In one embodiment, the method is useful for treating or preventing pain in an animal. In another embodiment, the method is useful for treating or preventing UI in an animal. In another embodiment, the method is useful for treating or preventing an ulcer in an animal. In another embodiment, the method is useful for treating or preventing IBD in an animal. In another embodiment, the method is useful for treating or preventing IBS in an animal.

[3207] Examples of tissue comprising cells capable of expressing VR1 include, but are not limited to, neuronal, brain, kidney, urothelium, and bladder tissue. Methods for assaying cells that express VR1 are well known in the art.

[3208] Applicants believe that the Benzoazolylpiperazine Compounds are antagonists for mGluR5.

[3209] The invention also relates to methods for inhibiting mGluR5 function in a cell comprising contacting a cell capable of expressing mGluR5 with an amount of a Benzoazolylpiperazine Compound effective to inhibit mGluR5 function in the cell. This method can be used in vitro, for example, as an assay to select cells that express mGluR5 and, accordingly, are useful as part of an assay to select compounds useful for treating or preventing pain, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, a pruritic condition, or psychosis. The method is also useful for inhibiting mGluR5 function in a cell in vivo, in an animal, a human in one embodiment, by contacting a cell, in an animal, with an amount of a Benzoazolylpiperazine Compound effective to inhibit mGluR5 function in the cell. In one embodiment, the method is useful for treating or preventing pain in an animal in need thereof. In another embodiment, the method is useful for treating or preventing an addictive disorder in an animal in need thereof. In another embodiment, the method is useful for treating or preventing Parkinson's disease in an animal in need thereof. In another embodiment, the method is useful for treating or preventing parkinsonism in an animal in need thereof. In another embodiment, the method is useful for treating or preventing anxiety in an animal in need thereof In another embodiment, the method is useful for treating or preventing a pruritic condition in an animal in need thereof. In another embodiment, the method is useful for treating or preventing psychosis in an animal in need thereof.

[3210] Examples of cells capable of expressing mGluR5 are neuronal and glial cells of the central nervous system, particularly the brain, especially in the nucleus accumbens. Methods for assaying cells that express mGluR5 are well known in the art.

[3211] Applicants believe that the Benzoazolylpiperazine Compounds are antagonists for mGluR1.

[3212] The invention also relates to methods for inhibiting mGluR1 function in a cell comprising contacting a cell capable of expressing mGluR1 with an amount of a Benzoazolylpiperazine Compound effective to inhibit mGluR1 function in the cell. This method can be used in vitro, for example, as an assay to select cells that express mGluR1 and, accordingly, are useful as part of an assay to select compounds useful for treating or preventing pain, UI, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression. The method is also useful for inhibiting mGluR1 function in a cell in vivo, in an animal, a human in one embodiment, by contacting a cell, in an animal, with an amount of a Benzoazolylpiperazine Compound effective to inhibit mGluR1 function in the cell. In one embodiment, the method is useful for treating or preventing pain in an animal in need thereof. In another embodiment, the method is useful for treating or preventing UI in an animal in need thereof. In another embodiment, the method is useful for treating or preventing an addictive disorder in an animal in need thereof. In another embodiment, the method is useful for treating or preventing Parkinson's disease in an animal in need thereof. In another embodiment, the method is useful for treating or preventing parkinsonism in an animal in need thereof. In another embodiment, the method is useful for treating or preventing anxiety in an animal in need thereof. In another embodiment, the method is useful for treating or preventing epilepsy in an animal in need thereof. In another embodiment, the method is useful for treating or preventing stroke in an animal in need thereof. In another embodiment, the method is useful for treating or preventing a seizure in an animal in need thereof. In another embodiment, the method is useful for treating or preventing a pruritic condition in an animal in need thereof. In another embodiment, the method is useful for treating or preventing psychosis in an animal in need thereof. In another embodiment, the method is useful for treating or preventing a cognitive disorder in an animal in need thereof In another embodiment, the method is useful for treating or preventing a memory deficit in an animal in need thereof. In another embodiment, the method is useful for treating or preventing restricted brain function in an animal in need thereof. In another embodiment, the method is useful for treating or preventing Huntington's chorea in an animal in need thereof. In another embodiment, the method is useful for treating or preventing ALS in an animal in need thereof In another embodiment, the method is useful for treating or preventing dementia in an animal in need thereof. In another embodiment, the method is useful for treating or preventing retinopathy in an animal in need thereof. In another embodiment, the method is useful for treating or preventing a muscle spasm in an animal in need thereof. In another embodiment, the method is useful for treating or preventing a migraine in an animal in need thereof. In another embodiment, the method is useful for treating or preventing vomiting in an animal in need thereof. In another embodiment, the method is useful for treating or preventing dyskinesia in an animal in need thereof. In another embodiment, the method is useful for treating or preventing depression in an animal in need thereof.

[3213] Examples of cells capable of expressing mGluR1 include, but are not limited to, cerebellar Purkinje neuron cells, Purkinje cell bodies (punctate), cells of spine(s) of the cerebellum; neurons and neurophil cells of olfactory-bulb glomeruli; cells of the superficial layer of the cerebral cortex; hippocampus cells; thalamus cells; superior colliculus cells; and spinal trigeminal nucleus cells. Methods for assaying cells that express mGluR1 are well known in the art.

4.3.1 Therapeutic/Prophylactic Administration and Compositions of the Invention

[3214] Due to their activity, the Benzoazolylpiperazine Compounds are advantageously useful in veterinary and human medicine. As described above, the Benzoazolylpiperazine Compounds are useful for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal in need thereof.

[3215] When administered to an animal, the Benzoazolylpiperazine Compounds can be administered as a component of a composition that comprises a pharmaceutically acceptable vehicle. The present compositions, which comprise a Benzoazolylpiperazine Compound, can be administered orally. The Benzoazolylpiperazine Compounds of the invention can also be administered by any other convenient route, for example, by infusion or bolus injection, by absorption through epithelial or mucocutaneous linings (e.g., oral, rectal, and intestinal mucosa, etc.) and can be administered together with another biologically active agent. Administration can be systemic or local. Various delivery systems are known, e.g., encapsulation in liposomes, microparticles, microcapsules, capsules, etc., and can be used to administer the Benzoazolylpiperazine Compound.

[3216] Methods of administration include, but are not limited to, intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intranasal, epidural, oral, sublingual, intracerebral, intravaginal, transdermal, rectal, by inhalation, or topical, particularly to the ears, nose, eyes, or skin. The mode of administration can be left to the discretion of the practitioner. In most instances, administration will result in the release of the Benzoazolylpiperazine Compounds into the bloodstream.

[3217] In specific embodiments, it can be desirable to administer the Benzoazolylpiperazine Compounds locally. This can be achieved, for example, and not by way of limitation, by local infuision during surgery, topical application, e.g., in conjunction with a wound dressing after surgery, by injection, by means of a catheter, by means of a suppository or enema, or by means of an implant, said implant being of a porous, non-porous, or gelatinous material, including membranes, such as sialastic membranes, or fibers.

[3218] In certain embodiments, it can be desirable to introduce the Benzoazolylpiperazine Compounds into the central nervous system or gastrointestinal tract by any suitable route, including intraventricular, intrathecal, and epidural injection, and enema. Intraventricular injection can be facilitated by an intraventricular catheter, for example, attached to a reservoir, such as an Ommaya reservoir.

[3219] Pulmonary administration can also be employed, e.g., by use of an inhaler or nebulizer, and formulation with an aerosolizing agent, or via perfusion in a fluorocarbon or synthetic pulmonary surfactant. In certain embodiments, the Benzoazolylpiperazine Compounds can be formulated as a suppository, with traditional binders and excipients such as triglycerides.

[3220] In another embodiment, the Benzoazolylpiperazine Compounds can be delivered in a vesicle, in particular a liposome (see Langer, Science 249:1527-1533 (1990) and Treat et al., Liposomes in the Therapy ofInfectious Disease and Cancer 317-327 and 353-365 (1989)).

[3221] In yet another embodiment, the Benzoazolylpiperazine Compounds can be delivered in a controlled-release system or sustained-release system (see, e.g., Goodson, in Medical Applications of Controlled Release, supra, vol. 2, pp. 115-138 (1984)). Other controlled- or sustained-release systems discussed in the review by Langer, Science 249:1527-1533 (1990) can be used. In one embodiment, a pump can be used (Langer, Science 249:1527-1533 (1990); Sefton, CRC Crit. Ref. Biomed. Eng. 14:201(1987); Buchwald et al., Surgery 88:507 (1980); and Saudek et al., N. Engl. J. Med. 321:574 (1989)). In another embodiment, polymeric materials can be used (see Medical Applications of Controlled Release (Langer and Wise eds., 1974); Controlled Drug Bioavailability, Drug Product Design and Performance (Smolen and Ball eds., 1984); Ranger and Peppas, J. Macromol. Sci. Rev. Macromol. Chem. 23:61 (1983); Levy et al., Science 228:190 (1985); During et al., Ann. Neurol. 25:351 (1989); and Howard et al., J. Neurosurg. 71:105 (1989)). In yet another embodiment, a controlled- or sustained-release system can be placed in proximity of a target of the Benzoazolylpiperazine Compounds, e.g., the spinal column, brain, or gastrointestinal tract, thus requiring only a fraction of the systemic dose.

[3222] In one embodiment, the pharmaceutically acceptable vehicle is an excipient Such a pharmaceutical excipient can be a liquid, such as water or an oil, including those of petroleum, animal, vegetable, or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. The pharmaceutical excipients can be saline, gum acacia, gelatin, starch paste, talc, keratin, colloidal silica, urea and the like. In addition, auxiliary, stabilizing, thickening, lubricating, and coloring agents can be used. In one embodiment, the pharmaceutically acceptable excipients are sterile when administered to an animal. Water is a particularly useful excipient when the Benzoazolylpiperazine Compound is administered intravenously. Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid excipients, particularly for injectable solutions. Suitable pharmaceutical excipients also include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol and the like. The present compositions, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents.

[3223] The present compositions can take the form of solutions, suspensions, emulsion, tablets, pills, pellets, capsules, capsules containing liquids, powders, sustained-release formulations, suppositories, emulsions, aerosols, sprays, suspensions, or any other form suitable for use. In one embodiment, the composition is in the form of a capsule (see e.g., U.S. Pat. No. 5,698,155). Other examples of suitable pharmaceutical excipients are described in Remington's Pharmaceutical Sciences 1447-1676 (Alfonso R. Gennaro ed., 19th ed. 1995), incorporated herein by reference.

[3224] In one embodiment, the Benzoazolylpiperazine Compounds are formulated in accordance with routine procedures as a composition adapted for oral administration to human beings. Compositions for oral delivery can be in the form of tablets, lozenges, aqueous or oily suspensions, granules, powders, emulsions, capsules, syrups, or elixirs, for example. Orally administered compositions can contain one or more agents, for example, sweetening agents such as fructose, aspartame or saccharin; flavoring agents such as peppermint, oil of wintergreen, or cherry; coloring agents; and preserving agents, to provide a pharmaceutically palatable preparation. Moreover, where in tablet or pill form, the compositions can be coated to delay disintegration and absorption in the gastrointestinal tract thereby providing a sustained action over an extended period of time. Selectively permeable membranes surrounding an osmotically active driving compound are also suitable for orally administered compositions. In these latter platforms, fluid from the environment surrounding the capsule is imbibed by the driving compound, which swells to displace the agent or agent composition through an aperture. These delivery platforms can provide an essentially zero order delivery profile as opposed to the spiked profiles of immediate release formulations. A time-delay material such as glycerol monostearate or glycerol stearate can also be used. Oral compositions can include standard excipients such as mannitol, lactose, starch, magnesium stearate, sodium saccharin, cellulose, and magnesium carbonate. In one embodiment, the excipients are of pharmaceutical grade.

[3225] In another embodiment, the Benzoazolylpiperazine Compounds can be formulated for intravenous administration. Typically, compositions for intravenous administration comprise sterile isotonic aqueous buffer. Where necessary, the compositions can also include a solubilizing agent. Compositions for intravenous administration can optionally include a local anesthetic such as lignocaine to lessen pain at the site of the injection. Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampule or sachette indicating the quantity of active agent. Where the Benzoazolylpiperazine Compounds are to be administered by infusion, they can be dispensed, for example, with an infusion bottle containing sterile pharmaceutical grade water or saline. Where the Benzoazolylpiperazine Compounds are administered by injection, an ampule of sterile water for injection or saline can be provided so that the ingredients can be mixed prior to administration.

[3226] The Benzoazolylpiperazine Compounds can be administered by controlled-release or sustained-release means or by delivery devices that are well known to those of ordinary skill in the art. Examples include, but are not limited to, those described in U.S. Pat. Nos. 3,845,770; 3,916,899; 3,536,809; 3,598,123; 4,008,719; 5,674,533; 5,059,595; 5,591,767; 5,120,548; 5,073,543; 5,639,476; 5,354,556; and 5,733,566, each of which is incorporated herein by reference. Such dosage forms can be used to provide controlled- or sustained-release of one or more active ingredients using, for example, hydropropylmethyl cellulose, other polymer matrices, gels, permeable membranes, osmotic systems, multilayer coatings, microparticles, liposomes, microspheres, or a combination thereof to provide the desired release profile in varying proportions. Suitable controlled- or sustained-release formulations known to those of ordinary skill in the art, including those described herein, can be readily selected for use with the active ingredients of the invention. The invention thus encompasses single unit dosage forms suitable for oral administration such as, but not limited to, tablets, capsules, gelcaps, and caplets that are adapted for controlled- or sustained-release.

[3227] Controlled- or sustained-release pharmaceutical compositions can have a common goal of improving drug therapy over that achieved by their non-controlled or non-sustained counterparts. In one embodiment, a controlled- or sustained-release composition comprises a minimal amount of a Benzoazolylpiperazine Compound to cure or control the condition in a minimum amount of time. Advantages of controlled- or sustained-release compositions include extended activity of the drug, reduced dosage frequency, and increased patient compliance. In addition, controlled- or sustained-release compositions can favorably affect the time of onset of action or other characteristics, such as blood levels of the Benzoazolylpiperazine Compound, and can thus reduce the occurrence of adverse side effects.

[3228] Controlled- or sustained-release compositions can initially release an amount of a Benzoazolylpiperazine Compound that promptly produces the desired therapeutic or prophylactic effect, and gradually and continually release other amounts of the Benzoazolylpiperazine Compound to maintain this level of therapeutic or prophylactic effect over an extended period of time. To maintain a constant level of the Benzoazolylpiperazine Compound in the body, the Benzoazolylpiperazine Compound can be released from the dosage form at a rate that will replace the amount of Benzoazolylpiperazine Compound being metabolized and excreted from the body. Controlled- or sustained-release of an active ingredient can be stimulated by various conditions, including but not limited to, changes in pH, changes in temperature, concentration or availability of enzymes, concentration or availability of water, or other physiological conditions or compounds.

[3229] The amount of the Benzoazolylpiperazine Compound that is effective in the treatment or prevention of pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression and can be determined by standard clinical techniques. In addition, in vitro or in vivo assays can optionally be employed to help identify optimal dosage ranges. The precise dose to be employed will also depend on the route of administration, and the seriousness of the condition being treated and should be decided according to the judgment of the practitioner and each patient's circumstances in view of, e.g., published clinical studies. Suitable effective dosage amounts, however, range from about 10 micrograms to about 2500 milligrams about every 4 h, although they are typically about 100 mg or less. In one embodiment, the effective dosage amount ranges from about 0.01 milligrams to about 100 milligrams of a Benzoazolylpiperazine Compound about every 4 h, in another embodiment, about 0.020 milligrams to about 50 milligrams about every 4 h, and in another embodiment, about 0.025 milligrams to about 20 milligrams about every 4 h. The effective dosage amounts described herein refer to total amounts administered; that is, if more than one Benzoazolylpiperazine Compound is administered, the effective dosage amounts correspond to the total amount administered.

[3230] Where a cell capable of expressing VR1, mGluR5, or mGluR1 is contacted with a Benzoazolylpiperazine Compound in vitro, the amount effective for inhibiting the receptor function in a cell will typically range from about 0.01 μg/L to about 5 mg/L, in one embodiment, from about 0.01 μg/L to about 2.5 mg/L, in another embodiment, from about 0.01 μg/L to about 0.5 mg/L, and in another embodiment, from about 0.01 μg/L to about 0.25 mg/L of a solution or suspension of a pharmaceutically acceptable carrier or excipient. In one embodiment, the volume of solution or suspension is from about 1 μL to about 1 mL. In another embodiment, the volume of solution or suspension is about 200 μL.

[3231] Where a cell capable of expressing VR1, mGluR5, or mGluR1 is contacted with a Benzoazolylpiperazine Compound in vivo, the amount effective for inhibiting the receptor function in a cell will typically range from about 0.01 mg to about 100 mg/kg of body weight per day, in one embodiment, from about 0.1 mg to about 50 mg/kg body weight per day, and in another embodiment, from about 1 mg to about 20 mg/kg of body weight per day.

[3232] The Benzoazolylpiperazine Compounds can be assayed in vitro or in vivo for the desired therapeutic or prophylactic activity prior to use in humans. Animal model systems can be used to demonstrate safety and efficacy.

[3233] The present methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal in need thereof can further comprise administering to the animal being administered a Benzoazolylpiperazine Compound another therapeutic agent. In one embodiment, the other therapeutic agent is administered in an effective amount.

[3234] The present methods for inhibiting VR1 function in a cell capable of expressing VR1 can further comprise contacting the cell with an effective amount of another therapeutic agent.

[3235] The present methods for inhibiting mGluR5 function in a cell capable of expressing mGluR5 can further comprise contacting the cell with an effective amount of another therapeutic agent.

[3236] The present methods for inhibiting mGluR1 function in a cell capable of expressing mGluR1 can further comprise contacting the cell with an effective amount of another therapeutic agent.

[3237] The other therapeutic agent includes, but is not limited to, an opioid agonist, a non-opioid analgesic, a non-steroid anti-inflammatory agent, an antimigraine agent, a Cox-II inhibitor, an antiemetic, a β-adrenergic blocker, an anticonvulsant, an antidepressant, a Ca2+-channel blocker, an anticancer agent, an agent for treating or preventing UI, an agent for treating or preventing an ulcer, an agent for treating or preventing IBD, an agent for treating or preventing IBS, an agent for treating addictive disorder, an agent for treating Parkinson's disease and parkinsonism, an agent for treating anxiety, an agent for treating epilepsy, an agent for treating a stroke, an agent for treating a seizure, an agent for treating a pruritic condition, an agent for treating psychosis, an agent for treating Huntington's chorea, an agent for treating ALS, an agent for treating a cognitive disorder, an agent for treating a migraine, an agent for treating vomiting, an agent for treating dyskinesia, or an agent for treating depression, and mixtures thereof.

[3238] Effective amounts of the other therapeutic agents are well known to those skilled in the art. However, it is well within the skilled artisan's purview to determine the other therapeutic agent's optimal effective-amount range. In one embodiment of the invention, where another therapeutic agent is administered to an animal, the effective amount of the Benzoazolylpiperazine Compound is less than its effective amount would be where the other therapeutic agent is not administered. In this case, without being bound by theory, it is believed that the Benzoazolylpiperazine Compounds and the other therapeutic agent act synergistically to treat or prevent pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression.

[3239] Examples of useful opioid agonists include, but are not limited to, alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, clonitazene, codeine, desomorphine, dextromoramide, dezocine, diampromide, diamorphone, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levorphanol, levophenacylmorphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metopon, morphine, myrophine, nalbuphine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, proheptazine, promedol, properidine, propiram, propoxyphene, sufentanil, tilidine, tramadol, pharmaceutically acceptable salts thereof, and mixtures thereof.

[3240] In certain embodiments, the opioid agonist is selected from codeine, hydromorphone, hydrocodone, oxycodone, dihydrocodeine, dihydromorphine, morphine, tramadol, oxymorphone, pharmaceutically acceptable salts thereof, and mixtures thereof.

[3241] Examples of useful non-opioid analgesics include non-steroidal anti-inflammatory agents, such as aspirin, ibuprofen, diclofenac, naproxen, benoxaprofen, flurbiprofen, fenoprofen, flubufen, ketoprofen, indoprofen, piroprofen, carprofen, oxaprozin, pramoprofen, muroprofen, trioxaprofen, suprofen, aminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxpinac, mefenarnic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflurisal, flufenisal, piroxicam, sudoxicam, isoxicam, and pharmaceutically acceptable salts thereof, and mixtures thereof. Other suitable non-opioid analgesics include the following, non-limiting, chemical classes of analgesic, antipyretic, nonsteroidal anti-inflammatory drugs: salicylic acid derivatives, including aspirin, sodium salicylate, choline magnesium trisalicylate, salsalate, diflunisal, salicylsalicylic acid, sulfasalazine, and olsalazin; para-aminophennol derivatives including acetaminophen and phenacetin; indole and indene acetic acids, including indomethacin, sulindac, and etodolac; heteroaryl acetic acids, including tolmetin, diclofenac, and ketorolac; anthranilic acids (fenamates), including mefenamic acid and meclofenamic acid;. enolic acids, including oxicams (piroxicam, tenoxicam), and pyrazolidinediones (phenylbutazone, oxyphenthartazone); and alkanones, including nabumetone. For a more detailed description of the NSAIDs, see Paul A. Insel, Analgesic-Antipyretic and Anti-inflammatory Agents and Drugs Employed in the Treatment of Gout, in Goodman & Gilman's The Pharmacological Basis of Therapeutics 617-57 (Perry B. Molinhoff and Raymond W. Ruddon eds., 9^(th) ed. 1996) and Glen R. Hanson, Analgesic, Antipyretic and Anti-Inflammatory Drugs in Remington: The Science and Practice ofPharmacy Vol II 1196-1221 (A.R. Gennaro ed. 19th ed. 1995) which are hereby incorporated by reference in their entireties.

[3242] Examples of useful Cox-II inhibitors and 5-lipoxygenase inhibitors, as well as combinations thereof, are described in U.S. Pat. No. 6,136,839, which is hereby incorporated by reference in its entirety. Examples of useful Cox-II inhibitors include, but are not limited to, rofecoxib and celecoxib.

[3243] Examples of useful antimigraine agents include, but are not limited to, alpiropride, dihydroergotamine, dolasetron, ergocornine, ergocorninine, ergocryptine, ergot, ergotamine, flumedroxone acetate, fonazine, lisuride, lomerizine, methysergide oxetorone, pizotyline, and mixtures thereof.

[3244] The other therapeutic agent can also be an agent useful for reducing any potential side effects of a Benzoazolylpiperazine Compounds. For example, the other therapeutic agent can be an antiemetic agent. Examples of useful antiemetic agents include, but are not limited to, metoclopromide, domperidone, prochlorperazine, promethazine, chlorpromazine, trimethobenzamide, ondansetron, granisetron, hydroxyzine, acetylleucine monoethanolamine, alizapride, azasetron, benzquinamide, bietanautine, bromopride, buclizine, clebopride, cyclizine, dimenhydrinate, diphenidol, dolasetron, meclizine, methallatal, metopimazine, nabilone, oxyperndyl, pipamazine, scopolamine, sulpiride, tetrahydrocannabinol, thiethylperazine, thioproperazine, tropisetron, and mixtures thereof.

[3245] Examples of useful β-adrenergic blockers include, but are not limited to, acebutolol, alprenolol, amosulabol, arotinolol, atenolol, befinolol, betaxolol, bevantolol, bisoprolol, bopindolol, bucumolol, bufetolol, bufuralol, bunitrolol, bupranolol, butidrine hydrochloride, butofilolol, carazolol, carteolol, carvedilol, celiprolol, cetamolol, cloranolol, dilevalol, epanolol, esmolol, indenolol, labetalol, levobunolol, mepindolol, metipranolol, metoprolol, moprolol, nadolol, nadoxolol, nebivalol, nifenalol, nipradilol, oxprenolol, penbutolol, pindolol, practolol, pronethalol, propranolol, sotalol, sulfinalol, talinolol, tertatolol, tilisolol, timolol, toliprolol, and xibenolol.

[3246] Examples of useful anticonvulsants include, but are not limited to, acetylpheneturide, albutoin, aloxidone, aminoglutethimide, 4-amino-3-hydroxybutyric acid, atrolactamide, beclamide, buramate, calcium bromide, carbamazepine, cinromide, clomethiazole, clonazepam, decimemide, diethadione, dimethadione, doxenitroin, eterobarb, ethadione, ethosuximide, ethotoin, felbamate, fluoresone, gabapentin, 5-hydroxytryptophan, lamotrigine, magnesium bromide, magnesium sulfate, mephenytoin, mephobarbital, metharbital, methetoin, methsuximide, 5-methyl-5-(3-phenanthryl)-hydantoin, 3-methyl-5-phenylhydantoin, narcobarbital, nimetazepam, nitrazepam, oxcarbazepine, paramethadione, phenacemide, phenetharbital, pheneturide, phenobarbital, phensuximide, phenylmethylbarbituric acid, phenytoin, phethenylate sodium, potassium bromide, pregabaline, primidone, progabide, sodium bromide, solanum, strontium bromide, suclofenide, sulthiame, tetrantoin, tiagabine, topiramate, trimethadione, valproic acid, valpromide, vigabatrin, and zonisamide.

[3247] Examples of useful antidepressants include, but are not limited to, binedaline, caroxazone, citalopram, dimethazan, fencamine, indalpine, indeloxazine hydrocholoride, nefopam, nomifensine, oxitriptan, oxypertine, paroxetine, sertraline, thiazesim, trazodone, benmoxine, iproclozide, iproniazid, isocarboxazid, nialamide, octamoxin, phenelzine, cotinine, rolicyprine, rolipram, maprotiline, metralindole, mianserin, mirtazepine, adinazolam, amitriptyline, amitriptylinoxide, amoxapine, butriptyline, clomipramine, demexiptiline, desipramine, dibenzepin, dimetacrine, dothiepin, doxepin, fluacizine, imipramine, imipramine N-oxide, iprindole, lofepramine, melitracen, metapramine, nortriptyline, noxiptilin, opipramol, pizotyline, propizepine, protriptyline, quinupramine, tianeptine, trimipramine, adrafinil, benactyzine, bupropion, butacetin, dioxadrol, duloxetine, etoperidone, febarbamate, femoxetine, fenpentadiol, fluoxetine, fluvoxamine, hematoporphyrin, hypericin, levophacetoperane, medifoxamine, milnacipran, minaprine, moclobemide, nefazodone, oxaflozane, piberaline, prolintane, pyrisuccideanol, ritanserin, roxindole, rubidium chloride, sulpiride, tandospirone, thozalinone, tofenacin, toloxatone, tranylcypromine, L-tryptophan, venlafaxine, viloxazine, and zimeldine.

[3248] Examples of useful Ca2+-channel blockers include, but are not limited to, bepridil, clentiazem, diltiazem, fendiline, gallopamil, mibefradil, prenylamine, semotiadil, terodiline, verapamil, amlodipine, aranidipine, barnidipine, benidipine, cilnidipine, efonidipine, elgodipine, felodipine, isradipine, lacidipine, lercanidipine, manidipine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, cinnarizine, flunarizine, lidoflazine, lomerizine, bencyclane, etafenone, fantofarone, and perhexiline.

[3249] Examples of useful anticancer agents include, but are not limited to, acivicin, aclarubicin, acodazole hydrochloride, acronine, adozelesin, aldesleukin, altretamine, ambomycin, ametantrone acetate, aminoglutethimide, amsacrine, anastrozole, anthramycin, asparaginase, asperlin, azacitidine, azetepa, azotomycin, batimastat, benzodepa, bicalutamide, bisantrene hydrochloride, bisnafide dimesylate, bizelesin, bleomycin sulfate, brequinar sodium, bropirimine, busulfan, cactinomycin, calusterone, caracemide, carbetimer, carboplatin, carmustine, carubicin hydrochloride, carzelesin, cedefingol, chlorambucil, cirolemycin, cisplatin, cladribine, crisnatol mesylate, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin hydrochloride, decitabine, dexormaplatin, dezaguanine, dezaguanine mesylate, diaziquone, docetaxel, doxorubicin, doxorubicin hydrochloride, droloxifene, droloxifene citrate, dromostanolone propionate, duazomycin, edatrexate, eflornithine hydrochloride, elsamitrucin, enloplatin, enpromate, epipropidine, epirubicin hydrochloride, erbulozole, esorubicin hydrochloride, estramustine, estramustine phosphate sodium, etanidazole, etoposide, etoposide phosphate, etoprine, fadrozole hydrochloride, fazarabine, fenretinide, floxuridine, fludarabine phosphate, fluorouracil, flurocitabine, fosquidone, fostriecin sodium, gemcitabine, gemcitabine hydrochloride, hydroxyurea, idarubicin hydrochloride, ifosfamide, ilmofosine, interleukin II (including recombinant interleukin II or rIL2), interferon alfa-2a, interferon alfa-2b, interferon alfa-n1, interferon alfa-n3, interferon beta-I a, interferon gamma-I b, iproplatin, irinotecan hydrochloride, lanreotide acetate, letrozole, leuprolide acetate, liarozole hydrochloride, lometrexol sodium, lomustine, losoxantrone hydrochloride, masoprocol, maytansine, mechlorethamine hydrochloride, megestrol acetate, melengestrol acetate, melphalan, menogaril, mercaptopurine, methotrexate, methotrexate sodium, metoprine, meturedepa, mitindomide, mitocarcin, mitocromin, mitogillin, mitomalcin, mitomycin, mitosper, mitotane, mitoxantrone hydrochloride, mycophenolic acid, nocodazole, nogalamycin, ormaplatin, oxisuran, paclitaxel, pegaspargase, peliomycin, pentamustine, peplomycin sulfate, perfosfamide, pipobroman, piposulfan, piroxantrone hydrochloride, plicamycin, plomestane, porfimer sodium, porfiromycin, prednimustine, procarbazine hydrochloride, puromycin, puromycin hydrochloride, pyrazofurin, riboprine, rogletimide, safingol, safingol hydrochloride, semustine, simtrazene, sparfosate sodium, sparsomycin, spirogermanium hydrochloride, spiromustine, spiroplatin, streptonigrin, streptozocin, sulofenur, talisomycin, tecogalan sodium, tegafur, teloxantrone hydrochloride, temoporfin, teniposide, teroxirone, testolactone, thiamiprine, thioguanine, thiotepa, tiazofturin, tirapazamine, toremifene citrate, trestolone acetate, triciribine phosphate, trimetrexate, trimetrexate glucuronate, triptorelin, tubulozole hydrochloride, uracil mustard, uredepa, vapreotide, verteporfin, vinblastine sulfate, vincristine sulfate, vindesine, vindesine sulfate, vinepidine sulfate, vinglycinate sulfate, vinleurosine sulfate, vinorelbine tartrate, vinrosidine sulfate, vinzolidine sulfate, vorozole, zeniplatin, zinostatin, zorubicin hydrochloride.

[3250] Examples of other anti-cancer drugs include, but are not limited to, 20-epi-1,25 dihydroxyvitamin D3; 5-ethynyluracil; abiraterone; aclarubicin; acylfulvene; adecypenol; adozelesin; aldesleukin; ALL-TK antagonists; altretamine; ambamustine; amidox; amifostine; aminolevulinic acid; amrubicin; amsacrine; anagrelide; anastrozole; andrographolide; angiogenesis inhibitors; antagonist D; antagonist G; antarelix; anti-dorsalizing morphogenetic protein1; antiandrogen, prostatic carcinoma; antiestrogen; antineoplaston; antisense oligonucleotides; aphidicolin glycinate; apoptosis gene modulators; apoptosis regulators; apurinic acid; ara-CDP-DL-PTBA; arginine deaminase; asulacrine; atamestane; atrimustine; axinastatin 1; axinastatin 2; axinastatin 3; azasetron; azatoxin; azatyrosine; baccatin III derivatives; balanol; batimastat; BCR/ABL antagonists; benzochlorins; benzoylstaurosporine; beta lactam derivatives; beta-alethine; betaclamycin B; betulinic acid; bFGF inhibitor; bicalutamide; bisantrene; bisaziridinylspermine; bisnafide; bistratene A; bizelesin; breflate; bropirimine; budotitane; buthionine sulfoximine; calcipotriol; calphostin C; camptothecin derivatives; canarypox IL-2; capecitabine; carboxamide-amino-triazole; carboxyamidotriazole; CaRest M3; CARN 700; cartilage derived inhibitor; carzelesin; casein kinase inhibitors (ICOS); castanospermine; cecropin B; cetrorelix; chlorlns; chloroquinoxaline sulfonamide; cicaprost; cis-porphyrin; cladribine; clomifene analogues; clotrimazole; collismycin. A; collismycin B; combretastatin A4; combretastatin analogue; conagenin; crambescidin 816; crisnatol; cryptophycin 8; cryptophycin A derivatives; curacin A; cyclopentanthraquinones; cycloplatam; cypemycin; cytarabine ocfosfate; cytolytic factor; cytostatin; dacliximab; decitabine; dehydrodidemnin B; deslorelin; dexamethasone; dexifosfamide; dexrazoxane; dexverapamil; diaziquone; didemnin B; didox; diethylnorspermine; dihydro-5-azacytidine; dihydrotaxol, 9-; dioxamycin; diphenyl spiromustine; docetaxel; docosanol; dolasetron; doxifluridine; droloxifene; dronabinol; duocarmycin SA; ebselen; ecomustine; edelfosine; edrecolomab; eflomithine; elemene; emitefur; epirubicin; epristeride; estramustine analogue; estrogen agonists; estrogen antagonists; etanidazole; etoposide phosphate; exemestane; fadrozole; fazarabine; fenretinide; filgrastim; finasteride; flavopiridol; flezelastine; fluasterone; fludarabine; fluorodaunorunicin hydrochloride; forfenimex; formestane; fostriecin; fotemustine; gadolinium texaphyrin; gallium nitrate; galocitabine; ganirelix; gelatinase inhibitors; gemcitabine; glutathione inhibitors; hepsulfam; heregulin; hexamethylene bisacetamide; hypericin; ibandronic acid; idarubicin; idoxifene; idramantone; ilmofosine; ilomastat; imidazoacridones; imiquimod; immunostimulant peptides; insulin-like growth factor-1 receptor inhibitor; interferon agonists; interferons; interleukins; iobenguane; iododoxorubicin; ipomeanol, 4-; iroplact; irsogladine; isobengazole; isohomohalicondrin B; itasetron; jasplakinolide; kahalalide F; lamellarin-N triacetate; lanreotide; leinamycin; lenograstim; lentinan sulfate; leptolstatin; letrozole; leukemia inhibiting factor; leukocyte alpha interferon; leuprolide+estrogen+progesterone; leuprorelin; levamisole; liarozole; linear polyamine analogue; lipophilic disaccharide peptide; lipophilic platinum compounds; lissoclinamide 7; lobaplatin; lombricine; lometrexol; lonidamine; losoxantrone; lovastatin; loxoribine; lurtotecan; lutetium texaphyrin; lysofylline; lytic peptides; maitansine; mannostatin A; marimastat; masoprocol; maspin; matrilysin inhibitors; matrix metalloproteinase inhibitors; menogaril; merbarone; meterelin; methioninase; metoclopramide; MIF inhibitor; mifepristone; miltefosine; mirimostim; mismatched double stranded RNA; mitoguazone; mitolactol; mitomycin analogues; mitonafide; mitotoxin fibroblast growth factor-saporin; mitoxantrone; mofarotene; molgramostim; monoclonal antibody, human chorionic gonadotrophin; monophosphoryl lipid A+myobacterium cell wall sk; mopidamol; multiple drug resistance gene inhibitor; multiple tumor suppressor 1-based therapy; mustard anticancer agent; mycaperoxide B; mycobacterial cell wall extract; myriaporone; N-acetyldinaline; N-substituted benzamides; nafarelin; nagrestip; naloxone+pentazocine; napavin; naphterpin; nartograstim; nedaplatin; nemorubicin; neridronic acid; neutral endopeptidase; nilutamide; nisamycin; nitric oxide modulators; nitroxide antioxidant; nitrullyn; O6-benzylguanine; octreotide; okicenone; oligonucleotides; onapristone; ondansetron; ondansetron; oracin; oral cytokine inducer; ormaplatin; osaterone; oxaliplatin; oxaunomycin; paclitaxel; paclitaxel analogues; paclitaxel derivatives; palauamine; palmitoylrhizoxin; pamidronic acid; panaxytriol; panomifene; parabactin; pazelliptine; pegaspargase; peldesine; pentosan polysulfate sodium; pentostatin; pentrozole; perflubron; perfosfamide; perillyl alcohol; phenazinomycin; phenylacetate; phosphatase inhibitors; picibanil; pilocarpine hydrochloride; pirarubicin; piritrexim; placetin A; placetin B; plasminogen activator inhibitor; platinum complex; platinum compounds; platinum-triamine complex; porfimer sodium; porfiromycin; prednisone; propyl bis-acridone; prostaglandin J2;proteasome inhibitors; protein A-based immune modulator; protein kinase C inhibitor; protein kinase C inhibitors, microalgal; protein tyrosine phosphatase inhibitors; purine nucleoside phosphorylase inhibitors; purpurins; pyrazoloacridine; pyridoxylated hemoglobin polyoxyethylene conjugate; raf antagonists; raltitrexed; ramosetron; ras farnesyl protein transferase inhibitors; ras inhibitors; ras-GAP inhibitor; retelliptine demethylated; rhenium Re 186 etidronate; rhizoxin; ribozymes; RII retinamide; rogletimide; rohitukine; romurtide; roquinimex; rubiginone B 1; ruboxyl; safingol; saintopin; SarCNU; sarcophytol A; sargramostim; Sdi 1 mimetics; semustine; senescence derived inhibitor 1; sense oligonucleotides; signal transduction inhibitors; signal transduction modulators; single chain antigen binding protein; sizofiran; sobuzoxane; sodium borocaptate; sodium phenylacetate; solverol; somatomedin binding protein; sonermin; sparfosic acid; spicamycin D; spiromustine; splenopentin; spongistatin 1; squalamine; stem cell inhibitor; stem-cell division inhibitors; stipiamide; stromelysin inhibitors; sulfinosine; superactive vasoactive intestinal peptide antagonist; suradista; suramin; swainsonine; synthetic glycosaminoglycans; tallimustine; tamoxifen methiodide; tauromustine; tazarotene; tecogalan sodium; tegafur; tellurapyrylium; telomerase inhibitors; temoporfin; temozolomide; teniposide; tetrachlorodecaoxide; tetrazomine; thaliblastine; thiocoraline; thrombopoietin; thrombopoietin mimetic; thymalfasin; thymopoietin receptor agonist; thymotrinan; thyroid stimulating hormone; tin ethyl etiopurpurin; tirapazamine; titanocene bichloride; topsentin; toremifene; totipotent stem cell factor; translation inhibitors; tretinoin; triacetyluridine; triciribine; trimetrexate; triptorelin; tropisetron; turosteride; tyrosine kinase inhibitors; tyrphostins; UBC inhibitors; ubenimex; urogenital sinus-derived growth inhibitory factor; urokinase receptor antagonists; vapreotide; variolin B; vector system, erythrocyte gene therapy; velaresol; veramine; verdins; verteporfin; vinorelbine; vinxaltine; vitaxin; vorozole; zanoterone; zeniplatin; zilascorb; and zinostatin stimalamer.

[3251] Examples of useful therapeutic agents for treating or preventing UI include, but are not limited to, propantheline, imipramine, hyoscyamine, oxybutynin, and dicyclomine.

[3252] Examples of useful therapeutic agents for treating or preventing an ulcer include, antacids such as aluminum hydroxide, magnesium hydroxide, sodium bicarbonate, and calcium bicarbonate; sucraflate; bismuth compounds such as bismuth subsalicylate and bismuth subcitrate; H₂ antagonists such as cimetidine, ranitidine, famotidine, and nizatidine; H⁺, K⁺-ATPase inhibitors such as omeprazole, iansoprazole, and lansoprazole; carbenoxolone; misprostol; and antibiotics such as tetracycline, metronidazole, timidazole, clarithromycin, and amoxicillin.

[3253] Examples of useful therapeutic agents for treating or preventing IBD include, but are not limited to, anticholinergic drugs; diphenoxylate; loperamide; deodorized opium tincture; codeine; broad-spectrum antibiotics such as metronidazole; sulfasalazine; olsalazie; mesalamine; prednisone; azathioprine; mercaptopurine; and methotrexate.

[3254] Examples of useful therapeutic agents for treating or preventing IBS include, but are not limited to, propantheline; muscarine receptor antogonists such as pirenzapine, methoctramine, ipratropium, tiotropium, scopolamine, methscopolamine, homatropine, homatropine methylbromide, and methantheline; and antidiarrheal drugs such as diphenoxylate and loperamide.

[3255] Examples of useful therapeutic agents for treating or preventing an addictive disorder include, but are not limited to, methadone, desipramine, amantadine, fluoxetine, buprenorphine, an opiate agonist, 3-phenoxypyridine, levomethadyl acetate hydrochloride, and serotonin antagonists.

[3256] Examples of useful therapeutic agents for treating or preventing Parkinson's disease and parkinsonism include, but are not limited to, carbidopa/levodopa, pergolide, bromocriptine, ropinirole, pramipexole, entacapone, tolcapone, selegiline, amantadine, and trihexyphenidyl hydrochloride.

[3257] Examples of useful therapeutic agents for treating or preventing anxiety include, but are not limited to, benzodiazepines, such as alprazolam, brotizolam, chlordiazepoxide, clobazam, clonazepam, clorazepate, demoxepam, diazepam, estazolam, flumazenil, flurazepam, halazepam, lorazepam, midazolam, nitrazepam, nordazepam, oxazepam, prazepam, quazepam, temazepam, and triazolam; non-benzodiazepine agents, such as buspirone, gepirone, ipsaprione, tiospirone, zolpicone, zolpidem, and zaleplon; tranquilizers, such as barbituates, e.g., amobarbital, aprobarbital, butabarbital, butalbital, mephobarbital, methohexital, pentobarbital, phenobarbital, secobarbital, and thiopental; and propanediol carbamates, such as meprobamate and tybamate.

[3258] Examples of useful therapeutic agents for treating or preventing epilepsy include, but are not limited to, carbamazepine, ethosuximide, gabapentin, lamotrignine, phenobarbital, phenytoin, primidone, valproic acid, trimethadione, bemzodiaepines, gabapentin, lamotrigine, γ-vinyl GABA, acetazolamide, and felbamate.

[3259] Examples of useful therapeutic agents for treating or preventing stroke include, but are not limited to, anticoagulants such as heparin, agents that break up clots such as streptokinase or tissue plasminogen activator, agents that reduce swelling such as mannitol or corticosteroids, and acetylsalicylic acid.

[3260] Examples of useful therapeutic agents for treating or preventing a seizure include, but are not limited to, carbamazepine, ethosuximide, gabapentin, lamotrignine, phenobarbital, phenytoin, primidone, valproic acid, trimethadione, bemzodiaepines, gabapentin, lamotrigine, γ-vinyl GABA, acetazolamide, and felbamate.

[3261] Examples of useful therapeutic agents for treating or preventing a pruritic condition include, but are not limited to, naltrexone; nalmefene; danazol; tricyclics such as amitriptyline, imipramine, and doxepin; antidepressants such as those given below, menthol; camphor; phenol; pramoxine; capsaicin; tar; steroids; and antihistamines.

[3262] Examples of useful therapeutic agents for treating or preventing psychosis include, but are not limited to, phenothiazines such as chlorpromazine hydrochloride, mesoridazine besylate, and thoridazine hydrochloride; thioxanthenes such as chloroprothixene and thiothixene hydrochloride; clozapine; risperidone; olanzapine; quetiapine; quetiapine fumarate; haloperidol; haloperidol decanoate; loxapine succinate; molindone hydrochloride; pimozide; and ziprasidone.

[3263] Examples of useful therapeutic agents for treating or preventing Huntington's chorea include, but are not limited to, haloperidol and pimozide.

[3264] Examples of useful therapeutic agents for treating or preventing ALS include, but are not limited to, baclofen, neurotrophic factors, riluzole, tizanidine, benzodiazepines such as clonazepan and dantrolene.

[3265] Examples of useful therapeutic agents for treating or preventing cognitive disorders include, but are not limited to, agents for treating or preventing dementia such as tacrine; donepezil; ibuprofen; antipsychotic drugs such as thioridazine and haloperidol; and antidepressant drugs such as those given below.

[3266] Examples of usefil therapeutic agents for treating or preventing a migraine include, but are not limited to, sumatriptan; methysergide; ergotamine; caffeine; and beta-blockers such as propranolol, verapamil, and divalproex.

[3267] Examples of useful therapeutic agents for treating or preventing vomiting include, but are not limited to, 5-HT₃ receptor antagonists such as ondansetron, dolasetron, granisetron, and tropisetron; dopamine receptor antagonists such as prochlorperazine, thiethylperazine, chlorpromazin, metoclopramide, and domperidone; glucocorticoids such as dexamethasone; and benzodiazepines such as lorazepam and alprazolam.

[3268] Examples of useful therapeutic agents for treating or preventing dyskinesia include, but are not limited to, reserpine and tetrabenazine.

[3269] Examples of usefil therapeutic agents for treating or preventing depression include, but are not limited to, tricyclic antidepressants such as amitryptyline, amoxapine, bupropion, clomipramine, desipramine, doxepin, imipramine, maprotilinr, nefazadone, nortriptyline, protriptyline, trazodone, trimipramine, and venlaflaxine; selective serotonin reuptake inhibitors such as fluoxetine, fluvoxamine, paroxetine, and setraline; monoamine oxidase inhibitors such as isocarboxazid, pargyline, phenelzine, and tranylcypromine; and psychostimulants such as dextroamphetamine and methylphenidate.

[3270] A Benzoazolylpiperazine Compound and the other therapeutic agent can act additively or, in one embodiment, synergistically. In one embodiment, a Benzoazolylpiperazine Compound is administered concurrently with another therapeutic agent. In one embodiment, a composition comprising an effective amount of a Benzoazolylpiperazine Compound and an effective amount of another therapeutic agent can be administered. Alternatively, a composition comprising an effective amount of a Benzoazolylpiperazine Compound and a different composition comprising an effective amount of another therapeutic agent can be concurrently administered. In another embodiment, an effective amount of a Benzoazolylpiperazine Compound is administered prior or subsequent to administration of an effective amount of another therapeutic agent. In this embodiment, the Benzoazolylpiperazine Compound is administered while the other therapeutic agent exerts its therapeutic effect, or the other therapeutic agent is administered while the Benzoazolylpiperazine Compound exerts its preventative or therapeutic effect for treating or preventing a Condition in an animal.

[3271] A composition of the invention is prepared by a method comprising admixing a Benzoazolylpiperazine Compound and a pharmaceutically acceptable carrier or excipient. Admixing can be accomplished using methods well known for admixing a compound (or salt) and a pharmaceutically acceptable vehicle. In one embodiment, the Benzoazolylpiperazine Compound is present in the composition in an effective amount.

4.3.2 Kits

[3272] The invention encompasses kits that can simplify the administration of a Benzoazolylpiperazine Compound to an animal.

[3273] A typical kit of the invention comprises a unit dosage form of a Benzoazolylpiperazine Compound. In one embodiment, the unit dosage form is a container, which can be sterile, containing an effective amount of a Benzoazolylpiperazine Compound and a pharmaceutically acceptable vehicle. The kit can further comprise a label or printed instructions instructing the use of the Benzoazolylpiperazine Compound to treat pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression. The kit can also further comprise a unit dosage form of another therapeutic agent, for example, a container containing an effective amount of the other therapeutic agent. In one embodiment, the kit comprises a container containing an effective amount of a Benzoazolylpiperazine Compound and an effective amount of another therapeutic agent. Examples of other therapeutic agents include, but are not limited to, those listed above.

[3274] Kits of the invention can further comprise a device that is useful for administering the unit dosage forms. Examples of such a device includes, but are not limited to, a syringe, a drip bag, a patch, an inhaler, and an enema bag.

[3275] The following examples are set forth to assist in understanding the invention and should not, of course, be construed as specifically limiting the invention described and claimed herein. Such variations of the invention, including the substitution of all equivalents now known or later developed, which would be within the purview of those skilled in the art, and changes in formulation or minor changes in experimental design, are to be considered to fall within the scope of the invention incorporated herein.

5. EXAMPLES 5.1. Example 1 Synthesis of Benzoazolylpiperazine Compounds of Formula (Ia) AAM, AAS, AAQ, AAP, AYF, AYD, AZW, AZZ, AYH, AYE, AYI, AYK, AYG, AYC, AZA, AZD, AYN, and AYM

[3276]

[3277] A solution of of 2-chloro-3-X-pyridine 1 (about 0.5 M -about 1 M) and 1 eq. of 2-Q-piperazine 2 in DMSO was heated to about 140° C. with stirring for about 2 to 4 h. The resulting reaction mixture was then cooled to room temperature and the DMSO was removed under reduced pressure to provide compound 3.

[3278] In a separate flask a solution of 0.75 eq. of chloroformate 4 in dichloromethane (DCM) (0.04M) was cooled to 0° C. and 0.75 eq. of 5-Z-6-Y-benzothiazol-2-ylamine 5 was slowly added to the cooled solution of chloroformate 4. The resulting reaction mixture was stirred at 0° C. for 5 min. and then 5 eq. of triethylamine was added to the reaction mixture. The reaction mixture was then warmed to room temperature and concentrated under reduced pressure at 40° C. to provide compound 6.

[3279] Compound 6 was dissolved in DCM (0.1 M) and 1 eq. of 3 as a 1 M solution in DCM was added to the solution of compound 6 at room temperature and the resulting reaction mixture was allowed to stir for about 10 min. The reaction mixture was then concentrated under reduced pressure at 40° C. to provide the Benzoazolylpiperazine Compound of formula (Ia). The Benzoazolylpiperazine Compound of formula (Ia) was purified using a silica gel column eluted with 5:95 ethyl acetate/hexane.

[3280] Table XXIII lists the Benzoazolylpiperazine Compounds that were prepared according to the method of Example 1. TABLE XXIII Benzoazolylpiperazine Compound X Q Y Z AAM —Cl —H —Cl —H AAS —Cl —H —OCH₂CH₃ —H AAQ —Cl —H —CF₃ —H AAP —Cl —H —CH₃ —H AYF —Cl (R)—CH₃ —Br —H AYD —Cl (R)—CH₃ —H —H AZW —CF₃ (R)—CH₃ —Cl —H AZZ —CF₃ (R)—CH₃ —CH₃ —H AYH —Cl (R)—CH₃ —CH₃ —H AYE —Cl (R)—CH₃ —Cl —H AYI —Cl (R)—CH₃ —CF₃ —H AYK —Cl (R)—CH₃ —OCH₂CH₃ —H AYG —Cl (R)—CH₃ —F —H AYC —Cl (R)—CH₃ —CH₃ —CH₃ AZA —CH₃ (R)—CH₃ —Cl —H AZD —CH₃ (R)—CH₃ —CH₃ —H AYN —Cl (R)—CH₃ —CH(CH₃)₂ —H AYM —Cl (R)—CH₃ —C(CH₃)₃ —H

[3281] The identity of Compound AAM was confirmed using H¹ NMR.

[3282] Compound AAM: ¹H NMR (400 MHz, CDCl₃), δ8.24-8.19 (m, 1H), 7.77-7.76 (m, 1H), 7.67-7.64 (m, 1H), 7.57-7.54 (m, 1H), 7.38-7.36 (m, 1H), 6.95-6.90 (m, 1H), 3.77-3.75 (m, 4H), 3.45-3.42 (m, 4H).

[3283] The identity of Compound AAS was confirmed using H¹ NMR.

[3284] Compound AAS: ¹H NMR (400 MHz, CDCl₃), δ10.17 (s, 1H), 8.19-8.15 (m, 1H), 7.61-7.58 (m, 1H), 7.51-7.46 (m,. 1H), 7.28-7.22 (m, 1H), 6.98-6.95 (m, 6.89-6.86 (m, 1H), 4.11-4.04 (m, 2H), 3.77-3.71 (m, 4H), 3.37-3.34 (m, 4H), 1.43 (t, 3H).

[3285] The identity of Compound AAQ was confirmed using H¹ NMR.

[3286] Compound AAQ: ¹H NMR (400 MHz, CDCl₃): δ8.22-8.19 (m, 1H), 8.09-8.05 (m, 1H), 7.76-7.71 (m, 1H), 7.66-7.64 (m, 2H), 6.94-6.91 (m, 1H), 3.80-3.75 (m, 4H), 3.47-3.45 (m, 4H).

[3287] The identity of Compound AAP was confirmed using H¹ NMR.

[3288] Compound AAP: ¹H NMR (CDCl₃), δ8.22-8.20 (m, 1H), 7.65-7.63 (m, 1H), 7.57-7.55 (m, 1H), 7.52-7.48 (m, 1H), 7.22-7.18 (m, 1H), 6.92-6.87 (m, 1H), 3.78-3.76 (m, 4H), 3.45-3.42 (m, 4H), 2.46 (s, 3H).

[3289] The identity of Compound AYF was confirmed using H¹ NMR.

[3290] Compound AYF: ¹H NMR (CDCl₃), δ 8.23-8.20 (m, 1H), 7.93-7.90 (m, 1H), 7.67-7.62 (m, 1H), 7.54-7.50 (m, 2H), 6.95-6.91 (m, 1H), 4.45 (bs, 1H), 4.11-4.05 (m, 1H), 3.86-3.76 (m, 2H), 3.57-3.46 (m, 1H), 3.12-3.06 (m, 1H), 3.02-2.94 (m, 1), 1.50 (d, 3H, J=6.8).

[3291] The identity of Compound AYD was confirmed using H¹ NMR and mass spectrometry.

[3292] Compound AYD: ¹H NMR (CDCl₃), δ 8.83 (br, 1H), 8.24-8.20 (m, 1H), 7.81-7.74 (m, 1H), 7.68-759 (m, 2H), 7.48-7.38 (m, 1H), 7.33-7.24 (m, 2H +CHCl₃), 696-6.87 (m, 1H), 4.55-4.43 (m, 1H), 4.17-4.06 (m, 1H), 3.89-3.75 (m, 2H), 3.58-3.42 (m, 1H), 3.16-2.89 (m, 1H), 1.45 (d, 3H, J=6.8 Hz).

[3293] (M+1) m/z: 388.0.

[3294] The identity of Compound AZW was confirmed using H¹ NMR.

[3295] Compound AZW: ¹H NMR (CDCl₃), δ8.49-8.45 (m, 1H), 7.94-7.90 (m, 1H), 7.57-7.54 (m, 1H), 7.52-7.46 (m, 1H), 7.22-7.18 (m, 1H), 7.11-7.06 (m, 1H), 4.46 (bs, 1H), 4.09-4.00 (m, 1H), 3.52-3.42 (m, 2H), 3.38-3.33 (m, 1H), 3.25-3.19 (m, 1H), 3.04-2.96 (m, 1H), 1.39 (d, 3H, J=6.8).

[3296] The identity of Compound AZZ was confirmed using H¹ NMR.

[3297] Compound AZZ: ¹H NMR (CDCl₃), δ8.50-8.46 (m, 1H), 7.94-7.91 (m, 1H), 7.55 (bs, 1H), 7.51-7.47 (m, 1H), 7.21-7.17 (m, 1H), 7.11-7.06 (m, 1H), 4.45 (bs, 1H), 4.09-4.01 (m, 1H), 3.53-3.45 (m, 2H), 3.41-3.34 (m, 1H), 3.26-3.20 (m, 1H), 3.07-2.95 (m, 1H), 2.46 (s, 3H), 1.38 (d, 3H, J=6.7).

[3298] The identity of Compound AYH was confirmed using H¹ NMR.

[3299] Compound AYH: ¹H NMR (CDC₃), δ8.71 (bs, 1H), 8.24-8.20 (m, 1H), 7.67-762 (m, 1H), 7.58 (bs, 1H), 7.55-7.49 (m, 1H), 7.25-7.19 (m, 1H), 6.94-6.89 (m, 1H), 4.46 (bs, 1H), 4.14-4.06 (m, 1H), 3.86-3.74 (M, 2H), 3.56-3.43 (m, 1H), 3.13-3.05 (m, 1H), 3.03-2.95 (m, 1H), 2.47 (s, 3H), 1.64 (s, 3H), 1.47 (d, 3H, J=7.0).

[3300] The identity of Compound AYE was confirmed using H¹ NMR.

[3301] Compound AYE: ¹H NMR (CDCl₃), δ8.37 (bs, 1H), 8.24-8.21 (m, 1H), 7.77-7.75 (m, 1H), 7.67-7.64 (m, 1H), 7.61-7.57 (m, 1H), 7.39-7.35 (m, 1H), 6.95-6.90 (m, 1H), 4.40 (bs, 1H), 4.15-4.01 (m, 1H), 3.90-3.77 (m, 1H), 3.58-3.47 (m, 1H), 3.14-3.07 (m, 1H), 3.05-2.96 (m, 1H), 1.51 (d, 3H, J=6.8).

[3302] The identity of Compound AYI was confirmed using H¹ NMR.

[3303] Compound AYI: ¹H NMR (CDCl₃), δ9.31 (bs, 1H), 8.22-8.19 (m, 1H), 8.08 (bs, 1H), 7.76-7.70 (m, 1H), 7.68-7.61 (m, 2H), 6.94-6.89 (m, 1H), 4.46 (bs, 1H), 4.11-4.02 (m, 1H), 3.85-3.74 (m, 2H), 3.59-3.48 (m, 1H), 3.12-3.05 (m, 1H), 3.02-2.92 (m, 1H), 1.49 (d, 3H, J=6.8).

[3304] The identity of Compound AYK was confirmed using H¹ NMR.

[3305] Compound AYK: ¹H NMR (CDCl₃), δ9.40 (bs, 1H), 8.22-8.18 (m, 1H), 7.64-7.60 (m, 1H), 7.57-7.51 (m, 1H), 7.30-7.25 (m, 1H+CHC1₃), 7.03-6.97 (m, 1H), 6.93-6.88 (m, 1H), 4.45 (bs, 1H), 4.14-4.00 (m, 3H), 3.81-3.69 (m, 2H), 3.53-3.43 (m, 1H), 3.09-3.02 (m, 1H), 3.00-2.91 (m, 1H), 1.48-1.43 (m, 6H).

[3306] The identity of Compound AYG was confirmed using H¹ NMR.

[3307] Compound AYG: ¹H NMR (CDCl₃), δ8.41 (bs, 1H), 8.24-8.20 (m, 1H), 7.68-7.56 (m, 2H), 7.52-7.46 (m, 1H), 7.18-7.11 (m, 1H), 6.95-6.90 (m, 1H). 4.41 (bs, 1H), 4.09-4.02 (m, 1H), 3.89-3.77 (m, 2H), 3.58-3.49 (m, 1H), 3.14-307 (m, 1H), 3.05-2.96 (m, 1H), 1.5 (d, 3H, J=6.8).

[3308] The identity of Compound AYC was confirmed using H¹ NMR.

[3309] Compound AYC: ¹H NMR (CDCl₃), δ8.23-8.19 (m, 1H), 765-7.61 (m, 1H), 7.52 (bs, 1H), 7.40 (bs, 1H), 6.93-6.88 (m, 1H), 4.50 (bs, 1H), 4.17-4.06 (m, 1H), 3.84-3.73 (m, 2H), 3.56-3.44 (m, 1H), 3.11-3.03 (m, 1H), 3.01-2.92 (m, 1H), 2.36 (s, 6H), 1.48 (d., 3H, J=6.8).

[3310] The identity of Compound AZA was confirmed using H¹ NMR.

[3311] Compound AZA: ¹H NMR (CDCl₃), δ8.93 (bs, 1H), 8.17-8.14 (m, 1H), 8.00-7.96 (m, 1H), 7.77 (bs, 1H), 7.60-7.53 (m, 1H), 7.41-7.33 (m, 1H), 4.49 (bs, 1H), 4.16-4.06 (m, 1H), 4.00-3.94 (m, 2H), 3.57-3.46 (m, 1H), 3.19-3.11 (m, 1H), 3.07-2.98 (m, 1H), 1.70 (s, 3H), 1.47 (d, 3H, J=6.8).

[3312] The identity of Compound AZD was confirmed using H¹ NMR.

[3313] Compound AZD: ¹H NMR (CDCl₃), δ8.68 (bs, 1H), 8.21-8.18 (m, 1H), 7.61-7.43 (m, 3H), 7.24-7.19 (m, 1H), 6.94-6.90 (m, 1H), 4.45 (bs, 1H), 4.13-4.04 (m, 1H), 3.54-3.41 (m, 2H), 3.37-3.32 (m, 1H), 3.12-3.04 (m, 1H), 3.64-2.90 (m 1H), 2.46 (s, 3H), 2.35 (s, 3H), 1.48 (d, 3H, J=6.8).

[3314] The identity of Compound AYN was confirmed using H¹ NMR.

[3315] Compound AYN: ¹H NMR (CDCl₃), δ8.20-8.18 (m, 1 H), 7.64-7.59 (m, 1 H), 7.58-7.50 (m, 1H), 7.29-7.25 (m, 1H+CHCl₃), 6.91-6.87 (m, 1H), 4.49 (bs, 1H), 4.14-4.05 (m, 1H), 3.79-3.68 (m, 2H), 3.07-2.89 (m, 3H), 1.44 (d, 3H, J=6.8), 1.31 (d, 3H, =7.0).

[3316] The identity of Compound AYM was confirmed using H¹ NMR.

[3317] Compound AYM: ¹H NMR (CDCl₃), δ8.24-8.20 (m, 1H), 7.76 (bs, 1H), 7.66-7.62 (m, 1H), 7.55-7.52 (m,. 1H), 7.49-7.43 (m, 1H), 6.94-6.89 (m, 1H), 4.46 (bs, 1H), 4.16-4.07 (m, 1H), 3.87-3.73 (m, 2H), 3.56-3.45 (m, 1H), 3.14-3.05 (m, 1H), 3.04-2.91 (m, 1H), 1.49 (d, 3H, J=6.8), 1.40 (s, 9H).:

5.2. Example 2 Synthesis of Benzoazolylpiperazine Compounds of Formula (Ib) BDJ and BDG

[3318] Compounds BDJ and BDG were prepared by a method analogous to that used in Example 1 except that 2, 3-dichloropyrazine was used in place of 2-chloro-3-X-pyridine 1. In the preparation of Compound BDJ, the 2-Q-piperazine 2 was (R)-2-methylpiperidine and the 5-Z-6-Y-benzothiazol-2-ylamine 5 was 6-methyl benzothiazol-2-ylamine. In the preparation of Compound BDG, the 2-Q-piperazine 2 was (R)-2-methylpiperidine and the 5-Z-6-Y-benzothiazol-2-ylamine 5 was 6-chloro benzothiazol-2-ylamine.

[3319] The identity of Compound BDJ was confirmed using H¹ NMR.

[3320] Compound BDJ: ¹H NMR (CDCl₃), δ8.16-8.13 (m, 1 H), 7.96-7.93 (m, 1H), 7.56 (bs, 1H), 7.47 (bs, 1H), 7.22-7.18 (m, 1H), 4.56 (bs, 1H), 4.19-4.13 (m, 1H), 3.94-3.85 (m, 2H), 3.49-3.41 (m, 1H), 3.13-3.06 (m, 1H), 3.01-2.94 (m, 1H), 2.45 (s, 3H), 1.41 (d, 3H, J=6.9).

[3321] The identity of Compound BDG was confirmed using H¹ NMR.

[3322] Compound BDG: ¹H NMR (CDCl₃), δ8.66 (bs, 1H), 8.17-8.15 (m, 1H), 8.00-7.97 (m, 1H), 7.76 (bs, 1H), 7.59-7.54 (m, 1H), 7.40-7.35 (m, 1H), 4.47 (bs, 1H), 4.16-4.07 (m, 1H), 4.02-3.92 (m, 2H), 3.57-3.48 (m, 1H), 3.20-3.13 (m, 1H), 3.09-2.98 (m, 1H), 1.48 (d, 3H, J=6.8).

5.3. Example 3 Synthesis of Benzoazolylpiperazine Compounds of Formula (Ib) BIL, BII, and BJE

[3323] Compounds BIL BII, and BJE were prepared by a method analogous to that used in Example 1 except that 4,5-dichlorothiadiazole was used in place of 2-chloro-3-X-pyridine 1 to make Compounds BIL and BII and 4-methyl-5-chlorothiadiazole was used to make Compound BJE. In the preparation of Compound BIL, the 2-Q-piperazine 2 was (R)-2-methylpiperidine and the 5-Z-6-Y-benzothiazol-2-ylamine 5 was 6-methyl benzothiazol-2-ylamine. In the preparation of Compounds BII, and BJE the 2-Q-piperazine 2 was (R)-2-methylpiperidine and the 5-Z-6-Y-benzothiazol-2-ylamine 5 was 6-chloro benzothiazol-2-ylamine.

[3324] The identity of Compound BIL was confirmed using H¹ NMR.

[3325] Compound BIL: ¹H NMR (CDCl₃), δ7.54 (bs, 1H), 7.49-7.42 (m, 1H), 7.24-7.17 (m, 1H), 4.55 (bs, 1H), 4.24-4.15 (m, 1H), 4.02-3.89 (m, 2H), 3.54-3.39 (m, 1H), 3.21-3.12 (m, 1H), 3.11-3.02 (m, 1H), 2.46 (s, 3H), 1.46 (d, 3H, J=6.8).

[3326] The identity of Compound BII was confirmed using H¹ NMR.

[3327] Compound BII: ¹H NMR (CDCl₃), δ8.64 (bs, 1H), 7.75 (bs, 1H), 7.58-7.51 (m, 1H), 7.41-7.34 (m, 1H), 4.50 (bs, 1H), 4.18-4.06 (m, 1H), 4.01-3.92 (m, 2H), 3.56-3.44 (m, 1H), 3.21-3.13 (m, 1H), 3.12-3.04 (m, 1H), 1.48 (d, 3H, J=6.8).

[3328] The identity of Compound BJE was confirmed using H¹ NMR.

[3329] Compound BJE: ¹H NMR (CDCl₃), δ8.59 (bs, 1H), 7.73 (bs, 1H), 7.53-7.47 (m, 1H), 7.41-7.34 (m, 1H), 4.55 (bs, 1H), 4.23-4.14 (m, 1H), 3.59-3.46 (m, 1H), 3.43-3.38 (m, 1H). 3.37-3.28 (m, 1H), 3.11-3.02 (m, 1H), 3.00-2.90 (m, 1H), 2.65 (s, 3H), 1.61 (d, 3H, J=6.8).

5.4. Example 4 Synthesis of Benzoazolylpiperazine Compound of Formula (IIa) and (IIb) CBG, CAW, CRU, CSE, DIS, DJC, DIQ, CSE, EAA, DZU, CTA, CTW, CRW, and CSB

[3330]

[3331] A solution of 2-chloro-3-X-pyridine 1 (about 0.5 M to about 1M) and 1 eq. of 2-Q-piperazine 2 in DMSO was heated to about 140° C. with stirring for about 2 to 4 h. The resulting reaction mixture was then cooled to room temperature and the DMSO was removed under reduced pressure to provide compound 3.

[3332] A solution of compound 3 (about 0.25 mmol-about 1 mmol) and 1 eq. of compound 7 in about 3 mL of toluene or xylene was heated at a temperature of between about 140° C. and 150° C. for about 3 days. The resulting reaction mixture was then concentrated under reduced pressure to provide a residue that was purified using flash chromatography (silica gel, gradient elution 2% methanol:DCM to 6% methanol:DCM).

[3333] Compound 7, wherein R₁₀ is —H was either commercially available or obtained from commercially available compounds 8 as illustrated below

[3334] Compound 8 (about 30 mmol) and carbodiimidazole (CDI) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) (about 2 eq) was dissolved in THF (about 50 to about 150 mL) and the resulting reaction mixture was heated at reflux temperature for about 4 hours. The reaction mixture was then concentrated under reduced pressure to provide a residue. About 50 to about 100 mL of ethyl acetate or ethyl acetate/hexane (20:80 to about 40:60) was added to the residue and the resulting insoluble material was collected by filtration and washed with ethyl acetate or ethyl acetate/hexane (20:80 to about 40:60) to provide compound 9. Compound 9 was then reacted with POCl₃ according to the procedure described in J Med. Chem. 40:586-593 (1997) to provide compound 7.

[3335] Compound 7, wherein R₁₀ is —CH₃ was obtained from compound 7 wherein R₁₀ is —H as illustrated below

[3336] NaH (about 2 eq) was added to a solution of a compound of Formula 8 wherein R₁₀ is —H in DMF at 0° C. and the resulting mixture was allowed to stir and to warm to room temperature over a period of about one hour. Methyl iodide (about 1.2 eq) was then added to the solution and the resulting reaction mixture was allowed to stir for several minutes. Water was then added to the reaction mixture to produce a precipitate of compound 8 wherein R₁₀ is —CH₃ which was filtered, collected, and dried.

[3337] Table XXIV lists the Benzoazolylpiperazine Compounds that were prepared according to the method of Example 4. TABLE XXIV Benzoazolylpiperazine Compound R₁₀ Y Z X Q CBG —H -tert-butyl —H —Cl —H CAW —H —CH₃ —CH₃ —Cl —H CRU —H —CH₃ —CH₃ —Cl (R)— CH₃ CRU —H —CH₃ —CH₃ —Cl (S)— CH₃ CSE —H -tert-butyl —H —Cl (R)— CH₃ DIS —CH₃ —CH₃ —CH₃ —Cl —H DJC —CH₃ -tert-butyl —H —Cl —H DIQ —CH₃ —H -tert- —Cl —H butyl CSE —H -tert-butyl —H —Cl (S)— CH₃ EAA —CH₃ -tert-butyl —H —Cl (R)— CH₃ DZO —CH₃ —H -tert- —Cl (R)— butyl CH₃ CTA —H -tert-butyl —H —CH₃ (R)— CH₃ CTW —H -tert-butyl —H —CF₃ (R)— CH₃ CRW —H —Cl —H —Cl (R)— CH₃ CSB —H —OCH₃ —H —Cl (R)— CH₃

[3338] The identity of Compound CBG was confirmed using H¹ NMR and mass spectrometry.

[3339] Compound CBG: ¹H NMR (CD₃OD), δ8.21(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.77(dd, 1H, J1=1.6 Hz, J2=7.6 Hz); 7.34(d, 1H, J=2 Hz); 7.21(d, 1H, J1=0.4 Hz, J2=8.4 Hz); 7.14(dd, 1H, J1=2 Hz, J2=8.4 Hz); 7.01(dd, 1H, J1=4.8 Hz, J2=7.6 Hz); 3.70(m, 4H); 3.49(m, 4H); 1.37(s, 9H).

[3340] MS: 370.2(M+1).

[3341] The identity of Compound CAW was confirmed using H¹ NMR and mass spectrometry.

[3342] Compound CAW: ¹H NMR (CD₃OD), δ 8.25(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.82(dd, 1H, J1=1.6 Hz, J2=8 Hz); 7.06(dd, 1H, J1=4.8 Hz, J2=7.6 Hz); 3.82(m, 4H); 3.58(m, 4H); 2.38(s, 6H).

[3343] MS: 342.1(M+1).

[3344] The identity of Compound CRU wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3345] Compound CRU wherein Q is (R)—CH₃: ¹H NMR (CD₃OD), δ 8.25(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.82(dd, 1H, J1=2 Hz, J2=8 Hz); 7.07(dd, 1H, J1=4.4 Hz, J2=8 Hz); 4.30(m 1H); 3.90(m, 4H); 3.26(dd, 1H, J1=13 Hz, J2=1.6 Hz); 3.17(m, 1H); 2.38(s, 6H); 1.59(d, 3H, J=6.8 Hz).

[3346] MS: 356.1(M+1).

[3347] The identity of Compound CRU wherein Q is (S)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3348] Compound CRU wherein Q is (S)—CH₃: ¹H NMR (CD₃OD), δ 8.25(dd, 1H, J1=1.2 Hz, J2=4.4 Hz); 7.81(dd, 1H, J1=1.6 Hz, J2=7.6 Hz); 7.07(dd, 1H, J1=4.8 Hz, J2=7.6 Hz); 4.31(m, 1H); 3.88(m, 4H); 3.26(dd, 1H, J1=3.6 Hz, J2=13 Hz); 3.16(m, 1H); 2.38(s, 6H); 1.59(d, 3H, J=6.4 Hz).

[3349] MS: 356.1(M+1).

[3350] The identity of Compound CSE wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3351] Compound CSE wherein Q is (R)—CH₃: ¹H NMR (CD₃OD), δ 8.22(dd, 1H, J1=1.6 Hz, J2=4.8 Hz0; 7.78(dd, 1H, J1=1.6 Hz, J2=7.6 Hz0; 7.33(dd, 1H, J1=0.8 Hz, J2=2 Hz); 7.19(dd, 1H, J1=0.8 Hz, J2=8.4 Hz0; 7.12(dd, 1H, J1=1.6 Hz, J2=8.4 Hz); 7.02(dd, 1H, J1=4.8 Hz, J2=8 Hz); 4.37(m, 1H); 3.84(m, 3H): 3.58(m, 1H); 3.20(dd, 1H, J1=4 Hz, J2=12 Hz); 3.08(dt, 1H, J1=3.2 Hz, J2=12 Hz); 1.45(d, 3H, J=6.4 Hz); 1.37(s, 9H),

[3352] MS: 420(M+36).

[3353] The identity of Compound DIS was confirmed using H¹ NMR and mass spectrometry.

[3354] Compound DIS: ¹H NMR (CD₃OD), δ 8.23(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.78(dd, 1 h, J1=2 Hz, J2=8 Hz); 727(bs, 1H); 7.14(bs, 1H); 7.02(dd, 1H, J1=4.8 Hz, J2=7.6 Hz); 3.69(s, 3H); 3.56(m, 4H); 3.45(m, 4H); 2.39(s, 3H); 2.35(s, 3H).

[3355] MS: 356.1(M+1).

[3356] The identity of Compound DJC was confirmed using H¹ NMR and mass spectrometry.

[3357] Compound DJC: ¹H NMR (CD₃OD), δ 8.23(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.78(dd, 1H, J1=2 Hz, J2=8 Hz); 7.53(dd, 1H, J1=0.8 Hz, J2=2 Hz); 7.31 (dd, 1H, J1=1.6 Hz, J2=8.4 Hz); 7.26(dd, 1H, J1=0.4 Hz, J2=8.4 Hz); 7.02(dd, 1H, J1=4.8 Hz, J2=8 Hz); 3.70(s, 3H); 3.57(m, 4H); 3.47(m, 4H); 1.39(s, 9H).

[3358] MS: 384.1(M+1).

[3359] The identity of Compound DIQ was confirmed using H¹ NMR and mass spectrometry.

[3360] Compound DIQ: ¹H NMR (CD₃OD), δ 8.23(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.78(dd, 1H, J1=2 Hz, J2=8 Hz); 7.41(dd, 1H, J1=0.4 Hz, J2=8.4 Hz); 7.36(d, 1H, J=1.2 Hz); 7.29(dd, 1H, J1=1.6 Hz, J2=8.4 Hz); 7.02(dd, 1H, J1=4.8 Hz, J2=7.6 Hz); 3.70(s, 3H); 3.57(m, 4H); 3.47(m, 4H); 1.41(s, 9H).

[3361] MS: 384.1(M+1).

[3362] The identity of Compound CSE wherein Q is (S)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3363] Compound CSE wherein Q is (S)—CH₃: ¹H NMR (CD₃OD), δ 8.22(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.78(dd, 1H, J1=1.6 Hz, J2=7.6 Hz); 7.34(d, 1H, J=1.6 Hz); 7.20(d, 1H, J=8.4 Hz); 7.13(dd, 1H, J1=2 Hz, J2=8.4 Hz); 7.02(dd, 1H, J1=4.8 Hz, J2=8 Hz); 4.36(m, 1H); 3.85(m, 3H); 3.60(dt, 1H, J1=2.8 Hz, J2=12 Hz); 3.20(dd, 1H, J1=4 Hz, J2=12 Hz); 3.08(dt, 1H, J1=3.2 Hz, J2=13 Hz); 1.45(d, 3H, J=6.4 Hz); 1.37(s, 9H).

[3364] MS: 420(M+36).

[3365] The identity of Compound EAA wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3366] Compound EAA wherein Q is (R)—CH₃: ¹H NMR (DMSO d₆), δ 8.23(dd, 1H, J1=1.6 Hz, J2=2.8 Hz); 7.63(dd, 1H, J1=1.6 Hz, J2=7.6 Hz); 7.61(d, 1H, J1=8.4 Hz); 7.32(dd, 1H, J=2 Hz, J2=8 Hz); 7.26(dd, 1H, J1=1.6 Hz, J2=8 Hz); 6.90(dd, 1H, J1=4.8 Hz, J2=8 Hz); 3.80(m, 1H); 3.70(s, 3H); 3.69(dd, 1H, J1=2.8 Hz, J2=12 Hz); 3.63(m, 1H) 3.45(m, 2H); 3.35(m, 1H); 3.24(dd, 1H, J1=7.6 Hz, J2=12 Hz); 1.43(s, 9H); 1.20(d, 3H, J=6.4 Hz).

[3367] MS: 398.1(M+1).

[3368] The identity of Compound DZO wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3369] Compound DZO wherein Q is (R)—CH₃: ¹H NMR (DMSO d₆), δ 8.23(dd, 1H, J1=2 Hz, J2=4.8 Hz); 7.75(d); 7.63(dd, 1H, J1=2 Hz, J2=7.6 Hz); 7.32(dd, 1H, J1=2 Hz, J2=8.4 Hz); 7.20(d, 1H, J=8.4 Hz); 6.89(dd, 1H, J1=4.8 Hz, J2=7.6 Hz); 3.82(m, 1H); 3.68(s, 3H); 3.68(m, 1H); 3.61(m, 1H); 3.48(m, 2H); 3.37(m, 1H); 3.28(dd, 1H, J1=8 Hz, J2=12 Hz); 1.41(s, 9H); 1.22(d, 3H, J=6.4 Hz).

[3370] MS: 398.3(M+1).

[3371] The identity of Compound CTA wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3372] Compound CTA wherein Q is (R)—CH₃: ¹H NMR (CDCl₃), δ 8.17(d,1H, J=4.8 Hz); 7.44(d, 1H, J=7.6 Hz); 7.42(s, 1H); 7.27(d, 1H, J=8.4 Hz); 7.13(d, 1H, J=8.4 Hz); 6.91(dd, 1H, J1=4.8 Hz, J2=7.2 Hz); 4.42(m, 1H); 3.97(d, 1H, J=12 Hz); 3.62(dt, 1H, J1=3.2 Hz, J2=12 Hz); 3.47(d, 1H, J=12 Hz); 3.33(d, 1H, J=13 Hz); 3.18(dd, 1H, J1=3.2 Hz, J2=12 Hz); 3.06(dt, 1H, J1=2.8 Hz, J2=12 Hz); 2.32(s, 3H); 1.45(d, 3H, J=6.8 Hz); 1.33(s, 9H);

[3373] MS: 364.2(M+1).

[3374] The identity of Compound CTW wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3375] Compound CTW wherein Q is (R)—CH₃: ¹H NMR (CDCl₃), δ 8.49(d, 1H, J=4.8 Hz); 7.93(dd, 1H, J1=1.6 Hz, J2=8.0 Hz); 7.42(s, 1H); 7.26(d, 1H, J=8.4 Hz); 7.14(dd, 1H, J1=1.6 Hz, J2=8.4 Hz); 7.08(dd, 1H, J1=4.8 Hz, J2=8.0 Hz); 4.37(m, 1H); 3.89(d, 1H, J=12 Hz); 3.64(dt, 1H, J1=3.2 Hz, J2=12 Hz); 3.56(d, 1H, J=13 Hz); 3.45(d, 1H, J=13 Hz); 3.37(dd, 1H, J1=3.6 Hz, J2=12 Hz); 3.17(dt, 1H, J1=3.2 Hz, J2=12 Hz); 1.39(d, 3H, J=6.8 Hz); 1.35(s, 9H).

[3376] MS: 418.2(M+1).

[3377] The identity of Compound CRW wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3378] Compound CRW wherein Q is (R)—CH₃: ¹H NMR (CD₃OD), δ 8.21(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.78(dd, 1H, J1=1.6 Hz, J2=7.6 Hz); 7.24(s, 1H); 7.20(d, 1H, J=8 Hz); 7.02(dd, 1H, J1=4.8 Hz, J2=8 Hz); 7.01(d, 1H, J=8 Hz); 4.36(m, 1H); 3.86(m, 3H); 3.62(dt, 1H, J1=3.2 Hz, J2=12 Hz); 3.18(dd, 1H, J1=2.8 Hz, J2=13 Hz); 3.07(dt, 1H, J1=3.2 Hz, J2=13 Hz); 1.46(d, 3H, J=6.8 Hz).

[3379] MS: 362.1(M+1).

[3380] The identity of Compound CSB wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3381] Compound CSB wherein Q is (R)—CH₃: ¹H NMR (CD₃OD), δ 8.24(dd, 1H, J1=1.8 Hz, J2=4.8 Hz); 7.80(dd, 1H, J1=1.8 Hz, J2=7.9 Hz); 4.31(m, 1H); 3.91(m, 2H); 3.80(dt, 1H, J1=3.5 Hz, J2=12 Hz); 3.25(dd, 1H, J1=3.2 Hz, J2=12 Hz); 3.15(dt, 1H, J1=4.0 Hz, J2=12 Hz); 1.56(d, 3H, J=6.6 Hz).

[3382] MS: 358.1(M+1).

5.5. Example 5 Synthesis of Benzoazolylpiperazine Compound of Formula (IIb) DBM

[3383] Compound DBM wherein R₃ is (R)—CH₃ was prepared by a method analogous to that used in Example 4 except that 4,5-dichlorothiadiazole was used in place of 2-chloro-3-X-pyridine 1 and the 2-Q-piperazine 2 was 2-(R)-methylpiperazine and the 5-Z-6-Y-2-chloro-1-H-benzoimidazole 7 was 6-tert-butyl-2-chloro-1-H-benzoimidazole.

[3384] The identity of Compound DBM wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3385] Compound DBM wherein Q is (R)—CH₃: ¹H NMR (CD₃OD), δ 7.34(s, 1H); 7.20(d, 1H, J=8.4 Hz); 7.13(dd, 1H, J1=1.6 Hz, J2=8.4 Hz); 4.38(m, 1H); 4.05(bd, 2H, J=12 Hz); 3.90(bd, 1H, J=13 Hz); 3.58(dt, 1H, J1=3.6 Hz, J2=12 Hz); 3.27(dd, 1H, J1=3.6 Hz, J2=12 Hz); 3.20(dt, 1H, J1=3.6 Hz, J2=12 Hz); 1.43(d, 3H, J=6.4 Hz); 1.37(s, 9H).

[3386] MS: 391.1(M+1).

5.6. Example 6 Synthesis of Benzoazolylpiperazine Compound of Formula 10

[3387] Benzoazolylpiperazine compound of Formula 10

[3388] was prepared by a method analogous to that used in Example 4 using compound 7 wherein Y is —CH₃ and Z is —CH(CH₃)₂ and 2-(R)-methylpiperazine for the 2-Q-piperazine 2.

[3389] The identity of Compound 10 wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3390] Compound 10 wherein Q is (R)—CH₃: ¹H NMR (CD₃OD), δ 8.22(dd, 1H, J1=1.8 Hz, J2=4.9 Hz); 7.78(dd, 1H, J1=1.6 Hz, J2=8.0 z); 7.20(s, 1H); 7.04(dd, 1H, J1=4.9 Hz, J2=7.7 Hz); 4.35(m, 1H); 3.85(m, 3H); 3.62(dt, 1H, J1=3.3 Hz, J2=12 Hz); 3.21(m, 2H); 3.06(dt, 1H, J1=4.0 Hz, J2=13 Hz); 2.40(s, 3H); 1.47(d, 3H, J=6.8 Hz); 1.27(d, 6H, J=6.8 Hz).

[3391] MS: 384.1(M+1).

5.7. Example 7 Synthesis of Benzoazolylpiperazine Compound of Formula (IIa) FUY and EXG

[3392]

[3393] Compound 3 (about 1 mmol), prepared as described above in Example 5.1 and 1 eq. of compound 11 were dissolved in toluene or p-xylene (about 0.5 to about 1 mL) and the resulting reaction mixture was heated in a sealed tube at a temperature of about 150° C. for about 24 h. The reaction mixture was then concentrated under reduced pressure to provide a residue. The resulting residue was purified using flash chromatography (silica gel, 5% methanol:DCM) to provide the Benzoazolylpiperazine Compounds of formula (IIIa).

[3394] Compound 11 was obtained as described below

[3395] Compound 12 (about 15 to about 20 mmol) and 1 eq. of compound 13, were dissolved in ethanol (about 30 to about 40 mL) and the resulting reaction mixture heated at reflux temperature for about 5 h. The reaction mixture was then concentrated under reduced pressure to provide a residue that was diluted with water (about 30 mL) and acidified with acetic acid to a pH value of about 6. The aqueous mixture was extracted with ethyl acetate, the ethyl acetate dried (Na₂SO₄), and the solvent removed under reduced pressure to provide compound 7 that was used without further purification.

[3396] Table XXV lists the Benzoazolylpiperazine Compounds that were prepared according to the method of Example 7. TABLE XXV Benzoazolylpiperazine Compound Y Z X Q FUY —H tert-butyl —Cl (R)—CH₃ EXG —H tert-butyl —Cl —H

[3397] The identity of Compound FUY was confirmed using H¹ NMR and mass spectrometry.

[3398] Compound FUY: ¹H NMR (CDCl₃), δ 8.23(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.65(dd, 1H, J1=2 Hz, J2=7.6 Hz); 7.47(d, 1H, J=2 Hz); 7.20(d, 1H, J=8.4 Hz); 7.10(dd, 1H, J1=2 Hz, J2=8.4 Hz); 6.91(dd, 1H, J1=4.8 Hz, J2=8 Hz); 4.60(m, 1H); 4.60(d, 1H, J=13 Hz); 3.84(m, 2H); 3.67(dt, 1H, J1=3.6 Hz, J2=13 Hz); 3.17(dd, 1H, J1=4 Hz, J2=12 Hz); 3.08(dt(1H, J1=3.2 Hz, J2=12 Hz); 1.52(d, 3H, J=6.8 Hz); 1.37(s, 9H).

[3399] MS: 385.2(M+1).

[3400] The identity of Compound EXG wherein Q is (R)—CH₃ was confirmed using H¹ NMR and mass spectrometry.

[3401] Compound EXG: ¹H NMR (CDCl₃), δ 8.23(dd, 1H, J1=1.6 Hz, J2=4.8 Hz); 7.65(dd, 1H, J1=2 Hz, J2=7.6 Hz); 7.46(d, 1H, J=1.6 Hz); 7.20(dd, 1H, J1=0.4 Hz, J2=8.4 Hz); 7.10(dd, 1H, J1=2 Hz, J2=8.4 Hz);6.91(dd, 1H, J1=5.2 Hz, J2=7.6 Hz); 3.88(m, 4H); 3.50(m, 4H); 1.37(s, 9H).

[3402] MS: 371.1(M+1).

5.8. Example 8 Synthesis of Benzoazolylpiperazine Compound of Formula (IIIa) FIU

[3403] Compound FIU was prepared by a method analogous to that used in Example 1 except that 5-chloro-benzooxoazol-2-ylamine was used in place of the 5-Z-6-Y-benzothiazol-2-ylamine.

[3404] The identity of Compound FIU was confirmed using H¹ NMR.

[3405] Compound FIU: ¹H NMR (CDCl₃), δ11.45 (bs, 1H), 8.23-8.18 (m, 1H), 7.66-7.61 (m, 1H), 7.25-7.21 (m, 1H), 7.18-7.12 (m, 1H), 6.92-6.86 (m, 1H), 5.06-4.71 (m, 1H), 4.67-4.32 (m, 1H), 3.87-3.72 (m, 2H), 3.56-3.29 (m, 1H), 3.07-2.86 (m, 2H), 1.45 (d, 3H, J=6.8).

5.9. Example 9 Synthesis of Benzoazolylpiperazine Compound of Formula 14

[3406]

[3407] 2-Amino-6-methyl-benzothiazole 15 (2.0 mmol, 328 mg) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) and 1,1′-thiocarbonyldiimidazole (2.0 mmol, 356 mg) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) were suspended in DMSO (3 mL). 4-Dimethyl-aminopyridine (30 mg) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) was then added to the suspension and the resulting reaction mixture heated to 100° C. and stirred at 100° C. for about 6 hours. The reaction mixture was then cooled to room temperature and (R)-4-(3-chloro-2-pyridinyl)-2-methylpiperazine (2.0 mmol, 422 mg) (commercially available from Sigma-Aldrich, St. Louis, Mo. (www.sigma-aldrich.com)) was added to the reaction mixture. The reaction mixture was heated to 100° C. and stirred at 100° C. for 16 hours. The solvent was then removed under reduced pressure to provide a residue that was purified using flash chromatography on a silica column eluted with ethyl acetate/hexane (gradient elution from 20:80 ethyl acetate/hexane to 10:90 ethyl acetate/hexane) to provide compound 14 as a yellow solid.

[3408] The identity of Compound 14 was confirmed using H¹ NMR.

[3409] Compound 14: ¹H NMR (CDCl₃), 8.21 (1H, dd, J=1.6, 4.7 Hz), 7.63 (1H, dd, J=1.6, 7.8 Hz), 7.40 (1H, d, J=0.5 Hz), 7.18 (2H, d, J=0.5 Hz), 6.89 (1H, dd, J=4.7, 7.8 Hz), 5.62 (1H, br), 5.27 (m, 1H), 3.84 (2H, t, J=10.6 Hz), 3.50 (1H, dt, J=2.9, 15.3 Hz), 3.08 (1H, dd, J=3.6, 12.6 Hz), 3.00 (1H, dt, J=3.3, 15.3 Hz), 2.44 (3H, s), 1.48 (3H, d, J=7.2 Hz) ppm.

[3410] (M+1) m/z: 418.0.

5.10. Example 10 Synthesis of Benzoazolylpiperazine Compound GIO

[3411]

[3412] Compound 17 (5 g, 30.7 mmol) and piperazine 2 (3.1 g, 30.7 mmol) were dissolved in 18 mL of DMSO and stirred at 100° C. for about 3 h. The reaction mixture was then cooled to room temperature and the solvent removed under reduced pressure to provide a mixture of compounds 18 and 19.

[3413] A solution of 6-fluoro-benzothiazol-2-ylamine 20 (3.7 g, 23.0 mmol) in DCM (15 mL) was added portionwise to a cooled solution of chloroformate 4. The resulting reaction mixture was stirred for 5 min. and 10 mL of triethylamine was added to the solution. The reaction mixture was then allowed to warm to room temperature and concentrated under reduced pressure at about 40° C. to provide the compound of formula 21. The compound of formula 21 was redissolved in DCM (30 mL) and to the resulting solution was added the mixture of compounds 18 and 19, prepared as described above, in DCM (10 mL). The resulting reaction mixture was allowed to stir for 5 min. and the solvent was removed under reduced pressure to provide a residue comprising Compound GIO and a Benzoazolylpiperazine Compound of Formula 22. The residue was purified using a silica gel column eluted with 5:95 ethyl acetate: hexane to provide 0.69 g of Compound GIO.

5.11. Example 11 Binding of Benzoazolylpiperazine Compounds to mGluR5

[3414] The following assay can be used to demonstrates Benzoazolylpiperazine Compounds that bind to and modulate the activity of mGluR5.

[3415] Cell cultures: Primary glial cultures are prepared from cortices of Sprague-Dawley 18 days old embryos. The cortices are dissected and then dissociated by trituration. The resulting cell homogenate is plated onto poly-D-lysine precoated T175 flasks (BIOCOAT, commercially available from Becton Dickinson and Company Inc. of Franklin Lakes, N.J. ) in Dulbelcco's Modified Eagle's Medium (“DMEM,” pH 7.4), buffered with 25 mM HEPES, and supplemented with 15% fetal calf serum (“FCS,” commercially available from Hyclone Laboratories Inc. of Omaha, Nebr. ), and incubated at 37° C. and 5% CO₂. After 24 hours, FCS supplementation is reduced to 10%. On day six, oligodendrocytes and microglia are removed by strongly tapping the sides of the flasks. One day following this purification step, secondary astrocyte cultures are established by subplating onto 96 poly-D-lysine precoated T175 flasks (BIOCOAT) at a density of 65,000 cells/well in DMEM and 10% FCS. After 24 hours, the astrocytes are washed with serum free medium and then cultured in DMEM, without glutamate, supplemented with 0.5% FCS, 20 mM HEPES, 10 ng/mL epidermal growth factor (“EGF”), 1 mM sodium pyruvate, and 1× penicillin/streptomycin at pH 7.5 for 3 to 5 days at 37° C. and 5% CO₂ The procedure allows the expression of the mGluR5 receptor by astrocytes, as demonstrated by S. Miller et al., J. Neuroscience 15(9):6103-6109 (1995).

[3416] Assay Protocol: After 3-5 days incubation with EGF, the astrocytes are washed with 127 mM NaCl, 5 mM KCl, 2 mM MgCl₂, 700 mM NaH₂PO₄, 2 mM CaCl₂, 5 mM NaHCO₃, 8 mM HEPES, 10 mM Glucose at pH 7.4 (“Assay Buffer”) and loaded with the dye Fluo-4 (commercially available from Molecular Probes Inc. of Eugene, Oreg.) using 0.1 mL of Assay Buffer containing Fluo-4 (3 mM final). After 90 minutes of dye loading, the cells are then washed twice with 0.2 mL Assay Buffer and resuspended in 0.1 mL of Assay Buffer. The plates containing the astrocytes are then transferred to a Fluorometric Imaging Plate reader (commercially available from Molecular Devices Corporation of Sunnyvale, Calif.) for the assessment of calcium mobilization flux in the presence of glutamate and in the presence or absence of antagonist. After monitoring fluorescence for 15 seconds to establish a base line, DMSO solutions containing various concentrations of a Benzoazolylpiperazine Compound diluted in Assay Buffer (0.05 mL of 4× dilutions for competition curves) are added to the cell plate and fluorescence is monitored for 2 minutes. 0.05 mL of a 4× glutamate solution (agonist) is then added to each well to provide a final glutamate concentration in each well of 10 mM. Plate fluorescence is then monitored for an additional 60 seconds after agonist addition. The final DMSO concentration in the assay is 1.0%. In each experiment, fluorescence is monitored as a function of time and the data analyzed using Microsoft Excel and GraphPad Prism. Dose-response curves are fit using a non-linear regression to determine IC₅₀ value. In each experiment, each data point is determined two times. The assay results will demonstrate Benzoazolylpiperazine Compounds that bind to and modulate the activity of mGluR5.

5.12. Example 12 In Vivo Assays for Prevention or Treatment of Pain

[3417] Test Animals: Each experiment uses rats weighing between 200-260 g at the start of the experiment. The rats are group-housed and have free access to food and water at all times, except prior to oral administration of a Benzoazolylpiperazine Compound when food is removed for 16 hours before dosing. A control group acts as a comparison to rats treated with a Benzoazolylpiperazine Compound. The control group is administered the carrier for the Benzoazolylpiperazine Compound. The volume of carrier administered to the control group is the same as the volume of carrier and Benzoazolylpiperazine Compound administered to the test group.

[3418] Acute Pain: To assess the actions of the Benzoazolylpiperazine Compounds for the treatment or prevention of acute pain the rat tail flick test can be used. Rats are placed inside a cotton pouch and the tail exposed to a focused beam of radiant heat at a point 3 cm from the tip using a tail flick unit (Model 7360, commercially available from Ugo Basile of Italy). Tail flick latencies are defined as the interval between the onset of the thermal stimulus and the flick of the tail. Animals not responding within 15 seconds are removed from the tail flick unit and assigned a withdrawal latency of 15 seconds. Tail flick latencies are measured immediately before (pre-treatment) and 1, 3, and 6 hours following administration of a Benzoazolylpiperazine Compound. Data are expressed as tail flick latency(s) and the percentage of the maximal possible effect (% MPE), i.e., 15 seconds, is calculated as follows: ${\% \quad {MPE}} = {\frac{\begin{matrix} \left\lbrack {\left( {{post}\quad {administration}\quad {latency}} \right) -} \right. \\ \left. \left( {{pre}\text{-}{administration}\quad {latency}} \right) \right\rbrack \end{matrix}}{\left. {15\quad s\quad {pre}\text{-}{administration}\quad {latency}} \right)} \times 100}$

[3419] The rat tail flick test is described in F. E. D'Amour et al., “A Method for Determining Loss of Pain Sensation,” J Pharmacol. Exp. Ther. 72:74-79 (1941). The results will demonstrate Benzoazolylpiperazine Compounds that are useful for treating or preventing acute pain.

[3420] Acute pain can also be assessed by measuring the animal's response to noxious mechanical stimuli by determining the paw withdrawal threshold (PWT), as described below.

[3421] Inflammatory Pain: To assess the actions of the Benzoazolylpiperazine Compounds for the treatment or prevention of inflammatory pain the Freund's complete adjuvant (FCA) model of inflammatory pain is used. FCA-induced inflammation of the rat hind paw is associated with the development of persistent inflammatory mechanical hyperalgesia and provides reliable prediction of the anti-hyperalgesic action of clinically useful analgesic drugs (L. Bartho et al., “Involvement of Capsaicin-sensitive Neurones in Hyperalgesia and Enhanced Opioid Antinociception in Inflammation,” Naunyn-Schmiedeberg's Archives of Pharmacology 342:666-670 (1990)). The left hind paw of each animal is administered a 50 μL intraplantar injection of 100% FCA. 24 hour post injection, the animal is assessed for response to noxious mechanical stimuli by determining the PWT, as described below. Rats are then administered a single injection of 1, 3, 10 or 30 mg/Kg of either a Benzoazolylpiperazine Compound, 30 mg/Kg indomethacin or carrier. Responses to noxious mechanical stimuli are then determined 2, 4, 6, and 24 hours post administration. Percentage reversal of hyperalgesia for each animal is defined as: ${\% \quad {Revesal}} = {\frac{\begin{matrix} \left\lbrack {\left( {{post}\quad {administration}\quad {PWT}} \right) -} \right. \\ \left. \left( {{pre}\text{-}{administration}\quad {PWT}} \right) \right\rbrack \end{matrix}}{\left( {{Baseline}\quad {pre}\text{-}{administration}\quad {PWT}} \right)} \times 100}$

[3422] The results will demonstrate Benzoazolylpiperazine Compounds that are useful for treating or preventing inflammatory pain.

[3423] Neuropathic Pain: To assess the actions of the Benzoazolylpiperazine Compounds for the treatment or prevention of neuropathic pain either the Seltzer model or the Chung model can be used.

[3424] In the Seltzer model, the partial sciatic nerve ligation model of neuropathic pain is used to produce neuropathic hyperalgesia in rats (Z. Seltzer et al., “A Novel Behavioral Model of Neuropathic Pain Disorders Produced in Rats by Partial Sciatic Nerve Injury,” Pain 43:205-218 (1990)). Partial ligation of the left sciatic nerve is performed under enflurane/O₂ inhalation anaesthesia. Following induction of anesthesia, the left thigh of the rat is shaved and the sciatic nerve exposed at high thigh level through a small incision and is carefully cleared of surrounding connective tissues at a site near the trocanther just distal to the point at which the posterior biceps semitendinosus nerve branches off of the common sciatic nerve. A 7-0 silk suture is inserted into the nerve with a {fraction (3/8)} curved, reversed-cutting mini-needle and tightly ligated so that the dorsal {fraction (1/3)} to {fraction (1/2)} of the nerve thickness is held within the ligature. The wound is closed with a single muscle suture (7-0 silk) and a Michelle clip. Following surgery, the wound area is dusted with antibiotic powder. Sham-treated rats undergo an identical surgical procedure except that the sciatic nerve is not manipulated. Following surgery, animals are weighed and placed on a warm pad until they recover from anesthesia. Animals are then returned to their home cages until behavioral testing begins. The animal is assessed for response to noxious mechanical stimuli by determining PWT, as described below, immediately prior to and 1, 3, and 6 hours after drug administration for both the left rear paw and right rear paw of the animal. Percentage reversal of neuropathic hyperalgesia is defined as:

% reversal=100×[(right pre-administration PWT−left post-administration PWT)/( right pre-administration PWT−left pre-administration PWT)]×100.

[3425] In the Chung model, the spinal nerve ligation model of neuropathic pain is used to produce mechanical hyperalgesia, themal hyperalgesia and tactile allodynia in rats. Surgery is performed under isoflurane/O₂ inhalation anaesthesia. Following induction of anaesthesia a 3 cm incision is made and the left paraspinal muscles are separated from the spinous process at the L₄-S₂ levels. The L₆ transverse process is carefully removed with a pair of small rongeurs to identify visually the L₄-L₆ spinal nerves. The left L₅ (or L₅ and L₆) spinal nerve(s) is isolated and tightly ligated with silk thread. A complete hemostasis is confirmed and the wound is sutured using non-absorbable sutures, such as nylon sutures or stainless steel staples. Sham-treated rats undergo an identical surgical procedure except that the spinal nerve(s) is not manipulated. Following surgery animals are weighed, administered a subcutaneous (s.c.) injection of saline or ringers lactate, the wound area is dusted with antibiotic powder and they are kept on a warm pad until they recover from the anesthesia. Animals are then be returned to their home cages until behavioral testing begins. The animals are assessed for response to noxious mechanical stimuli by determining PWT, as described below, immediately prior to and 1, 3, and 5 hours after being administered a Benzoazolylpiperazine Compound for both the left rear paw and right rear paw of the animal. The animal can also be assessed for response to noxious thermal stimuli or for tactile allodynia, as described below. The Chung model for neuropathic pain is described in S. H. Kim, “An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat,” Pain 50(3):355-363 (1992). The results show demonstrate Benzoazolylpiperazine Compounds that are useful for treating or preventing neuropathic pain.

[3426] Response to Mechanical Stimuli as an Assessment of Mechanical Hyperalgesia: The paw pressure assay can be used to assess mechanical hyperalgesia. For this assay, hind paw withdrawal thresholds (PWT) to a noxious mechanical stimulus are determined using an analgesymeter (Model 7200, commercially available from Ugo Basile of Italy) as described in C. Stein, “Unilateral Inflammation of the Hindpaw in Rats as a Model of Prolonged Noxious Stimulation: Alterations in Behavior and Nociceptive Thresholds,” Pharmacology Biochemistry and Behavior 31:451-455 (1988). The maximum weight that can be applied to the hind paw is set at 250 g and the end point is taken as complete withdrawal of the paw. PWT is determined once for each rat at each time point and only the affected (ipsilateral) paw is tested.

[3427] Response to Thermal Stimuli as an Assessment of Thermal Hyperalgesia: The plantar test can be used to assess thermal hyperalgesia. For this test, hind paw withdrawal latencies to a noxious thermal stimulus are determined using a plantar test apparatus (commercially available from Ugo Basile of Italy) following the technique described by K. Hargreaves et al., “A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia,” Pain 32(1):77-88 (1988). The maximum exposure time is set at 32 seconds to avoid tissue damage and any directed paw withdrawal from the heat source is taken as the end point. Three latencies are determined at each time point and averaged. Only the affected (ipsilateral) paw is tested.

[3428] Assessment of Tactile Allodvnia: To assess tactile allodynia, rats are placed in clear, plexiglass compartments with a wire mesh floor and allowed to habituate for a period of at least 15 minutes. After habituation, a series of von Frey monofilaments are presented to the plantar surface of the left (operated) foot of each rat. The series of von Frey monofilaments consists of six monofilaments of increasing diameter, with the smallest diameter fiber presented first. Five trials are conducted with each filament with each trial separated by approximately 2 minutes. Each presentation lasts for a period of 4-8 seconds or until a nociceptive withdrawal behavior is observed. Flinching, paw withdrawal or licking of the paw are considered nociceptive behavioral responses.

5.13 Example 13 In Vivo Assays for Prevention or Treatment of Anxiety

[3429] The elevated plus maze test or the shock-probe burying test can be used to assess the anxiolytic activity of Benzoazolylpiperazine Compounds in rats or mice.

[3430] The Elevated Plus Maze Test: The elevated plus maze consists of a platform with 4 arms, two open and two closed (50×10×50 cm enclosed with an open roof). Rats (or mice) are placed in the center of the platform, at the crossroad of the 4 arms, facing one of the closed arms. Time spent in the open arms vs the closed arms and number of open arm entries during the testing period are recorded. This test is conducted prior to drug administration and again after drug administration. Test results are expressed as the mean time spent in open arms and the mean number of entries into open arms. Known anxiolytic drugs increase both the time spent in open arms and number of open arm entries. The elevated plus maze test is described in D. Treit, “Animal Models for the Study of Anti-anxiety Agents: A Review,” Neuroscience & Biobehavioral Reviews 9(2):203-222 (1985).

[3431] The Shock-Probe Burying Test: For the shock-probe burying test the testing apparatus consists of a plexiglass box measuring 40×30×40 cm, evenly covered with approximately 5 cm of bedding material (odor absorbent kitty litter) with a small hole in one end through which a shock probe (6.5 cm long and 0.5 cm in diameter) is inserted. The plexiglass shock probe is helically wrapped with two copper wires through which an electric current is administered. The current is set at 2 mA. Rats are habituated to the testing apparatus for 30 min on 4 consecutive days without the shock probe in the box. On test day, rats are placed in one corner of the test chamber following drug administration. The probe is not electrified until the rat touches it with its snout or fore paws, at which point the rat receives a brief 2 mA shock. The 15 min testing period begins once the rat receives its first shock and the probe remains electrified for the remainder of the testing period. The shock elicits burying behavior by the rat. Following the first shock, the duration of time the rat spends spraying bedding material toward or over the probe with its snout or fore paws (burying behavior) is measured as well as the number of contact-induced shocks the rat receives from the probe. Known anxiolytic drugs reduce the amount of burying behavior. In addition, an index of the rat's reactivity to each shock is scored on a 4 point scale. The total time spent immobile during the 15 min testing period is used as an index of general activity. The shock-probe burying test is described in D. Treit, 1985, supra. The results of this test will demonstrate Benzoazolylpiperazine Compounds that are useful for treating or preventing anxiety.

5.14. Example 14 In Vivo Assays for Prevention or Treatment of an Addictive Disorder

[3432] The condition place preference test or drug self-administration test can be used to assess the ability of Benzoazolylpiperazine Compounds to attenuate the rewarding properties of known drugs of abuse.

[3433] The Condition Place Preference Test: The apparatus for the conditioned place preference test consists of two large compartments (45×45×30 cm) made of wood with a plexiglass front wall. These two large compartments are distinctly different. Doors at the back of each large compartment lead to a smaller box (36×18×20 cm) box made of wood, painted grey, with a ceiling of wire mesh. The two large compartments differ in terms of shading (white vs black), level of illumination (the plexiglass door of the white compartment is covered with aluminum foil except for a window of 7×7 cm), texture (the white compartment has a 3 cm thick floor board (40×40 cm) with nine equally spaced 5 cm diameter holes and the black has a wire mesh floor), and olfactory cues (saline in the white compartment and 1 mL of 10% acetic acid in the black compartment). On habituation and testing days, the doors to the small box remain open, giving the rat free access to both large compartments.

[3434] The first session that a rat is placed in the apparatus is a habituation session and entrances to the smaller grey compartment remain open giving the rat free access to both large compartments. During habituation, rats generally show no preference for either compartment. Following habituation, rats are given 6 conditioning sessions. Rats are divided into 4 groups: carrier pre-treatment+carrier (control group), 2-Pyrimidinylpiperazine Compound pre-treatment+carrier, carrier pre-treatment+morphine, 2-Pyrimidinylpiperazine Compound pre-treatment+morphine. During each conditioning session the rat is injected with one of the drug combinations and confined to one compartment for 30 min. On the following day, the rat receives a carrier+carrier treatment and is confined to the other large compartment. Each rat receives three conditioning sessions consisting of 3 drug combination-compartment and 3 carrier-compartment pairings. The order of injections and the drug/compartment pairings are counterbalanced within groups. On the test day, rats are injected prior to testing (30 min to 1 hour) with either morphine or carrier and the rat is placed in the apparatus, the doors to the grey compartment remain open and the rat is allowed to explore the entire apparatus for 20 min. The time spent in each compartment is recorded. Known drugs of abuse increase the time spent in the drug-paired compartment during the testing session. If the Benzoazolylpiperazine Compound blocks the acquisition of morphine conditioned place preference (reward), there will be no difference in time spent in each side in rats pre-treated with a Benzoazolylpiperazine Compound and the group will not be different from the group of rats that was given carrier+carrier in both compartments. Data will be analyzed as time spent in each compartment (drug combination-paired vs carrier-paired). Generally, the experiment is repeated with a minimum of 3 doses of a Benzoazolylpiperazine Compound.

[3435] The Drug Self-Administration Test: The apparatus for the drug self-administration test is a standard commercially available operant conditioning chamber. Before drug trials begin rats are trained to press a lever for a food reward. After stable lever pressing behavior is acquired, rats are tested for acquisition of lever pressing for drug reward. Rats are implanted with chronically indwelling jugular catheters for i.v. administration of compounds and are allowed to recover for 7 days before training begins. Experimental sessions are conducted daily for 5 days in 3 hour sessions. Rats are trained to self-administer a known drug of abuse, such as morphine. Rats are then presented with two levers, an “active” lever and an “inactive” lever. Pressing of the active lever results in drug infusion on a fixed ratio 1 (FR1) schedule (i.e., one lever press gives an infusion) followed by a 20 second time out period (signaled by illumination of a light above the levers). Pressing of the inactive lever results in infusion of excipient. Training continues until the total number of morphine infusions stabilizes to within ±10% per session. Trained rats are then used to evaluate the effect of Benzoazolylpiperazine Compounds pre-treatment on drug self-administration. On test day, rats are pre-treated with a Benzoazolylpiperazine Compound or excipient and then are allowed to self-administer drug as usual. If the Benzoazolylpiperazine Compound blocks the rewarding effects of morphine, rats pre-treated with the Benzoazolylpiperazine Compound will show a lower rate of responding compared to their previous rate of responding and compared to excipient pre-treated rats. Data is analyzed as the change in number of drug infusions per testing session (number of infusions during test session−number of infusions during training session). The results will demonstrate Benzoazolylpiperazine Compounds are useful for treating or preventing an addictive disorder.

5.15. Example 15 Functional Assay for Characterizing mGluR 1 Antagonistic Properties

[3436] Functional assays for the characterization of mGluR 1 antagonistic properties are well known in the art. For example, the following procedure can be used.

[3437] A CHO-rat mGluR1 cell line is generated using cDNA encoding rat mGluR1 receptor (M. Masu and S. Nakanishi, Nature 349: 760-765 (1991)). The cDNA encoding rat mGluR1 receptor can be obtained from, e.g., Prof. S. Nakanishi (Kyoto, Japan).

[3438] 40,000 CHO-rat mGluR1 cells/well are plated into a Costar 3409, black, clear bottom, 96 well, tissue culture treated plate (commercially available from Fisher Scientific of Chicago, Ill.) and are incubated in Dulbecco's Modified Eagle's Medium (DMEM, pH 7.4) supplemented with glutamine, 10% FBS, 1% Pen/Strep, and 500 μg/mL Geneticin for about 12 h. The CHO-rat mGluR1 cells are then washed and treated with Optimem medium (commercially available from Invitrogen, Carlsbad, Calif.) and incubated for a time period ranging from 1 to 4 hours prior to loading the cells with the dye Fluo-4 (commercially available from Molecular Probes Inc., Eugene Oreg.). After incubation, the cell plates are washed with loading buffer (127 mM NaCl, 5 mM KCl, 2 mM MgCl₂, 700 μM, NaH₂PO₄, 2 mM CaCl₂, 5 mMNaHCO₃, 8 mM HEPES, and 10 mM glucose, pH 7.4) and incubated with 3 μM Fluo-4 in 0.1 mL loading buffer for 90 min. The cells are then washed twice with 0.2 mL loading buffer, resuspended in 0.1 mL of loading buffer, and transferred to a Fluorometric Imaging Plate Reader (FLIPR) (commercially available from Molecular Devices Corp., Sunnyvale, Calif.) for measurement of calcium mobilization flux in the presence of glutamate and in the presence or absence of a Benzoazolylpiperazine Compound.

[3439] To measure calcium mobilization flux, fluoresence is monitored for about 15 s to establish a baseline and DMSO solutions containing various concentrations of a Benzoazolylpiperazine Compound ranging from about 50 μM to about 0.8 nM diluted in loading buffer (0.05 mL of a 4× dilution) are added to the cell plate and fluoresence is monitored for about 2 min. 0.05 mL of a 4× Glutamate solution (agonist) is then added to each well to provide a final glutamate concentration in each well of 10 μM and fluoresence is monitored for about 1 additional min. The final DMSO concentration in the assay is 1%. In each experiment fluoresence is monitored as a function of time and the data is analyzed using a non-linear regression to determine the IC₅₀ value. In each experiment each data point is determined twice.

5.16 Example 16 Binding of Benzoazolylpiperazine Compounds to VR1

[3440] Methods for demonstrating a compound's ability to inhibit VR1 are well known to those skilled in the art, for example, those methods disclosed in U.S. Pat. No. 6,239,267 to Duckworth et al.; U.S. Pat. No. 6,406,908 to McIntyre et al.; or U.S. Pat. No. 6,335,180 to Julius et al. The results of this assay will demonstrate Benzoazolylpiperazine Compounds that bind to and modulate the activity of VR1.

[3441] Binding of Compound AAQ to VR1: Assay Protocol

[3442] Human VR1 cloning. Human spinal cord RNA (commercially available from Clontech, Palo Alto, Calif.) was used. Reverse transcription was conducted on 1.0 μg total RNA using Thermoscript Reverse Transcriptase (commercially available from Invitrogen, Carlsbad, Calif.) and oligo dT primers as detailed in its product description. Reverse transcription reactions were incubated at 55° C. for 1 h, heat-inactivated at 85° C. for 5 min, and RNase H-treated at 37° C. for 20 min.

[3443] Human VR1 cDNA sequence was obtained by comparison of the human genomic sequence, prior to annotation, to the published rat sequence. Intron sequences were removed and flanking exonic sequences were joined to generate the hypothetical human cDNA. Primers flanking the coding region of human VR1 were designed as follows: forward primer, AAGATCTTCGCTGGTTGCACACTGGGCCACA; and reverse primer, GAAGATCTTCGGGGACAGTGACGGTTGGATGT.

[3444] PCR of VR1 was performed on one tenth of the reverse transcription reaction mixture using Expand Long Template Polymerase and Expand Buffer 2 in a final volume of 50 μL according to the manufacturer's instructions (Roche Applied Sciences, Indianapolis, Ind.). After denaturation at 94° C. for 2 min PCR amplification was performed for 25 cycles at 94° C. for 15 sec, 58° C. for 30 sec, and 68° C. for 3 min followed by a final incubation at 72° C. for 7 min to complete the amplification. A PCR product of ˜2.8 kb was gel-isolated using a 1.0% agarose, Tris-Acetate gel containing 1.6 μg/ML of crystal violet and purified with a S.N.A.P. UV-Free Gel Purification Kit (commercially available from Invitrogen). The VR1 PCR product was cloned into the pIND/V5-His-TOPO vector (commercially available from Invitrogen) according to the manufacturer's instructions. DNA preparations, restriction enzyme digestions, and preliminary DNA sequencing were performed according to standard protocols. Full-length sequencing confirmed the identity of the human VR1.

[3445] Generation of inducible cell lines. Unless noted otherwise, cell culture reagents were purchased from Life Technologies of Rockville, Md. HEK293-EcR cells expressing the ecdysone receptor (commercially available from Invitrogen) were cultured in Growth Medium (Dulbecco's Modified Eagles Medium containing 10% fetal bovine serum (commercially available from HYCLONE, Logan, Utah), 1× penicillin/streptomycin, 1× glutamine, 1 mM sodium pyruvate and 400 μg/mL Zeocin (commercially available from Invitrogen)). The VR1-pIND constructs were transfected into the HEK293-EcR cell line using Fugene transfection reagent (commercially available from Roche Applied Sciences, Basel, Switzerland). After 48 h, cells were transferred to Selection Medium (Growth Medium containing 300 μg/mL G418 (commercially available from Invitrogen)). Approximately 3 weeks later individual Zeocin/G418 resistant colonies were isolated and expanded. To identify functional clones, multiple colonies were plated into 96-well plates and expression was induced for 48 h using Selection Medium supplemented with 5 μM ponasterone A (“PonA”) (commercially available from Invitrogen). On the day of assay, cells were loaded with Fluo-4 (a calcium-sensitive dye that is commercially available from Molecular Probes, Eugene, Oreg.) and CAP-mediated calcium influx was measured using a Fluorometric Imaging Plate Reader (“FLIPR”) (commercially available from Molecular Devices Corp., Sunnyvale, Calif.) as described below. Functional clones were re-assayed, expanded, and cryopreserved.

[3446] pH-Based Assay. Two days prior to performing this assay, cells were seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Becton-Dickinson) at 75,000 cells/well in growth media containing 5 μM PonA (commercially available from Invitrogen) to induce expression. On the day of the assay, the plates were washed with 0.2 mL 1× Hank's Balanced Salt Solution (commercially available from Life Technologies) containing 1.6 mM CaCl₂ and 20 mM HEPES, pH 7.4 (“wash buffer”), and loaded using 0.1 mL of wash buffer containing Fluo-4 (3 μM final concentration, commercially available from Molecular Probes). After 1 h, the cells were washed twice with 0.2 mL wash buffer and resuspended in 0.05 mL 1× Hank's Balanced Salt Solution (commercially available from Life Technologies) containing 3.5 mM CaCl₂ and 10 mM Citrate, pH 7.4 (“assay buffer”). Plates were then transferred to a FLIPR (commercially available from Molecular Devices) for assay. Compound AAQ was diluted in assay buffer, and 50 mL of the resultant solution were added to the cell plates and the solution monitored for two minutes. The final concentration of Compound AAQ ranged from about 50 pM to about 3 μM. Agonist buffer (wash buffer titrated with 1N HCl to provide a solution having a pH of 5.5 when mixed 1:1 with assay buffer) (0.1 mL) was then added to each well, and the plates were incubated for 1 additional min. Data were collected over the entire time course and analyzed using Excel and Graph Pad Prism. Compound AAQ when assayed according to this protocol had an IC₅₀ of 261.8±75.1 (n=6).

[3447] Capsaicin-based Assay. Two days prior to performing this assay, cells were seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth media containing 5 μM PonA (commercially available from Invitrogen) to induce expression. On the day of the assay, the plates were washed with 0.2 mL 1× Hank's Balanced Salt Solution (commercially available from Life Technologies) containing 1 mM CaCl₂ and 20 mM HEPES, pH 7.4, and cells were loaded using 0.1 mL of wash buffer containing Fluo-4 (3 μM final). After one h, the cells were washed twice with 0.2 mL of wash buffer and resuspended in 0.1 mL of wash buffer. The plates were transferred to a FLIPR (commercially available from Molecular Devices) for assay. 50 μL of Compound AAQ diluted with assay buffer were added to the cell plates and incubated for 2 min. The final concentration of Compound AAQ ranged from about 50 pM to about 3 μM. Human VR1 was activated by the addition of 50 μL of capsaicin (400 nM), and the plates were incubated for an additional 3 min. Data were collected over the entire time course and analyzed using Excel and GraphPad Prism. Compound AAQ when assayed according to this protocol had an IC₅₀ of 50.7±14.7 (n=3).

[3448] The results of the pH-based assay and the capsaicin-based assay demonstrate that Compound AAQ, an illustrative Benzoazolylpiperazine Compound, binds to and modulates the activity of human VR1 and, accordingly, is useful for treating or preventing pain, UI, an ulcer, IBD, or IBS.

[3449] The present invention is not to be limited in scope by the specific embodiments disclosed in the examples which are intended as illustrations of a few aspects of the invention and any embodiments that are functionally equivalent are within the scope of this invention. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art and are intended to fall within the scope of the appended claims.

[3450] A number of references have been cited, the entire disclosures of which are incorporated herein by reference. 

What is claimed is:
 1. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

A is

R₁ is —Cl, —Br, —I, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; each R₃ is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₄ is —H or —(C₁-C₆)alkyl; each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each -halo is —F, —Cl, —Br,— or —I; n is an integer ranging from 0 to 3; p is an integer ranging from 0 to 2; m is 0 or 1; and x is 0 or
 1. 2. The compound of claim 1, wherein Ar₁ is a pyridyl group.
 3. The compound of claim 1, wherein x is 1 and A is —C(O)N(R₄)—.
 4. The compound of claim 1, wherein Ar₁ is a pyridyl group, x is 1, and A is —C(O)N(R₄)—.
 5. The compound of claim 1, wherein Ar₁ is a pyridyl group, x is 1, and A is —C(S)N(R₄)—.
 6. The compound of claim 1, wherein n or p is
 0. 7. The compound of claim 1, wherein n or p is
 1. 8. The compound of claim 1, wherein x is
 0. 9. The compound of claim 1, wherein Ar₁ is a pyrimidinyl group
 10. The compound of claim 1, wherein Ar₁ is a pyrimidinyl group, x is 1, and A is —C(O)N(R₄)—.
 11. The compound of claim 1, wherein Ar₁ is a pyrimidinyl group, x is 1, and A is —C(S)N(R₄)—.
 12. The compound of claim 1, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 0; n or p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or-F.
 13. The compound of claim 12, wherein Ar₁ is a pyridyl group.
 14. The compound of claim 13, wherein R₁ is —CH₃ and R₉ is —Cl.
 15. The compound of claim 13, wherein R₁ is —CH₃ and R₉ is —Br.
 16. The compound of claim 13, wherein R₁ is —CH₃ and R₉ is —F.
 17. The compound of claim 13, wherein R₁ is —Cl and R₉ is —Cl.
 18. The compound of claim 13, wherein R₁ is —Cl and R₉ is —Br.
 19. The compound of claim 13, wherein R₁ is —Cl and R₉ is —Cl.
 20. The compound of claim 1, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 1; R₃ is —(C₁-C₁₀)alkyl; n or p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 21. The compound of claim 20, wherein R₃ is —CH₃.
 22. The compound of claim 20, wherein the carbon to which R₃ is attached is in the (R) configuration.
 23. The compound of claim 20, wherein R₃ is attached to a carbon atom adjacent to a nitrogen atom attached to the —C(O)—N(R₄)-group.
 24. The compound of claim 20, wherein Ar₁ is a pyridyl group.
 25. The compound of claim 24, wherein R₁ is —CH₃ and R₉ is —Cl.
 26. The compound of claim 25, wherein the carbon to which R₃ is attached is in the (R) configuration.
 27. The compound of claim 24, wherein R₁ is —CH₃ and R₉ is —Br.
 28. The compound of claim 27, wherein the carbon to which R₃ is attached is in the (R) configuration.
 29. The compound of claim 24, wherein R₁ is —CH₃ and R₉ is —F.
 30. The compound of claim 29, wherein the carbon to which R₃ is attached is in the (R) configuration.
 31. The compound of claim 24, wherein R₁ is —Cl and R₉ is —Cl.
 32. The compound of claim 31, wherein the carbon to which R₃ is attached is in the (R) configuration.
 33. The compound of claim 24, wherein R₁ is —Cl and R₉ is —Br.
 34. The compound of claim 33, wherein the carbon to which R₃ is attached is in the (R) configuration.
 35. The compound of claim 24, wherein R₁ is —Cl and R₉ is —Cl.
 36. The compound of claim 35, wherein the carbon to which R₃ is attached is in the (R) configuration.
 37. The compound of claim 1, wherein m is 1 and the carbon to which R₃ is attached is in the (R) configuration.
 38. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

A is

R₁ is —H, -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂—C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; each R₃ is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₄ is —H or —(C₁-C₆)alkyl; each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each -halo is —F, —Cl, —Br,— or —I; p is an integer ranging from 0 to 2; m is0or 1; and x is0or
 1. 39. The compound of claim 38, wherein x is 1 and A is —C(O)N(R₄)—.
 40. The compound of claim 38, wherein Ar₁ is a pyrazinyl group.
 41. The compound of claim 38, wherein Ar₁ is a pyridazinyl group.
 42. The compound of claim 38, wherein Ar₁ is a thiazanyl group.
 43. The compound of claim 38, wherein Ar₁ is a pyrazinyl group, x is 1, and A is —C(O)N(R₄)—.
 44. The compound of claim 38, wherein Ar₁ is a pyrazinyl group, x is 1, and A is —C(S)N(R₄)—.
 45. The compound of claim 38, wherein Ar₁ is a pyridazinyl group, x is 1, and A is —C(O)N(R₄)—.
 46. The compound of claim 38, wherein Ar₁ is a pyridazinyl group, x is 1, and A is —C(S)N(R₄)—.
 47. The compound of claim 38, wherein Ar₁ is a thiazanyl group, x is 1, and A is —C(O)N(R₄)—.
 48. The compound of claim 38, wherein Ar₁ is a thiazanyl group, x is 1, and A is —C(S)N(R₄)—.
 49. The compound of claim 38, wherein p is
 0. 50. The compound of claim 38, wherein p is
 1. 51. The compound of claim 38, wherein x is
 0. 52. The compound of claim 38, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 0; p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or-F.
 53. The compound of claim 52, wherein R₁ is —CH₃ and R₉ is —Cl.
 54. The compound of claim 52, wherein R₁ is —CH₃ and R₉ is —Br.
 55. The compound of claim 52, wherein R₁ is —CH₃ and R₉ is —F.
 56. The compound of claim 52, wherein R₁ is —Cl and R₉ is —Cl.
 57. The compound of claim 52, wherein R₁ is —Cl and R₉ is —Br.
 58. The compound of claim 52, wherein R₁ is —Cl and R₉ is —Cl.
 59. The compound of claim 38, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 1; R₃ is —(C₁-C₁₀)alkyl; p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or-F.
 60. The compound of claim 59, wherein R₃ is —CH₃.
 61. The compound of claim 59, wherein the carbon to which R₃ is attached is in the (R) configuration.
 62. The compound of claim 59, wherein R₃ is attached to a carbon atom adjacent to a nitrogen atom attached to the —C(O)—N(R₄)-group.
 63. The compound of claim 59, wherein R₁ is —CH₃ and R₉ is —Cl.
 64. The compound of claim 63, wherein the carbon to which R₃ is attached is in the (R) configuration.
 65. The compound of claim 59, wherein R₁ is —CH₃ and R₉ is —Br.
 66. The compound of claim 65, wherein the carbon to which R₃ is attached is in the (R) configuration.
 67. The compound of claim 59, wherein R₁ is —CH₃ and R₉ is —F.
 68. The compound of claim 67, wherein the carbon to which R₃ is attached is in the (R) configuration.
 69. The compound of claim 59, wherein R₁ is —Cl and R₉ is —Cl.
 70. The compound of claim 69, wherein the carbon to which R₃ is attached is in the (R) configuration.
 71. The compound of claim 59, wherein R₁ is —Cl and R₉ is —Br.
 72. The compound of claim 71, wherein the carbon to which R₃ is attached is in the (R) configuration.
 73. The compound of claim 59, wherein R₁ is —Cl and R₉ is —Cl.
 74. The compound of claim 73, wherein the carbon to which R₃ is attached is in the (R) configuration.
 75. The compound of claim 38, wherein m is 1 and the carbon to which R₃ is attached is in the (R) configuration.
 76. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

R₁ is —Cl, —Br, —I, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; each R₃ is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; R₁₀ is —H or —(C₁-C₄)alkyl; each -halo is —F, —Cl, —Br,—or —I; n is an integer ranging from 0 to 3; p is an integer ranging from 0 to 2; and m is 0 or
 1. 77. The compound of claim 76, wherein Ar₁ is a pyridyl group.
 78. The compound of claim 76, wherein Ar₁ is a pyrimidinyl group.
 79. The compound of claim 76, wherein Ar₁ is a pyrazinyl group.
 80. The compound of claim 76, wherein n or p is
 0. 81. The compound of claim 76, wherein n or p is
 1. 82. The compound of claim 76, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 0; n or p is 0; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 83. The compound of claim 82, wherein Ar₁ is a pyridyl group.
 84. The compound of claim 76, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 1; R₃ is —(C₁-C₁₀)alkyl; n or p is 0; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 85. The compound of claim 84, wherein R₃ is —CH₃.
 86. The compound of claim 84, wherein the carbon to which R₃ is attached is in the (R) configuration.
 87. The compound of claim 76, wherein the carbon to which R₃ is attached is in the (R) configuration.
 88. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

A is

R₁ is —H, -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; each R₃ is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-Cl₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₄ is —H or —(C₁-C₆)alkyl; each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; R₁₀ is —H or —(C₁-C₄)alkyl; each -halo is —F, —Cl, —Br,— or —I; p is an integer ranging from 0 to 2; m is 0 or 1; and x is 0 or
 1. 89. The compound of claim 88, wherein Ar₁ is a pyridazinyl group.
 90. The compound of claim 88, wherein Ar₁ is a thiazanyl group.
 91. The compound of claim 88, wherein x is 1 and A is —C(O)N(R₄)—.
 92. The compound of claim 88, wherein Ar₁ is a pyridazinyl group, x is 1, and A is —C(O)N(R₄)—.
 93. The compound of claim 88, wherein Ar₁ is a pyridazinyl group, x is 1, and A is —C(S)N(R₄)—.
 94. The compound of claim 88, wherein p is
 0. 95. The compound of claim 88, wherein p is
 1. 96. The compound of claim 88, wherein x is
 0. 97. The compound of claim 88, wherein Ar₁ is a thiazanyl group.
 98. The compound of claim 88, wherein Ar₁ is a thiazanyl group, x is 1, and A is —C(O)N(R₄)—.
 99. The compound of claim 88, wherein Ar₁ is a thiazanyl group, x is 1, and A is —C(S)N(R₄)—.
 100. The compound of claim 88, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 0; p is 0; x is 1; A is —C(O)—N(R₄)—; R₄is —H; R₈is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 101. The compound of claim 88, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 1; R₃ is —(C₁-C₁₀)alkyl; p is 0; x is 1; A is —C(O)—N(R₄)—; R₄is —H; R₈is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 102. The compound of claim 101, wherein R₃ is —CH₃.
 103. The compound of claim 101, wherein the carbon to which R₃ is attached is in the (R) configuration.
 104. The compound of claim 101, wherein R₃ is attached to a carbon atom adjacent to a nitrogen atom attached to the —C(O)—N(R₄)-group.
 105. The compound of claim 88, wherein m is 1 and the carbon to which R₃ is attached is in the (R) configuration.
 106. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

A is

R₁ is —Cl, —Br, —I, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; each R₃ is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH_(2;) (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₄ is —H or —(C₁-C₆)alkyl; each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each -halo is —F, —Cl, —Br,— or —I; n is an integer ranging from 0 to 3; p is an integer ranging from 0 to 2; m is 0 or 1; and x is0 or
 1. 107. The compound of claim 106, wherein Ar₁ is a pyridyl group.
 108. The compound of claim 106, wherein x is 1 and A is —C(O)N(R₄)—.
 109. The compound of claim 106, wherein Ar₁ is a pyridyl group, x is 1, and A is —C(O)N(R₄)—.
 110. The compound of claim 106, wherein Ar₁ is a pyridyl group, x is 1, and A is —C(S)N(R₄)—.
 111. The compound of claim 106, wherein n or p is
 0. 112. The compound of claim 106, wherein n or p is
 1. 113. The compound of claim 106, wherein x is
 0. 114. The compound of claim 106, wherein Ar₁ is a pyrimidinyl group
 115. The compound of claim 106, wherein Ar₁ is a pyrimidinyl group, x is 1, and A is —C(O)N(R₄)—.
 116. The compound of claim 106, wherein Ar₁ is a pyrimidinyl group, x is 1, and A is —C(S)N(R₄)—.
 117. The compound of claim 106, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 0; n or p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or-F.
 118. The compound of claim 106, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 1; R₃ is —(C₁-C₁₀)alkyl; n or p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 119. The compound of claim 118, wherein R₃ is —CH₃.
 120. The compound of claim 118, wherein the carbon to which R₃ is attached is in the (R) configuration.
 121. The compound of claim 118, wherein R₃ is attached to a carbon atom adjacent to a nitrogen atom attached to the —C(O)—N(R₄)-group.
 122. The compound of claim 106, wherein m is 1 and the carbon to which R₃ is attached is in the (R) configuration.
 123. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

A is

R₁ is —H, -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, or —(C₁₄)aryl each of which is unsubstituted or substituted with one or more R₆ groups; each R₃ is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₂₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₄ is —H or —(C₁-C₆)alkyl; each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each -halo is —F, —Cl, —Br,— or —I; p is an integer ranging from 0 to 2; m is 0 or 1; and x is 0 or
 1. 124. The compound of claim 123, wherein Ar₁ is a pyrazinyl group.
 125. The compound of claim 123, wherein x is 1 and A is —C(O)N(R₄)—.
 126. The compound of claim 123, wherein Ar₁ is a pyrazinyl group, x is 1, and A is —C(O)N(R₄)—.
 127. The compound of claim 123, wherein Ar₁ is a pyrazinyl group, x is 1, and A is —C(S)N(R₄)—.
 128. The compound of claim 123, wherein p is
 0. 129. The compound of claim 123, wherein p is
 1. 130. The compound of claim 123, wherein x is
 0. 131. The compound of claim 123, wherein Ar₁ is a pyridazinyl group
 132. The compound of claim 123, wherein Ar₁ is a pyridazinyl group, x is 1, and A is —C(O)N(R₄)—.
 133. The compound of claim 123, wherein Ar₁ is a pyridazinyl group, x is 1, and A is —C(S)N(R₄)—.
 134. The compound of claim 123, wherein Ar₁ is a thiazanyl group.
 135. The compound of claim 123, wherein Ar₁ is a thiazanyl group, x is 1, and A is —C(O)N(R₄)—.
 136. The compound of claim 123, wherein Ar₁ is a thiazanyl group, x is 1, and A is —C(S)N(R₄)—.
 137. The compound of claim 123, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 0; p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 138. The compound of claim 123, wherein: R₁ is —CH₃, CF₃, —Cl, —Br, or —I; m is 1; R₃ is —(C₁-C₁₀)alkyl; p is 0; x is 1; A is —C(O)—N(R₄)—; R₄ is —H; R₈ is —H; and R₉ is —CH₃, CF₃, —OCH₂CH₃, tert-butyl, Cl, —Br—, or —F.
 139. The compound of claim 138, wherein R₃ is —CH₃.
 140. The compound of claim 138, wherein the carbon to which R₃ is attached is in the (R) configuration.
 141. The compound of claim 138, wherein R₃ is attached to a carbon atom adjacent to a nitrogen atom attached to the —C(O)—N(R₄)-group.
 142. The compound of claim 123, wherein m is 1 and the carbon to which R₃ is attached is in the (R) configuration.
 143. A composition comprising the compound or a pharmaceutically acceptable salt of the compound of claim 1 and a pharmaceutically acceptable vehicle.
 144. A method for treating or preventing pain in an animal, comprising administering to an animal in need thereof an effective amount of the compound or a pharmaceutically acceptable salt of the compound of claim
 1. 145. A method for treating or preventing a condition selected from the group consisting of urinary incontinence, an ulcer, irritable-bowel syndrome, inflammatory-bowel disease, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, and depression, in an animal, comprising administering to an animal in need thereof an effective amount of the compound or a pharmaceutically acceptable salt of the compound of claim
 1. 146. A method for inhibiting VR1 function in a cell comprising contacting a cell capable of expressing VR1 with an effective amount of the compound or a pharmaceutically acceptable salt of the compound of claim
 1. 147. A method for inhibiting mGluR5 function in a cell comprising contacting a cell capable of expressing mGluR5 with an effective amount of the compound or a pharmaceutically acceptable salt of the compound of claim
 1. 148. A method for inhibiting mGluR1 function in a cell comprising contacting a cell capable of expressing mGluR1 with an effective amount of the compound or a pharmaceutically acceptable salt of the compound of claim
 1. 149. A kit comprising a container containing an effective amount of the compound or a pharmaceutically acceptable salt of the compound of claim
 1. 150. A method for preparing a composition comprising the step of admixing a compound or a pharmaceutically acceptable salt of the compound of claim 1 and a pharmaceutically acceptable vehicle.
 151. A compound selected from the group consisting of

and pharmaceutically acceptable salts thereof.
 152. A compound selected from the group consisting of

and pharmaceutically acceptable salts thereof.
 153. A compound selected from the group consisting of

and pharmaceutically acceptable salts thereof.
 154. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

Ar₂ is

R₁ is -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₃ is —H or —CH₃: each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)Cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each -halo is —F, —Cl, —Br,—or —I; n is an integer ranging from 0 to 3; and p is an integer ranging from 0 to
 2. 155. A compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

Ar₂ is

A is

R₁ is -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₃ is —CH₃; R₄ is —H or —(C₁-C₆)alkyl; each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇; —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each -halo is —F, —Cl, —Br,—or —I; n is an integer ranging from 0 to 3; p is an integer ranging from 0 to 2; and x is 0 or
 1. 156. A composition comprising: (i) an effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof, wherein Ar₁ is

Ar₂ is

R₁ is -halo, —(C₁-C₆)alkyl, —NO₂, —CN, —OH, —OCH₃, —NH₂, —C(halo)₃, —CH(halo)₂, or —CH₂(halo); each R² is independently: (a) -halo, —CN, —OH, —O(C₁-C₆)alkyl, —NO₂, or —NH₂; (b) —(C₁-C₁₀)alkyl, —(C₂-C₁₀)alkenyl, —(C₂-C₁₀)alkynyl, —(C₃-C₁₀)cycloalkyl, —(C₈-C₁₄)bicycloalkyl, —(C₈-C₁₄)tricycloalkyl, —(C₅-C₁₀)cycloalkenyl,-(C₈-C₁₄)bicycloalkenyl, —(C₈-C₁₄)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R₅ groups; or (c) -phenyl, -naphthyl, —(C₁₄)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R₆ groups; R₃ is —H or —CH₃: each R₅ is independently —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₆ is independently —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —CN, —OH, -halo, —N₃, —NO₂, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each R₇ is independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —(C₃-C₅)heterocycle, —C(halo)₃, —CH₂(halo), or —CH(halo)₂; R₈ and R₉ are each independently —H, —(C₁-C₆)alkyl, —(C₂-C₆)alkenyl, —(C₂-C₆)alkynyl, —(C₃-C₈)cycloalkyl, —(C₅-C₈)cycloalkenyl, -phenyl, —C(halo)₃, —CH(halo)₂, —CH₂(halo), —OC(halo)₃, —OCH(halo)₂, —OCH₂(halo), —CN, —OH, -halo, —N₃, —N(R₇)₂, —CH═NR₇, —NR₇OH, —OR₇, —COR₇, —C(O)OR₇, —OC(O)R₇, —OC(O)OR₇, —SR₇, —S(O)R₇, or —S(O)₂R₇; each -halo is —F, —Cl, —Br,— or —I; n is an integer ranging from 0 to 3; and p is an integer ranging from 0 to 2; and (ii) a pharmaceutically acceptable carrier or excipient. 